A syringe is essentially a device used in medicine to inject fluid into or withdraw fluid from the body. Medical syringes consist of a needle attached to a hollow cylinder that is fitted with a sliding plunger. The downward movement of the plunger injects fluid; upward movement withdraws fluid. A prefilled syringe is a single-dose packet of vaccine to which a needle has been fixed by the manufacturer. A prefilled syringe is not positioned as a high technology product such as needle free injectors which involves pioneering drug delivery technologies. Neither is it a simple technology (for example tabulating). Instead it is positioned in the middle, being on the border line of simple to advance. The growth rate is to be expected to remain at a high level of more than 10% annually. This is due to a number of factors such as greater medication safety and increased convenience from using a prefillable device. Prefilled syringes accommodate volumes that typically range from 0.25 to 5.0 ml. They are therefore best suited to products administered by subcutaneous or intramuscular injection. The categories account for the bulk of prefilled syringes: vaccines, blood stimulants, therapeutic proteins, erythroproteins, interferons and rheumatoid arthritis

1. CALL
NOW FOR
EARLY BIRD
2nd Prefilled
DISCOUNTS
Syringes Americas
Examining the current market demand and developing safer, stable, cost-effective pre-filled syringes
April 5th - 7th 2011, USA BOOK NOW!
Key Speakers
Dr.Ingrid Markovic,Expert Review Scientist , Food and Drug Administration
Pankaj Paranjpe, Manager, R&D Operations, Bristol-Myers Squibb
Jennifer Johns, Principal Packaging Engineer, Bristol-Myers Squibb
Amanda Wolf, Scientist - Pharmaceutical Research and Development, Pfizer
Crisanta Ransom, MS&T - Commercialization Technical Center, Eli Lilly
Raul Soikes, Sr. Director Program Management, Baxter BioPharma Solutions
Dr. Jan Jezek, Chief Scientific Officer, Arecor
Jim Spolyar, Sales and Technical Director, SKAN US
Stephen A. Barat, Director, Toxicology and Operations, Forest Research Institute
Vinod Vilivalam, Director, West Pharmaceutical
Dr. Arno Fries Director Product Management Tubular Glass, Gerresheimer Bünde
Dr.Silke Conrad, Manager Regulatory Affairs, Ypsomed AG
Patty Kiang, Consultant, Kiang Consultant Services
Pre-conference Workshop, Tuesday April 5th 2011
Develop syringe materials and components that minimize and eliminate: contamination from leachables and extractables
Led by: Dr. Patty Kiang, PhD, Consultant, Kiang Consultant Services
Associate Sponsor
Driving the Industry Forward | www.futurepharmaus.com
Organised By
Media Partners
To Book Call: +44 (0) 20 7336 6100 | www.visiongain.com/pfsamericas

2. Conference Introduction
2nd Prefilled Syringes Americas
April 5th - 7th 2011, USA
Dear Colleague,
ontinuous growth in vaccines, blood stimulants, therapeutic proteins,
C Poster Presentation
erythroproteins, interferons and rheumatoid arthritis has driven the growth of pre-
filled syringes market At a busy conference it is hard to make sure everyone who
ith promising growth of 10-15% per annum, there were 2 billion pre-filled syringe
W shares your interests knows what you are doing. Maximise
units sold in 2009 alone and expected to continue reaching 3.64bn units in 2015 your time at Visiongain’s 2nd Prefilled syringes Americas
and 6.83bn by 20251.
meeting by sharing your results in a poster presentation.
afety, stability, convenience and cost-effectiveness are main factors driving growth
S
With a plethora of key decision makers, take advantage of
of the pre-filled syringes market. Prefilled syringe manufacturers have had to
therefore respond to increasing demand, new requirements and more sophisticated this senior networking opportunity.
forms of drug delivery.
