Hematology Rivas2008 Lecture1

Hematology - Oncology Introduction to Hematology Antonio Rivas PA-C January 2009

Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hematology : • From the Greek, haima-blood and logos discourse Hematology is the study of the blood and its main constituents: plasma and cells • Blood accounts for 7-8% of total body weight in an average 70kg adult • Total volume of blood is about 5-6L • The plasma is the fluid portion of the blood: 90% water and 10% proteins: Albumin,Globulins, and Fibrinogen • The formed elements are: the red blood cells, the white blood cells and the platelets.

Hematology-Albumin ,[object Object],[object Object],[object Object]

Hematology - Globulins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hematology - Fibrinogen ,[object Object],[object Object]

Functions of the blood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hematopoiesis: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hematopoiesis ,[object Object],[object Object],[object Object],[object Object]

Ontogeny: ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pluripotent Stem cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Regulation of Hematopoiesis ,[object Object],[object Object],[object Object]

Cytokines and their activities. ,[object Object],[object Object],[object Object],[object Object]

Hematopoietic Differentiation Pathway

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Myeloid lineage-Erythrocytes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Erythrocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Erythropoiesis ,[object Object],[object Object],[object Object]

Erythrocyte maturation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemoglobin ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hemoglobin-Iron cycle ,[object Object],[object Object],[object Object],[object Object],[object Object]

Iron cycle ,[object Object],[object Object],[object Object],[object Object]

Erythrocyte destruction ,[object Object],[object Object],[object Object],[object Object]

Leukocytes - WBCs ,[object Object],[object Object],[object Object]

Granulocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Granulocytes origin and maturation ,[object Object],[object Object],[object Object]

Neutrophils ,[object Object],[object Object],[object Object],[object Object],[object Object]

Neutrophils ,[object Object],[object Object],[object Object],[object Object]

Neutrophils ,[object Object],[object Object]

Neutrophils ,[object Object],[object Object],[object Object]

Neutropenia <1800/mm 3 or <1.8 × 10 9 /L ,[object Object],[object Object]

Eosinophils ,[object Object],[object Object],[object Object],[object Object],[object Object]

Eosinophils ,[object Object],[object Object]

Eosinophils ,[object Object],[object Object],[object Object],[object Object]

Eosinophilia (increased circulating eosinophils) > 5% or > 500 cells/mm 3 or > 0.5 × 10 9 /L ,[object Object],[object Object],[object Object],[object Object]

Basophils ,[object Object],[object Object],[object Object],[object Object],[object Object]

Monocytes/Macrophages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Monocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Thrombocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Lymphocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Lymphocytes ,[object Object],[object Object],[object Object],[object Object]

B-Lymphocytes ,[object Object],[object Object],[object Object]

T-Lymphocytes ,[object Object],[object Object],[object Object],[object Object]

T- Helper / Suppressor ,[object Object],[object Object],[object Object],[object Object],[object Object]

Laboratory tests ,[object Object],[object Object],[object Object]

Complete Blood Count ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

WBC count ,[object Object],[object Object],[object Object],[object Object]

Leukocytosis ,[object Object],[object Object],[object Object],[object Object]

Leukocytosis ,[object Object],[object Object]

Other causes of leukocytosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Leukocytosis and no evidence of clinical disease ,[object Object],[object Object],[object Object]

Steroid therapy modifies the leukocyte response ,[object Object],[object Object]

Leukopenia: WBC < 4000/mm 3 or < 4.0 × 10 3 /mm 3 or < 4.0 cells × 10 9 /L ,[object Object],[object Object],[object Object]

Leukopenia ,[object Object],[object Object],[object Object],[object Object]

Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object]

Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Differential White Blood Cell Count (Diff; Differential Leukocyte Count) ,[object Object],[object Object],[object Object]

Total RBC count ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Total RBC count ,[object Object],[object Object],[object Object]

Hemoglobin ,[object Object],[object Object],[object Object]

Hematocrit ,[object Object],[object Object],[object Object],[object Object]

Platelet count ,[object Object],[object Object],[object Object]

Red blood cell indices ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RBCs indices ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RBCs indices ,[object Object],[object Object],[object Object]

RBCS morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RBCs morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RBC morphology ,[object Object],[object Object],[object Object]

NRBC, and Basophilic Sttipling

Hematology Rivas2008 Lecture1

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Hematology Rivas2008 Lecture1