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                            NEUROSCIENCE DIVISION
ND PHARMA & BIOTECH
                            PRODUCT LIST




       ndpharmabiotech@europe.com | NeuroSciences Division
NeuroScience Division Catalog 2012




NEUROSCIENCE DIVISION
    CATALOG 2012
    PRODUCT LIST




                                                2
NeuroScience Division Catalog 2012



                                     PRODUCT LIST

1.    Levodopa
2.    Gamma amino butyric acid(GABA)
3.    Melatonin 99%,
4.    Yohimbine hydrochloride
5.    Natural Reishi P.E, 20%-50%
6.    Pterostilbene ,98%
7.    Sulbutiamine
8.    5-HTP (Griffonia Simplicifolia Extract)
9.    Beta Alanine
10.   N Acetyl Tyrosine
11.   Alpha Lipoic Acid
12.   Acetyl L Carnitine
13.   L-glutamine
14.   L-Theanine
15.   L-alpha-Glycerylphosphoryl choline (Alpha GPC)
16.   CDP-choline (choline Bitartrate)
17.   Pyritinol
18.   Pyridoxal 5-phosphate monohydrate
19.   Picamilon
20.   Phenibut
21.   L-Theanine
22.   Nervonic Acid
23.   Centrophenoxine
24.   Idebenone
25.   Galantamine Hydrobromide
26.   Calcium Glycerophosphate
27.   L-α-Glycerylphosphorylcholine hydrate
28.   Cytidine Triphosphate Disodium(CTP)
29.   Polycytidylic Acid
30.   S-Adenosyl-L-methionine disulfate tosylate
31.   SAMe (S-Adenosyl-L-methionine)
32.   Citicoline Sodium
33.   Adenosine Triphosphate Disodium
34.   Aniracetam
35.   Nefiracetam
36.   Oxiracetam
37.   Pramiracetam
38.   Piracetam
39.   5-HTP, 5-Hydroxytryptophan,Griffonia Seed Extract




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NeuroScience Division Catalog 2012




                      © ND Pharma & Biotech NeuroSciences Division.



The present brochure/catalogue does not constitute an offer neither an invitation to treat. For
every transaction or interest in any of the products please be advised by our Commercial
Department. No price or quotation will be send to any request unless properly identified as
Business Company, Commercial Company or Scientific Corporation. Please ask for the price and
payment policy before any order placement.

Additional information about products, please contact with the Scientific Department or write
us an e-mail to:

                               ndpharmabiotech@europe.com

                                 ndpharmabiotech@usa.com

                                 ndpharmabiotech@asia.com




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NeuroScience Division Catalog 2012




PRODUCT CATALOG




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NeuroScience Division Catalog 2012


1. LEVODOPA

  CAS: 59-92-7
  Presentation: 25 Kg/ Card Drum
  Molecular Formula: C9H11NO4
  MW: 197.1879
  Appearance: White poder

  Function:
  Levodopa dopamine and left for medicine are tremor paralysis pill. This product
  through the blood brain barrier into the brain function. Applicable to primary
  tremor paralysis and the medicine of the tremor paralysis syndrome. This product
  after taking nausea, vomiting, loss of appetite, insomnia, illusion.




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NeuroScience Division Catalog 2012




        2. GAMMA AMINO BUTYRIC ACID ( GABA)


CAS#:56-12-2

MF:C4H9NO2

MW:103.1198

Appearance: White crystal powder; have the smelly, taste the pain

Assay: 99%



Function



1.Calm & Relax The Mind and Body

2.Improve Sleep (Promotes R.E.M. Sleep)

3.Stabilizes Blood Pressure

4.Improve Brain Functioning & Mental Clarity

5.Improve Neurotransmitter Functioning

6.Increase Human Growth Hormone (HGH)

7.Reduce Pain From Chronic Conditions (Arthritis & Lower Back Pain)

8.Remove Wrinkle instantly




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NeuroScience Division Catalog 2012




3. MELATONIN 99%

  Natural Pterostilbene, 98%
  CAS#:73-31-4
  MF: C13H16N2O2
  MW: 232.2783
  Appearance: White crystal or off White crystal
  Assay:98%




  Function

  1. Helps regulate other hormones and maintains the body's circadian rhythm.
  2. Melatonin also helps control the timing
  3. Melatonin helps determine
  4. melatonin has strong antioxidant effects.
  5. release of female reproductive hormones.




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NeuroScience Division Catalog 2012




4. YOHIMBINE HYDROCHLORIDE

   CAS#:65-19-0
   MF:C21H27N2O3
   MW:355.4501
   Assay:98%
   Appearance: White fine powder




   Function

   1.It can increase muscle tension, has noninvasive effect on suppression of urine
   2.Accelerate body energy metabolism
   3.Increase energy supply




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NeuroScience Division Catalog 2012




5. NATURAL REISHI P.E, 20%-50%

   Natural Reishi P.E, 20%-50%

   Specification:       RSH-1 Polysaccharide 10% UV

                      RSH-2 Polysaccharide 25% UV
                      RSH-3 Polysaccharide 20% UV/Triterpene 4% UV
   Appearance: Brown Powder

   Function:

   1)Reishi Extract is reputed as the elixir of life since ancient times, and is a rare and
   traditional Chinese medicine in China.
   2)Reishi Extract is used for treatment of general fatigue and weakness, asthma,
   insomnia, and cough.
   3)Reishi Extract can also preserve the vigour, strengthen the physique, have a rosy
   complexion, antisenile, prolong life,curing the consumptive disease and the
   haemorrhoids.




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NeuroScience Division Catalog 2012




6. PTEROSTILBENE,98%

   Pterostilbene, 98%

   CAS: 537-42-8

   MF: 537-42-8

   MW: C16H16O3

   Appearance: Off white crystal powder

   Assay: 98%




   Function:

   Pterostilbene is a stilbenoid chemically related to resveratrol. It is thought to be
   the key compound found predominantly in blueberries (as well as grapes) that
   exhibit     anti-cancer,     anti-hypercholesterolemia,       anti-hypertriglyceridemia
   properties, as well as fight off and reverse cognitive decline. It is believed that the
   compound also has anti-diabetic properties, but so far very little has been studied
   on this issue. Additionally, it is also touted as a potent anti-fungal.
   In 2002, Rimando and UIC collaborators found in experiments using rat mammary
   glands that pterostilbene possessed potent anti-oxidant characteristics and
   possible cancer-fighting properties at concentrations similar to resveratrol.




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NeuroScience Division Catalog 2012




7. SULBUTIAMINE

   Sulbutiamine




   CAS#:3286-46-2

   MF:C32H46N8O6S2

   MW:702.8876

   Appearance:White to off-white crystalline powder

   Assay:≥98%




   Function

   1. Sulbutiamine is a novel fat soluble derivatives of thiamine, which has two
   different properties in comparison with vitamin B1 as

   2. Sulbutiamine is a novel fat soluble derivatives of thiamine, which has two
   different properties in comparison with vitamin B1 as a result of structural
   modification of free thiamine.

   3. Sulbutiamine can cross the blood brain barrier more easily than vitamin B1
   because of its lipophilic. It can be rapidly absorbed and the concentration is
   maximum in 1-2 hours after oral administration. The molecule rapidly distribute in
   the whole body and is eliminated with a biological half-life of 5 hours.

   4. Sulbutiamine is also used to increase mental focus, provide a clear mind and
   promote general vigilance. It has beneficial effects on working and episodic
   memory by improving memory formation and has been described as a centrally
   acting cholinergic agent.