Please send your 200 word abstract, in English, to:
ollowing the success of visiongain’s previous pre-filled syringes conferences, we are
F info@visiongainglobal.com for approval. The deadline
proud to present the 2nd Pre-filled Syringes Americas conference.
for submissions is Monday, March 21st, 2011. Please include
t this global event of pre-filled syringes, meet industry leaders from around the
A
contact details for the corresponding author(s).
world to discuss every aspect of pre-filled syringes market from technological
needs, design to safety and quality through to regulatory issues. Spend three days in Academic institutions will not be charged a fee if booked as
partnering; participate in special panel discussions and evening networking drinks.
full-price delegates. Posters submitted by pharmaceutical
tay ahead of competition by learning about the latest developments on
S
and biotechnology firms will be charged a fee of £199.
technological advances in design, component materials, process engineering,
siliconisation, dosage accuracy, auto-injections, quality, safety and regulatory issues. Posters submitted by service providers / vendors are
welcome and will be subject to evaluation. Upon
By attending this conference, you will:
approval a fee of £500 will apply. Two delegates from
• ear about new technological developments and changing market scenario
H
your organisation must be booked at full price to present
• nderstand pharmaceutical industry expectations from manufacturers of pre-
U
a poster.
fillable syringes
• earn about recent achievements and trends for formulation and delivery of
L Please note that all posters will be displayed at the
protein pharmaceuticals, vaccines and blood stimulant drugs discretion of Visiongain Ltd and are subject to approval.
• ain insight about developments in the areas of component materials, surface
G Due to limited space, please register your interest early.
treatments and filling processing and packaging
• vercome challenges in prefilled syringes design, liquid viscosity, injection speed/
O
flow rate, needle inner diameter, needle length etc
• xplore auto-injection devices: convenience items, or a key component of
E Who will attend?
injectable products
• ptimize siliconization with regard to product requirements, autoinjector
O Vice/Presidents, Directors, Heads of:
compatibility, general syringe performance
• Packaging
• iscover about applications & advantages of bubble-free filling for today’s
D
parenteral products • Labelling
• evelop syringe materials and components that minimize and eliminate:
D
contamination from leachables and extractables
• Manufacturing
• tay ahead by learning about Ingenious advanced labelling technologies, including
S • Product design
peel off tabs and radio frequency transmitters, to increase product safety and
security • Technical support
• eview current state of art and future technological developments in the field of
R • Drug product process development
RABS, isolators, e-beam and alternatives
• xamine factors and recent developments in processing syringe nests
E • Drug device process development
• valuate benefits and challenges of outsourcing
E • Pharmaceutical sciences
• ssess the impact of new post-market surveillance regulations on pre-filled
A
medical devices • Safe medication practice
• btain the latest market analysis, and meet manufacturers showcasing their
O • Drug discovery & delivery
leading products
• Strategic alliances
I look forward to meeting you at the conference
• Clinical product resourcing
Best regards
• Supply outsourcing
• Contract management
• Process development
Sonia Tomar • Investment and venture capital
Conference Producer
1
Pre-Filled Syringes and Related Systems: World Market Outlook 2010-2025

3. Pre-Conference Interactive Workshop
2nd Prefilled Syringes Americas
Tuesday April 5th 2011
Develop syringe materials and components that minimize and
eliminate: contamination from leachables and extractables
Led by: Dr. Patty Kiang Timings: 9:30 - 10:00 Coffee & Registration
0
Consultant 10:00 - 17:00 Workshop
Kiang Consultant Services T
iming includes lunch and refreshment breaks
Workshop Agenda: About your workshop leader:
The objective of this workshop is to provide the information Dr. Patty Kiang
of critical factors which will impact the success of the prefilled Patty H Kiang, Ph.D. is a Pharmaceutical Consultant on
syringe development. The material composition, component / Pharmaceutical packaging and delivery devices for liquid and
lyophilized products, Prefilled syringe system, and CMC filing
device design, manufacturing and sterilization processes are
for Combination Products.
all the important factors which will impact the extractables
Prior to the consultant position, she was Account Director for Catalent Pharma
and leachables from the syringe system. Improved glass syringe Solutions; she was responsible for business development of Analytical & Biotech
operation and COC resin or Daikyo CZ resin syringes plus Services to Biotech and Pharmaceutical companies on the West Coast of USA,
Canada and Asia pacific territory.
