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2010 Conference - Toward a Treatment Standard for Pathological Gambling (Grant)
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2010 Conference - Toward a Treatment Standard for Pathological Gambling (Grant)
13.
12
Placebo 20mg 40mg PG-YBOCS Urges 10 8 p=.027 6 4 2 4 6 8 10 Visit
14.
1.0
.9 .8 Naltrexone / Proportion Nonrelapsed Asp40 Allele (A/G, G/G) .7 Naltrexone .6 Asn40 Allele (A/A) .5 Placebo / Asp40 Allele (A/G, G/G) .4 Placebo / Asn40 Allele (A/Al) .3 .2 .1 0.0 0 14 28 42 56 70 84 Days
15.
Analysis of Maximum
Likelihood Estimates (N=282) Variable Parameter Standard Chi- Pr>ChiSq Hazard Estimate Error Square Ratio FH-AUD 0.55 0.24 7.53 0.006 1.74 Baseline urges were significantly associated with response to higher doses of opiate antagonists (i.e. nalmefene 50mg or 100mg or naltrexone 100mg or 150mg) (parameter estimate = 1.77; SE= 0.84; Wald 2 =4.41; p= .036; HR= 5.86; HR 95% CI=1.12-30.6
18.
N-Acetyl Cysteine: 12-Week
Open-Label 56% reduction in urges; 57% reduction in total gambling symptoms
22.
Visit 1 Visit
6 p-value PG-YBOCS total score 21.8 8.9 <.001 Responder, n (%) n/a 18 <.001 (62.1) Dollars lost per week 743 309 <.001 Hours gambled per week 10.4 4.0 <.001
23.
PG B v
E PG B v C PG E v C T P t p t p IDED total 2.20 0.037 2.09 0.041 1.06 0.294 errors
24.
Lexapro Treatment of
Anxious Gamblers
25.
*
* * * p<.05 Hollander et al, 2002
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