Dr. Ravi Dhar reviews " Bioincubators in India 2014"

Brief Review on Bio-incubator
Scenario in India
Ravi Dhar, Ph.D.
2014
(rdhar_in@yahoo.com)
7.2.2013 RD_Bioincubators in India_2014 1

Information Sources
• DBT website
• ISBA (2013) conference
• BIRAC website
• BioSpectrum, India
• Venture Center, NCL, Pune
• National News papers
• Various Books, Journals & numerous websites
• Genetic Engineering & Biotechnology News

WHAT IS A BIOINCUBATOR?
“A bio-incubator is a program designed to promote the
successful development of biotechnology start-ups and
early-stage companies, mostly prior to proof-of-concept.
Similar to business incubator programs, which offer an
array of business support resources and services to
stimulate the entrepreneurial development of young
companies, a bio-incubator is targeted towards the Life
Sciences industry. Biotech start-ups benefit from seed
capital, use of research and development facilities and an
array of business support resources to accelerate
successful development”. (Wikipedia)

Definition as Perceived
“A Bioincubator is a building designed for
housing R&D driven companies active in Life
sciences. It is mostly closely related to a
neighbouring university. A Bioincubator is a
Business incubator targeted towards Life
Sciences helping start-up companies.
Entrepreneurs with feasible projects in Life
Sciences are selected and admitted into the
incubators, where they are offered a specialized
menu of support resources and services,
including mentoring”

Models of Incubators
S.
No.
Type Remarks
1. Technology Business
Incubators
Computers, Servers, small investment
Generate business
2. Bio-incubators
(U.S.A./Europe)
Fosters successful entrepreneurs in
dozens
3. Bio-incubators (India-
DBT_BIRAC)
Meant to foster entrepreneurs – some
success (2006/ 2010…)
4. Taube-Koret Type, U.S.A. Non-profit incubator + academic
interactions; up-scaling by various
players (2010)
5. Science Incubators
(U.S.A.)
Synthesis centers: meant to add value
to existing data only (2012…)
(compiled by R.D. in 2013)

Incubators
1. Information Technology Type
2. U.S.A/European (highly evolved)
3. India: DBT_BIRAC (evolving)
4. Taube-Koret Type (Non-profit Incubator +
academic interactions; up-scaling by various
players)(2010)
5. Science Incubators (Synthesis centers: to add
value to existing data)

Building a Successful Biotech Incubator
Proximity to Academic Hubs and Capital Remains a Crucial Factor in
Hatching a Thriving Cluster. Examples:-
San Francisco companies:
University of California at San Francisco
Stanford University
UC-Berkeley and
& to some extent, Cal Tech.
Boston has:
Harvard University
MIT
Boston University
 Seattle has:
University of Washington.
Research Triangle Park is relatively near:
Duke and the University of North Carolina. Buffalo, NY, cites the
Hauptman-Woodward Medical Research Institute, as well as the
University of New York at Buffalo with its strong departments of
chemistry, engineering, and bioinformatics.

A model non-profit biotechnology incubator to facilitate academic drug discovery and
development
The Taube-Koret Center acts as a bidirectional bridge between academia and industry to reduce the risk in the development of therapeutics. Discoveries
with therapeutic potential are made in academic laboratories and are transferred to the Taube-Koret Center within the same institution. The Center
maintains the necessary expertise in drug discovery and medicinal chemistry to validate targets and discover and optimize small molecules to modulate
these targets. Contract research organizations are used by the Center as needed to carry out specific steps in drug development. Leads that fail to meet
performance targets are returned to the academic labs that discovered them for further optimization. Leads that meet milestones are advanced until
partners can be found to co-develop them further. The potential paths to therapeutics via partners (black arrows) can involve foundations, the NIH, existing
biotechnology companies, new companies created by venture capitalists, or major pharmaceutical (pharma) companies. Since the Center's overarching goal
is to find effective therapies for neurodegenerative diseases, rather than to make a profit from proprietary programs, it can make its new technologies,
assays and disease models available to external entities that want to evaluate the efficacy of their lead programs (gray arrows).
Nature Medicine, 16, 1227–1232 (2010)