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NeuroScience Division Catalog 2012




8.   5- HTP GRIFFONIA SIMPLICFOLIA EXTRACT

     5-HTP (Griffonia Simplicifolia Extract)




     CAS #:114-03-4

     MF:C11H12N2O3

     MW:220.2246

     Appearance:Off white Crystalline powder

     Assay:99%




     [ Function]
     1.Anti-hypochondria
     2.Improve sleep
     3. Weight losing
     4. Relieve prior menses syndrome (PMS)
     5. abstain from addiction
     6.Cure hemicranias




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NeuroScience Division Catalog 2012




9. BETA- ALANINE

   CAS#: 107-95-9

   MF:C3H7NO2

   MW:89.09

   Appearance:White fine powder

   Assay:99%




   Function:

   Mainly used for synthetic pantothenic acid and pantothenic acid calcium, muscle
   peptide,
   palmer meters phosphonate.... Widely used in medicine, feed, food area ect
   Increases strength endurance
   Increases force output
   Increases anaerobic threshold
   Increases work capacity
   Delays fatigue
   May improve body composition
   Works synergistically with Creatine
   Enhances performance in all athletes regardless of the intensity or duration
   required by the athletic discipline




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NeuroScience Division Catalog 2012




10. N-ACETYL –TYROSINE

   CAS#537-55-3

   MF:C11H12NO4

   MW:222.2178

   Appearance:White crystal or white crystalline powder

   Assay:99%




   Function:

   N-Acetyl-L-tyrosine is used in pharmaceutical intermediates,biochemical study,life
   sciences,etc..

   1.N-Acetyl-L-Tyrosine is a highly bioavailable form of L-tyrosine for the natural
   precursor treatment of low moods N-acetyl-L-tyrosine can be used in lower doses
   than L-tyrosine.
   2.N-Acetyl-L-Tyrosine is an acetylated derivative of the essential amino acid L-
   tyrosine. Ordinary L-tyrosine is less stable and insoluble in water, which may result
   in reduced bioavailability.
   3. N-acetyl-L-tyrosine, which is converted in the body to L-tyrosine, is 20 times as
   soluble in water as L-tyrosine itself. For this reason, it serves as an efficient
   supplement for raising tyrosine levels in the body, since undissolved substances
   are not absorbed from the digestive tract.
   4. N-acetyl-L-tyrosine enhances the solubility and stability making it a more rapidly
   absorbed and bioavailable form of the amino acid L-tyrosine which is less prone to
   urinary excretion




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NeuroScience Division Catalog 2012




11. ALPHA LIPOIC ACID

   CAS#:62-46-4

   MF:C8H13O2S2

   MW:205.3182

   Appearance: Yellow crystalline powder, almost tasteless.

   Assay:99%




   Function:

   R-(+)Lipoic Acid has been called the mitochondrial antioxidant because it is a key
   component of mitochondrial dehydrogenase complexes, which may help slow the
   natural aging process in animals. R-lipoic acid may be more effective than other
   forms of lipoic acid in increasing or maintaining levels of other antioxidants that
   may decline with age, including CoQ10, vitamins C and E, and glutathione,
   according to animal research.




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NeuroScience Division Catalog 2012




12. ACETYL L-CARNITINE

   CAS#:5080-50-2

   MF:C9H18ClNO4

   MW:239.6965

   Appearance: White crystalline powder

   Assay:99%




   Function

   1.Improving memory problems in elderly people.
   2.Improving memory in people who use alcohol excessively




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NeuroScience Division Catalog 2012




13. L-GLUTAMINE

   CAS#:56-85-9

   MF:C10H20N4O6

   MW:292.289

   Appearance: White needle crystal

   Assay:99%




   Function:
    L-Glutamine is the most prevalent amino acid in the bloodstream. Glutamine is
   involved in more metabolic processes than any other amino acid. Glutamine is
   converted to glucose when more glucose is required by the body as an energy
   source. Glutamine also plays a part in maintaining proper blood glucose levels and
   the right pH range. It serves as a source of fuel for cells lining the intestines.
   Without it, these cells waste away. It is also used by white blood cells and is
   important for immune function. Glutamine assists in maintaining the proper
   acid/alkaline balance in the body, and is the basis of the building blocks for the
   synthesis of RNA and DNA.




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NeuroScience Division Catalog 2012




14. L-THEANINE

   CAS#:3081-61-6

   MF:C7H13N2O3

   MW:174.2

   Appearance: White crystalline powder

   Assay:98.0-102.0%




   Function:

   1) diminishing symptoms of PMS,
   2) improving learning performance,
   3) heightening mental acuity - neurotransmitter,
   4) promoting concentration,
   5) acting antagonistically against the paralysis induced by caffeine,
   6) supporting the immune system,
   7) lowering blood pressure,
   8) increasing formation of the inhibitory neurotransmitter GABA, and
   9) increasing brain dopamine levels among other positive benefits with no known
   downside




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NeuroScience Division Catalog 2012




15. L-ALPHA GLYCERYLPHOSPHORYLCHOLINE ( ALPHA GPC)

   CAS#:283-77-9

   MF:C8H20 N O6 P

   MW:257.22

   Appearance: White powder or Clearance liquid

   Aaaay:99%




   Function

   1. Increase human Growth Hormone (hGH)
   2. Improve mental focus and cognitive function
   3. Improve strength.




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NeuroScience Division Catalog 2012




16. CDP - CHOLINE (CHOLINE BITARTARATE ).

   CAS#:33818-15-4

   MF:C14H25N4NaO11P2

   MW:510.3058

   Appearance: White or off-white powder

   Assay:99%




   Function: Immune & Anti-Fatigue

   1.improves Learning ability

   2.slows the progression of Alzheimer Disease

   3.increases Blood Circulation and Oxygen utilization within the Brain

   4.is used mitigate brain damage following a head injury

   5.is helpful in the treatment of severe Depression.

   6.improves Memory (especially in cases of Memory impairment)

   7.is a valuable co-therapy for Parkinson Disease.




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NeuroScience Division Catalog 2012




17. PYRITINOL

   CAS#:1098-97-1

   MF:C16H20N2O4S2

   MW:368.47

   Appearance: white crystalline powder

   Assay: 99%




   Function

   Pyritinol is a pyridoxine class compound. Two pyridoxines are linked together by
   two sulfur atoms. Pyritinol (or Pyrithioxin) is a nootropic which enhances oxygen
   and glucose uptake in the brain. It is also an antioxidant which scavenges hydroxyl
   radicals. But it has no vitamin B6 activity.




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NeuroScience Division Catalog 2012




18. PYRIDOXAL 5-PHOSPHATE MONOHYDRATE

   CAS#:41468-25-1

   MF: C8H10NO6P.H2O

   MW: 265.15

   Appearance: like white or light yellow powder

   Assay:99%




    Function and uses:
   P5P acts as a coenzyme in all transamination reactions,and in some
   decarboxylation and deamination reactions of amino acids.It is also needed for
   hemoglobin production as well as for fatty acid and prosta-
   glandin metabolism.In addition, P5P is necessary for neurotransmitter production,
   specifically for the production of dopamine,noradrenaline, serotonin, GABA and
   glutamate. P5P is essential to any natural antidepressant program,and helps to
   relieve premenstrual symptoms, boost immune functions and maintain healthy
   blood sugar level. It may be protective against some cancers and has anti-
   convulsant effects. It may be effective with some forms of fertility and helps with
   skin disorders.




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19. PICAMILON

   CAS#:34562-97-5

   MF:C10H11N2NaO3

   MW:230.1957

   Appearance: white crystalline powder

   Assay:99%

   Function

   Picamilon (also known as nicotinoyl-GABAm Pycamilon, Pikamilon, etc) is a dietary
   supplement formed by combining niacin with GABA. Picamilon is able to cross the
   blood-brain barrier and then is hydrolyzed into GABA and niacin. The released
   GABA in theory would activate GABA receptors potentially producing an anxiolytic
   response.The second released component, niacin acts as a strong vasodilator,
   which might be useful for the treatment of migraine headaches.




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20. PHENIBUT

   CAS No.:1078-21-3

   MF:C10H14ClNO2

   MW:215.6767

   Appearance: White crystalline powder

   Assay:>99%




   Function:

   1.Antimelancholic (psychotropic drugs)

   2.Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter
   GABA.

