High throughput screening drug discovery

RITMIR002: High Throughput Screening – A Market Insight Report, Jan 2014
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High Throughput Screening Global Market Size
Scope of the Study
This report gives an insight into High Throughput Screening (HTS) technologies, tools and services. The
report covers HTS technologies including Ultra High Throughput Screening, High Content Screening,
Bioinformatics and Lab-on-a-Chip/Micro fluidics.
The study includes estimates and projections for the total global HTS market. The market covered for Micro
fluidics and Bioinformatics pertains to the applications of HTS.
Projections and estimates are also illustrated by region, by technology and by product segment. The report
serves as a guide to HTS industry, covering more than 600 companies engaged in HTS studies/screening,
products and services.
Business profiles of 43 major global companies are discussed. Major Contract Research Organizations
serving HTS industry are also covered in the corporate directory section of this report.
Information related to recent product releases, product developments, partnerships, collaborations, and
mergers and acquisitions is also covered.
High Throughput Screening report is an ideal research tool providing strategic business intelligence to the
corporate sector.
This report may help strategists, investors, laboratories, pharmaceutical companies, contract research
organizations, biotechnology companies and drug approval authorities in--
 Gauging Competitive Intelligence
 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets

Analytics and data presented in this report pertain to several parameters such as
 Global and Regional Market Sizes, Market Shares, Market Trends
 Product (Global and Regional) Market Sizes, Market Shares, Market Trends
 Technology Trends
 Corporate Intelligence
 Key Companies by Sales, Brands, Products
 Consumer Behavioral Patterns
 Other Strategic Business Affecting Data

Research Methodology
RI Technologies publishes business intelligence reports by going through a cycle of diligent research and
analysis activity.
Research is done using both online and offline resources. The study outline of this report is sketched on the
following lines – global market analysis, regional market analysis, product segmentation,
Global and regional market analysis by product segment, market trends, M&A, R&D, competitive
landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the
industry and is also helpful for doing market evaluations, and estimating the market size for the future.
This report is uniquely researched and the methodology includes:
 Need and Scope of Study
 Product Definitions
 Segmental Analysis
 Regional Analysis
 Exclusive Data Analytics
 Corporate Intelligence
 Feedback
Right from concept to final compilation of this report, both primary and secondary research methods are
applied.
We have provided exclusive feedback forms/pre-release questionnaires for this report to use the
information for authentication of our own findings.
Secondary research includes government publications, investment research reports, web based surveys,
website information of both companies and markets, and other offline resources such as print publications
and CDs.
Our compilation of easy to navigate PDF reports are essential value addition resources for leading and
growing companies.

II. REPORT SYNOPSIS
Foreword
High Throughput Screening (HTS) is the process by which thousands of compounds that possess the
potential of emerging as a new drug are tested using automated machines.
The main objective of carrying out HTS is to remove the inactive compounds at the initial stage and
accumulate the active compounds called hits.
These hits are then put through various tests to obtain the leads. The process of HTS when employed on
half a million compounds, for example, would provide 300 - 400 hits and this in turn would create 3 to 4
Leads.
Strategic partnerships between pharmaceutical and biotechnology companies are the order of the day, and
the trend is increasing globally.
Another significant trend is the alliances between Pharma and Biotech companies and information
technology companies such as Microsoft, IBM, Oracle, Sun, and Infosys, etc.
The computer platforms generated by such companies help in managing and analyzing the huge amounts
of data produced through High Throughput Screening (HTS) and other computational techniques.
Effective R&D strategy involves efficient data management and implementation plans.
The new technologies promise improved efficacy, decreased toxicity in patients, and reduced time frames
and expenditures.
Changing business paradigms brought in by globalization and liberalization are making pharmaceutical
companies change strategies for sustenance and growth.
Many companies are venturing into HTS studies instead of going for alliances, to become self sufficient and
reduce costs.
The R&D wings are increasingly becoming target oriented to face the numerous challenges posed in the
drug discovery and development industry.
Technology and Product Segmentation
Global HTS market is segmented by technology into Ultra High Throughput Screening, High Content
Screening, Bioinformatics and Lab-on-a-Chip/Micro fluidics segments; and by products into HTS Services,
HTS Tools, Other HTS Products and/or Services.

Global Market Analysis
Global High Throughput Screening market is projected to reach about US$ XX.XX billion by 2020 from an
estimated US$ XX.XX billion in 2012, growing at a very high compounded annual growth rate (CAGR) of
XX.XX % during the analysis period 2005-2020.
Exhibit 1. High Throughput Screening – Global Value Market Estimations and Predictions (2005-
2020) in US$ Billion

III. MARKET DYNAMICS
Global HTS Market
Exhibit 2. High Throughput Screening – Global Market Estimations and Predictions (2005-2020) in US$
Million for North America, Europe, Asia-Pacific and Rest of World

Analysis by Technology
Ultra High Throughput Screening
Ultra High Throughput Screening (uHTS) is carried out in cell based assays under various physiological
environments.
This technology finds application in screening of libraries, holding compounds in millions. When counter
screening is employed in cell assays with orthogonal structure, the false positives can be eliminated with
ease.
Exhibit 3. uHTS – Global Value Market Estimations and Predictions (2005-2020) in US$ Million for North
America, Europe, Asia-Pacific, and Rest of World