Bio-incubator Scenario in India
• Life science (mixed) incubators: 52
• North : 10
• South : 27
• East : 5
• West : 8
Exact Classification not clear
(Source: VC, NCL, Pune-2012)

Development of Bio-incubators
is related to
Evolution of Biotechnology over years
Basic Research/Discovery
Innovation
Enterprise

Evolution of Biotechnology in India
over years
Innovation
Enterprise
Govt.FundingSupport

Evolution of Biotechnology
over years
Innovation
Enterprise
Phase-I:BasicInfrastructure/Capacity
FundingSupport

Evolution of Biotechnology
over years
Innovation
Enterprise
Phase-I:BasicInfrastructure/CapacityPhase-II:ProductDevelopment
Public or
Private
Incubator
Space or
SMEs
FundingSupport
I
II

Phase I to II Syndrome ?
We need to get out of this
syndrome
Maintaining a Balance between
Basic and Translational Research

Parks & Incubators
Govt. of India through DBT & BIRAC initiated
several Parks & incubators
sometime back
Definitions:
Science Parks:
An area usually linked with a university where scientific research and
commercial development are carried on in cooperation
Bio-incubators:
Incubators specifically are meant to allow young incubatees / start-up
companies to initiate and dabble into entrepreneurship

Indian Govt. Mandate
• Funding of various Research & Technology
schemes by DBT/DST/ICMR
• National Biotech Policy (2007) mandated
30% funding for PPP
• BIRAC (=BIRAP) funded schemes:
• SBIRI
• BIPP
• Bio-Incubators
• CRS
• BIG
• Capacity Building + Training
• Corporate Social Responsibility Initiatives
• Technology Acquisition Efforts
BIRACDBT

Indian Government Mandate on BioIncubators
 Trigger & Transform Biotech Start-ups to convert innovative
research in Public and Private sector
 Support & Strengthen Entrepreneurship, SME’s, facilitates high risk research,
innovation and product development
 Financial, Infrastructural, Institutional & Mentoring support for budding
entrepreneurs
 Encourage Knowledge Networking among biotech entrepreneurs at National
International Level
 Policy and Institutional Support for all Stakeholders in Biotech
 Conceptualize and Support development of affordable, novel, deployable
products and technologies in Healthcare, Agriculture, Environment Bio-energy
involved in PPP
 Promote Secondary Agriculture for providing opportunity in entrepreneurship
& employment.

Evolution of Biotechnology in India
over years to foster
Public Private Partnerships
Innovation
Enterprise
Phase-I:BasicInfrastructure/CapacityPhase-II:ProductDevelopment
Public or Private
Incubator Space
or SMEs
FundingSupport:
(A)TaskForceProjects
(B)BIG/SBIRI/BIPP/CRS
BIG
Grant
CRS

Funding Support (loans or grants) in INR
BIG SIBRI BIPP CRS BISS +UIC
50 Lacs 2 Cr 50 Cr > Case to case Case to case
National Biotechnology Policy
7.2.2013 19RD_Bioincubators in India_2014
+ UIC

An Ideal Incubator
• Building designed for housing incubatees or start-up
entrepreneurs active in Life Science
• Presence of neighbouring academic organizations or
universities or hospitals or R&D Industrial units.
• It, therefore, is a like a Business Incubator targeted
towards Life Sciences helping start-ups.
• Entrepreneurs with feasible projects in Biotechnology are
selected and admitted into the incubators as tenants,
where they are offered a specialized menu of support
resources and services, including mentoring.