   3.Phenibut is used by bodybuilders to reduce fatigue and improve neurological
   functions.4.Phenibut has been and is still used medically to treat stress, relieve
   tension, improve sleep, and as a potentiate for other medications.




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NeuroScience Division Catalog 2012




21. NERVONIC ACID

   CAS No.:506-37-6

   MF:C24H46O2

   MW:366.62

   Assay:>90%by HPLC

   Appearance: White crystalline




   Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been
   identified as important in the biosynthesis of nerve cell myelin. It is found in the
   sphingolipids of white matter in human brain.




   Nervonic acid is used in the treatment of disorders involving demyelination, such
   as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of
   nervonic acid in sphingolipids.




   Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been
   identified as important in the biosynthesis of nerve cell myelin. It is found in the
   sphingolipids of white matter in human brain.

   Nervonic acid is used in the treatment of disorders involving demyelination, such
   as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of
   nervonic acid in sphingolipids.




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NeuroScience Division Catalog 2012




22. CENTROPHENOXINE.

   CAS: 3685-84-5
   Molecular Formula: C12H17Cl2NO3

   Molecular weight :294.1743

   Quality Standard; Enterprise standard

   Assay: 99.0%min




   Function

   Centrophenoxine - formerly known as Lucidril increases the brain's use of glucose
   and improves brain energy levels. It also removes a potassium build up in the
   brain, heart, lung and skin cells, and is vital for the efficient communication of a
   cell to transfer potassium and sodium across its membranes. Centrophenoxine has
   shown an ability to remove the visible signs of excessive potassium build up - age
   or liver spots




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23. IDEBENONE

   CAS NO.:58186-27-9

   MF:C19H30O5

   MW:338.4385

   Assay:> 98.5%(HPLC)

   Appearace: orange yellow or orange crystalline powder




   Function

   1. Idebenone increases nerve growth factor (NGF) in the brain.
   2. Idebenone is a powerful antioxidant and positively affects brain chemistry.
   3. Idebenone has been shown to promote information transfer across the corpus
   callosum, the membrane separating the right and left brain hemispheres.
   4. Idebenone has been used to treat Alzheimer's and to lessen damage from
   strokes.
   5. Idebenone can increase production of the brain neurotransmitters serotonin,
   dopamine, adrenalin, and noradrenanlin.
   Idebenone is closely related to CoQ10 in its structure. It can replace CoQ10 in the
   process of cellular energy production and, just as CoQ10, idebenone is also an
   antioxidant. There are some important distinctions though. Idebenone is more
   water-soluble than CoQ10; its cellular distribution and antioxidant profile are
   somewhat different too. This makes idebenone superior to CoQ10 in neutralizing
   some types of free radicals and inferior in fighting other types. Notably, idebnone
   is more effective than CoQ10 in protecting cells from the free radical damage
   resulting from reduced blood flow. On the other hand, idebenone appears more
   conducive than CoQ10 to certain types of noxious free-radical leakage in the cell's

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   mitochondria. Unfortunately, there have been very few studies directly comparing
   CoQ10 and idebenone in the treatment of various conditions.



24. GALANTAMINE HYDROBROMIDE (GALANTHAMINE HBR.)

   CAS Number:1953-04-4

   Origin:Lycoris radiata (LHer.) Herb.

   Molecular Formula:C17H21NO3·HBr

   Molecular Weight:368.27

   Appearance:White Powder

   Assay by HPLC:98% Min




   Function

   Galantamine Hydrobromide is an effective,competitive and reversible
   acetylcholine esterase inhibitor,especially used in curing lightly and moderate
   Alzheimer's Diseas




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NeuroScience Division Catalog 2012




25. CALCIUM GLYCEROPHOSPHATE.

   CAS:27214-00-2

   MF:C6H14Ca2O12P2

   MW:420.27

   Assay:99%

   Appearance: White or light yellow powder




   Function:

   A kind of nutrition medicine. Used for auxiliary curing. With nutritious function,
   mostly used in convalescence period,

   and generally used in medicine made of two or more ingredients preparations.




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NeuroScience Division Catalog 2012




26. L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE HYDRATE

   L-α-Glycerylphosphorylcholine hydrate

   CAS#:28319-77-9

   MF: C8H21NO6P·nH2O

   MW:257.20

   Assay:98%

   Appearance:Clear liquid very viscous




   Function:



   L-alpha-GPC (L-alpha-glycerophosphorylcholine) is an easily absorbed source of
   choline, which increases neurotransmitter production for better memory, mood
   and learning. Neurotransmitters support effective communication and are needed
   for a healthy brain and cognitive function. Studies have shown L-alpha-GPC is
   effective in the treatment of Alzheimer’s type dementia.
   Phosphatidylcholine (PC) and Phosphatidylserine (PS) are the major phospholipids
   in the body and the brain. PC supports brain function by stimulating production of
   choline, which in turn forms acetylcholine. PS has been shown to improve age-
   related memory loss, boosting learning, vocabulary skills and concentration, and
   even reversing early stages of Alzheimer’s disease.




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27. CTP CYTIDINE TRIPHOSPHATE DISODIUM

   CAS:18423-42-2
   MF:C9H14N3Na2O14P3
   MW:527.12
   Purity:99%
   Appearance: white powder




   Function
   Made of CMP. it can be used in the therapy of cerebrovascular accident &
   sequelae; cerebral concussion, trauma coma, dysfunction after craniocerebral
   operations; neurosis; cerebrovascular angiosclerosis, presenile dementia;
   peripheral nerve injury; atelencephalia




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28. POLYCYRIDYLIC ACID

   Polycytidylic Acid(PolyC)
   CAS No.:24939-03-5
   MF:(C9H14N3O8P)n
   Purity:99%
   Appearnce:White powder
   Function:
   1. it also can offer good effects to hepatitis B, epidemic hemorrhagic fever, virus
   flu and flat wart.
   2.Moreover, it can cure nasopharyngeal cancer and Gynecologic Cancers.




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29. 5- ADENOSYL-L- METHIONINE DISULFATE TOSYLATE

   Synonyms: Ademetionine disulfate tosylate

   CAS: 97540-22-2



   Molecular Formula: C15H22N6O5S.2 (H2SO4).C7H8SO3
   Molecular Weight: 766.79
   Assay:99%

   Function:

   1.It can be used in the therapy of depression, arthritis, chronic hepatitis

   and cholestasia;

   2.moreover, it can be used in the preventation of liver cancer, or relieve the
   poisoning of chemicals, alcohol and cancer to liver, improve the curing of wound
   and growth of cartilage tissue;

   3. it also can adjust the function of nerve centre system.




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NeuroScience Division Catalog 2012




30. SAME (S-ADENOSYL-L-METHIONINE)

   CAS-No: 29908-03-0
   Mol. Formula:C15H22N6O5S
   Mol. Weight:398.44
   Assay: 98%
   Appearance: White fine powder



   Function
   1.SAMe is an improvement of the cell metabolism biochemical drugs
   2.SAMe is a kind of good liver nutrition agent
   3.SAMe have diminish inflammation, relieve pain and tissue repair function,
   especially for arthropathy.




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NeuroScience Division Catalog 2012




31. CITICOLINE SODIUM

   CAS-No:33818-15-4
   Mol. Formula:C14H25N4NaO11P2
   Mol. Weight:510.31
   Assay: 99%
   Appearance: white powder or off-white crystal

   Function
   1.it can reduce the resistance of blood vessel of brain and accelerate substance
   metabolism of brain
   2.It also can activate the mechanism of reticular formation of brain stem.
   3. It can be used in the therapy of acute craniocerebral trauma and disturbance of
   consciousness after brain operation.




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NeuroScience Division Catalog 2012




32. ADENOSINE TRIPHOSPHATE DISODIUM

   CAS-No:987-65-5
   Mol. Formula:C10H14N5Na
   Mol. Weight:551.15
   Assay: 99%
   Appearance:white powder or off-white crystal

   Function
   1.used in the disease caused by tissue injury and activity reduction of ecto enzyme
   2.used in treatment of heart failure, carditis, miocardial infarction, cerebral
   arteriosclersis, coronary sclerosis
   3 used in treatment of progressive muscular atrophy , cerebral hemorrhage ,
   chronic hepatitis, cirrhosis of liver and hearing handicap, etc.




