Did you know custom-formulated dietary supplement can be made product based on plant-based ingredients, including whole foods, extracts and phytochemicals just for you based on Your DNA?.

1. Ginny Bank
Brief Bio
Ginny Bank is the Director of Product Education and Technical Support for GeneWize
Life Sciences.
Ms. Bank has significant experience in the dietary supplement and functional food
industries and began her career as a natural products chemist with a research
company (Hauser, Inc.) which focused on developing natural product extracts and
purified plant compounds for the dietary supplement, pharmaceutical and food
industries.
She is considered an industry expert in antioxidant research and throughout her career
has been researching and developing plant-based functional ingredients for a variety
of nutritional supplement applications. Ms. Bank holds four U.S. patents pertaining to
antioxidants and their applications and is a contributing editor for Prepared Foods
/NutraSolutions Magazine. She received her bachelor’s degree in Chemistry and a
Master’s Degree in Science Education from the University of Colorado, Boulder.

2. LifeMap Nutrition™ Formulas
An Overview
• The LifeMap Nutrition™ System is a custom-formulated
dietary supplement product based on plant-based
ingredients, including whole foods, extracts and
phytochemicals.
• Products are custom-created for each individual based
on the results of their LifeMap Healthy Aging
Assessment™.
– Base formula - Foundational blend of ingredients that are
important for optimal nutrition for adults.
– SNPActives™ - Specific ingredients chosen to mitigate and/or
compensate for the altered biochemical pathways related to
each SNP.

3. What are the Ingredients?
• Fruits, vegetables and botanical products
– “Whole foods”: air-dried (no heat or very
low temperature drying).
– Concentrated “juices”
• Remove skin, seeds, fiber and other insolubles followed by spray-drying
(increased temperature for short time amount of time).
– Extracts
• Plant material extracted with water and/or ethanol to increase the
concentration of certain phytochemicals.
– Usually standardized to one or more phytochemicals.
• Pure Vitamins, Minerals and macronutrients/nutritional
compounds
– USP/NF-grade. (United States Pharmacopeia/National
Formulary)

4. Other Quality Topics
• There are no binders or fillers in any formula
• Some formulas may contain small amounts of excipient used as a
carrier for the active ingredient to:
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Allow for convenient and accurate dosage.
Improve stability
Improve solubility
Keep ingredients from “caking”
• The LifeMap Nutrition™ formulas do not contain any of the eight
major food allergens. (milk, eggs, fish, Crustacean shellfish, tree
nuts, peanuts, wheat/gluten, and soybeans)
• Most vitamins/minerals are synthetically manufactured (5-10% of
formula)
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Significantly lower cost
USP standardized and tested
Higher purity (fewer contaminants).
Higher potency (can be delivered in smaller doses)

5. The Science – Base Formula
Base Formula contains ingredients important to
everyone’s diets.
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Vitamins (A, E, all B’s, folate, biotin)
Natural Vitamin C from Acerola Cherry Extract
Zinc
Omega 3’s from flax seeds
Prebiotic Fiber (Fructooligosaccharides from chicory)
Digestive Enzymes
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Lipase
Protease
Cellulase
Amylase

6. The Science – Base Formula
• 10 Fruit and Vegetable juice powders
• High-potency superfruits
– Mangosteen Extract
– Gogi Berry Extract
– Acai Juice
• OxyPhyte® Ultra Blend - High ORAC Antioxidant
Blend
• Cat’s Claw Extract

7. The Science - OxyPhyte® Ultra Blend
• Clinically-proven bioavailability
dosage of 400 mg/day (average
formula dosage)
• High purity blend of White tea,
Apple, Rosemary extracts
• Rich in phytochemicals such as
polyphenols, catechins,
flavonoids and rosmarinic acid.
• High ORAC (Oxygen Radical
Absorbance Capacity)
• Provides the bulk ORAC units
for each formula.
– Antioxidant equivalent of 3-8
servings of vegetables depending
on individual formula.
Plasma ORAC
(moles TE/g)
570
560
550
540
530
520
510
500
490
480
470
Baseline
30 to 60
minutes
Spiller, et al. Data presented at the 43rd Annual Meeting
of The American College on Nutrition. Oct 2002

