Advanced Orthopedic Technologies, Implants and Regenerative Products

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Advanced Orthopedic Technologies, Implants and Regenerative
Products
Published on January 2011

Report Summary

THE REPORT CONTAINS

The total market for advanced orthopedic technology and products was estimated to exceed $27.7 billion in 2009, from $26.4 billion
the previous year (2008). By 2015, the advanced orthopedic technology and product market is likely to reach $32.4 billion, with
average growth estimated at 2.7%.
Worldwide, the bone repair and regenerative product market has increased over the past several years. In 2009, the market
experienced an increase over the $2.9 billion in 2008 to reach $3.1 billion.
Worldwide, the total joint replacement, implant and regenerative product markets generated approximately $23.2 billion in 2009,over
$22.3 billion estimated for 2008

INTRODUCTION

STUDY GOALS AND OBJECTIVES

This report provides an overview of products in the advanced orthopedic market, offers detailed market analyses, and discusses
competitive environments. The study includes information about significant products and players, issues and trends, as well as other
data affecting the orthopedic device industry.

REASONS FOR DOING THE STUDY

With technology advancements and a better understanding of the body, the orthopedic device market offers a range of highly complex
and leading-edge products. They now are a significant part of the industry. While there are many conventional and generally less
expensive products, new items and biotechnological advancements are beginning to revolutionize future growth of the orthopedic
device market. The latest technological products are competing in a fast track market that looks to improve the quality of life for
millions of individuals who need procedures such as hip and knee transplants.

Ongoing patient management studies, combined with a drive to produce technologically superior products, will increase the number of
patients who can benefit from developments in the advanced orthopedic product market. This study will provide readers with the
knowledge needed to adequately view and assess this market and will provide insights into the market potentials, including trends
that are, and will continue to drive this segment in the future.

SCOPE OF THE REPORT

This study will be a helpful business tool providing a thorough evaluation of the advanced orthopedic market. Its geographic scope is
global with special emphasis on the United States and the European Union. The report identifies markets in three general segments:

Bone repair and regenerative products
Cartilage and soft tissue repair and regenerative products

Advanced Orthopedic Technologies, Implants and Regenerative Products Page 1/13


Joint replacement, implants, and regenerative products.

Each market segment provides detailed information based on product categories, product use, forecasts, and competitive analyses.

Advanced orthopedics deals with those products involving new techniques and therapies. They provide a significant patient outcome
over traditional methods, as well as improving healing and lowering overall care costs. These products incorporate biotechnological
advancements and improved methods for dealing with orthopedic injuries and conditions.

Products in this study are considered to be at the forefront of orthopedic device technology. Products not considered advanced
include external bracing, slings, casting materials etc. Those classified by industry experts as advanced orthopedic products include:
human bone products and materials, bone growth stimulators, synthetic bone replacements, cartilage and soft tissue fixation systems,
biologics/biomaterials, complex joint replacement devices, spine devices, and joint fluid replacements.

METHODOLOGY

The information for this report was obtained through primary and secondary data collection methods. Primary sources included
interviews with more than 50 key executives, product managers, clinical specialists and other related key personnel involved with the
orthopedic industry. Secondary sources included published literature, investment reports, company literature, and various business
journals that have emphases on orthopedic devices and related areas.

Market data for this report pertains to the world market in U.S. dollars at the manufacturers' level. The base year of the report is 2010,
with historical data provided for 2008 and 2009 and with forecast data provided for 2015. Historical, base year, and forecast data are
provided for each market segment of the report. Growth rates are determined through a compilation of data including past trends,
future trends, demographics, incidence, mortality, products in research and development, current product growth, etc. Competitor
market share estimates are provided for each market segment for the 2010 base year.

ABOUT THE AUTHOR

Melissa Elder is an experienced healthcare market analyst specializing in prescription and over-the-counter pharmaceuticals, medical
devices, and emerging healthcare technologies. Ms. Elder has more than 15 years experience in the healthcare industry, specializing
in market research for the past 12 years. This experience has given her substantial insights into pharmaceutical market analysis. Her
work in the medical community, including emergency room medical training and healthcare information system coordination, has
enhanced her ability to provide insight into many healthcare markets.