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33. ANIRACETAM

   Aniracetam
   1-(4-methoxybenzoyl)-2-pyrrolidinon



   CAS-No: [72432-10-1]
   Assay 99.6%
   Grade: EP5
   Mol. Formula: C12H13NO3
   Mol. Weight: 219.24
   Appearance: white Crystalline Powder



   Function:
   Aniracetam is an ampakine and nootropic of the racetam chemical class purported
   to be considerably more potent than piracetam. It is lipid soluble and has possible
   cognition enhancing effects. It has been tested in animals extensively, Alzheimer's
   patients and temporarily-impaired healthy subjects. It has shown potential as an
   anxiolytic in three clinical animal models. It is sold in the United States as a dietary
   supplement.

   Aniracetam has also been shown to selectively modulate the AMPA receptor[2]
   and was used as the parent compound to derive a class of drugs known as the
   ampakines which are being investigated as nootropics and neuroprotective drugs
   for the treatment of Alzheimer's disease and other neurodegenerative conditions.




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34. NEFIRACETAM

   Nefiracetam
   Synonyms:        n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;       [(2,6-
   dimethylphenyl)aminocarbonylmethyl]chloride;



   CAS: 77191-36-7
   Assay: 99.0%min
   Molecular Formula: C14H18N2O2
   Molecular Weight: 246.31
   Quality Standard; Enterprise standard
   Appearance: A white Crystalline Powder
   Action: raw materials for the cardiovascular and cerebral diseases




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NeuroScience Division Catalog 2012




35. OXIRACETAM

   Oxiracetam
   CAS No: 62613-82-5
   Assay: 98.0~101.0%
   Molecular Formula: C6H10N2O3
   Molecular Weight: 158.16
   Appearance: White crystalline power




   USES: used in medicine, intelligent promote senile brain dysfunction syndrome,
   mental behavior of mental disorder, etc




   Density 1.416g/cm3
   Melting point 165-168oC
   Density 1.416g/cm3
   Loss on drying: 0.5%max
   Melting point 165-168°C
   Density:1.416g/cm3
   Melting point:165-168°C
   Boiling point:494.6°C at 760 mmHg
   Refractive index:1.57
   Flash point:252.9°C
   Vapour Pressur:7.39E-12mmHg




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NeuroScience Division Catalog 2012




36. PRAMIRACETAM

   Pramiracetam

   Chemical Name: N-(2-(Bis(1-methylethyl)amino)ethyl)-2-oxo-1-
   pyrrolidineacetamide

   CAS No.: 68497-62-1

   Molecular Formula: C14H27N3O2
   Molecular Weight: 269.38

   Appearance: White crystal;

   Pharmacology Action:
   Pramiracetam is a nootropic drug derived from piracetam, and is more potent (i.e.
   lower dosage is used). It belongs to the racetam family of
   nootropics.Pramiracetam was developed by Parke-Davis based on Piracetam, and
   is 8-30 times stronger than Piracetam. It goes by the trade name Neupramir or
   Pramistar.




                                                                                 41
NeuroScience Division Catalog 2012




37. PIRACETAM

   Piracetam anti-brain aging
   Grade: CP, BP, EP
   Purity: 98%,99%
   Appearance: White or off-white crystalline powder
   Packing: 25 Kg / Drum




   Clarify of solution Be up to the standard
   PH 5.0-7.0
   Related substances The area of total impurities'peak isn't more than the area of
   the comparative solution's principal peak
   Loss on drying ≤0.5%
   Residue on ignition ≤0.1%
   Heavy Metals ≤20PPM
   Assay(HPLC) 98.0 percent to 102.0 percent
   Packaging 20kg or 25kg per Platinum paper barrel;
   20kg or 25kg per carton




   Piracetam (sold under many brand names) is a drug. It appears to enhance and ,
   slow brain aging, increase blood flow and oxygen to the brain, aid stroke recovery,
   and ameliorate Alzheimer's, Down's syndrome, dementia, and dyslexia, among
   other diseases and conditions. Piracetam's chemical name is 2-oxo-1-pyrrolidine
   acetamide; it shares the same 2-oxo-pyrrolidone base structure with (). Piracetam
   is a cyclic derivative of . It is one of the . Piracetam is prescribed by doctors for
   some conditions, mainly , but is used off-label for a much wider range of
   applications.




                                                                                     42
NeuroScience Division Catalog 2012




38. 5-HTP, 5-HYDROXYTRYPTOPHAN, (GRIFFONIA SEED EXTRACT)

   CAS:56-69-9
   Packaging:25kg/drum
   Description
   Purity: 99% HPLC
   Appearance: white powder or off-white crystal

   Function:
   1. Improve sleep
   2. Weight losing
   3. Relieve prior menses syndrome (PMS)
   4. Abstain from addiction
   5. Cure of hemicrania




                                                                                  43
NeuroScience Division Catalog 2012




SAMPLE TECHNIC SHEET




                                              44
NeuroScience Division Catalog 2012

                      Reishi Mushroom P.E. – polysaccharide




Product Type: Herbal Extract

Variety: Reishi Mushroom P.E.

Form: Powder

Part: fruiting body

Extraction Type: Solvent Extraction

Packaging: Bottle, Drum, Vacuum Packed

Place of Origin: China (Mainland)

Grade: First Class

Brand Name: ND Pharma & Biotech

Model Number: Polysaccharide 10%, 20%, 30% by H...

Latin name: Ganoderma lucidum

Product Type: Fine Brown Powder

Part of the Plant Used: Fruit Body

Appearance: yellow powder       Package: 25kg/drum

Packaging & Delivery

Packaging Detail:

25kg / Fiber Drum with double-layer plastic bag inside.



Specifications

1): 100% Natural Reishi Mushroom Extract

                                                                                         45
NeuroScience Division Catalog 2012

2): Polysaccharide 10%, 20%, 30% by HPLC

3): European Standard




Reishi Mushroom P.E. - polysaccharide
Brief Introduction

Synonyms

Ganodema lucidum Mushroom, Mannentake

Beta-Glucan

Chemical Name:

Beta-Glucan, Beta-D-Glucan, Beta-(1,3)-D-Glucan

Molecular Formula:

C18H30O14X2

Mol. Wt.:

470.42

Molecular Structure

Triterpenes (Ganoderic acids)

Chemical Name:

Triterpenes, Triterpene saponins, Ganoderic acid A (a compound isolated from the Reishi
mushroom)

Cas No.:

81907-62-2

Molecular Formula:


                                                                                    46
NeuroScience Division Catalog 2012

C30H44O7

Mol. Wt.:

516.67

Molecular Structure:




Benefits

Reishi Mushroom contains a high concentration of beta-glucan and Granoderic acids
(Triterpenes), compounds which has been shown to stimulate immune system and anti-tumor:

• Up-regulate the immune system (Immunomodulatory and immunotherapeutic activities)

• Anti-cancer, anti-tumor, and anti-neoplastic effects

•Prevent cancer metastasis

•Anti-bacterial and anti-viral activities

• Beneficial effect on Lowering Blood Pressure(via inhibition of angiotensin-converting
enzyme)

• Beneficial effect on Lowering Blood Sugar

• Beneficial effect on Lowering Cholesterol

• Protective effects against liver injury by viruses and other toxic agents

• Weight loss aid



Safety

Reishi Mushroom Extract is safe. No side and harmful effect have been found.



Dosage

• The typical dose is 500-1500mg per day (usually in 2-3 doses throughout the day).

• Consult physicians for different condition specifics.

