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Combining placido and oct imaging technologies bringing diagnostic power to corneal analysis
1. Combining Placido and OCT Imaging Technologies:
Bringing Diagnostic Power to Corneal Analysis
8 Shareef Mahdavi • SM2 Strategic • Pleasanton, CA 7
The ability of ophthalmic clinicians to evaluate the cornea a direct and magnified view of the cornea; keratometry,
has improved dramatically over the past quarter century. From measuring the change in curvature in the central 3 mm
the era of manual keratometry, new methods of imaging and of the cornea; and contact pachymetry, showing cor-
analyzing corneal structure have emerged and have moved cor- neal thickness at each point of applanation. By the mid
neal care from an analog to a digital world. 1980s, published papers by Rowsey, et al showed how
In the past 10 years, an explosion of technology has emerged Placido rings could be used to construct the cornea, and
that at times can overwhelm the eye care practitioner. SM2 in 1987 Stephen Klyce, PhD (along with Leo Maguire,
Strategic was asked by Carl Zeiss Meditec (Dublin, CA) to help MD) introduced the color-coded contour map and scale
eye doctors understand the path of development that has taken to standardize interpretation, which evolved and became
place and the tools that are now available to help with corneal an ANSI Standard. The following year saw the intro-
analysis in everyday clinical practice. Three leading corneal spe- duction of the first computerized corneal topographer
cialists as well as a pioneer in corneal imaging were interviewed: (Computed Anatomy). The modern age of corneal imag-
Amin Ashrafzadeh, MD (Modesto, CA), Robert Cionni, MD (Salt ing was officially underway.
Lake City, UT), Roger Steinert, MD (Irvine, CA) and Stephen Since that first device, innovation in both imaging
Klyce, PhD (Port Washington, NY). These doctors provided their and interpretation has been spurred by clinical need
perspective on the technological milestones that have led to the and the rise of refractive surgery. In the 1990s, corneal
current state-of-the-art in corneal imaging. topography proliferated and gave refractive surgeons
This report summarizes those interviews and intends to pro- the ability to measure the eye’s surface out to 10 mm
vide ophthalmologists with an appreciation of how rapidly the (ie, beyond the optical zone) both before and after laser
field has changed, while offering guidance in terms of decision- vision correction. Devices from Tomey, EyeSys, and
making with respect to future investment in corneal diagnostics. Humphrey (acquired from ORC) proved most popular
with clinicians. By the late 1990s, surgeons realized that
Technology Development they needed a better way to screen for corneal thinning
The past quarter century has provided stellar innova- and determine which prospective LASIK patients were
tion in the realm of imaging and diagnosis of the cornea most at risk for ectasia and/or keratoconus.
(see Figure 1). For most of the 20th century, clinicians Product developers focused on new approaches to
had three basic tools available: the slit lamp, providing imaging. Orbtec's Orbscan device used a scanning
Figure 1: 25 Years of Corneal Analysis Development Timeline
1987 Late 1980’s 2001 2005 2009
Klyce color scale Ultrasonic Scheimpflug Anterior Placido +
to standardize biomicroscopy corneal segment OCT
interpretation tomography OCT (Zeiss)
(Oculus) (Zeiss)
1984 1987 Early 1990’s Mid & Late 1990s 2000 2002 2007
First papers on First Commercial Slit scanning Placido + Digital VHF Placido +
use of Placido computerized Placido devices device wavefront ultrasound Scheimpflug
to construct/ Placido + slit (Tomey, EyeSys, (Orbscan I) (Nidek) (Artemis 2) (Ziemer)
model cornea device Humphrey) Slit scan + Placido
(Computed (Orbscan II)
Anatomy)
1984 1990 2000 2009
2. slit-beam to image the back surface of the cornea, giv- measuring corneal thickness manually at a handful of
ing clinicians posterior measurements and the ability well-spaced locations in the central cornea.