Wet Lab space &
Equipment
Office Cubicles
for
Incubatees/Data
Admin/IT/
Security/
services/Library
Food Court/
Canteen
Resting space
Reagents &
Chemical Store

Who Occupies the Bio-incubator
• Incubatees (fresh M.Tech/Ph.D./M.B.B.S/ M.Sc etc)
• Entrepreneurs
• Parties graduating to be SMEs

Bio-incubation is a Time
Consuming Process
• Biotech requires more time
• Biotech requires more funding
• Importance of shared infrastructure
• Specialized management is crucial
• Special mentors for incubatees

Benefits of Incubators
• Job Creation
• Building or accelerating growth of local
academic and industry clusters
• Fostering a community's entrepreneurial
climate
• Technology commercialization
• Diversifying local economies
• Business creation and retention
• Encouraging women or minority entrepreneurship
• Identifying potential spin-in or spin-out business
opportunities
• Community revitalization

Scientific Quality/Quantum is
Essential for Entrepreneurship......
Canada
Korea
Italy
Netherlands
Switzerland
India
Belgium
Sweden
Russian Federation
Poland
Australia
Brazil
Spain
United States
Germany
France
China
Japan
United Kingdom
1998 2008/2010
Canada
Korea
Italy
Netherlands
Switzerland
India
Belgium
Sweden
Russian Federation.
Poland
China
Japan
Australia
Brazil
Spain
United States
Germany
France
United Kingdom
Source: OECD (2010) Measuring Innovation: A New Perspective (modified)
?
7.2.2013 RD_Bioincubators in India_2014
?
25

Support system for Scientific Output,
Entrepreneurship
&
Job Creation

Where is India Positioned?
TDB-TBIs/NSTEDB/Private players
DBT Bio-incubators
CIC at Delhi University & Baroda
Seed fund for 1 year only
UIC:
National Knowledge Commission
+ Initiated
BIRAC

University Innovation Biocluster
&
Bio-incubators
2014
Approval Granted to 5 Universities
(Source: BIRAC website + Newspapers)

Issues in India
• Seed Funding
• Long term Sustainability
• Business Models in mind:
– Incubatees : generally bereft
– SMEs: have a strategy
• Technology Platform Model: (Start-ups that rent/sell their
technology/product to pharma/biotech companies) (?)
• RIPCO Model: (Start-ups that research and develop a new
product to finally license it to a big pharma/biotech company in
exchange for a royalty on sales)
• FIPCO Model: (Start-ups that launch their own Product)
• NRDO model: (Start-ups that buy a “discarded” promising drug
from big pharma and use their technology to bring it to market)

Indian Govt. Initiative on Bio-Incubator
Department of Biotechnology
Ministry of Science and Technology
Government of India
Call for Letters of Intent (LOI) (2010)
For DBT-BIRAP Support for Establishing and Strengthening Bio-Incubators/Innovation Centers for Research, Innovation and
Technopreneurship.
Biotechnology Industry Research Assistance Programme, (BIRAP) is a programme of the Department of Biotechnology, Govt. of India,
with an objective to assist and promote emerging biotech entrepreneurs and facilitate innovative research and development in existing
small, medium as well as large industries.
Biotech incubator acts as a catalyst that would stimulate research & develop and for creating of new biotechnology ventures/startups. In
order to give thrust to the biotechnology industry in the country, DBT-BIRAP aims to provide financial support in form of soft loans and
grants for Strengthening the already existing Bio-incubators and also for establishing new generation Biotechnology Incubators with an
objective to create knowledge and develop entrepreneurship in biotechnology. The focus could be on the following areas in the
biotechnology sectors: Biopharma, Bioagri, Industrial Biotechnology, Bioenergy and other areas of life sciences. The Bio-incubators for
SMEs and start-ups/Innovation Centre only for start-ups could be as a standalone facility or as a part of an existing University/ Institute or
Park. They would cater to the requirements of start-up’s and SMEs.
BIRAP invites Letters of Intent (LOI) from interested public and private academic institutions (Universities, Research Institutes) / SEZs / etc
for the development of Biotechnology Incubator Projects/s.
Interested Parties may download the “Project Information Memorandum”, LOI format and other required detailed information from
www.birapdbt.nic.in. Short listing of the LOIs would be done in two weeks based on the listed criteria and the selected participants will be
informed. Subsequently a detailed proposal will have to be submitted.
The last date for submission of LOI documents is 15th July, 2011. LOIs are to be submitted by e-mail with all the documents and
attachments in a single file to rdhar.birap@nic.in / rkumar.birap@nic.in
For further details contact:
Dr. Ravi Dhar, Consultant
IP cell, BIRAP Email; rdhar.birap@nic.in
Mr. Rajneesh Kumar, Programme Manager,
Technology Transfer, BIRAP
Email: rkumar.birap@nic.in
Phone Number: 011-47744500 (Times of India)

