Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter http://www.senology.org/newsletter/Newsl_Dec2011.htm
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Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Romero C et al.: "Impact on breast cancer diagnosis in a multidisciplinary unit after the
incorporation of mammography digitalization and computer-aided detection systems", AJR Am J
Roentgenol. 2011 Dec;197(6):1492-7
Cho N et al.: "Distinguishing Benign from Malignant Masses at Breast US: Combined US
Elastography and Color Doppler US--Influence on Radiologist Accuracy", Radiology. 2011 Nov 14.
[Epub ahead of print]
Sandri MT et al.: "Prognostic role of CA15.3 in 7942 patients with operable breast cancer", Breast
Cancer Res Treat. 2011 Nov 9. [Epub ahead of print]
Amir E et al.: "Prospective Study Evaluating the Impact of Tissue Confirmation of Metastatic Disease
in Patients With Breast Cancer", J Clin Oncol. 2011 Nov 28. [Epub ahead of print]
Fasching PA et al.: "Ki67, chemotherapy response, and prognosis in breast cancer patients
receiving neoadjuvant treatment", BMC Cancer. 2011 Nov 14;11(1):486. [Epub ahead of print]
He X et al.: "Metformin and thiazolidinediones are associated with improved breast cancer-specific
survival of diabetic women with HER2+ breast cancer", Ann Oncol. 2011 Nov 22. [Epub ahead of
print]
Pellegrini I et al.: "Tailored chemotherapy based on tumour gene expression analysis: breast cancer
patients' misinterpretations and positive attitudes", Eur J Cancer Care 2011 Nov 9 [Epub ahead of
print]
Romano S et al.: "Serial measurements of NT-proBNP are predictive of not-high-dose anthracycline
cardiotoxicity in breast cancer patients", Br J Cancer. 2011 Nov 8. doi: 10.1038/bjc.2011.439. [Epub
ahead of print]
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2. Senology Newsletter http://www.senology.org/newsletter/Newsl_Dec2011.htm
Wang J et al.: "Predictors of Nipple-Areolar Complex Involvement by Breast Carcinoma:
Histopathologic Analysis of 787 Consecutive Therapeutic Mastectomy Specimens", Ann Surg Oncol.
2011 Nov. [Epub ahead of print
Kesler SR et al.: "Prefrontal cortex and executive function impairments in primary breast cancer",
Arch Neurol. 2011 Nov;68(11):1447-53
Pemmaraju N et al.: "Retrospective review of male breast cancer patients: analysis of tamoxifen-
related side-effects", Ann Oncol. 2011 Nov 15. [Epub ahead of print]
Comment
"Intermediate mammograms increase the false-positive rate except in specific groups" - Nieves
Ascunce Elizaga, Navarra Breast Cancer Screening Programme, Public Health Institute, Pamplona, Spain
""Intermediate mammograms (IM) in breast screening offer potential benefits but also disadvantages, like
false positives (FP) results. Although annual screening has not been shown to reduce more the mortality
than biennial screening, some studies have reported an increased detection rate, detection of smaller
tumours and a reduction in interval cancers. On the other hand, in the whole IMs increase the rate of FP.
However in the case of younger women undergoing their initial screen and those with risk factors (previous
invasive procedures, a family history of breast cancer or hormone replacement therapy use) the risk of a FP
result is significantly lower. In order to guarantee the quality of screening programmes, a better
characterization of the IM indications should be done, according to the presence of those maximising
benefits and minimising adverse effects"
(Comment on: Ascunce N et al.: "Impact of intermediate mammography assessment on the
likelihood of false-positive results in breast cancer screening programmes", Eur Radiol. 2011. [Epub
ahead of print])
Discussion
- Article in The Lancet: MRI of little benefit to women with breast cancer despite its increasing use. What
do you think? Share your opinion on LinkedIn®
Calendar of Events
The 2011 CTRC-AACR San Antonio Breast Cancer Symposium, December 6-10, 2011, San Antonio,
TX
The World Cancer Immunotherapy Conference, January 25-26, 2012, San Diego, CA
Fragments of History
William S Halsted (New York, 1852-1922), "The results of radical operations for the cure of carcinoma
of the breast", Ann Surg. July 1907:46(1):1-19: “Fortunately we no longer need the proof which our
figures so unmistakably give that the slightest delay is dangerous and that, other things being equal, the
prognosis is quite good in the early stage of breast cancer, two in three being cured, and bad, three in four
succumbing, when the axillary glands are demonstrably involved"
Literature Selection
Engels EA et al.: "Spectrum of cancer risk among US solid organ transplant recipients", JAMA. 2011
Nov 2;306(17):1891-901
Aune D et al.: "Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and
dose-response meta-analysis of prospective studies", BMJ. 2011 Nov 10;343:d6617. doi:
10.1136/bmj.d6617
Meng Z et al.: "Randomized controlled trial of acupuncture for prevention of radiation-induced
xerostomia among patients with nasopharyngeal carcinoma", Cancer. 2011 Nov 9. doi:
10.1002/cncr.26550. [Epub ahead of print]
Chen QY et al.: "Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal
Carcinoma: Phase III Randomized Trial", J Natl Cancer Inst. 2011 Nov 4. [Epub ahead of print]
Castro MR et al.: "Predictors of malignancy in patients with cytologically suspicious thyroid
nodules", Thyroid. 2011 Nov;21(11):1191-8
Warde P et al.: "Combined androgen deprivation therapy and radiation therapy for locally advanced
prostate cancer: a randomised, phase 3 trial", Lancet. 2011 Nov 2. [Epub ahead of print]
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3. Senology Newsletter http://www.senology.org/newsletter/Newsl_Dec2011.htm
Azoulay L et al.: "Androgen-deprivation therapy and the risk of stroke in patients with prostate
cancer", Eur Urol. 2011 Dec;60(6):1244-50
Kim DY et al.: "Adjuvant Hepatic Arterial Infusional Chemotherapy with 5-Fluorouracil and Cisplatin
after Curative Resection of Hepatocellular Carcinoma", Oncology. 2011 Nov 8;81(3-4):184-191. [Epub
ahead of print]
Aftab BT et al.: "Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer",
Cancer Res. 2011 Nov 1;71(21):6764-72
Dhar SU et al.: "Outcomes of integrating genetics in management of patients with retinoblastoma",
Arch Ophthalmol. 2011 Nov;129(11):1428-34
Literature Selection
Moorman PG et al.: "Effect of Hysterectomy With Ovarian Preservation on Ovarian Function", Obstet
Gynecol. 2011 Nov 7. [Epub ahead of print]
Imkampe AK et al.: "Correlation of Age at Oral Contraceptive Pill Start with Age at Breast Cancer
Diagnosis", Breast J. 2011 Nov 8. doi: 10.1111/j.1524-4741.2011.01181.x. [Epub ahead of print]
Crandall CJ et al.: "Breast tenderness and breast cancer risk in the estrogen plus progestin and
estrogen-alone women's health initiative clinical trials", Breast Cancer Res Treat. 2011 Nov 1. [Epub
ahead of print]
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Recent Advances in Clinical Medicine
Dooley MA et al.: "Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis", N
Engl J Med. 2011 Nov 17;365(20):1886-95
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