Table of Content

Chapter- 1: INTRODUCTION

STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THE STUDY 1
SCOPE OF THE REPORT 1
METHODOLOGY 2
RELATED BCC STUDIES 2
ABOUT THE AUTHOR 3
BCC ONLINE SERVICES 3
DISCLAIMER 3
DISCLAIMER (CONTINUED) 4



Chapter-2: SUMMARY

SUMMARY 5
SUMMARY (CONTINUED) 6
SUMMARY TABLE GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, THROUGH 2015 ($
MILLIONS) 7
SUMMARY FIGURE ADVANCED ORTHOPEDIC TECHNOLOGY, IMPLANTS AND REGNERATIVE PRODUCTS, 2008-2015 ($
MILLIONS) 8

Chapter-3: INDUSTRY OVERVIEW

HISTORY OF THE ORTHOPEDIC INDUSTRY 9
ADVANCED ORTHOPEDIC MARKET DEVELOPMENT 9
GOVERNMENT REGULATION OF DEVICES 10
Regulation, Cost and Classification of Devices by Region 10
Costs 10
FIGURE 1 STANDARD SUBMISSION FEES AND EXPENDITURES FOR DEVICE APPROVALS PER COUNTRY, 2010 (FILING
FEES FOR 510(K) AND SIMILAR DEVICES 11
United States (FDA) 11
510(k) Exemptions 12
TABLE 1 PARTS 862-892 OF 21 CFR 13
Humanitarian Device Exemption (U.S.) 14
TABLE 2 LISTING OF ORTHOPEDIC-RELATED CDRH HUMANITARIAN DEVICE EXEMPTIONS, CURRENT THROUGH
SEPTEMBER 2010 15
TABLE 2 (CONTINUED) 16
Investigational Device Exemption (IDE) 17
Changes in FDA Advisor Roles 17
Canada (Health Canada) 18
Europe (MDD) 19
Japan 20
Japan (Continued) 21
Australia 22
TREATMENT SETTINGS 23
Ambulatory Treatment Facilities 23
TABLE 3 U.S. AMBULATORY VISITS ALL AGES BY FACILITY TYPE, 1996 AND 2006 (PER 100 POPULATION) 23
TABLE 4 U.S. EMERGENCY ROOM VISITS BY INJURY LOCATION AND SPORT/ACTIVITY, 2006-2008 24
Orthopedic Rehabilitation Facilities and Physical Therapy 24
Orthopedic Surgeons 25
TABLE 5 U.S. PHYSICIANS BY SELECTED SPECIALTY, 1980'2007 (THOUSANDS) 25

Chapter-4: ISSUES AFFECTING THE MARKET

INSURANCE AND REIMBURSEMENT ISSUES 26
TABLE 6 MEDICARE REIMBURSEMENT RATES FOR COMMON ORTHOPEDIC PROCEDURES, 2009 ($) 27
TABLE 7 HEALTH EXPENDITURES AS PERCENT OF GDP BY COUNTRY: 1980 TO 2006 (%) 28
FIGURE 2 HEALTH EXPENDITURES AS PERCENT OF GDP BY COUNTRY: 1980 TO 2006 (%) 29
MEDICAL DEVICE PRICING TRENDS 29
MARKETING AND ADVERTISING ISSUES AND TRENDS 29
LEADING MANUFACTURERS' STRATEGIES 30