to calculate elevation from the front to the back of While this device could be used in tandem with a
the cornea. It was limited to 4 diopters of elevation corneal topographer to provide greater information, it
change and required higher-skilled technicians to pre- initially lacked the interpretative power afforded by the
vent patient eye movement and get reliable readings. In Holladay report. By 2007, corneal analysis software for
2000, Nidek’s OPD Scan combined Placido + wavefront the ATLAS 9000 (known as Pathfinder II) gave clini-
measurement in a single device. The use of ultrasound cians an anterior topographic screening module to help
(e.g., ultrasonic biomicroscopy) gave high quality images identify abnormal corneal conditions. And by 2009,
of corneal structure, but had fallen out of favor with Zeiss linked both the ATLAS and Visante together, call-
clinicians due to the required contact via a probe or ing the merged technologies Visante Omni. Each device
water bath. In contrast to Placido-based topographers, now accessed the other’s data, first to ensure proper
Oculus' Pentacam tomographer used slits to generate biometric registration of the eye, then to conduct pre-
cross-sections of the cornea and reconstruct them into a cise analysis of corneal structure and changes over time.
singular image. There were now two different technolo- Interpretation was greatly enhanced when Visante Omni
gies popular for clinical incorporated the tradi-
diagnosis, each deriving Figure 2: Corneal Imaging Technologies and Applications tional Holladay report
its final answer from plus several new color-
different approaches: GALILEI ORBSCAN PENTACAM VISANTE OMNI scale maps to help diag-
the Pentacam, using Placido + Placido + Placido nose, specifically early
Scheimpflug imaging, TECHNOLOGY: Scheimpflug Slit Scanning Scheimpflug + OCT corneal pathology such
measured elevation Anterior & Posterior as suspect keratoconus.
Topography
directly and then calcu-
Narrow angle evaluation Clinical Significance
lated corneal curvature,
Clear Corneal Wound
while Placido measured Evaluation Many diagnostic
corneal curvature Cataract Evaluation and innovations sought to
directly. IOL Placement Analysis improve upon Placido
Surgeons were drawn Evaluation of Pars Plana measurements and
to the Pentacam’s ease- Corneal Transplant render them obsolete,
Planning & Follow-up
of-use with patients yet hindsight reveals a
Iris Tumors
and the interpretive different outcome. “We
Imaging Through Opaque/
software developed by White Corneas have come full circle,”
Jack Holladay, MD; as Phakic IOL Planning noted Roger Steinert,
a result, the Pentacam Full Capability Limited Capability No Capability MD. “We now realize
sold briskly to refractive Placido-based technolo-
surgeons in the early 2000s. By 2005, Carl Zeiss had gies as the most reliable way to analyze anterior corneal
developed an anterior segment OCT device to comple- topography.” Cornea specialist Amin Ashrafzadeh, MD
ment their rapidly-adopted posterior segment version for has been using corneal topography to plan and analyze
use in retina and glaucoma. The Visante OCT provided surgical outcomes since 2001 and believes the Placido
extremely crisp images of corneal structures, allow- disk “remains one of the most essential instruments for
ing both increased width of coverage (out to 16 mm) as imaging the corneal surface.” He lamented, however,
well as depth of coverage (up to 6 mm). This advanced that “up until several years ago, you still had a lot of
technology took multiple “Optical A-scan” images of work to do in figuring out why you had an odd-looking
the cornea and then re-constructed these slices into a cornea.”
“Optical B-scan” image, putting directly into the clinic That burden changed, according to both Steinert
images never before available (except in part from histol- and Ashrafzadeh, when surgeons gained the ability to
ogy slides). The new “map” of the eye included a differ- correlate topography with corneal thinning. Both had
ent pachymetric approach that automated pachymetry attempted to use Scheimpflug – which had become com-
measurement with exponentially greater data points monplace for routine refractive cases – to help with
(2,048). This eliminated the potential inaccuracy from this more sophisticated analysis, but found that they
3. were too often led down in reaching diagnosis,” remarked Dr. Steinert. Figure 2
“The real value of the wrong path in reach- shows the different capabilities of four popular corneal
Visante Omni is its ing the correct diagnosis. imaging devices. An earlier survey by SM2 Strategic of 32
“Anterior topography from of the first users of Visante showed significantly greater
ability to evaluate the Pentacam was pointing usage than anticipated once they had the device in their
numerous data... to a completely different practice and had become familiar with its capabilities.