8. SNPActives™
ADDED
SUPPORT
MAXIMUM SUPPORT
Optimal Genetic
Function
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Heterozygous Disadvantaged :
Homozygous Disadvantaged:
Homozygous Advantaged :
One chromosome carries the SNP
Both chromosomes carries the SNP
Neither chromosome carries the SNP
• Amount of SNPActive™ in each individual formula is dependent
upon results of the Healthy Aging Assessment™
• Formulas designed to address the key biochemical pathways
measured by our DNA assessments.
– Mitigation - to lessen in force
– Compensation - to counterbalance
• Formulas developed and validated by our Scientific Advisory
Board, based on independent third-party, peer-reviewed
research (genetics, medicine, natural products chemistry, and
nutritional sciences)

9. The Science – VDR SNPActive™
• Our bodies are constantly forming new bone cells, as well as breaking
down bone (resorption).
– Formation outpaces resorption until peak bone mass (maximum bone density
and strength) is reached around age 30 when resorption slowly begins to
exceed bone formation.
– Factors which put one at risk for bone loss include:
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Gender
Body size
Age
Genetic factors.
– An acute imbalance between bone loss and reformation can cause
osteoporosis.
• The Vitamin D Receptor gene (VDR) accounts for 75% of the entire genetic
influence on bone density.
• SNPs in the VDR gene are manifested as reduced bone mineral density
and sub-optimal peak bone mass.
VDR SNPActive™ provides vitamins and minerals to:
 Maximize bone formation
 Increase bone mineral density and reduce fracture rate

10. The Science - VDR SNPActive™
• Calcium
– Optimal dietary calcium intake is the most critical factor for maintaining bone
health.
– Clinical studies have reported that calcium supplementation may significantly
increase bone mineral density in preadolescent girls with VDR polymorphisms.
• Vitamin D
– Vitamin D is essential for maximizing calcium absorption in our bodies.
– Vitamin D supplementation was specifically shown to increase bone mineral
density in elderly patients, post-menopausal women and men 41-70 years of
age with polymorphisms on then VDR gene.
• Vitamin K
– The Nurse’s Health Study, (a major epidemiological study that followed more
than 72,000 women for ten years) reported a significant correlation between
high intakes of Vitamin K and reduced risk o fractures.
– Another epidemiological study of over 800 elderly men and women found that
men and women with the highest dietary Vitamin K intakes had a 65% lower
risk of hip fractures.

11. The Science – EPHX SNPActive™
• Human microsomal Epoxide Hydrolase (EPHX) is a phase-I xenobiotic
metabolizing enzyme that detoxifies potentially toxic epoxides.
Xenobiotics are foreign substances (e.g. pollutants, drugs).
• Majority of detoxification mechanisms takes place in the liver.
• Epoxides are also highly reactive and mutagenic  certain cancers
• Poorly performing detoxification system leads to:
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Fatigue
Loss of appetite
Skin problems
Premature aging
EPHX SNPActive™ provides ingredients that:
 Increase activity of the EPHX enzyme
 Support and enhance all of the natural mechanisms the liver uses to detoxify

12. The Science - EPHX SNPActive™
• Green Tea Extract (Polyphenols, Catechins)
– Green tea consumption is correlated with fewer disorders
of the liver and certain cancers caused by environmental
xenobiotics.
– in vitro studies have shown that green tea extract resulted
in dramatic increase in the gene expression for EPHX.
• Thistle Family
– Milk Thistle Extract (Silymarin)
• Strong liver antioxidant.
• Increases synthesis of glutathione (an essential element for
detoxification and optimal immune function).
• Animal studies have shown it provides good defense against
various toxic models of experimental liver diseases.
– Artichoke Extract (Phenolic compounds)
• Exerts a major effect on bile flow and liver protection.
• Cruceriferous vegetables
– Broccoli and Kale (Indole-3-carbinols, Sulphoraphane)
• Stimulate detoxification enzymes.
• Sulphoraphane activates phase II detoxification enzymes in
the liver and has strong anti-cancer properties.

