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[object Object],[object Object],Lectures on Medical Biophysics Dept. of Biophysics, Medical faculty,  Masaryk University in Brno
What is a biosignal? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of Biosignals ,[object Object],[object Object],[object Object],[object Object],[object Object]
Origin of  Biopotentials ,[object Object],[object Object],[object Object]
Instruments for Measuring Active Biosignals ,[object Object],[object Object],[object Object],[object Object],[object Object],Two types of ECG electrodes Medical Temp sensors
Monitoring Biosignals in an Intensive Care Unit
Ele c trod es  for Biopotentials: contact Voltage Problems  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Non-polarisable Ag-AgCl electrode
Ele c trod es  for Biopotentials: Electrode Sizes ,[object Object],[object Object]
Bipolar and Unipolar Electrode Pairs ,[object Object],[object Object],A bipolar ECG electrode pair – depiction of the 1st limb lead
Signal processing: Amplifier ,[object Object],[object Object]
E C G - electrocardiogram ,[object Object],[object Object],[object Object],Calibration 1mV voltage impulse
Einthoven triangle Heart is modeled as a dipole electric field
Multiple electrodes placed on the surface of the body allow us to calculate voltage values  throughout the torso (V (x,y,z) biosignal).  Thus, we can localise problems with stimulus conduction throughout the myocardium. 2D and 3D Biopotential images
EEG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Color Brain Mapping: V (x,y,z) biosignal
Anaesthesia: The EEG and the Bispectral Index ,[object Object],The BiS is the bottom trace.
Comments on BiS etc. The Bispectral Index is an example of a “descriptive indices”.  These are not real physical quantities. They are parameters calculated from many measured parameters and by searching knowledge databases which contain measurements of many different patients (of various ethnic origins) with different health status. Complete algorithms of calculations and contents of knowledge databases are producer secrets. The medical doctor (user) need only get acquainted with meaning of the respective index and the values which it can have ,   but it is not necessary to  know  how it is calculated.
...  comments ... It is usually enough to give some information about the patient for the computer to correctly search in the knowledge databases.  It is almost always necessary to enter age, sex, race, body height and mass.  There are sometimes strange questions about e.g. length of fingers or toes. Such “strange questions” are frequent ly found when monitoring the cardiovascular system. However, these questions can be important. When the respective answers are omitted, the software can use an incorrect statistical patient model and an incorrect index value will be displayed.
Artefacts ,[object Object],[object Object]
EKG Artefacts 50Hz AC superimposed on the EKG Muscle tremors Moving baseline from patient movement, dirty electrodes, loose electrodes http://mauvila.com/ECG/ecg_artifact.htm
Some EEG artefacts Pulse wave artefact: movement of electrode arising from patient pulse under the electrode. EKG signal artefact: EKG signal also picked up by the EEG electrodes. Both easily recognized because they are periodic. http://www.brown.edu/Departments/Clinical_Neurosciences/louis/artefct.html
Temperature Measurement “ If a part of the human body is warmer or even colder than the surrounding parts, it is necessary to look for the disease focus in this place”  Hippocrates
Main purposes of temperature measurements ,[object Object],[object Object],[object Object],Important specifications of thermometers: ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Types of Thermometry in diagnostics
Mercury-in-glass thermometer gives maximum temperature Its capillary is narrowed to avoid return of mercury into the reservoir. Disadvantage: long response time (long time necessary for a stable reading  3 - 5 min.) Medical high-speed thermometer :  Alcohol filled – the capillary is not narrowed, the temperature must be read during the measurement, response time 1 min.  Dilatation thermometers (i.e., based on expansion of some substance)
Digital Thermometers
Removable hygienic t i p  Tympanic (ear)  thermometer They are based on the measurement of infra-red radiation which is emitted from the ear drum. The temperature reading is obtained only 1 second after attachment of the sensor to the distal end of the acoustic meatus.
Digital Thermometers: Thermistor sensor based R – resistance  temperature in Kelvin T R o  – resistance at temperature T o B – constant
Digital thermometers: Thermocouple sensor based Digital thermocouple sensor Thermovoltage  U   =    (t – t 0 )
A uthors:  C ontent   collaboration and language revision:   P resentation   design:  Lucie Mornsteinová L ast revision:   September  200 9 Vojtěch Mornstein,  Jan Dvo řák,  Věra Maryšková Carmel J. Caruana , Ivo Hrazdira

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Biosignals andthermometry fin

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  • 6. Monitoring Biosignals in an Intensive Care Unit
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  • 13. Einthoven triangle Heart is modeled as a dipole electric field
  • 14. Multiple electrodes placed on the surface of the body allow us to calculate voltage values throughout the torso (V (x,y,z) biosignal). Thus, we can localise problems with stimulus conduction throughout the myocardium. 2D and 3D Biopotential images
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  • 16. Color Brain Mapping: V (x,y,z) biosignal
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  • 18. Comments on BiS etc. The Bispectral Index is an example of a “descriptive indices”. These are not real physical quantities. They are parameters calculated from many measured parameters and by searching knowledge databases which contain measurements of many different patients (of various ethnic origins) with different health status. Complete algorithms of calculations and contents of knowledge databases are producer secrets. The medical doctor (user) need only get acquainted with meaning of the respective index and the values which it can have , but it is not necessary to know how it is calculated.
  • 19. ... comments ... It is usually enough to give some information about the patient for the computer to correctly search in the knowledge databases. It is almost always necessary to enter age, sex, race, body height and mass. There are sometimes strange questions about e.g. length of fingers or toes. Such “strange questions” are frequent ly found when monitoring the cardiovascular system. However, these questions can be important. When the respective answers are omitted, the software can use an incorrect statistical patient model and an incorrect index value will be displayed.
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  • 21. EKG Artefacts 50Hz AC superimposed on the EKG Muscle tremors Moving baseline from patient movement, dirty electrodes, loose electrodes http://mauvila.com/ECG/ecg_artifact.htm
  • 22. Some EEG artefacts Pulse wave artefact: movement of electrode arising from patient pulse under the electrode. EKG signal artefact: EKG signal also picked up by the EEG electrodes. Both easily recognized because they are periodic. http://www.brown.edu/Departments/Clinical_Neurosciences/louis/artefct.html
  • 23. Temperature Measurement “ If a part of the human body is warmer or even colder than the surrounding parts, it is necessary to look for the disease focus in this place” Hippocrates
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  • 26. Mercury-in-glass thermometer gives maximum temperature Its capillary is narrowed to avoid return of mercury into the reservoir. Disadvantage: long response time (long time necessary for a stable reading 3 - 5 min.) Medical high-speed thermometer : Alcohol filled – the capillary is not narrowed, the temperature must be read during the measurement, response time 1 min. Dilatation thermometers (i.e., based on expansion of some substance)
  • 28. Removable hygienic t i p Tympanic (ear) thermometer They are based on the measurement of infra-red radiation which is emitted from the ear drum. The temperature reading is obtained only 1 second after attachment of the sensor to the distal end of the acoustic meatus.
  • 29. Digital Thermometers: Thermistor sensor based R – resistance temperature in Kelvin T R o – resistance at temperature T o B – constant
  • 30. Digital thermometers: Thermocouple sensor based Digital thermocouple sensor Thermovoltage U =  (t – t 0 )
  • 31. A uthors: C ontent collaboration and language revision: P resentation design: Lucie Mornsteinová L ast revision: September 200 9 Vojtěch Mornstein, Jan Dvo řák, Věra Maryšková Carmel J. Caruana , Ivo Hrazdira