ASP.NET MVC is a web application framework that implements the model-view-controller pattern, giving developers more control over HTML and improving testability compared to ASP.NET WebForms. The presentation describes what MVC is, why it is useful for separation of concerns, better testing and maintainability, discusses how requests flow through the MVC pattern in an application, and demonstrates building an MVC application from scratch. Resources for learning more about ASP.NET MVC are also provided.