13. The Science – NQ01 SNPActive™
• The coenzyme Q10 reductase (NQO1) converts CoQ10
(ubiquinone) to its reduced form, ubiquinol, which scavenges
free radicals in the mitochondria and lipid membranes.
• Individuals with a SNP in the NQO1 gene have reduced ability
to make this conversionfrom ubiquinone to ubiquinol,
resulting in very low blood levels of this key antioxidant.
• Consequently, people with this SNP are at high risk of free
radical attack.
• Because NQO1 is also involved in the detoxification of
compounds foreign to the body, a SNP in the NQO1 gene may
cause aberrant cellular changes as well.
NQ01 SNPActive™ provides:
 50 mg Ubiquinol (Red and Yellow)
 50 mg Ubiquinone (Green)

14. The Science – SOD2 SNPActive™
• The Superoxide radical is one of the main free radicals found in the
cell and is extremely biologically toxic to cellular DNA and cell
machinery.
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Premature aging
Breast cancer
Age-related macular degeneration (AMD)
Prostate cancer
• SOD2 gene encodes for Superoxide Dismutase (SOD), is an
antioxidant enzyme which helps neutralize these radicals.
• SNPs on the SOD2 gene can lead to a damaging build-up of the
superoxide radicals.
SOD2 SNPActive™ provides:
 Antioxidant ingredients with specific activity against the superoxide radical
 Ingredients that enhance SOD activity

15. The Science – SOD2 SNPActive™
• Green Tea and White Tea Extracts (Polyphenols, Catechins)
– The potent antioxidant activity of these teas has been supported by epidemiological
studies, cellular research and animal studies.
– Tea catechins have shown direct scavenging activity against superoxide radicals.
– Epigallocatechin-3-gallate (EGCG) was shown to specifically augment the activity of
superoxide dismutase, as well as reduce oxidative stress in animal studies.
– Enhancement of superoxide dismutase activity combined with reduction of
superoxide radical concentration was seen in heart tissue of animals supplemented
with tea catechins.
• Bilberry Extract (Anthocyanins)
– Anthocyanins found in bilberry have known superoxide scavenging activity.
– Bilberry extracts have been indicated in the prevention of age-related macular
degeneration (AMD) and cataract formation in animal studies.
• Spirulina
– Spirulina contains a relatively high level of superoxide dismutase.
– Phycocyanin, the main plant pigment found in spirulina, has been shown to
significantly decrease cardiac production of the superoxide anion in animal studies.
• Niacin (Vitamin B3)
– Nicotinamide, a derivative of niacin, is required by the body for the production of
certain coenzymes essential for proper functioning of superoxide dismutase.

16. The Science – GPX1 SNPActive™
• GPX1 is the most abundant antioxidant enzyme in the Glutathione
Peroxidase family with specific activity against hydrogen peroxide.
– Coverts dangerous hydrogen peroxide molecules into water.
– Plays important roles in DNA synthesis and repair, metabolism of toxins, and
immune system enhancement.
– Contains selenium in its protein structure and therefore how much GPX1 a
person produces is dependent on their selenium levels.
• A SNP on the GPX1 gene can reduce a person’s ability to utilize
selenium.
GPX1 SNPActive™ provides
 Extra selenium
 Ingredients that protect the body against hydrogen peroxide
damage
 Ingredients that increase glutathione peroxidase activity