Salient Features of Bio-incubator Support
Scheme Support:
• Provide incubator space to Start-ups and
Entrepreneurs.
• Provide access to a pool of special equipments
in the Central Equipment Facility.
• Connect and facilitate Industry –Academia
Interaction
• Provide enabling services and required
mentorship for IP and Technology Management,
Legal and Contract, resource mobilization and
networking platform.
• Governance models would be cooperative or
autonomous.
•12 existing Bio-incubatosr across India have
been supported; approx. 70,000 sq.ft Bio-
Incubator has been created.
Target Groups:
• Existing Bio-incubators across the
country
•New Bio-incubators
Purpose:
(1) Strengthening and Up-gradation
of the existing Bio-incubators;
and
(2) To establish New World Class Bio-
incubators in certain strategic
locations.

Key features of BISS Scheme
Establishing common equipment facility
High end equipment facility
Man-power-Technical & Business
Refurbishing & Renovation
Conducting workshops/mentoring of incubatees by
incubators
Limited support for Journals/books
Support for external consultancy to bio-incubator
for legal, business & marketing
Other administrative & operational expenses

Selection Criteria
For Up scaling Existing Incubators
• The proposals selected for evaluation based on the following criteria:
• Technical merit of the proposal
• Target Beneficiaries
• Services/facilities to be provided
• Respondent’s qualification in the field of the assignment.
• Respondent’s technical and managerial capabilities.
• Respondent’s core business and years in business, if any
• Qualifications of the respondent’s key staff that would work on this
assignment specifically.
• Respondent’s experience in supporting businesses, notably
entrepreneurs in at the national and international level.
For New World Class Incubators
• High level experts, Policy makers decide to develop New World Class
Incubators in R&D Clusters

Government Support for Existing
Incubators
70,000 sq feet space
Equipment
Mentoring
Other facilities

Recently Commissioned or
Proposed Incubators in India
RCB: Target; approved (World Class)
(In process)
Medical Devices, Diagnostics & Vaccines
C_CAMP: for providing cGMP facility to industry
KIITs University
NABI_Mohali (under consideration) (Agriculture)

Infrastructure Requirements
For world Class Bio-incubators
1. Modular lab Infrastructure- PLUG N PLAY
2. C-GMP and GLP labs complying to industry
standards
3. Clean room facility
4. Modular Pilot Plant Facility for scale up
5. Plant Tissue culture lab/climate chambers
6. Translational facility:
 Investigational Medicine Units
 Animal Research Facility
 Bio-material development and testing
 Toxicology facility
 Stem Cell identification and Isolation

Infrastructure
Bio-Incubator I : 12 modules of 250 m²
Bio-Incubator II : 24 modules of 125 m²
Bio-Incubator III: 24 modules of 125 m²
Modules with lab and workspace:
State of the art (L2 compatible):
• Flexible interior arrangement;
• Coupling of multiple modules is possible.
Included:
• Manager supporting general and technical needs, guiding the demands of
necessary environmental licenses and working out solutions for logistical
problems;
• Meeting rooms & facilities;
• Lunch facilities.
Extras:
• Storage room;
• Coordination of installation;
• Environmental issues: waste management,…;
• Technical support.