                                                                                            47
NeuroScience Division Catalog 2012



Reishi Mushroom Extract Features and Benefits:

Reishi Mushroom Extract with many advantages as list in the following, produced as our
patent-pending process and know-how technology from Ganodema lucidum Mushroom

• Produced with pure water only

• High purity: over 30% (Polysaccharides as Beta-glucan and 4% Treiterpenes

• NO solvent - residual free

• Pesticide-free

• Crystal yellow-Brown in appearance

• High solubility in water

• High anti-bacteria, and longer shelf life




NOTES:

All our products are accompanied of the proper CERTIFICATE OF ANALYSYS

All our products are manufactured under the higher standards of quality and Certification ISO.

All our plants and providers are regularly audited and supervised by our Technical and
Scientific Inspectors.

We are Leaders in R+D+ Innovation.




                                                                                            48
NeuroScience Division Catalog 2012




ND Pharma & Biotech NeuroScience Division
            Poligono de Valdredo, 12

        33157 Oviñana, Cudillero, Asturias

         ndpharmabiotech@europe.com




                                                                49

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Product list and catalog 2012

  • 1. /2012 NEUROSCIENCE DIVISION ND PHARMA & BIOTECH PRODUCT LIST ndpharmabiotech@europe.com | NeuroSciences Division
  • 2. NeuroScience Division Catalog 2012 NEUROSCIENCE DIVISION CATALOG 2012 PRODUCT LIST 2
  • 3. NeuroScience Division Catalog 2012 PRODUCT LIST 1. Levodopa 2. Gamma amino butyric acid(GABA) 3. Melatonin 99%, 4. Yohimbine hydrochloride 5. Natural Reishi P.E, 20%-50% 6. Pterostilbene ,98% 7. Sulbutiamine 8. 5-HTP (Griffonia Simplicifolia Extract) 9. Beta Alanine 10. N Acetyl Tyrosine 11. Alpha Lipoic Acid 12. Acetyl L Carnitine 13. L-glutamine 14. L-Theanine 15. L-alpha-Glycerylphosphoryl choline (Alpha GPC) 16. CDP-choline (choline Bitartrate) 17. Pyritinol 18. Pyridoxal 5-phosphate monohydrate 19. Picamilon 20. Phenibut 21. L-Theanine 22. Nervonic Acid 23. Centrophenoxine 24. Idebenone 25. Galantamine Hydrobromide 26. Calcium Glycerophosphate 27. L-α-Glycerylphosphorylcholine hydrate 28. Cytidine Triphosphate Disodium(CTP) 29. Polycytidylic Acid 30. S-Adenosyl-L-methionine disulfate tosylate 31. SAMe (S-Adenosyl-L-methionine) 32. Citicoline Sodium 33. Adenosine Triphosphate Disodium 34. Aniracetam 35. Nefiracetam 36. Oxiracetam 37. Pramiracetam 38. Piracetam 39. 5-HTP, 5-Hydroxytryptophan,Griffonia Seed Extract 3
  • 4. NeuroScience Division Catalog 2012 © ND Pharma & Biotech NeuroSciences Division. The present brochure/catalogue does not constitute an offer neither an invitation to treat. For every transaction or interest in any of the products please be advised by our Commercial Department. No price or quotation will be send to any request unless properly identified as Business Company, Commercial Company or Scientific Corporation. Please ask for the price and payment policy before any order placement. Additional information about products, please contact with the Scientific Department or write us an e-mail to: ndpharmabiotech@europe.com ndpharmabiotech@usa.com ndpharmabiotech@asia.com 4
  • 5. NeuroScience Division Catalog 2012 PRODUCT CATALOG 5
  • 6. NeuroScience Division Catalog 2012 1. LEVODOPA CAS: 59-92-7 Presentation: 25 Kg/ Card Drum Molecular Formula: C9H11NO4 MW: 197.1879 Appearance: White poder Function: Levodopa dopamine and left for medicine are tremor paralysis pill. This product through the blood brain barrier into the brain function. Applicable to primary tremor paralysis and the medicine of the tremor paralysis syndrome. This product after taking nausea, vomiting, loss of appetite, insomnia, illusion. 6
  • 7. NeuroScience Division Catalog 2012 2. GAMMA AMINO BUTYRIC ACID ( GABA) CAS#:56-12-2 MF:C4H9NO2 MW:103.1198 Appearance: White crystal powder; have the smelly, taste the pain Assay: 99% Function 1.Calm & Relax The Mind and Body 2.Improve Sleep (Promotes R.E.M. Sleep) 3.Stabilizes Blood Pressure 4.Improve Brain Functioning & Mental Clarity 5.Improve Neurotransmitter Functioning 6.Increase Human Growth Hormone (HGH) 7.Reduce Pain From Chronic Conditions (Arthritis & Lower Back Pain) 8.Remove Wrinkle instantly 7
  • 8. NeuroScience Division Catalog 2012 3. MELATONIN 99% Natural Pterostilbene, 98% CAS#:73-31-4 MF: C13H16N2O2 MW: 232.2783 Appearance: White crystal or off White crystal Assay:98% Function 1. Helps regulate other hormones and maintains the body's circadian rhythm. 2. Melatonin also helps control the timing 3. Melatonin helps determine 4. melatonin has strong antioxidant effects. 5. release of female reproductive hormones. 8
  • 9. NeuroScience Division Catalog 2012 4. YOHIMBINE HYDROCHLORIDE CAS#:65-19-0 MF:C21H27N2O3 MW:355.4501 Assay:98% Appearance: White fine powder Function 1.It can increase muscle tension, has noninvasive effect on suppression of urine 2.Accelerate body energy metabolism 3.Increase energy supply 9
  • 10. NeuroScience Division Catalog 2012 5. NATURAL REISHI P.E, 20%-50% Natural Reishi P.E, 20%-50% Specification: RSH-1 Polysaccharide 10% UV RSH-2 Polysaccharide 25% UV RSH-3 Polysaccharide 20% UV/Triterpene 4% UV Appearance: Brown Powder Function: 1)Reishi Extract is reputed as the elixir of life since ancient times, and is a rare and traditional Chinese medicine in China. 2)Reishi Extract is used for treatment of general fatigue and weakness, asthma, insomnia, and cough. 3)Reishi Extract can also preserve the vigour, strengthen the physique, have a rosy complexion, antisenile, prolong life,curing the consumptive disease and the haemorrhoids. 10
  • 11. NeuroScience Division Catalog 2012 6. PTEROSTILBENE,98% Pterostilbene, 98% CAS: 537-42-8 MF: 537-42-8 MW: C16H16O3 Appearance: Off white crystal powder Assay: 98% Function: Pterostilbene is a stilbenoid chemically related to resveratrol. It is thought to be the key compound found predominantly in blueberries (as well as grapes) that exhibit anti-cancer, anti-hypercholesterolemia, anti-hypertriglyceridemia properties, as well as fight off and reverse cognitive decline. It is believed that the compound also has anti-diabetic properties, but so far very little has been studied on this issue. Additionally, it is also touted as a potent anti-fungal. In 2002, Rimando and UIC collaborators found in experiments using rat mammary glands that pterostilbene possessed potent anti-oxidant characteristics and possible cancer-fighting properties at concentrations similar to resveratrol. 11
  • 12. NeuroScience Division Catalog 2012 7. SULBUTIAMINE Sulbutiamine CAS#:3286-46-2 MF:C32H46N8O6S2 MW:702.8876 Appearance:White to off-white crystalline powder Assay:≥98% Function 1. Sulbutiamine is a novel fat soluble derivatives of thiamine, which has two different properties in comparison with vitamin B1 as 2. Sulbutiamine is a novel fat soluble derivatives of thiamine, which has two different properties in comparison with vitamin B1 as a result of structural modification of free thiamine. 3. Sulbutiamine can cross the blood brain barrier more easily than vitamin B1 because of its lipophilic. It can be rapidly absorbed and the concentration is maximum in 1-2 hours after oral administration. The molecule rapidly distribute in the whole body and is eliminated with a biological half-life of 5 hours. 4. Sulbutiamine is also used to increase mental focus, provide a clear mind and promote general vigilance. It has beneficial effects on working and episodic memory by improving memory formation and has been described as a centrally acting cholinergic agent. 12