17. The Science – GPX1 SNPActive™
• Turmeric Extract (Curcumin)
– Dietary curcumin was shown to enhance serum GPX activity and lower blood
lipid peroxide levels in animals.
• Alpha Lipoic Acid
– Animal studies have shown that dietary alpha lipoic acid supplementation
increases GPX activity.
• Flavonoids
– Citrus Bioflavonoids (Naringin, Hesperidin)
• Naringin has been shown to suppress DNA damage induced by hydrogen peroxide.
• Hesperidin has been shown to protect against the damaging effects of hydrogen
peroxide.
– Ginkgo leaf, Astragulus Root
• Specific activity against hydrogen peroxide-induced lipid peroxidation and cell death.
– Milk Thistle
• Silymarin reduces oxidative stress caused by hydrogen peroxide as well as increases
the antioxidant activity of various antioxidant enzymes including GPX1.
– Anthocyanins (from blueberries, black currants, and grapes)
• Enormous amount of research confirming antioxidant activity of anthocyanins. These
include protection against cardiovascular disorders, advancing age-induced oxidative
stress, inflammatory responses, and other degenerative diseases.

18. The Science – MMP-1 SNPActive™
• MMP-1 (collagenase) is an enzyme that degrades collagen
– Collagen is the main protein of connective tissue (cartilage, joints, skin)
and the most abundant protein in our bodies.
– Collagen is constantly synthesized and broken down in an ongoing
cycle to form new tissue.
– Collagen decrease (age and free radical damage)  imbalance
between collagen breakdown and its reformation.
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Premature aging
Inflammation
Joint pain
Increased risk of skin photo-aging.
• SNPs in the MMP-1 gene causes increased rates of collagenase
production
MMP-1 SNPActive™ provides ingredients that:
 Strengthen collagen
 Protect collagen against free radical damage

19. The Science – MMP-1 SNPActive™
• Tomato Powder (Lycopene)
– Lycopene quenches singlet-oxygen resulting from direct absorption of UV radiation. Singletoxygen causes free radical damage to the collagen in the skin.
– Research suggests that reduced lycopene concentrations in the skin  higher risk for
sunlight-induced skin damage.
– Clinical trial reported daily supplementation with lycopene-containing tomato paste for 10
weeks resulted in 40% less artificially-induced sunburn than the control group.
• Grape Seed Extract (Polyphenols/OPCs)
– OPCs protect and stabilize collagen by increasing the cross-linkage of collagen fibril.
– Polyphenols prevent excessive cross-linking which leads to stiff, brittle collagen tissue.
– Studies have shown that multiple small exposures to UV leads to sustained elevations of
collagenase and OPCs inhibit the activity of collagenase.
• White Tea Extract (Polyphenols, Catechins)
– Catechin- and EGCG-treated collagen exhibited significant resistance against collagenolytic
hydrolysis by collagenase and directly inhibits collagenase activity.
– EGCG hampers UV-B-induced MMP-1 production and may be a potential agent for the
prevention and treatment of skin photo-aging.
• Synergy
– Supplements containing a combination of extracts from white tea, grape seed and tomato
showed significant improvement in the condition, structure and firmness of the skin of postmenopausal women based on several measurable parameters of skin aging.

20. The Science – MTRR SNPActive™
• The enzyme Methionine Synthase Reductase (MTRR),
transforms homocysteine back to either methionine or
cysteine.
• SNPs in the MTRR gene hinder the ability to clear
homocysteine from the blood.
• Excess homocysteine is also converted to glutathione (an
antioxidant) to protect cells from damage.
MTRR SNPActive™ provides ingredients that:
 Lower homocysteine levels
 Enhance glutathione activity
 Support overall cardiovascular health

21. The Science - MTRR SNPActive™
• B Vitamins
– Numerous studies have shown that Vitamins B6, folic acid and B12, work
synergistically to aid the body in processing homocysteine and this
combination is recommended as a homocysteine-lowering therapy.
– Vitamin B6 is necessary for the conversion of homocysteine into glutathione.
– Niacin (Vitamin B3) has been used for decades for overall cardioprotection
by lowering the plasma concentrations of cholesterol, free fatty acids, and
triglycerides in humans,
• Trimethylglycine (Betaine)
• Dong Quai Extract
– Dong Quai suppresses fast rhythms of the heart and lowers blood pressure
by dilating the coronary vessels, increasing coronary flow and reducing
respiratory rate.
– Dong Quai increases the activity of glutathione enzymes in the liver to
reduce oxidative damage caused by elevated homocysteine levels.
• Zinc
– Zinc is a cofactor in the conversion of homocysteine to methionine. Zinc acts
in conjunction with vitamin B6 to promote this reaction.

