Stained Glass to Cancer Cure: Nanotech Past and Future

STAINED GLASS TO CANCER TREATMENT? Nanotechnology : then and now!

SIMILAR….YET VERY DIFFERENT Depiction of a forest glass shop from Sir John Mandeville's Travels , dated 1420 – 1450. British Library, London

SIMILAR….YET VERY DIFFERENT Both show NANOTECHNOLOGISTS!! Depiction of a forest glass shop from Sir John Mandeville's Travels , dated 1420 – 1450. British Library, London

WHAT IS NANOTECHNOLOGY? Nanotechnology is the understanding and control of matter at dimensions of roughly 1 to 100 nanometers, where unique phenomena enable novel applications. Encompassing nanoscale science, engineering and technology, nanotechnology involves imaging, measuring, modeling, and manipulating matter at this length scale. --National Nanotechnology Initiative (2003) … But what does that mean?

WHAT IS NANOTECHNOLOGY? … How small is extremely small? ,[object Object],[object Object],[object Object]

EXACTLY HOW SMALL IS NANO? meter 1/100 th of a meter (centimeter) 1/1000 th of a meter (millimeter) All these are still visible with your eyes. 1/10 th of a meter

… ..SMALLER THAN YOU CAN SEE! One-millionth of meter (micrometer) Nanoscale objects are 1,000 times SMALLER!!! 6-8 µm

… ..SMALLER THAN YOU CAN SEE! Viruses 3-50 nm DNA 2.5 nm Atoms <1 nm A nanometer is one-BILLIONTH of a meter!! Buckyball ~1 nm Nanotube ~1 nm

MEDIEVAL NANOTECHNOLOGISTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

THINGS ARE DIFFERENT….. Size really does matter! Bulk Nano

THINGS ARE DIFFERENT….. Size really does matter! Bulk Nano Nanoparticles interact differently with light.

Chang, Kenneth. “Tiny is Beautiful: Translating ‘Nano’ Into Practical.” New York Times 22 Feb 2005: Science. CHANGING THE SIZE OF THE GOLD PARTICLES AFFECTS THEIR COLOR Size=25 nm Shape: spherical Color: RED Size=50 nm Shape: spherical Color: GREEN Size=100 nm Shape: spherical Color: ORANGE

Chang, Kenneth. “Tiny is Beautiful: Translating ‘Nano’ Into Practical.” New York Times 22 Feb 2005: Science. CHANGING THE SIZE AND SHAPE OF THE SILVER PARTICLES AFFECTS THEIR COLOR Size=100 nm Shape: spherical Color: YELLOW Size=40 nm Shape: spherical Color: BLUE Size=100 nm Shape: triangular Color: RED

GOLD NANOPARTICLES TODAY ,[object Object],[object Object],[object Object],[object Object],[object Object],glass bead N. Halas, J. West (Rice University); Hirsch , et al. PNAS. 100: 13549 (2003 ) 60-100 nm

SILVER NANOPARTICLES TODAY Silver nanoparticles are used to kill bacteria in: Athletic apparel Socks Refrigerators Plastic containers Washing machines

YOUR TURN! ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],This project was supported by the National Science Foundation under Grant No. ESI-0532536. Any opinions, findings, and conclusions or recommendations are those of the author and do not necessarily reflect the views of the Foundation .

Stained Glass to Cancer Cure: Nanotech Past and Future

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Stained Glass to Cancer Cure: Nanotech Past and Future