1. The Science: Diabetes Control The National Diabetes Education Program Changing the Way Diabetes is Treated.

9. Glucose control is key to preventing or delaying complications of diabetes Any sustained lowering of blood glucose helps , even if the person has a history of poor control DCCT Findings DCCT. New England Journal of Medicine, 329(14), September 30, 1993.

12. Mirrored the findings of DCCT in people with type 2 diabetes—better glucose control reduced development of microvascular complications Demonstrated the need for management of high blood pressure and cholesterol as well as blood glucose levels (the ABCs of diabetes) UKPDS Findings UKPDS. BMJ. 2000; 321:405-412.

13. UKPDS Findings Stratton IM, et al. BMJ . 2000;321:405-412. P <.0001 P = .035 P = .021 P = .0001 Risk reduction with 1% decline in annual mean A1C 0% 15% 30% 45% Micro-vascular Disease 37% PVD 43% Stroke MI 14% 12% Heart Failure Cataract Extraction 16% 19%

16. Cumulative Incidence Years from Study Entry EDIC Findings: Cardiovascular Events Cumulative Incidence of First of Any Event 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 Risk reduction 42% 95% CI: 9% to 63% P = 0.02 0.12 0.10 0.08 0.06 0.04 0.02 0.00 Conventional Intensive DCCT/EDIC N Engl J Med 2005: 353:2643-2653.

17. Conventional Intensive Non-Fatal MI, Stroke, or CVD Death EDIC Findings: Cardiovascular Events 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 Years from Study Entry 0.00 0.02 0.04 0.06 0.08 0.10 0.12 Cumulative Incidence Risk reduction 57% 95% CI: 12% to 79% P = 0.02 DCCT/EDIC N Engl J Med 2005: 353:2643-2653.

26. National Diabetes Education Program Materials

27. Diabetes Control: Patient Materials

28. Diabetes Control: Health Care Professionals

29. NDEP Websites