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DIAGNOSIS AND TREATMENT OF TYPE 2 DIABETES IN CHILDREN Sample-RHK
Outline of Discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis of Type 2 Diabetes ELEVATED  GLUCOSE PANCREAS 1. Increased Hepatic Glucose Production 2. Impaired Pancreatic Insulin Secretion 3. Peripheral Insulin Resistance MUSCLE LIVER   
Outline of Discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diabetes Trends in the United States ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mokdad et al.  Diabetes Care . 2000;23:1278.
World wide trend of Type 2 Diabetes from 2000 to 2010 Numbers of people with diabetes (in millions) for 2000 and 2010 (top and middle values, respectively), and the percentage increase. Source :  Nature   414 , 782 - 787 (2001)
Projected Obesity prevalence from 1960 to 2025 Source: Nature 404, 2000
Type 2 Diabetes in Children Epidemiology:  Population-Based J Pediatr . May 2000.
Type 2 Diabetes in Children: Diagnosis by Year Patients
Prevalence of IFG in Nondiabetic US Adolescents (Aged 12–19 Yrs)
ADA Guidelines for Screening,  Treatment of Children, Adolescents
ADA Guidelines for Screening,  Treatment of Children, Adolescents (cont.)
C-Peptide Values at  Diagnosis in T1DM and T2DM Unstimulated C-peptide values  C-peptide (%ULN) N=38 N=42 P <0.001 140 120 100 80 60 40 20 0 T1DM T2DM
Outline of Discussion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Special Issues In Children ,[object Object],[object Object],[object Object]
Special Issues in Children With T2DM ,[object Object],[object Object],[object Object]
Need for Initial Insulin Use in Children ,[object Object],[object Object],[object Object],[object Object]
 
Summary ,[object Object],[object Object],[object Object]

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Sample

  • 1. DIAGNOSIS AND TREATMENT OF TYPE 2 DIABETES IN CHILDREN Sample-RHK
  • 2.
  • 3. Pathogenesis of Type 2 Diabetes ELEVATED GLUCOSE PANCREAS 1. Increased Hepatic Glucose Production 2. Impaired Pancreatic Insulin Secretion 3. Peripheral Insulin Resistance MUSCLE LIVER   
  • 4.
  • 5.
  • 6. World wide trend of Type 2 Diabetes from 2000 to 2010 Numbers of people with diabetes (in millions) for 2000 and 2010 (top and middle values, respectively), and the percentage increase. Source : Nature 414 , 782 - 787 (2001)
  • 7. Projected Obesity prevalence from 1960 to 2025 Source: Nature 404, 2000
  • 8. Type 2 Diabetes in Children Epidemiology: Population-Based J Pediatr . May 2000.
  • 9. Type 2 Diabetes in Children: Diagnosis by Year Patients
  • 10. Prevalence of IFG in Nondiabetic US Adolescents (Aged 12–19 Yrs)
  • 11. ADA Guidelines for Screening, Treatment of Children, Adolescents
  • 12. ADA Guidelines for Screening, Treatment of Children, Adolescents (cont.)
  • 13. C-Peptide Values at Diagnosis in T1DM and T2DM Unstimulated C-peptide values C-peptide (%ULN) N=38 N=42 P <0.001 140 120 100 80 60 40 20 0 T1DM T2DM
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.  
  • 19.