Manufacture, Distribution and Supply 31
TABLE 8 ADVANCED ORTHOPEDIC MANUFACTURING AND SUPPLY FACILITIES 32
Alphatec 33
Biomet, Inc. 33
DJO, Inc. 33
Exactech 33
LifeCell 34
Orthovita 34
Smith & Nephew 34
Stryker 34
Wright Medical 35
Zimmer Holding 35
Sales and Marketing 35
TABLE 9 ADVANCED ORTHOPEDIC SALES, MARKETING AND ADMINISTRATIVE EXPENDITURES BY MANUFACTURER FOR
FISCAL YEARS 2009 AND 2010 ($ MILLIONS) 36
FIGURE 3 ADVANCED ORTHOPEDIC SALES, MARKETING AND ADMINISTRATIVE EXPENDITURES BY MANUFACTURER FOR
FISCAL YEARS 2009 AND 2010 ($ MILLIONS) 38
Arthrocare 38
Biomet, Inc. 38
Exactech 39
Genzyme Biosurgery 39
Integra Life Sciences 39
Orthovita 39
Smith & Nephew 40
Stryker 40
Wright Medical 40
Zimmer Holding 40
Research and Development Trends 41
TABLE 10 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED ORTHOPEDIC MANUFACTURERS AND
SUPPLIERS, 2008-2010 (ESTIMATED) ($ MILLIONS) 42
FIGURE 4 RESEARCH AND DEVELOPMENT EXPENDITURES FOR ADVANCED ORTHOPEDIC MANUFACTURERS AND
SUPPLIERS, 2008-2010 ESTIMATED ($ MILLIONS) 43
Acquisitions, Alliances, and Agreements 43
Alphatec 43
Baxter International, Inc. 44
Exactech 44
Medtronic 45
NuVasive 45
Smith & Nephew 45
Wright Medical 45
Employee Snapshot and Distribution 46
TABLE 11 EMPLOYEE DISTRIBUTION FOR ORTHOPEDIC MANUFACTURERS AND SUPPLIERS, 2009 ($ MILLIONS) 46
MEDICAL TOURISM IMPACT ON THE ORTHOPEDIC MARKET 47
TABLE 12 HIP REPLACEMENT: GLOBAL COST VARIATIONS, 2008 DATA 48
FIGURE 5 HIP REPLACEMENT: GLOBAL COST VARIATIONS, 2008 48
TABLE 13 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 49
FIGURE 6 U.S. HEALTH INSURANCE COVERAGE BY AGE GROUP (%) 50
TABLE 14 WORLD HEALTH ORGANIZATION RANKING OF HEALTHCARE SYSTEMS, TOP 50 51



DEMOGRAPHICS AND AGING POPULATIONS 52
World Demographics 52
TABLE 15 ESTIMATED WORLD POPULATION AND ANNUAL GROWTH BY SELECTED AGE GROUP AND SELECTED YEARS,
THROUGH 2030 (MILLIONS) 53
FIGURE 7 ESTIMATED WORLD POPULATION BY SELECTED AGE GROUP AND SELECTED YEARS, 2000-2030 (MILLIONS) 53
TABLE 16 WORLD POPULATION BY SELECTED COUNTRIES, THROUGH 2015 (MILLIONS) 54
FIGURE 8 WORLD POPULATION BY SELECTED COUNTRIES, 2008-2015 (MILLIONS) 55
U.S. Demographics 55
TABLE 17 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP, 1900 TO 2050 (THOUSANDS) 56
FIGURE 9 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP, 1900 TO 2050 (THOUSANDS) 56
Gender, Age, and Life Expectancy 57
TABLE 18 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH PROJECTIONS BY SEX, 2000 AND 2020
(YEARS) 57
FIGURE 10 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH PROJECTIONS BY SEX, 2000 AND 2020
(YEARS) 58
INCIDENCE OF ORTHOPEDIC CONDITIONS 58
Osteoarthritis 58
Rheumatoid Arthritis 59
Ankylosing Spondylitis 59
Fibromyalgia 59
Gout 60
Scleroderma 60
Lupus 60
Bursitis and Tendonitis 60
Osteoporosis 61
Low Bone Mass 61
TABLE 19 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE GLOBAL ORTHOPEDIC
INDUSTRY, AVERAGE FIGURE, 2008'2010 (MILLIONS) 61
FIGURE 11 ESTIMATED* PREVALENCE/INCIDENCE OF CONDITIONS AFFECTING THE GLOBAL ORTHOPEDIC INDUSTRY,
AVERAGE FIGURE 2008'2010 (%) 62
FIGURE 11 (CONTINUED) 63
ORTHOPEDIC PROCEDURE VOLUMES IN THE UNITED STATES 63
FIGURE 12 NUMBER OF U.S. HIP REPLACEMENT PROCEDURES, 2000'2010 (THOUSANDS) 64
FIGURE 13 NUMBER OF U.S. KNEE REPLACEMENT PROCEDURES, 2000'2010 64
FIGURE 13 (CONTINUED) 65
FIGURE 14 NUMBER OF U.S. SPINAL FUSION PROCEDURES, 2000'2010 (THOUSANDS) 65
FIGURE 15 NUMBER OF U.S. PHYSICIAN VISITS FOR ROTATOR CUFF PROBLEMS, 2000'2010 (MILLIONS) 66
RISING ORTHOPEDIC INCIDENCE AND EVOLVING LIFESTYLE TRENDS 66
Overweight and Obesity 66
TABLE 20 U.S. AGE-ADJUSTED PERCENT DISTRIBUTION OF BODY MASS INDEX (BMI) AMONG PERSONS 18 YEARS AND
OVER BY SELECTED CHARACTERISTICS, 2003-2006 67
FIGURE 16 OBESITY PERCENTAGES BY COUNTRY, 2006 (%) 68
Smoking 69
TABLE 21 PERCENT OF SMOKERS IN THE U.S. POPULATION 18 AND OLDER BY AGE AND SEX, 2007 69
TABLE 22 DAILY TOBACCO CONSUMPTION BY COUNTRY: 1990 COMPARED TO 2006 70
Sedentary Lifestyle 70
TABLE 23 PERCENT OF U.S. ADULTS ENGAGING IN PHYSICAL ACTIVITY AND FITNESS BY SELECTED CHARACTERISTICS,
2006 71