Fluorocarbon film laminated plungers have demonstrated the
She was Head of Device Development for Genentech Inc. in South San Francisco,
reduction of contamination from extractables and leachables will
CA. She was responsible for the development of a new autopen injector for
be discussed in the workshop Growth Hormone; she was also responsible for setting up the Extractable /
Leachable program for evaluation of primary container/closure systems and
was a CMC leader for a prefilled syringe drug development. Prior to joining
Genentech, she was Director, Delivery Device and Packaging Support for
N
EW
Schering Plough, in Kenilworth, NJ. She was responsible for the development
RE
Pre-Filled Syringes and Related Systems: of PEG-Interferon dual chamber pen injector and various delivery devices. Prior
PO
World Market Outlook 2010-2025
RT
to joining Schering Plough, she was Director of Technology Development for
– how will rising demand and technological West Pharmaceutical Services in Lionville, PA, a developer and manufacturer of
developments create opportunities?
parental drug packaging components, where she coordinated with corporate
The market for pre-filled syringes has achieved growth partners in Japan and Germany in the development of various new products.
in recent years. In 2009, an estimated 2 billion pre-
filled syringe units were sold and the market for that She was a member of the faculty of the PDA’s Training and Research Institute,
technology was estimated to be worth up to $2.5 where she taught courses on Parenteral Packaging, and served as a member
billion. There is a trend towards pre-filled drug injection
of USP’s Expert Committee on Drug Packaging, Storage and Distribution. She
systems, away from vials/ampules, for both new and
existing products. Examples are filled glass and plastic was the chairperson for PDA Gamma Radiation Sterilization of Polymeric
syringes, pens and low-volume auto-injection devices, Materials Committee. She is an expert in the area of drug and container/closure
including refills. That sector has shown growth of
interactions and compability issues.
10-15% in recent years, forming one of the fastest-
expanding sectors in the pharmaceutical industry. In our She is a frequent speaker and has chaired many symposia on the packaging of
new report, we predict that the pre-filled drug delivery pharmaceutical and biotechnology derived products. Most recently she chaired
market will grow steadily from 2010, as the number
of products launched in pre-filled injectable forms the PDA 2006 Global Prefilled Syringe & Injection Device Conference. Dr. Kiang
increases. Medical professionals, patients and other holds five patents in the field of polymeric surface coatings. She received a Ph.D. in
stakeholders see the benefits of that more-convenient Analytical Chemistry from Villanova University and holds an MBA from Pennsylvania
system, raising demand at the expense of older formats.
State University.

4. Day 1
2nd Prefilled Syringes Americas
Wednesday April 6th 2011
09:00 Registration and refreshments 12:40 Networking lunch
09:30 Opening address from the chair 13:40 Overview of drug delivery devices for pre-filled
Pankaj Paranjpe syringe products
Bristol-Myers Squibb • User Benefit
• A new generation of device and compromises in device design
Jennifer Johns
• Aseptic pre-filled drug-delivery systems
Bristol-Myers Squibb
• Future opportunities
09:40 Update on pre-filled syringes: trends, materials,
14:20 Sponsor Spotlight Session
components, processes and quality
T
ake this unique opportunity to be a part of the conference theme,
• Market dynamics and trends
network, share ideas and provide an overview of your product/services
• New syringe materials
to the audience.
• Value added components
For more information please contact ronald.magali@visiongainglobal.com
• Syringes for biotech drugs
• Quality aspects
Dr. Arno Fries
15:00 Afternoon Refreshments
Director Product Management Tubular Glass
Gerresheimer
15:20 Panel discussion: New technological developments
and changing market scenario
10:20 Recent trends in the application of plastic prefillable
P
anlists will discuss the market trends and emerging requirements, latest
syringe systems for biopharmaceutical drug delivery developments in all areas of pre-filled syringe product development; from
• yclic olefin polymers: properties, applications and commercial drug products
C formulation to manufacturing, considerations for component and system
• ecent trends in the use of newer plastics for delivering mAbs,
R selection, supplier role in quality for any questions or participation please
proteins and vaccines contact sonia.tomar@visiongainglobal.com
• olve challenges associated with glass prefilled syringes, including
S
breakage reactivity and leachables like silicone, tungsten and glue
• arket and scientific needs for plastic prefillable syringes for
M
biopharmaceutical drugs and high viscosity formulations 16:00 Advanced formulations of biologics
• lastic vials for break resistant, less reactive and cold temperature
P • Stability of biologics
storage/transport containers for biologics and stem cells • Stable aqueous formulations for pre-filled syringes
• Reduced rate of aggregation
Vinod Vilivalam • High concentrations of antibodies
Director • Terminal sterilization by gamma radiation or e-beam
West Pharmaceutical
Dr. Jan Jezek
Chief Scientific Officer
Arecor Limited
11:00 Morning refreshments
16:40 Closing remarks from the chair
11:20 Rational selection of primary packaging components
for pre-filled syringe products
• Primary packaging components
• Packaging and drug delivery trends 16:50 Networking Drinks
• Developing primary and critical secondary packaging components Take your discussions further and build new
relationships in a relaxed and informal setting.
