Screening Of Mdr1 [Autosaved]

•Download as PPT, PDF•

1 like•348 views

Pooja1923

Health & Medicine Technology

Screening of MDR1 Gene Polymorphisms in Non Tribal Population of Kerala Pooja Gupta MSc Project Thesis Internal Guide: Mrs K.Narayani, SRM Arts and Science College, Chennai External Guide: Dr.Moinak Banerjee, Rajiv Gandhi Centre for Biotechnology, Trivandrum

Objective & Scope ,[object Object],[object Object],[object Object]

Epilepsy ,[object Object],[object Object],[object Object]

Pharmacoresistance in Epilepsy ,[object Object],[object Object],[object Object],[object Object]

Multidrug Transporters ,[object Object],[object Object],[object Object],[object Object]

P-gp Expression and Genotype ,[object Object],[object Object],[object Object]

Results PRIMER PRIMER SEQUENCE AMPLIFIED PRODUCT SIZE SNP MDR13 MDR14 AGGTTTCATTTTGGTGCCTG GAACAAAAGGATGCACACGAC 299 In07+139 C/T MDR9 MDR10a TGCAGGCTATAGGTTCCAGG TTTAGTTTGACTCACCTTCCCG 224 Ex22 G2677T MDR11 MDR12 TGTTTTCAGCTGCTTGATGG AAGGCATGTATGTTGGCCTC 197 Ex27 C3435T

Gradient PCR In 07+139C/T Ex22 G2677T Ex27 C3435T 56.3ºC 53ºC 61.3ºC

Linkage Disequilibrium Analysis 1- In07+139C/T 2- Ex 2677G/T 3- Ex 3435C/T In07+139C/T was found to be in strong linkage disequilibrium with Ex 2677G/T(D’=0.649,r²=0.387) but not in significant LD with Ex 3435C/T (D’=0.393,r²=0.12)

Summary and Conclusion ,[object Object],[object Object],[object Object]

Contd….. ,[object Object],[object Object],[object Object]

What's hot

Genetic polymorphisms cindyzeta

Application of RDT in gene therapyANUGYA JAISWAL

2016 BDSRA Cotman, Chandrachud, Hillje, Ilo, Nowell, Oh CLN2, CLN3, CLN6, Adu...Batten Disease Support and Research Association

2014 BDSRA Palmer CLN 5 and CLN 6Batten Disease Support and Research Association

Sjogren pptJacqueline Garcia

BDSRA 2015 CLN1 CLN2 CLN3 Sleat, Lobel Batten Disease Support and Research Association

Pharmaceurtical role of nucleic acidLaraibTariq5

Whole Exome Sequencing at Stanford UniversityGolden Helix

1.3 dfEURORDIS Rare Diseases Europe

Topological analysis of coexpression networks in neoplastic tissues (BITS2012...Roberto Anglani

BDSRA 2015 CLN1 HofmannBatten Disease Support and Research Association

2013 ANCL MoleBatten Disease Support and Research Association

SSR 2015-poster-A Hypoxia-HIF-Kdm3a Pathway Controls Trophoblast Stem Cell Li...Wei Cui

20140824 Abnormalities in human pluripotent cells due to reprogramming mechan...Alim Polat

BDSRA 2015 CLN10 Burrow, Spaeth, Sisk, HallinanBatten Disease Support and Research Association

2013 a6b1 a7b1 MartaMonica Ghidinelli

A New molecular biology techniques for gene therapyVanessa Chappell

Cell biology review paperBrendan Kelemen

Gene Therapy by LekhanLekhan Lodhi

What's hot (20)

Genetic polymorphisms

Application of RDT in gene therapy

2016 BDSRA Cotman, Chandrachud, Hillje, Ilo, Nowell, Oh CLN2, CLN3, CLN6, Adu...

2014 BDSRA Palmer CLN 5 and CLN 6

Sjogren ppt

BDSRA 2015 CLN1 CLN2 CLN3 Sleat, Lobel

Pharmaceurtical role of nucleic acid

Whole Exome Sequencing at Stanford University

1.3 df

Topological analysis of coexpression networks in neoplastic tissues (BITS2012...

BDSRA 2015 CLN1 Hofmann

2013 ANCL Mole

SSR 2015-poster-A Hypoxia-HIF-Kdm3a Pathway Controls Trophoblast Stem Cell Li...