Nutrition 71
COMPARISON OF BONE MINERAL DENSITY LEVELS IN POPULATIONS 71
Comparison of Bone Mineral ' (Continued) 72

Chapter-5: TECHNOLOGY

INTRODUCTION 73
PATENT TRENDS 73
ORTHOPEDIC PATENTS BY YEAR 73
TABLE 24 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 1995'2010* 74
FIGURE 17 NUMBER OF ORTHOPEDIC PATENTS ISSUED BY YEAR, 1995'2010* 75
INTERNATIONAL PATENTS BY COUNTRY OF ORIGIN 75
TABLE 25 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 1976'2010 76
FIGURE 18 ORTHOPEDIC PATENTS BY COUNTRY OF ORIGIN, 1976'2010 76
PATENT TRENDS BY ASSIGNEE 77
TABLE 26 ADVANCED ORTHOPEDIC PATENT INFORMATION BY ASSIGNEE 77
FIGURE 19 TOTAL NUMBER OF PATENTS HELD, BY ASSIGNEE 81
Biomet 81
ConMed 82
DePuy 82
Encore Medical (now DJO Surgical) 82
Exactech 82
Medtronic Sofamor Danek 83
Smith & Nephew 83
Stryker 83
Synthes 84
Warsaw Orthopedic 84
Wright Medical 85
Zimmer 85
ADVANCED ORTHOPEDIC TECHNOLOGIES 85
Bone Growth Stimulation Devices 86
Orthopedic Growth Factors 86
Transcutaneous Electrical Nerve Stimulation Units (TENS) 87
Light Therapy (Light-Emitting Diodes and Infrared) 87
Light Therapy '(Continued) 88
Thermal Imaging 89
Nanotechnology and Microprocessors 89
Digital X-rays 90
Bone Density Improvements 90
High-resolution Cartilage Imaging 90
Stem Cells 91
Government Limitations 91
Embryonic Stem Cells 92
Adult Stem Cells 92
Bone Technology and Stem Cells 92
Synthetic Bone Grafting 93
Bone Modeling for Osteoporotic Spinal Fracture Testing 93



Advanced Mechanical Implant Creation 93
Advanced Mechanical ' (Continued) 94

Chapter-6: BONE REPAIR AND REGENERATIVE PRODUCTS

SEGMENT OVERVIEW 95
BONE GRAFTS 95
TABLE 27 BONE GRAFT PRODUCTS AND MATERIALS 96
PROCEDURES USING BONE GRAFTS 97
PRODUCT DESCRIPTIONS 97
HUMAN BONE PRODUCTS 98
TABLE 28 HUMAN BONE PRODUCTS AND COMPETITORS 98
Biomet 99
DePuy 99
Exactech 99
LifeCell, Inc. 100
Medtronic 101
Smith & Nephew 101
Wright Medical 101
Zimmer Holding 102
BONE GROWTH STIMULATORS 102
TABLE 29 BONE GROWTH STIMULATOR (BIOLOGICAL) PRODUCTS AND COMPETITORS 102
TABLE 30 BONE GROWTH STIMULATOR (ELECTRICAL/ULTRASOUND DEVICES) PRODUCTS AND COMPETITORS 103
Biomet 103
DJO, Inc. 103
Medtronic 104
NuVasive 105
Orthofix International 105
Smith & Nephew 106
Stryker 106
SYNTHETIC BONE REPLACEMENTS 107
TABLE 31 SYNTHETIC BONE REPLACEMENT PRODUCTS AND COMPETITORS 107
Apatech 108
Biomet 108
DePuy 108
Exactech 109
Medtronic 109
Orthovita 109
Smith & Nephew 110
Stryker 110
Synthes 110
Wright Medical 110
Zimmer Holdings, Inc. 111
NEW DEVELOPMENTS 111
ALPHATEC 111
KAKEN PHARMACEUTICALS CO, LTD. 111