12:00 Fill-finish for prefilled syringes in a contract
manufacturing setting with the following emphasis
N
EW
• lient Teams dedicated to your product – relentless focus on your product
C Pharma Business Daily
SL
by knowledgeable individuals
ET
Each issue of Pharma Business Daily newsletter focuses on latest
• etrics to drive performance – leading indicating metrics; tangible output
M
TE
breaking stories in your market. Delivered directly to your Inbox or
R
translating to a timely deliverable available through the website, all the industry news is available to you
• CMO-Client partnership – conclusion highlighting best practices all the time. When you want the news its there for you - it really is that
simple. Over 25+ stories everyday as they happen. Never again will any
Raul Soikes of your colleagues be aware of news that you aren’t.
Sr. Director Program Management Plus exclusive features from visiongain conferences and in-depth
Baxter BioPharma Solutions analysis from visiongain analysts will be available to you thanks to your
subscription to PharmaBusinessDaily. This information is not available
anywhere else.
Call +44 (0)207 336 6100 or visit www.visiongain.com to sign up.
Due to unforeseen circumstances the programme may change and visiongain reserves the right to alter the venue and/or speakers c Copyright visiongain Ltd, 2011

5. Day 2
2nd Prefilled Syringes Americas
Thursday April 7th 2011
09:00 Registration and refreshments 13:40 Pre-filled syringe processing with RABS, Isolators,
E-beam & Alternatives
• Isolator technology with latest E-Beam design features
09:30 Opening address from the chair • Comparison of RABS vs Isolators
• Alternative tub entry system for slow speed production
• Expansion of the areas of application of syringe technology
Jim Spolyar
09:40 Extractables and leachables in pre-filled syringes
Sales and Technical Director
Dr. Ingrid Markovic SKAN US
Expert Review Scientist
Food and Drug Administration
14:20 Processing solutions for pre-filled syringes from
conditioning to aseptic filling and final assembly
10:20 How to select syringe components - Minimize • yringe conditioning including the processing steps washing, silicone
S
potential extractables and leachables coating, needle or needle shield assembly, nesting and packaging
• Tips to establish user requirements - Special topic: Features and challenges of the silicone coating process
• Examples of extractable/leachable failure modes experienced by industry • n-line washing and sterilizing solutions (for syringes without a glued-in needle)
I
• Risk based approach in evaluating extractables/leachables - pecial topic: Sterilizing tunnel for syringes with non-glass-to-glass
S
• trategy for selecting syringe components used for different drug products
S contact transport system
and coming from various sources • septic filling including the processing steps debagging, delidding, filling
A
and closing
Crisanta Ransom, Ph.D. - pecial topic: Vacuum filling and closing as well as in-process control
S
MS&T - Commercialization Technical Center (IPC) capabilities
Eli Lilly and Company • ssembly including the processing steps denesting, plunger rod assembly,
A
labeling, safety device assembly
- Special topic: Needle protection labels and safety devices
11:00 Morning refreshments Markus K. Hoersch
Technical Sales Manager
BAUSCH + STROEBEL
11:20 Toxicological risk assessment of leachable substances
from container-closure systems
• eneral background on leachables from container-closure systems
G 15:00 Regulatory issues relating to combination products
• egulatory expectations for the safety assessment of
R with delivery devices
leachable substances • Definition of “combination product”
• Current approaches to evaluate the potential for safety concerns • Regulatory paths for combination products / Primary Mode of Action
• orking examples to demonstrate how to conduct a
W • eCTD content planning for combination products with delivery devices
toxicological assessment • hallenges in eCTD content planning for combination products with
C
delivery devices
Stephen A. Barat, Ph.D.
