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- 1. A Big Blind Spot inA Big Blind Spot in AnticoagulationAnticoagulation GuidelinesGuidelines Aching Joints inAching Joints in Diabetes: What Drug IsDiabetes: What Drug Is at Fault?at Fault? Smoking and Seizures:Smoking and Seizures: Where the EvidenceWhere the Evidence StandsStands Vitamin D: Time forVitamin D: Time for Rational Decision-Rational Decision- MakingMaking PrintPrint EmailEmail Drugs & Therapy Perspectives [1,2,18-21] MOST POPULAR ARTICLES According to FAMILYMEDICINE PHYSICIANS Whistleblower Doctor Warns About Hospitals Hiring Physicians 1. Vitamin D: Time for Rational Decision- Making 2. High-Spending Doctors Less Likely to3. Drug Ther Perspect. 2001;17(20) In Brief and Introduction Levosimendan Boosts Contractility Favourable Pharmacokinetics Best Results in Decompensated CHF May Be Useful in Stable CHF... Good Tolerability Profile Adis Evaluation Differential features References RELATED DRUGS & DISEASES Levosimendan http://www.medscape.com/viewarticle/406544_10 1 of 3 12.11.2015 11:01
- 2. 10 of 10Previous Page Feature Levosimendan Milrinone Dobutamine Class Calcium sensitiser Phosphodiesterase inhibitor Catecholamine Increases intracellular calcium concentrations? No Yes Yes Increases cardiac contractility? Yes Yes Yes Vasodilator? Coronary and systemic Peripheral Mild peripheral Increase myocardial oxygen demand? No No Yes Arrhythmogenic potential No evidence of arrhythmogenesis to date Ventricular (12.1%) and supraventricular arrhythmias (3.8%) Ventricular ectopic activity (5%); less arrhythmogenic than milrinone Available formulations IVa IV, PO IV Drug interactions? No clinically important interactions reported Few clinically important interactions No clinically important interactions reported Can be given with ß-blockers? Yes Yes Yes Adverse events Headache, hypotension Ventricular irregularities, hypotension, headache Tachycardia and increased SBP on overdosage a An oral formulation is under development IV = intravenously; PO = orally; SBP = systolic blood pressure. Be Sued 10 New Malpractice Concerns, and Ho to Avoid Them 4. Acupuncture, Alexander Technique Effective in Neck Pain 5. VIEW MOR Apolipoprotein B Apolipoprotein A-I Levosimendan http://www.medscape.com/viewarticle/406544_10 2 of 3 12.11.2015 11:01
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