22. The Science – MTHFR SNPActive™
• The MTHFR enzyme is responsible for creating the circulating form of folate.
Folate is important in regulating our homocysteine levels.
• Elevated homocysteine levels are a significant risk factor for coronary artery and
other vascular diseases – even more predictive than cholesterol levels.
– Elevated levels of homocysteine have been identified in patients with
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Coronary artery disease
Cerebrovascular and peripheral vascular disease
Liver and kidney diseases
Thyroid conditions
Alzheimer’s
Depression
• SNPs in the MTHFR gene cause the manufacture of defective enzymes which
can’t metabolize folic acid and therefore clear elevated homocysteine from the
blood efficiently. There is a direct association between a SNP in the MTHFR
gene and elevated levels of homocysteine.
MTHFR SNPActive™ contains:
 L-methylfolate – circulating form of folate
 Ingredients that help reduce homocysteine levels

23. The Science - MTHFR SNPActive™
• L-methylfolate
– Circulating form of folate. Synthetic folic acid or folic acid from green vegetables must
be broken down in a series of metabolic steps in order to become L-methylfolate.
Individuals with SNPs on MTHFR gene cannot metabolize folic acid into this circulating
form.
• Trimethylglycine/TMG (Betaine)
– In a clinical trials, TMG supplementation resulted in lowered plasma homocysteine
concentrations.
– TMG also enhances the activity of the B Vitamins, which are important in balancing the
homocysteine-methionine cycle.
• Choline
– Choline is oxidized in the body to form TMG.
– Similar to TMG, it has a direct effect on homocysteine levels and has been linked to
decreased plasma homocysteine levels.
• Synergy between Choline and TMG
– Decreased dietary choline and TMG intake was correlated with elevated homocysteine
levels in a study of 1400 healthy women.

24. The Science – TNF-α SNPActive™
• Tumor Necrosis Factor- alpha (TNF-α) is a chemical messenger which mobilizes
white blood cells to fight infections and other invaders.
• Unbalanced immune response leads to TNF-α build up  excessive and
uncontrolled inflammation.
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Atherosclerosis
Arthritis
Cancer
Heart Disease
Diabetes
Alzheimer’s Disease
• SNPs on the TNF-α gene may result in an over-reactive inflammatory response.
TNF-α SNPActive™ provides
 antioxidants that specifically regulate TNF-α levels

25. The Science – TNFα SNPActive™
• Polyphenols from Green Tea, Grape Seed and
Pomegranate Extracts
– Green Tea polyphenols reduced the expression of TNF-α in both in vitro
studies and animal studies.
– Polyphenols in pomegranate were shown to modulate inflammatory cell
signaling in colon cancer cells by suppressing TNF-α induction of various
inflammatory proteins.
– Polyphenol compounds in grape seed extract (OPCs) have a potent
inhibitory effect on the expression of the vascular cell adhesion molecule-1
gene, (VCAM-1) which is induced by TNF-α. VCAM-1 promotes the
adhesion of immune response blood cells to endothelial cells, which in
turns plays a critical role in the initiation and development of vascular
inflammation.
• Milk Thistle Extract (Silymarin)
– Silymarin has been shown to block TNF-α-induced activation of NF-KB, a
protein complex regulating the immune response.
– Silymarin also suppressed TNF-α- induced production of reactive oxygen
species and lipid peroxidation.
– Animal studies have also shown Silymarin inhibits of TNF-α gene
expression.