all in one place” area for astigmatism, and
treating this made cylinder Interpretation Becomes Critical
Robert Cionni, MD worse not better,” said Dr. The sheer volume of data on the cornea now avail-
Steinert. “I went back and able to clinicians places a premium on software analytics
checked the Placido images and found they were accurate; that can reliably distill the images and data points so they
this triggered the realization that we needed to go back to make sense in diagnosis. “The amount of information
Placido based topography.” While the ability to use a sin- can be overwhelming,” according to Dr. Ashrafzadeh.
gle device was indeed convenient, Dr. Ashrafzadeh found “The Holladay report helps tremendously but still has
that the Pentacam software would “fill in” missing data deficiencies that cause me to evaluate the ring image over-
points improperly on slightly irregular surfaces. “I liked laid atop the report.” The real value of Visante Omni,
the way that Scheimpflug image looked, but even looks remarked Dr. Cionni, is it’s ability to evaluate numer-
can be deceiving.” Both remarked that the presence of ous data such as topography, corneal aberrations, ICL
artifacts in Scheimpflug images of suspicious corneas positioning, pachymetry, ectasia analysis, angle measure-
has been a troublesome aspect of that technology. ments… all in one place. Indeed, clinicians should view
This issue appears to have been solved through the Visante Omni as a workstation with multiple capabilities
linking of Placido and OCT, and the applications extend rather than a niche device.
beyond the cornea. Robert Cionni, MD has found that
the Omni allows him greater ability to evaluate aberra- Early Detection Capabilities
tions relevant only to the cornea. “I get better astigmatic Each surgeon interviewed agreed that the Pentacam
analysis with Atlas and my toric IOLs are now more pre- itself is sufficient for the refractive surgeon who is mainly
dictable,” according to Dr. Cionni. concerned about corneal elevation. If you are dealing
Evaluation of glaucoma patients has been greatly only with normal corneas, they say, then the Pentacam
enhanced by Omni. “Pupil size and the resultant angle is fine. The dividing line is drawn around earlier detec-
opening are not influenced by Visante's non-visible light, tion of corneal abnormalities. Dr. Ash did a comparison
providing an exquisitely accurate measure of physiologic study of 60 eyes, measuring them both on the Pentacam
angle opening,” stated Dr. Ashrafzadeh. and the Visante Omni. His findings were that on corneas
with no prior surgery and no opacities, there was good
Efficiency in the Clinic agreement between the devices. But in patients with
Some clinicians view it a disadvantage to have to prior refractive surgery, significant differences emerge. In
use two devices rather than one as part of their corneal this study, Visante showed much greater consistency in
screening. Dr. Ashrafzadeh finds it actually works to his posterior surface findings compared to the variability in
advantage. “I can counsel the patient while I’m doing readings from the Pentacam, which also tended to under-
their Omni readings.” He described how this interaction detect post-LASIK ectasia. The findings on the Visante
allows him to educate the patient and discuss candidacy Omni correlated much more closely to what he was see-
for refractive surgery, while also giving the patient “sig- ing clinically.
nificant confidence in seeing the whole process in action. This type of study illus-
Omni takes away a lot of the mystery by allowing me to “At present, Visante trates the sentiment of Dr.
describe what I’m doing and what the images are telling Omni is the only Steinert regarding a surgeon’s
me…in real time.” technology that I ability to trust the device
Dr. Cionni added, “I am able to show a patient how you are using: “You need
removing their astigmatism will improve their quality of can truly rely upon confidence in your device
vision as well.” for subtle changes.” if you are doing refractive
“If you use Visante for other applications such as Roger Steinert, MD surgery to pick up the subtle
evaluating the angle, then you actually gain efficiency things like Form Fruste