  • 13. NeuroScience Division Catalog 2012 8. 5- HTP GRIFFONIA SIMPLICFOLIA EXTRACT 5-HTP (Griffonia Simplicifolia Extract) CAS #:114-03-4 MF:C11H12N2O3 MW:220.2246 Appearance:Off white Crystalline powder Assay:99% [ Function] 1.Anti-hypochondria 2.Improve sleep 3. Weight losing 4. Relieve prior menses syndrome (PMS) 5. abstain from addiction 6.Cure hemicranias 13
  • 14. NeuroScience Division Catalog 2012 9. BETA- ALANINE CAS#: 107-95-9 MF:C3H7NO2 MW:89.09 Appearance:White fine powder Assay:99% Function: Mainly used for synthetic pantothenic acid and pantothenic acid calcium, muscle peptide, palmer meters phosphonate.... Widely used in medicine, feed, food area ect Increases strength endurance Increases force output Increases anaerobic threshold Increases work capacity Delays fatigue May improve body composition Works synergistically with Creatine Enhances performance in all athletes regardless of the intensity or duration required by the athletic discipline 14
  • 15. NeuroScience Division Catalog 2012 10. N-ACETYL –TYROSINE CAS#537-55-3 MF:C11H12NO4 MW:222.2178 Appearance:White crystal or white crystalline powder Assay:99% Function: N-Acetyl-L-tyrosine is used in pharmaceutical intermediates,biochemical study,life sciences,etc.. 1.N-Acetyl-L-Tyrosine is a highly bioavailable form of L-tyrosine for the natural precursor treatment of low moods N-acetyl-L-tyrosine can be used in lower doses than L-tyrosine. 2.N-Acetyl-L-Tyrosine is an acetylated derivative of the essential amino acid L- tyrosine. Ordinary L-tyrosine is less stable and insoluble in water, which may result in reduced bioavailability. 3. N-acetyl-L-tyrosine, which is converted in the body to L-tyrosine, is 20 times as soluble in water as L-tyrosine itself. For this reason, it serves as an efficient supplement for raising tyrosine levels in the body, since undissolved substances are not absorbed from the digestive tract. 4. N-acetyl-L-tyrosine enhances the solubility and stability making it a more rapidly absorbed and bioavailable form of the amino acid L-tyrosine which is less prone to urinary excretion 15
  • 16. NeuroScience Division Catalog 2012 11. ALPHA LIPOIC ACID CAS#:62-46-4 MF:C8H13O2S2 MW:205.3182 Appearance: Yellow crystalline powder, almost tasteless. Assay:99% Function: R-(+)Lipoic Acid has been called the mitochondrial antioxidant because it is a key component of mitochondrial dehydrogenase complexes, which may help slow the natural aging process in animals. R-lipoic acid may be more effective than other forms of lipoic acid in increasing or maintaining levels of other antioxidants that may decline with age, including CoQ10, vitamins C and E, and glutathione, according to animal research. 16
  • 17. NeuroScience Division Catalog 2012 12. ACETYL L-CARNITINE CAS#:5080-50-2 MF:C9H18ClNO4 MW:239.6965 Appearance: White crystalline powder Assay:99% Function 1.Improving memory problems in elderly people. 2.Improving memory in people who use alcohol excessively 17
  • 18. NeuroScience Division Catalog 2012 13. L-GLUTAMINE CAS#:56-85-9 MF:C10H20N4O6 MW:292.289 Appearance: White needle crystal Assay:99% Function: L-Glutamine is the most prevalent amino acid in the bloodstream. Glutamine is involved in more metabolic processes than any other amino acid. Glutamine is converted to glucose when more glucose is required by the body as an energy source. Glutamine also plays a part in maintaining proper blood glucose levels and the right pH range. It serves as a source of fuel for cells lining the intestines. Without it, these cells waste away. It is also used by white blood cells and is important for immune function. Glutamine assists in maintaining the proper acid/alkaline balance in the body, and is the basis of the building blocks for the synthesis of RNA and DNA. 18
  • 19. NeuroScience Division Catalog 2012 14. L-THEANINE CAS#:3081-61-6 MF:C7H13N2O3 MW:174.2 Appearance: White crystalline powder Assay:98.0-102.0% Function: 1) diminishing symptoms of PMS, 2) improving learning performance, 3) heightening mental acuity - neurotransmitter, 4) promoting concentration, 5) acting antagonistically against the paralysis induced by caffeine, 6) supporting the immune system, 7) lowering blood pressure, 8) increasing formation of the inhibitory neurotransmitter GABA, and 9) increasing brain dopamine levels among other positive benefits with no known downside 19
  • 20. NeuroScience Division Catalog 2012 15. L-ALPHA GLYCERYLPHOSPHORYLCHOLINE ( ALPHA GPC) CAS#:283-77-9 MF:C8H20 N O6 P MW:257.22 Appearance: White powder or Clearance liquid Aaaay:99% Function 1. Increase human Growth Hormone (hGH) 2. Improve mental focus and cognitive function 3. Improve strength. 20
  • 21. NeuroScience Division Catalog 2012 16. CDP - CHOLINE (CHOLINE BITARTARATE ). CAS#:33818-15-4 MF:C14H25N4NaO11P2 MW:510.3058 Appearance: White or off-white powder Assay:99% Function: Immune & Anti-Fatigue 1.improves Learning ability 2.slows the progression of Alzheimer Disease 3.increases Blood Circulation and Oxygen utilization within the Brain 4.is used mitigate brain damage following a head injury 5.is helpful in the treatment of severe Depression. 6.improves Memory (especially in cases of Memory impairment) 7.is a valuable co-therapy for Parkinson Disease. 21
  • 22. NeuroScience Division Catalog 2012 17. PYRITINOL CAS#:1098-97-1 MF:C16H20N2O4S2 MW:368.47 Appearance: white crystalline powder Assay: 99% Function Pyritinol is a pyridoxine class compound. Two pyridoxines are linked together by two sulfur atoms. Pyritinol (or Pyrithioxin) is a nootropic which enhances oxygen and glucose uptake in the brain. It is also an antioxidant which scavenges hydroxyl radicals. But it has no vitamin B6 activity. 22
  • 23. NeuroScience Division Catalog 2012 18. PYRIDOXAL 5-PHOSPHATE MONOHYDRATE CAS#:41468-25-1 MF: C8H10NO6P.H2O MW: 265.15 Appearance: like white or light yellow powder Assay:99% Function and uses: P5P acts as a coenzyme in all transamination reactions,and in some decarboxylation and deamination reactions of amino acids.It is also needed for hemoglobin production as well as for fatty acid and prosta- glandin metabolism.In addition, P5P is necessary for neurotransmitter production, specifically for the production of dopamine,noradrenaline, serotonin, GABA and glutamate. P5P is essential to any natural antidepressant program,and helps to relieve premenstrual symptoms, boost immune functions and maintain healthy blood sugar level. It may be protective against some cancers and has anti- convulsant effects. It may be effective with some forms of fertility and helps with skin disorders. 23
  • 24. NeuroScience Division Catalog 2012 19. PICAMILON CAS#:34562-97-5 MF:C10H11N2NaO3 MW:230.1957 Appearance: white crystalline powder Assay:99% Function Picamilon (also known as nicotinoyl-GABAm Pycamilon, Pikamilon, etc) is a dietary supplement formed by combining niacin with GABA. Picamilon is able to cross the blood-brain barrier and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response.The second released component, niacin acts as a strong vasodilator, which might be useful for the treatment of migraine headaches. 24