Issues in India during Project
Implementation
 Concept not well understood – think as funding
instrument only?
 Weak project writing skills
 Incomplete Paper work, Approvals
 Incomplete information given in proposal
 Resistance of host organization to address queries
raised by various funding agencies
 Regulatory issues (Environmental)
 SIRO Recognition issues
 Customs Issues for equipment

Issues: Regulatory Compliance
Issues : Infrastructure
• Land Issues
• Building G-2/G-3 issues related to building
• Regulatory Approvals from Pollution Board
• Safety norms for incubators
• Management Structure
• Use of Instruments by incubatees
• Display of list of Instruments for optimum use
• Operational Model & Log book for use of
instruments

Funding - India
The existing system of public incubators:
• Duration: 2-5 years
• Funding per project: varies; based on
milestones; Funding varies
• Government participation: 50%-85%
• Ownership: Joint governance during funding;
subsequently could belong to host
organization! Different models tried

S.No. Ownership Management Examples
1. Public Public Universities/IARI
2. Private Private IAN-Tie, Delhi
3. Public Private BTIC, Genome Valley
4. Public + Private Private IKP, Hyderabad
(compiled by R.D.)
Governance Models

Government of India
DBT National Incubators
• C-CAMP, Bangalore
• (Protein Characterization facility under GLP conditions for
Industry)
• DBT_BIRAC Incubator at Alexandria, Genome
Valley, Hyderabad (BTIC)
• NABI, Agri Bioincubator, Mohali
• RCB Biotech Science Cluster, Faridabad

Translational facilities
1. Clinical research facility for Phase-1 clinical trials
EG. AIIMS-CDSA Phase-1 clinical trials proposal.
2. Up gradation of the of the Vaccines units
complying international standards e.g., BIBCOL

http://www.biospectrumindia.com/biospecindia/news/158542/incubators-accelerate-
entrepreneurial-spirit

Successful
Bio-incubatees from
India

Companies Graduated
from
Indian Bio-Incubators

IKP Knowledge Park encourages companies to graduate from the Park to their own facility or to set up their own facility.
18 companies have successfully graduated from the Park till date. While Optiwave Photonics was the first company to
graduate - in 2003, Matrix and GVK Biosciences have achieved phenomenal success after graduating from the Park.

List of Current or Past Incubatee companies at
IKP
»i-Trace Nanotech Pvt. Ltd. Technology development and application of
nanoparticles.
»iSensor Diagnostics Pvt. Ltd. iSensor is a start-up biotech company offering novel
low cost diagnostic solutions to point-of-care diagnostics and critical care medical
diagnostic instrumentation that dramatically improve the quality of life of patients in
developing countries.
»Onan Biotech Pvt. Ltd. ONAN Biotech is working on rDNA technology and
developing PCR based molecular techniques to develop and manufacture innovative
products for the detection of infectious and non infectious diseases.
»Regain Biotech Pvt. Ltd. Regain Biotech is focussed on Plant based therapeutics
»Remidio Innovative Solutions Pvt. Ltd. Remedio is involved in development of low
cost medical devices for the Indian Market. The team has developed an inexpensive
retina scanner to detect Diabetic Retinopathy.
»Revelations Biotech Pvt. Ltd. Revelations Biotech is involved in structure guided
drug design services and traditional medicines/botanicals.
Their aim is to leverage on advance molecular biology, system biology and
crystallographic techniques for drug design and discovery of new molecules

Factors Enabling Value Creation in
Bio-incubators
Bio-environment assets
Basic research infrastructure
Entrepreneurship
Prospecting
Selection
Technology validation
Access to physical infrastructure
Mentoring
Internal IP services
Access to funding
Networking
Assistance with “exit” strategy

On Incubators World-wide?
• No. of Life science incubators, India
: 52 mixed
• International Scenario: 1100 nos.
• U.S.A. : 12% functional
• France : 4% functional
• Germany : 32% functional
• India : Relatively new – growing

International Models
• Alexandria : Private
• Israel : Entrepreneur driven
• Germany : Entrepreneur driven
• Nottingham : Private + Public

