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Cancer Biology Antonio Rivas PA-C Feb.2008
Objectives  ,[object Object],[object Object],[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object],[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object],[object Object]
Oncology Terminology ,[object Object],[object Object],[object Object],[object Object]
2006 Estimated US Cancer Deaths* Lung & bronchus 31% Colon & rectum 10% Prostate   9% Pancreas   6% Leukemia  4% Liver & intrahepatic   4% bile duct Esophagus   4% Non-Hodgkin  3%  Urinary bladder   3% Kidney  3 % All other sites  23 % 291,270 deaths in Men 26% Lung & bronchus 15% Breast 10% Colon & rectum 6% Pancreas 6% Ovary 4% Leukemia 3% Non-Hodgkin   lymphoma 3% Uterine corpus 2% Multiple myeloma 2% Brain/ONS 23%  All other sites 273,560 deaths in Women
2006 Estimated US Cancer Cases* Prostate   33% Lung & bronchus 13% Colon & rectum 10% Urinary bladder 6% Melanoma of skin 5% Non-Hodgkin 4%  lymphoma Kidney   3% Oral cavity 3% Leukemia   3% Pancreas   2% All Other Sites  18% Men 720,280 31% Breast 12% Lung & bronchus 11% Colon & rectum 6% Uterine corpus  4% Non-Hodgkin   lymphoma  4% Melanoma of skin 3%  Thyroid 3% Ovary 2% Urinary bladder 2% Pancreas 22% All Other Sites Women 679,510
Five-year Relative Survival (%)* during Three Time Periods By Cancer Site   74-76   83-85   95-2001 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hallmarks of the Cancer Phenotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathways to Cancer ,[object Object],[object Object],[object Object],[object Object]
Genes responsible for cancer ,[object Object],[object Object],[object Object]
Epidemiology  ,[object Object],[object Object],[object Object]
Epidemiology ,[object Object],[object Object],[object Object]
Cancer Etiologic factors ,[object Object],[object Object],[object Object]
By simply identifying smokers, advising them to quit, and sending them to a free telephone service, clinicians can save thousands of lives.
Cancer Etiologic factors ,[object Object],[object Object],[object Object]
Cancer Prevention ,[object Object],[object Object],[object Object]
Primary Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object]
Secondary Prevention ,[object Object],[object Object],[object Object],[object Object]
Criteria for Screening test ,[object Object],[object Object],[object Object],[object Object],[object Object]
Screening tests ,[object Object],[object Object],[object Object],[object Object]
Screening tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Screening tests ,[object Object],[object Object]
Genetic Screening ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic Screening ,[object Object],[object Object],[object Object],[object Object],[object Object]
Principles of Cancer Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis and Staging ,[object Object],[object Object],[object Object],[object Object],[object Object]
TNM method for Staging of Tumor ,[object Object],[object Object],[object Object]
Tumor Staging ,[object Object],[object Object]
Tumor Staging ,[object Object],[object Object],[object Object],[object Object],[object Object]
Biomarkers  ,[object Object],[object Object],[object Object]
Tumor markers ,[object Object],[object Object],[object Object]
Surgery in cancer  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Surgery in cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation therapy  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation side effects ,[object Object],[object Object],[object Object]
Medical therapy ,[object Object],[object Object],[object Object]
Medical therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemotherapeutic Agents
Medical therapy ,[object Object],[object Object],[object Object],[object Object]
Evaluation of Response  ,[object Object],[object Object],[object Object],[object Object]
Evaluation of Response ,[object Object],[object Object],[object Object]
Targeted Therapeutic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Targeted Therapeutic Agents
Imatinib Mechanism
Limitations of Chemotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Supportive care   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]

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1 Introduction To Oncology

  • 1. Cancer Biology Antonio Rivas PA-C Feb.2008
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  • 9. 2006 Estimated US Cancer Deaths* Lung & bronchus 31% Colon & rectum 10% Prostate 9% Pancreas 6% Leukemia 4% Liver & intrahepatic 4% bile duct Esophagus 4% Non-Hodgkin 3% Urinary bladder 3% Kidney 3 % All other sites 23 % 291,270 deaths in Men 26% Lung & bronchus 15% Breast 10% Colon & rectum 6% Pancreas 6% Ovary 4% Leukemia 3% Non-Hodgkin lymphoma 3% Uterine corpus 2% Multiple myeloma 2% Brain/ONS 23% All other sites 273,560 deaths in Women
  • 10. 2006 Estimated US Cancer Cases* Prostate 33% Lung & bronchus 13% Colon & rectum 10% Urinary bladder 6% Melanoma of skin 5% Non-Hodgkin 4% lymphoma Kidney 3% Oral cavity 3% Leukemia 3% Pancreas 2% All Other Sites 18% Men 720,280 31% Breast 12% Lung & bronchus 11% Colon & rectum 6% Uterine corpus 4% Non-Hodgkin lymphoma 4% Melanoma of skin 3% Thyroid 3% Ovary 2% Urinary bladder 2% Pancreas 22% All Other Sites Women 679,510
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  • 18. By simply identifying smokers, advising them to quit, and sending them to a free telephone service, clinicians can save thousands of lives.
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