20140824 Abnormalities in human pluripotent cells due to reprogramming mechan...

BDSRA 2015 CLN10 Burrow, Spaeth, Sisk, Hallinan

2013 a6b1 a7b1 Marta

A New molecular biology techniques for gene therapy

Cell biology review paper

Gene Therapy by Lekhan

Viewers also liked

Curso Telescópio Aula 4Maracaju Vip

Presentationirvingjd10

Tutorial vb projeto em vb.netMaracaju Vip

Last dayson9524

CamaraEscuela

Php 4 a bíbliaMaracaju Vip

Curso de torneiro mecanicoMaracaju Vip

CamaraEscuela

Indo-network pilar 1arya setiyaki

PROTEINASEscuela

Curso telescopio Aula 1Maracaju Vip

Indo-network Pilar 2arya setiyaki

B2B Informatie over het Logo spel van Koninklijke JumboMascha Rood

Biblia de acordes para jazz (guitarra)Maracaju Vip

Projeto telescópio faça você mesmoMaracaju Vip

A bíblia do carroMaracaju Vip

Caso barrio ituzaingó anexoEscuela

Probiotics1Pooja1923

Viewers also liked (18)

Curso Telescópio Aula 4

Presentation

Tutorial vb projeto em vb.net

Last day

Camara

Php 4 a bíblia

Curso de torneiro mecanico

Camara

Indo-network pilar 1

PROTEINAS

Curso telescopio Aula 1

Indo-network Pilar 2

B2B Informatie over het Logo spel van Koninklijke Jumbo

Biblia de acordes para jazz (guitarra)

Projeto telescópio faça você mesmo

A bíblia do carro

Caso barrio ituzaingó anexo

Probiotics1

Similar to Screening Of Mdr1 [Autosaved]

Dr. Ángel Carracedo - Simposio Internacional 'La enfermedad de la duda: el TOC'Fundación Ramón Areces

Genome Wide Association Studies in PsychiatryDr.Guru S Gowda

Open Source Pharma /Genomics and clinical practice / Prof Hosur opensourcepharmafound

From reads to pathways for efficient disease gene findingJoaquin Dopazo

Will the real proteins please stand upChris Southan

Diaz-Arrastia, RamonNational Neurotrauma Symposium

A New Generation Of Mechanism-Based Biomarkers For The ClinicJoaquin Dopazo

MathiasHibbard_604FinalPaperMathias Hibbard

Spilman tropisetron brain researchpatricia spilman

mmc2Lei Ying

Analisis de la expresion de genes en la depresionCinthya Yessenia

Genetics differences affect drug metabolismfaysalahmed35

Schizophreniaguest0781e91

PIIS0016508514604509Mariah Baril-Dore

Altered proliferation and networks in neural cells derived from idiopathic au...Masuma Sani

Integrative regulatory genomics for target gene prioritisation in SLEEnrico Ferrero

Gasparini_2014_02ThesisClaudia Gasparini

6 55 ESean Paul

1995 Research PublicationPhil Myers

26 ASBMB TODAY FEBRUARY 2021Discovering an old DoGs’ neMargaritoWhitt221

Similar to Screening Of Mdr1 [Autosaved] (20)

Dr. Ángel Carracedo - Simposio Internacional 'La enfermedad de la duda: el TOC'

Genome Wide Association Studies in Psychiatry

Open Source Pharma /Genomics and clinical practice / Prof Hosur

From reads to pathways for efficient disease gene finding

Will the real proteins please stand up

Diaz-Arrastia, Ramon

A New Generation Of Mechanism-Based Biomarkers For The Clinic

MathiasHibbard_604FinalPaper

Spilman tropisetron brain research

mmc2

Analisis de la expresion de genes en la depresion

Genetics differences affect drug metabolism

Schizophrenia

PIIS0016508514604509

Altered proliferation and networks in neural cells derived from idiopathic au...

Integrative regulatory genomics for target gene prioritisation in SLE

Gasparini_2014_02Thesis

6 55 E

1995 Research Publication

26 ASBMB TODAY FEBRUARY 2021Discovering an old DoGs’ ne

Recently uploaded

Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...Dipal Arora

💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...Sheetaleventcompany

Bandra East [ best call girls in Mumbai Get 50% Off On VIP Escorts Service 90...Angel

💚Chandigarh Call Girls 💯Riya 📲🔝8868886958🔝Call Girls In Chandigarh No💰Advance...Sheetaleventcompany

Kolkata Call Girls Naktala 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...Namrata Singh

Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...Sheetaleventcompany

Dehradun Call Girl Service ❤️🍑 8854095900 👄🫦Independent Escort Service DehradunSheetaleventcompany

Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room DeliveryJyoti singh

Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...Oleg Kshivets

Jual Obat Aborsi Di Dubai UAE Wa 0838-4800-7379 Obat Penggugur Kandungan Cytotecjualobat34

❤️Chandigarh Escorts Service☎️9814379184☎️ Call Girl service in Chandigarh☎️ ...Sheetaleventcompany

Genuine Call Girls Hyderabad 9630942363 Book High Profile Call Girl in Hydera...GENUINE ESCORT AGENCY

👉Chandigarh Call Girl Service📲Niamh 8868886958 📲Book 24hours Now📲👉Sexy Call G...Sheetaleventcompany

Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...gragneelam30

👉 Amritsar Call Girls 👉📞 8725944379 👉📞 Just📲 Call Ruhi Call Girl Near Me Amri...Sheetaleventcompany

❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...Sheetaleventcompany

Intramuscular & Intravenous Injection.pptxsaranpratha12

👉 Chennai Sexy Aunty’s WhatsApp Number 👉📞 7427069034 👉📞 Just📲 Call Ruhi Colle...rajnisinghkjn

Dehradun Call Girls Service {8854095900} ❤️VVIP ROCKY Call Girl in Dehradun U...Sheetaleventcompany

Chandigarh Call Girls Service ❤️🍑 9809698092 👄🫦Independent Escort Service Cha...Sheetaleventcompany

Recently uploaded (20)

Bhawanipatna Call Girls 📞9332606886 Call Girls in Bhawanipatna Escorts servic...

💚Call Girls In Amritsar 💯Anvi 📲🔝8725944379🔝Amritsar Call Girl No💰Advance Cash...

Bandra East [ best call girls in Mumbai Get 50% Off On VIP Escorts Service 90...

💚Chandigarh Call Girls 💯Riya 📲🔝8868886958🔝Call Girls In Chandigarh No💰Advance...

Kolkata Call Girls Naktala 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...

Goa Call Girl Service 📞9xx000xx09📞Just Call Divya📲 Call Girl In Goa No💰Advanc...

Dehradun Call Girl Service ❤️🍑 8854095900 👄🫦Independent Escort Service Dehradun

Call 8250092165 Patna Call Girls ₹4.5k Cash Payment With Room Delivery

Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...

Jual Obat Aborsi Di Dubai UAE Wa 0838-4800-7379 Obat Penggugur Kandungan Cytotec

❤️Chandigarh Escorts Service☎️9814379184☎️ Call Girl service in Chandigarh☎️ ...

Genuine Call Girls Hyderabad 9630942363 Book High Profile Call Girl in Hydera...

👉Chandigarh Call Girl Service📲Niamh 8868886958 📲Book 24hours Now📲👉Sexy Call G...

Call Girls Bangalore - 450+ Call Girl Cash Payment 💯Call Us 🔝 6378878445 🔝 💃 ...

👉 Amritsar Call Girls 👉📞 8725944379 👉📞 Just📲 Call Ruhi Call Girl Near Me Amri...

❤️Call Girl Service In Chandigarh☎️9814379184☎️ Call Girl in Chandigarh☎️ Cha...

Intramuscular & Intravenous Injection.pptx

👉 Chennai Sexy Aunty’s WhatsApp Number 👉📞 7427069034 👉📞 Just📲 Call Ruhi Colle...

Dehradun Call Girls Service {8854095900} ❤️VVIP ROCKY Call Girl in Dehradun U...

Chandigarh Call Girls Service ❤️🍑 9809698092 👄🫦Independent Escort Service Cha...

Screening Of Mdr1 [Autosaved]

1. Screening of MDR1 Gene Polymorphisms in Non Tribal Population of Kerala Pooja Gupta MSc Project Thesis Internal Guide: Mrs K.Narayani, SRM Arts and Science College, Chennai External Guide: Dr.Moinak Banerjee, Rajiv Gandhi Centre for Biotechnology, Trivandrum

5. Course of an AED

7. Common MDR transporters

9. Structure of P-gp

10. Plan of Work

11. Methodology

12.

13. Results PRIMER PRIMER SEQUENCE AMPLIFIED PRODUCT SIZE SNP MDR13 MDR14 AGGTTTCATTTTGGTGCCTG GAACAAAAGGATGCACACGAC 299 In07+139 C/T MDR9 MDR10a TGCAGGCTATAGGTTCCAGG TTTAGTTTGACTCACCTTCCCG 224 Ex22 G2677T MDR11 MDR12 TGTTTTCAGCTGCTTGATGG AAGGCATGTATGTTGGCCTC 197 Ex27 C3435T

14. Gradient PCR In 07+139C/T Ex22 G2677T Ex27 C3435T 56.3ºC 53ºC 61.3ºC

15. RFLP Results

16. Genotypes obtained by RFLP

17.

18.

19.

20.

21.

22.

23. Linkage Disequilibrium Analysis 1- In07+139C/T 2- Ex 2677G/T 3- Ex 3435C/T In07+139C/T was found to be in strong linkage disequilibrium with Ex 2677G/T(D’=0.649,r²=0.387) but not in significant LD with Ex 3435C/T (D’=0.393,r²=0.12)

24.

25.

26.

27.

Screening Of Mdr1 [Autosaved]

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Viewers also liked

Viewers also liked (18)

Similar to Screening Of Mdr1 [Autosaved]

Similar to Screening Of Mdr1 [Autosaved] (20)

Recently uploaded

Recently uploaded (20)

Screening Of Mdr1 [Autosaved]