A model non-profit biotechnology incubator to facilitate academic drug discovery and
development
The Taube-Koret Center acts as a bidirectional bridge between academia and industry to reduce the risk in the development of
therapeutics. Discoveries with therapeutic potential are made in academic laboratories and are transferred to the Taube-Koret Center
within the same institution. The Center maintains the necessary expertise in drug discovery and medicinal chemistry to validate targets
and discover and optimize small molecules to modulate these targets. Contract research organizations are used by the Center as needed
to carry out specific steps in drug development. Leads that fail to meet performance targets are returned to the academic labs that
discovered them for further optimization. Leads that meet milestones are advanced until partners can be found to co-develop them
further. The potential paths to therapeutics via partners (black arrows) can involve foundations, the NIH, existing biotechnology
companies, new companies created by venture capitalists, or major pharmaceutical (pharma) companies. Since the Center's overarching
goal is to find effective therapies for neurodegenerative diseases, rather than to make a profit from proprietary programs, it can make its
new technologies, assays and disease models available to external entities that want to evaluate the efficacy of their lead programs (gray
arrows).
Nature Medicine, 16, 1227–1232 (2010)

Bio-incubators in Israel
The existing system of public incubators:
• Duration: up to 2 years
• Funding per project: up to $350,000
• Government participation: 85%
• Ownership:
 Entrepreneur - 50%
 Private investors - 20%
 Incubator - 20%
 Other staff members - 10%

Bio-incubators for Entrepreneurship
Nat Biotechnol. 2013 Feb 7;31(2):104-7. doi: 10.1038/nbt.2493.
“Giving voice to India's entrepreneurs”
PMID: 23392503 [PubMed - in process]

CAUTION !!!!!
J Homosex. 2013 Feb;60(2-3):232-49. doi: 10.1080/00918369.2013.744669.
The rise of repeal: policy entrepreneurship and
don't ask, don't tell.
Neff CL, Edgell Blas LR.
Department of Government and International Relations , University of Sydney ,
Sydney , Australia.
We report on policy entrepreneurship by Servicemembers Legal Defense Network SDN)
and how its legislative strategies used mini-windows of opportunity to shift Capitol Hill
perspectives of Don't Ask, Don't Tell (DADT) from political plutonium to an emerging
issue requiring a second look. Four phases in the legislative history of DADT are
identified: radioactive, contested, emerging, and viable. In all, this article argues that
SLDN's entrepreneurship focused on contesting congressional sensibilities to wait or
defer on repeal, maintained that every discharge was damaging and transitioned toward
a post-repeal mind set.
Finally, we illustrate the importance of these transitions by comparing SLDN’ 2004
estimated vote count for the introduction of the Military Readiness Enhancement Act
with the final 2010 voting results on the Don't Ask, Don't Tell Repeal Act.

Future of Entrepreneurship
Intellect Dev Disabil. 2012 Dec;50(6):505-18. doi: 10.1352/1934-9556-50.06.505
The potential of social entrepreneurship: conceptual tools for applying
citizenship theory to policy and practice.
Caldwell K, Harris SP, Renko M.
Department of Disability and Human Development, University of Illinois at Chicago, 1640 West Roosevelt Road (MC626), Chicago,
IL 60608, USA. kcaldw3@uic.edu
Contemporary policy encourages self-employment and entrepreneurship as a vehicle for empowerment and
self-sufficiency among people with disabilities. However, such encouragement raises important citizenship
questions concerning the participation of people with intellectual and developmental disabilities (IDD). As an
innovative strategy for addressing pressing social and economic problems, "social entrepreneurship" has
become a phrase that is gaining momentum in the IDDcommunity--one that carries with it a very distinct
history. Although social entrepreneurship holds the potential to be an empowering source of job creation and
social innovation, it also has the potential to be used to further disenfranchise this marginalized population. It
is crucial that in moving forward society takes care not to perpetuate existing models of oppression, particularly
in regard to the social and economic participation of people with IDD. The conceptual tools addressed in this
article can inform the way that researchers, policymakers, and practitioners approach complex issues, such as
social entrepreneurship, to improve communication among disciplines while retaining an integral focus on
rights and social justice by framing this issue within citizenship theory.

Startup Companies in Europe

Thank You
(rdhar_in@yahoo.com)

Dr. Ravi Dhar reviews " Bioincubators in India 2014"

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Dr. Ravi Dhar reviews " Bioincubators in India 2014"