  • 25. NeuroScience Division Catalog 2012 20. PHENIBUT CAS No.:1078-21-3 MF:C10H14ClNO2 MW:215.6767 Appearance: White crystalline powder Assay:>99% Function: 1.Antimelancholic (psychotropic drugs) 2.Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA. 3.Phenibut is used by bodybuilders to reduce fatigue and improve neurological functions.4.Phenibut has been and is still used medically to treat stress, relieve tension, improve sleep, and as a potentiate for other medications. 25
  • 26. NeuroScience Division Catalog 2012 21. NERVONIC ACID CAS No.:506-37-6 MF:C24H46O2 MW:366.62 Assay:>90%by HPLC Appearance: White crystalline Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been identified as important in the biosynthesis of nerve cell myelin. It is found in the sphingolipids of white matter in human brain. Nervonic acid is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids. Nervonic acid is a monounsaturated omega-9 fatty acid. Nervonic acid has been identified as important in the biosynthesis of nerve cell myelin. It is found in the sphingolipids of white matter in human brain. Nervonic acid is used in the treatment of disorders involving demyelination, such as adrenoleukodystrophy and multiple sclerosis where there is a decreased level of nervonic acid in sphingolipids. 26
  • 27. NeuroScience Division Catalog 2012 22. CENTROPHENOXINE. CAS: 3685-84-5 Molecular Formula: C12H17Cl2NO3 Molecular weight :294.1743 Quality Standard; Enterprise standard Assay: 99.0%min Function Centrophenoxine - formerly known as Lucidril increases the brain's use of glucose and improves brain energy levels. It also removes a potassium build up in the brain, heart, lung and skin cells, and is vital for the efficient communication of a cell to transfer potassium and sodium across its membranes. Centrophenoxine has shown an ability to remove the visible signs of excessive potassium build up - age or liver spots 27
  • 28. NeuroScience Division Catalog 2012 23. IDEBENONE CAS NO.:58186-27-9 MF:C19H30O5 MW:338.4385 Assay:> 98.5%(HPLC) Appearace: orange yellow or orange crystalline powder Function 1. Idebenone increases nerve growth factor (NGF) in the brain. 2. Idebenone is a powerful antioxidant and positively affects brain chemistry. 3. Idebenone has been shown to promote information transfer across the corpus callosum, the membrane separating the right and left brain hemispheres. 4. Idebenone has been used to treat Alzheimer's and to lessen damage from strokes. 5. Idebenone can increase production of the brain neurotransmitters serotonin, dopamine, adrenalin, and noradrenanlin. Idebenone is closely related to CoQ10 in its structure. It can replace CoQ10 in the process of cellular energy production and, just as CoQ10, idebenone is also an antioxidant. There are some important distinctions though. Idebenone is more water-soluble than CoQ10; its cellular distribution and antioxidant profile are somewhat different too. This makes idebenone superior to CoQ10 in neutralizing some types of free radicals and inferior in fighting other types. Notably, idebnone is more effective than CoQ10 in protecting cells from the free radical damage resulting from reduced blood flow. On the other hand, idebenone appears more conducive than CoQ10 to certain types of noxious free-radical leakage in the cell's 28
  • 29. NeuroScience Division Catalog 2012 mitochondria. Unfortunately, there have been very few studies directly comparing CoQ10 and idebenone in the treatment of various conditions. 24. GALANTAMINE HYDROBROMIDE (GALANTHAMINE HBR.) CAS Number:1953-04-4 Origin:Lycoris radiata (LHer.) Herb. Molecular Formula:C17H21NO3·HBr Molecular Weight:368.27 Appearance:White Powder Assay by HPLC:98% Min Function Galantamine Hydrobromide is an effective,competitive and reversible acetylcholine esterase inhibitor,especially used in curing lightly and moderate Alzheimer's Diseas 29
  • 30. NeuroScience Division Catalog 2012 25. CALCIUM GLYCEROPHOSPHATE. CAS:27214-00-2 MF:C6H14Ca2O12P2 MW:420.27 Assay:99% Appearance: White or light yellow powder Function: A kind of nutrition medicine. Used for auxiliary curing. With nutritious function, mostly used in convalescence period, and generally used in medicine made of two or more ingredients preparations. 30
  • 31. NeuroScience Division Catalog 2012 26. L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE HYDRATE L-α-Glycerylphosphorylcholine hydrate CAS#:28319-77-9 MF: C8H21NO6P·nH2O MW:257.20 Assay:98% Appearance:Clear liquid very viscous Function: L-alpha-GPC (L-alpha-glycerophosphorylcholine) is an easily absorbed source of choline, which increases neurotransmitter production for better memory, mood and learning. Neurotransmitters support effective communication and are needed for a healthy brain and cognitive function. Studies have shown L-alpha-GPC is effective in the treatment of Alzheimer’s type dementia. Phosphatidylcholine (PC) and Phosphatidylserine (PS) are the major phospholipids in the body and the brain. PC supports brain function by stimulating production of choline, which in turn forms acetylcholine. PS has been shown to improve age- related memory loss, boosting learning, vocabulary skills and concentration, and even reversing early stages of Alzheimer’s disease. 31
  • 32. NeuroScience Division Catalog 2012 27. CTP CYTIDINE TRIPHOSPHATE DISODIUM CAS:18423-42-2 MF:C9H14N3Na2O14P3 MW:527.12 Purity:99% Appearance: white powder Function Made of CMP. it can be used in the therapy of cerebrovascular accident & sequelae; cerebral concussion, trauma coma, dysfunction after craniocerebral operations; neurosis; cerebrovascular angiosclerosis, presenile dementia; peripheral nerve injury; atelencephalia 32
  • 33. NeuroScience Division Catalog 2012 28. POLYCYRIDYLIC ACID Polycytidylic Acid(PolyC) CAS No.:24939-03-5 MF:(C9H14N3O8P)n Purity:99% Appearnce:White powder Function: 1. it also can offer good effects to hepatitis B, epidemic hemorrhagic fever, virus flu and flat wart. 2.Moreover, it can cure nasopharyngeal cancer and Gynecologic Cancers. 33
  • 34. NeuroScience Division Catalog 2012 29. 5- ADENOSYL-L- METHIONINE DISULFATE TOSYLATE Synonyms: Ademetionine disulfate tosylate CAS: 97540-22-2 Molecular Formula: C15H22N6O5S.2 (H2SO4).C7H8SO3 Molecular Weight: 766.79 Assay:99% Function: 1.It can be used in the therapy of depression, arthritis, chronic hepatitis and cholestasia; 2.moreover, it can be used in the preventation of liver cancer, or relieve the poisoning of chemicals, alcohol and cancer to liver, improve the curing of wound and growth of cartilage tissue; 3. it also can adjust the function of nerve centre system. 34
  • 35. NeuroScience Division Catalog 2012 30. SAME (S-ADENOSYL-L-METHIONINE) CAS-No: 29908-03-0 Mol. Formula:C15H22N6O5S Mol. Weight:398.44 Assay: 98% Appearance: White fine powder Function 1.SAMe is an improvement of the cell metabolism biochemical drugs 2.SAMe is a kind of good liver nutrition agent 3.SAMe have diminish inflammation, relieve pain and tissue repair function, especially for arthropathy. 35
  • 36. NeuroScience Division Catalog 2012 31. CITICOLINE SODIUM CAS-No:33818-15-4 Mol. Formula:C14H25N4NaO11P2 Mol. Weight:510.31 Assay: 99% Appearance: white powder or off-white crystal Function 1.it can reduce the resistance of blood vessel of brain and accelerate substance metabolism of brain 2.It also can activate the mechanism of reticular formation of brain stem. 3. It can be used in the therapy of acute craniocerebral trauma and disturbance of consciousness after brain operation. 36