ORTHOVITA 111
MARKET ANALYSIS 112
MARKETS BY PRODUCT TYPE 112
Markets by Product Type (Continued) 113
TABLE 32 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET, THROUGH 2015 ($ MILLIONS) 114
FIGURE 20 BONE REPAIR AND REGENERATIVE PRODUCTS MARKET, 2008-2015 ($ MILLIONS) 114
SALES DISTRIBUTION BY PROCEDURE TYPE 114
TABLE 33 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY PROCEDURE TYPE, 2010 (%/$
MILLIONS) 115
FIGURE 21 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 ($
MILLIONS) 115
MARKETS BY WORLD REGION 116
TABLE 34 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 (%/$
MILLIONS) 117
FIGURE 22 REVENUE DISTRIBUTION FOR BONE REPAIR AND REGENERATIVE PRODUCTS BY WORLD REGION, 2010 (%)
117
LEADING SUPPLIERS AND PARTICIPANTS 117
Leading Suppliers and Participants (Continued) 118
TABLE 35 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2010 (%/$
MILLIONS) 119
FIGURE 23 SUMMARY OF BONE REPAIR AND REGENERATIVE PRODUCTS BY COMPETITOR REVENUES, 2010 ($
MILLIONS) 120

Chapter-7: CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS

SEGMENT OVERVIEW 121
PRODUCT DESCRIPTIONS 122
FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES 122
TABLE 36 FIXATION SYSTEMS AND OTHER SPECIALIZED DEVICES AND MARKETERS 122
Arthrex 124
ArthroCare 124
Biomet 124
Conmed Linvatec 124
Covidien 125
DePuy 125
Ortheon Medical 126
Smith & Nephew 126
Stryker 127
Zimmer Holding 127
BIOLOGICS AND BIOMATERIALS 127
TABLE 37 CARTILAGE AND SOFT TISSUE BIOLOGICS AND BIOMATERIALS SEGMENT 127
Aesculap 128
Biomet 128
DePuy 128
LifeCell, Inc. 129
Organogenesis 129



Stryker 129
Synovis 129
Wright Medical 129
Zimmer Holding 130
Arthrocare 130
Wright Medical 130
Zimmer 130
MARKET ANALYSIS 131
TABLE 38 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS MARKET, THROUGH 2015 ($
MILLIONS) 133
FIGURE 24 CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS MARKET, 2008-2015 ($
MILLIONS) 133
MARKETS BY WORLD REGION 133
TABLE 39 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER SOFT TISSUE REPAIR AND
REGENERATIVE PRODUCTS BY REGION, 2010 (%) 134
FIGURE 25 GLOBAL DISTRIBUTION OF REVENUES FROM CARTILAGE AND OTHER SOFT TISSUE REPAIR AND
REGENERATIVE PRODUCTS BY REGION, 2010 (%) 135
Leading Suppliers and ' (Continued) 136
TABLE 40 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BY
COMPETITOR REVENUES, 2010 (%/$ MILLIONS) 137
FIGURE 26 SUMMARY OF CARTILAGE AND OTHER SOFT TISSUE REPAIR AND REGENERATIVE PRODUCTS BY
COMPETITOR REVENUES, 2010 ($ MILLIONS) 137

Chapter-8: JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS

SEGMENT OVERVIEW 138
SEGMENT OVERVIEW (CONTINUED) 139
PRODUCT DESCRIPTION 140
Hip Replacements 140
TABLE 41 HIP REPLACEMENT PRODUCT SUPPLIERS 141
Biomet 141
DePuy 142
DJO, Inc. 142
Exactech 143
Smith & Nephew 143
Stryker 144
Wright Medical 145
Zimmer Holding 145
Knee Replacements 146
TABLE 42 KNEE REPLACEMENT PRODUCT SUPPLIERS 146
Biomet 146
DePuy 147
DJO, Inc. 147
Exactech 147
Smith & Nephew 148
Stryker 148



