1. Síntesis de Proteínas

2. La síntesis de proteínas se da en el
Reticulo Endoplasmico rugoso.

3. Traducción: Paso de mRNA a Proteína.
DNA
tRNA
Proteína
RNA
Ribosoma
(rRNA)

17. Inicio de la traducción

18. Elongación

19. Elongación

20. Elongación

21. Termino

22. Inicio de la traducción

23. Elongación

24. Termino

25. INHIBITOR SPECIFIC EFFECT
Acting only on bacteria
Tetracycline blocks binding of aminoacyl-tRNA to A-site of
ribosome
Streptomycin prevents the transition from initiation complex to
chain-elongating ribosome and also causes
miscoding
Chloramphenicol blocks the peptidyl transferase reaction on
ribosomes
Erythromycin blocks the translocation reaction on ribosomes
Rifamycin blocks initiation of RNA chains by binding to
RNA polymerase (prevents RNA synthesis)
Acting on bacteria and eucaryotes
Puromycin causes the premature release of nascent
polypeptide chains by its addition to growing
chain end
Actinomycin D binds to DNA and blocks the movement of RNA
polymerase (prevents RNA synthesis)
Acting on eucaryotes but not bacteria
Cycloheximide blocks the translocation reaction on ribosomes
Anisomycin blocks the peptidyl transferase reaction on
ribosomes
α-Amanitin blocks mRNA synthesis by binding preferentially
to RNA polymerase II

29. Degradación
de Proteínas

30. Proteosoma

31. Regulación de
síntesis de proteínas

46. Plegamiento