  • 37. NeuroScience Division Catalog 2012 32. ADENOSINE TRIPHOSPHATE DISODIUM CAS-No:987-65-5 Mol. Formula:C10H14N5Na Mol. Weight:551.15 Assay: 99% Appearance:white powder or off-white crystal Function 1.used in the disease caused by tissue injury and activity reduction of ecto enzyme 2.used in treatment of heart failure, carditis, miocardial infarction, cerebral arteriosclersis, coronary sclerosis 3 used in treatment of progressive muscular atrophy , cerebral hemorrhage , chronic hepatitis, cirrhosis of liver and hearing handicap, etc. 37
  • 38. NeuroScience Division Catalog 2012 33. ANIRACETAM Aniracetam 1-(4-methoxybenzoyl)-2-pyrrolidinon CAS-No: [72432-10-1] Assay 99.6% Grade: EP5 Mol. Formula: C12H13NO3 Mol. Weight: 219.24 Appearance: white Crystalline Powder Function: Aniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects. It has been tested in animals extensively, Alzheimer's patients and temporarily-impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in the United States as a dietary supplement. Aniracetam has also been shown to selectively modulate the AMPA receptor[2] and was used as the parent compound to derive a class of drugs known as the ampakines which are being investigated as nootropics and neuroprotective drugs for the treatment of Alzheimer's disease and other neurodegenerative conditions. 38
  • 39. NeuroScience Division Catalog 2012 34. NEFIRACETAM Nefiracetam Synonyms: n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide; [(2,6- dimethylphenyl)aminocarbonylmethyl]chloride; CAS: 77191-36-7 Assay: 99.0%min Molecular Formula: C14H18N2O2 Molecular Weight: 246.31 Quality Standard; Enterprise standard Appearance: A white Crystalline Powder Action: raw materials for the cardiovascular and cerebral diseases 39
  • 40. NeuroScience Division Catalog 2012 35. OXIRACETAM Oxiracetam CAS No: 62613-82-5 Assay: 98.0~101.0% Molecular Formula: C6H10N2O3 Molecular Weight: 158.16 Appearance: White crystalline power USES: used in medicine, intelligent promote senile brain dysfunction syndrome, mental behavior of mental disorder, etc Density 1.416g/cm3 Melting point 165-168oC Density 1.416g/cm3 Loss on drying: 0.5%max Melting point 165-168°C Density:1.416g/cm3 Melting point:165-168°C Boiling point:494.6°C at 760 mmHg Refractive index:1.57 Flash point:252.9°C Vapour Pressur:7.39E-12mmHg 40
  • 41. NeuroScience Division Catalog 2012 36. PRAMIRACETAM Pramiracetam Chemical Name: N-(2-(Bis(1-methylethyl)amino)ethyl)-2-oxo-1- pyrrolidineacetamide CAS No.: 68497-62-1 Molecular Formula: C14H27N3O2 Molecular Weight: 269.38 Appearance: White crystal; Pharmacology Action: Pramiracetam is a nootropic drug derived from piracetam, and is more potent (i.e. lower dosage is used). It belongs to the racetam family of nootropics.Pramiracetam was developed by Parke-Davis based on Piracetam, and is 8-30 times stronger than Piracetam. It goes by the trade name Neupramir or Pramistar. 41
  • 42. NeuroScience Division Catalog 2012 37. PIRACETAM Piracetam anti-brain aging Grade: CP, BP, EP Purity: 98%,99% Appearance: White or off-white crystalline powder Packing: 25 Kg / Drum Clarify of solution Be up to the standard PH 5.0-7.0 Related substances The area of total impurities'peak isn't more than the area of the comparative solution's principal peak Loss on drying ≤0.5% Residue on ignition ≤0.1% Heavy Metals ≤20PPM Assay(HPLC) 98.0 percent to 102.0 percent Packaging 20kg or 25kg per Platinum paper barrel; 20kg or 25kg per carton Piracetam (sold under many brand names) is a drug. It appears to enhance and , slow brain aging, increase blood flow and oxygen to the brain, aid stroke recovery, and ameliorate Alzheimer's, Down's syndrome, dementia, and dyslexia, among other diseases and conditions. Piracetam's chemical name is 2-oxo-1-pyrrolidine acetamide; it shares the same 2-oxo-pyrrolidone base structure with (). Piracetam is a cyclic derivative of . It is one of the . Piracetam is prescribed by doctors for some conditions, mainly , but is used off-label for a much wider range of applications. 42
  • 43. NeuroScience Division Catalog 2012 38. 5-HTP, 5-HYDROXYTRYPTOPHAN, (GRIFFONIA SEED EXTRACT) CAS:56-69-9 Packaging:25kg/drum Description Purity: 99% HPLC Appearance: white powder or off-white crystal Function: 1. Improve sleep 2. Weight losing 3. Relieve prior menses syndrome (PMS) 4. Abstain from addiction 5. Cure of hemicrania 43
  • 44. NeuroScience Division Catalog 2012 SAMPLE TECHNIC SHEET 44
  • 45. NeuroScience Division Catalog 2012 Reishi Mushroom P.E. – polysaccharide Product Type: Herbal Extract Variety: Reishi Mushroom P.E. Form: Powder Part: fruiting body Extraction Type: Solvent Extraction Packaging: Bottle, Drum, Vacuum Packed Place of Origin: China (Mainland) Grade: First Class Brand Name: ND Pharma & Biotech Model Number: Polysaccharide 10%, 20%, 30% by H... Latin name: Ganoderma lucidum Product Type: Fine Brown Powder Part of the Plant Used: Fruit Body Appearance: yellow powder Package: 25kg/drum Packaging & Delivery Packaging Detail: 25kg / Fiber Drum with double-layer plastic bag inside. Specifications 1): 100% Natural Reishi Mushroom Extract 45
  • 46. NeuroScience Division Catalog 2012 2): Polysaccharide 10%, 20%, 30% by HPLC 3): European Standard Reishi Mushroom P.E. - polysaccharide Brief Introduction Synonyms Ganodema lucidum Mushroom, Mannentake Beta-Glucan Chemical Name: Beta-Glucan, Beta-D-Glucan, Beta-(1,3)-D-Glucan Molecular Formula: C18H30O14X2 Mol. Wt.: 470.42 Molecular Structure Triterpenes (Ganoderic acids) Chemical Name: Triterpenes, Triterpene saponins, Ganoderic acid A (a compound isolated from the Reishi mushroom) Cas No.: 81907-62-2 Molecular Formula: 46
  • 47. NeuroScience Division Catalog 2012 C30H44O7 Mol. Wt.: 516.67 Molecular Structure: Benefits Reishi Mushroom contains a high concentration of beta-glucan and Granoderic acids (Triterpenes), compounds which has been shown to stimulate immune system and anti-tumor: • Up-regulate the immune system (Immunomodulatory and immunotherapeutic activities) • Anti-cancer, anti-tumor, and anti-neoplastic effects •Prevent cancer metastasis •Anti-bacterial and anti-viral activities • Beneficial effect on Lowering Blood Pressure(via inhibition of angiotensin-converting enzyme) • Beneficial effect on Lowering Blood Sugar • Beneficial effect on Lowering Cholesterol • Protective effects against liver injury by viruses and other toxic agents • Weight loss aid Safety Reishi Mushroom Extract is safe. No side and harmful effect have been found. Dosage • The typical dose is 500-1500mg per day (usually in 2-3 doses throughout the day). • Consult physicians for different condition specifics. 47
  • 48. NeuroScience Division Catalog 2012 Reishi Mushroom Extract Features and Benefits: Reishi Mushroom Extract with many advantages as list in the following, produced as our patent-pending process and know-how technology from Ganodema lucidum Mushroom • Produced with pure water only • High purity: over 30% (Polysaccharides as Beta-glucan and 4% Treiterpenes • NO solvent - residual free • Pesticide-free • Crystal yellow-Brown in appearance • High solubility in water • High anti-bacteria, and longer shelf life NOTES: All our products are accompanied of the proper CERTIFICATE OF ANALYSYS All our products are manufactured under the higher standards of quality and Certification ISO. All our plants and providers are regularly audited and supervised by our Technical and Scientific Inspectors. We are Leaders in R+D+ Innovation. 48
  • 49. NeuroScience Division Catalog 2012 ND Pharma & Biotech NeuroScience Division Poligono de Valdredo, 12 33157 Oviñana, Cudillero, Asturias ndpharmabiotech@europe.com 49