Wright Medical 149
Zimmer Holding 149
Spine Replacements 150
TABLE 43 SPINE REPLACEMENT PRODUCT SUPPLIERS 150
Aesculap 151
Alphatec 151
Biomet Spine 151
DePuy Spine 152
Exactech 152
Integra Life Sciences (Integra Spine) 152
Medtronic 153
Orthofix International 154
Stryker 154
Synthes 155
Zimmer 155
Other Extremity Replacements and Joint Products 156
TABLE 44 OTHER EXTREMITY REPLACEMENTS, JOINT PRODUCT SUPPLIERS 156
Biomet 156
DePuy 157
DJO, Inc. 157
Exactech 157
Small Bone Innovations 158
Stryker 158
Wright Medical 158
Zimmer Holding 159
Biological Joint Products and Other Related Devices 159
TABLE 45 BIOLOGICAL JOINT PRODUCTS AND OTHER RELATED DEVICES 160
Bioniche Pharma (Mylan) 160
DePuy 160
Ferring Pharmaceuticals 161
Sanofi-Aventis 161
Smith & Nephew 162
Alphatec 162
Biomet 163
DePuy 163
ConMed Linvatec 164
Osiris Therapeutics 164
NuVasive 165
Wright Medical 165
MARKET ANALYSIS 165
TABLE 46 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT MARKETS, THROUGH 2015 ($ MILLIONS) 168
FIGURE 27 JOINT REPLACEMENT, IMPLANT AND REGENERATIVE PRODUCT MARKETS, THROUGH 2015 ($ MILLIONS) 168
MARKETS BY WORLD REGIONS 169
TABLE 47 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS,



2010 (%) 169
FIGURE 28 GLOBAL REVENUE DISTRIBUTION FOR JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS,
2010 (%) 170
LEADING SUPPLIERS AND PARTICIPANTS (CONTINUED) 171
TABLE 48 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS BY COMPETITOR
REVENUES, 2010 ($ MILLIONS) 172
FIGURE 29 SUMMARY OF JOINT REPLACEMENTS, IMPLANTS AND REGENERATIVE PRODUCTS BY COMPETITOR
REVENUES, 2010 ($ MILLIONS) 173

Chapter-9: MARKET SUMMARY

GLOBAL MARKET ANALYSIS 174
TABLE 49 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, THROUGH 2015 ($ MILLIONS) 175
FIGURE 30 GLOBAL MARKET FOR ADVANCED ORTHOPEDICS BY PRODUCT SEGMENT, 2008-2015 ($ MILLIONS) 176
GEOGRAPHIC MARKET ANALYSIS 176
TABLE 50 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION BY REGION, 2010 ($ BILLIONS) 177
FIGURE 31 GLOBAL ADVANCED ORTHOPEDIC PRODUCT REVENUE DISTRIBUTION BY REGION, 2010 ($ BILLIONS) 178
INDUSTRY PARTICIPANTS 178
TABLE 51 ADVANCED ORTHOPEDIC TECHNOLOGY INDUSTRY PARTICIPANTS BY TYPE, 2009'2010 179
INDUSTRY PARTICIPANTS (CONTINUED) 180
TABLE 52 ADVANCED ORTHOPEDIC COMPETITORS' MARKET SHARE ESTIMATES, 2010 ($ BILLIONS) 181
FIGURE 32 DISTRIBUTION OF SALES BY COMPETITOR, 2010 ($ BILLIONS) 181

Chapter-10: COMPANY PROFILES

INTRODUCTION 182
ARTHREX, INC. 182
ARTHROCARE CORP. 183
BIOMET, INC. 184
CONMED LINVATEC 185
DEPUY, INC. 185
EXACTECH, INC. 186
GENZYME BIOSURGERY 187
INTEGRA LIFE SCIENCES 188
MEDTRONIC SOFAMOR DANEK 188
NUVASIVE, INC. 189
ORTHOFIX INTERNATIONAL N.V. 190
SMITH & NEPHEW, PLC 191
STRYKER CORP. 191
SYNTHES GMBH 192
WRIGHT MEDICAL TECHNOLOGY, INC. 193
ZIMMER HOLDINGS, INC. 194

Chapter-11: APPENDIX

APPENDIX: LEADING PRODUCT MANUFACTURERS 195
LEADING PRODUCT MANUFACTURERS 195
LEADING PRODUCT MANUFACTURERS (CONTINUED) 196



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