26. The Science – PON-1 SNPActive™
• The PON-1 gene produces Paraxonase 1, an enzyme which
is transported on HDL in the plasma.
– PON-1 attaches itself to HDL and protects both LDL and HDL from
oxidation and also inhibits formation of macrophage fatty streaks
(the first sign of atherosclerosis).
• Low levels of PON-1 have been correlated with higher
levels of oxidized LDL, which increases the risk of
cardiovascular diseases.
PON-1 SNPActive™ provides ingredients that:
 Protect LDL oxidation
 Increase PON-1 activity

27. The Science – PON1 SNPActive™
• Mushroom Extracts (Polysaccharides)
– Polysaccharides in Reishi, Maitake and Shitake mushroom have
been shown to lower cholesterol.
– Reishi and Maitake mushrooms also contain compounds that inhibit
cholesterol synthesis in vitro as well as decrease serum LDL,
increase HDL and reduce lipid peroxidation in animals.
– Shiitake mushrooms have been shown to inhibit atherosclerotic
development.
• Vitamin E
– Numerous epidemiological studies, (e.g. Nurses’ Health Study) have
shown correlations between increased consumption of Vitamin E
from diet and supplementation and reduced risk of heart disease.
– Vitamin E functions as an antioxidant in preventing the oxidation of
LDL and reducing total plasma cholesterol and LDL.
– Vitamin E has been shown to increase plasma HDL and PON-1
activity.
– A recent human clinical study has also shown that Vitamin E,
prevents exercise-induced reduction of serum PON-1.

28. The Science – CYP11B2 SNPActive™
• The CYP11B2 gene encodes an enzyme called Aldosterone
Synthase, which plays a role in regulating blood pressure.
• A SNP on the CYP11B2 gene can decrease the ability of
blood vessels to relax and constrict  hypertension.
– Atherosclerosis
– Stroke
– Chronic heart failure
CYP11B2 SNPActive™ provides ingredients to:
Help maintain blood pressure levels
Strengthen the heart to help hypertension

29. The Science – CYP11B2 SNPActive™
• Hawthorn Berry Extract (Polyphenols,
Flavonoids)
– Two clinical investigations have shown reductions in
resting diastolic blood pressure after supplementation.
– A 2008 double-blind randomized clinical trial in patients
with chronic heart failure reported that
supplementation:
• Increased exercise tolerance
• Decreased cardiac oxygen consumption
• Reduced shortness of breath and fatigue
• Magnesium and Potassium
– USDA recommends diets rich in potassium as they may
reduce the risk of high blood pressure and stroke.
– NIH also recommends increased dietary intake of
magnesium and potassium based on results from DASH
study (Dietary Approaches to Stop Hypertension)

30. The Science – ApoB SNPActive™
• ApoB is an apolipoprotein (a lipid-binding protein) that is
the major protein component of LDL (bad cholesterol).
Without ApoB, LDL cannot form.
– Increased ApoB levels are associated with coronary heart disease
(CHD).
– ApoB levels are a better predictor of CHD than LDL level.
• SNPs on the ApoB gene produce higher ApoB levels 
increases in total cholesterol and LDL.
ApoB SNPActive™ provides dietary ingredients to:
 Reduce ApoB production
 Prevent LDL oxidation
 Reduce LDL

31. The Science – ApoB SNPActive™
• Green Tea Extract (Polyphenols, Catechins)
– Supplementation with 500 mg/day tea catechins decreased plasma
oxidized LDL levels in healthy adults. ApoB Active contains 500 mg of
catechins from green tea.
– Green tea catechins have also been shown to be a potent inhibitor of
ApoB secretion from liver cells.
– Epidemiological evidence also supports green tea’s positive effect on
cholesterol.
• Grape Skin Extract (Polyphenols, Resveratrol)
– Red wine polyphenols have been shown in vitro to directly reduce
the ApoB levels produced by human liver cells. The effect was similar
to astorvastin, a cholesterol-lowering drug.
• Artichoke Extract (Chlorogenic acid, Caffeoylquinic acids)
– Numerous clinical studies on patients with hyperlipidemia have
shown the artichoke extract decreases total cholesterol, LDL and
LDL/HDL.
– Artichoke extract also has been shown to positively modulates
endothelial function. Endothelial dysfunction represents the first
stage of atherosclerotic disease
– Common cholesterol-lowering therapy used in Europe.

32. Thank You!