Analysis by Product Segment
HTS Services
HTS Services market is projected to reach US$ XX.XX billion by 2020, registering a CAGR of XX.XX % during
2005-2020, from an estimated US$ XX.XX billion in 2010.
The North America and Europe accounted for about XX.XX % and XX.XX % of global market for HTS tools in
2010 with estimated market worth US$ XX.XX billion and US$ XX.XX billion respectively.
Asia-Pacific is projected to grow faster, compared to all other regions during the same period.
Exhibit 4. High Throughput Screening Services – Global Value Market Estimations and Predictions (2005-
2020) in US$ Million for United States, Europe, Asia-Pacific, Canada and Rest of World

Global Market Analysis – Cell Based Assays
Global market for Cell Based Assays was estimated at US$ XX.XX million in 2010 and is projected to reach
US$ XX.XX billion by 2020. During the period 2005-2020, worldwide Cell Based Assays market is expected to
register a CAGR of XX.XX %.
Exhibit 5. Cell-Based Assays – Global Value Market Estimations and Predictions (2005-2020) in US$
Million

HIGH THROUGHPUT SCREENING – MARKET OUTLOOK
Global HTS market is projected to grow at a high rate of XX.XX % compounded annually from 2005 through
2020.
This growth is especially driven by the advancements in HTS technologies and the increasing usage of
innovative techniques such as Bioinformatics and Lab-on-a-Chip/Microfluidics.
The success of Human Genome Project and latest findings in genomics and proteomics are creating an
enormous market for HTS by identifying huge number of drug targets.
Currently, automation in HTS industry is in high gear. The companies are investing heavily in laboratory
automation products such as HTS software, database systems, robotics arms and robot based workstations.
The United States is projected to remain the leader in global HTS market until the end of the analysis
period, slightly losing market share from of about XX.XX % in 2010 to XX.XX % in 2020. At the same time
emerging markets including Europe and Asia-Pacific are expected to increase their global market shares.
The European market for HTS is expected to register similar CAGR as that of Asia-Pacific during the analysis
period. While the United States is reaching market saturation for HTS, many major companies including
Biotage AB, Kibron Inc., Biacore International, Evotec AG, Cerep SA, ID Business Solutions Ltd., and Sygnis
Pharma AG are driving the growth of the market in this region.
The UK and Germany are expected to lead the market and account for more than half of the total European
market. Switzerland, The Netherlands, France, Belgium, Sweden and Italy are projected to be the promising
markets in the near future…..

IV. PRODUCT/TECHNOLOGY RESEARCH
High Throughput Screening (HTS) is one of the several tools available for the discovery of a new drug. Paul
Ehrlich used HTS almost a century ago to identify effective compounds for the treatment of syphilis.
Majority of drugs in the market were discovered by using natural product screening. These drugs include
anticancer agents, antibacterial agents and anti parasitic agents.
Conventional screening methods proved to be ineffective in terms of cost, and screening lost its charm,
during the late 1970s and 1980s, as innovative methods began to generate larger number of discovery
leads.
The process of utilization of screening technology on chemical compounds for therapeutical and
pharmaceutical usage is being carried out globally for the past 35 years.
The screening process utilizes the properties of chemical compounds which are made to react with other
compounds, to accomplish the invention of the wonder drug.
This can be considered as the journey of a chemical compound in transforming into an effective drug. The
chemicals that do not comply with the primary screening process are rejected and kept in storage for some
other pharmaceutical use.
With increase in the varieties of diseases attacking mankind, the role of pharmaceutical industries is
becoming more and more challenging.
This has led to enormous improvement and sophistication in medicine discovery, pharmaceutical business,
and research and development, etc.
All these transformations in pharmaceutical industry have further developed the screening technology. The
screening technology has undergone rapid changes to adapt to modern requirements.
The main changes acquired in the screening technology encompass improvements in the instruments,
machineries and testing procedures.
Screening started to regain its importance in the pharmaceutical industry during the mid 1990s. Re-
establishment of HTS is driven by the following factors:
 Identification of large number of drug targets as a result of molecular genetics and recombinant DNA
usage
 Availability of cloned genes that have rejuvenated the screening procedures
 Improvements in combinatorial chemistry that generate more compounds for screening
 Technological advances in biotechnology that have led to the implementation of cost effective
screening systems with the help of innovative detection systems
 Automation in screening process that facilitate the screening of more samples in a short period of time
 Computerized data handling and analysis

Exhibit 6. Global Market for Cell Based Assays (2005 & 2007): Percentage Breakdown of Market Shares
for GE Healthcare, PerkinElmer, BD Biosciences, Beckman Coulter, Life Technologies, and Other
About RI Technologies
RI Technologies is a premier source of market research on the Biotechnology & Healthcare sector. We
emphasize on factual insights and forecasts with maximum global coverage.
RI Technologies is constantly monitoring the biotechnology & Healthcare industry, tracking market trends,
and forecasting industry based on specialized analysis.
The life sciences sector is an ever growing marketplace with emerging technologies in areas of discovery,
design and development.

Research – As Good as the Methodology is!
 Gauging Competitive Intelligence
 Identifying Key Growth Areas and Opportunities
 Understanding Geographic Relevance to Product
 Knowing Regional Market Sizes and Growth Opportunities and Restraints
 Keeping Tab on Emerging Technologies
 Equity Analysis
 Tapping New Markets
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High throughput screening drug discovery

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High throughput screening drug discovery