Director, Toxicology and Operations Dr. Silke Conrad
Forest Research Institute Manager Regulatory Affairs
Ypsomed AG
12:00 Practical considerations for shipment of pre filled
15:20 Afternoon refreshments
syringes and experimental approaches taken
• Overview on practical consideration for shipment
• Shipping and handling charges
• Current practices in shipping and handling 16:00 Panel discussion: Evaluate benefits and challenges
of outsourcing
Amanda Wolf
Panelists will assess the importance of pharma-device alliances and design
Scientist
partnerships on pre-filled syringe products, discuss how to make most of the
Pfizer
partnership with contract manufacturers for any questions or participation
please contact sonia.tomar@visiongainglobal.com
12:40 Networking lunch
16:40 Chair’s closing remarks
16:50 End of Conference

6. Partners
2nd Prefilled Syringes Americas
April 5th - 7th 2011, USA
Associate Sponsor:
The BAUSCH + STROEBEL product range Sponsorship and exhibition opportunities:
specializes in machines for pharmaceutical
This event offers a unique opportunity to meet and do business
primary packaging, including equipment for
washing, sterilizing / depyrogenating, filling, closing and labeling with some of the key players in the pharmaceutical and biotech
of containers such as ampoules, cartridges, disposable syringes,
industries. If you have a service or product to promote, you can
vials and bottles of all kinds. Our systems are designed to comply
with the latest FDA and GMP requirements and are available for all do so at this event by:
capacity ranges, starting from laboratory testing and clinical batches
to fully integrated commercial production. With more than 40 years • Hosting a networking drinks reception
of experience and over 10,000 machines delivered BAUSCH +
STROEBEL is a leading manufacturer of high-quality equipment for • Taking an exhibition space at the conference
the pharmaceutical industry.
• Advertising in the delegate documentation pack
For further information please visit: www.bausch-stroebel.com
• Providing branded bags, pens, gifts, etc.
Media Partners:
PharmiWeb.com is the leading industry-sponsored If you would like more information on the range of
portal for the pharmaceutical sector. Supported sponsorship or exhibition possibilities for visiongain's
by most of the leading pharmaceutical corporations, PharmiWeb.
com provides dynamic real-time news, features, events listings and 2nd Prefilled Syringes Americas Conference,
international jobs to industry professionals across Europe and the US. please contact us.
For further information please email: corporate@pharmiweb.com
Ronald Magali, +44 (0)20 7549 9934
BIOTECHNOLOGY EUROPE is owned by
BIOTECHNOLOGY WORLD. It is based and located ronald.magali@visiongainglobal.com
in Warsaw, Poland. Biotechnology World was founded in 2007 to
provide the world’s biotech and pharma information and market to
make it universally accessible and useful for scientific and business
processes. Its first step to fulfilling that mission was building the
BIOTECHNOLOGY EUROPE platform that will allow a quick
spread of information in different channels. BIOTECHNOLOGY
About visiongain:
EUROPE offers companies completed internet public relations,
publication and marketing solutions. One of the mains goals of Visiongain is a specialist business information company focused on
BIOTECHNOLOGY EUROPE is to integrate the Biotech and Pharma providing cutting edge products and services across the Pharmaceutical/
Sector in Europe to global biotechnology, pharmaceutical and life
Biotech, Telecommunications, Defence and Finance sectors, which
science activities.
For further information please visit www.biotechnology-europe.com include reports, conferences, online daily news and offline news
analysis and bespoke consultancy. With a commitment to innovation
InPharm is the online platform for exclusive
pharmaceutical news, comment, contracts, services, and excellence, visiongain offers flexible solutions to meet our clients’
jobs and events and is home to InPharmjobs.com, Pharmafile and business intelligence needs, providing the right information at the
Pharmafocus.
right time to facilitate the commercial decision-making process. Our
For further information please visit: www.In-Pharm.com
pharmaceutical products include Pharma Business Daily, the leading
Future Pharmaceuticals has forged powerful
Driving the Industry Forward | www.futurepharmaus.com
relationships with key industry leaders to provide a daily email newsletter for the pharmaceutical, biotech and healthcare
platform for successful brand recognition, and for senior decision- industries, and a range of independent, high-quality, in-depth reports
makers to have the means to procure and plan implementation covering focused and topical areas of concern. Our pharmaceutical
strategies based on the topics covered. Positioned to be an
authoritative resource within top pharma companies as well as conferences address the hottest commercial, regulatory and technical
small, specialty, and biotech, Future Pharmaceuticals magazine topics and provide an ideal forum for debate and networking for
is geared to create a deep penetration into a highly targeted and pharmaceutical professionals from around the world.
responsive audience, bridging the gap between the industries’ top
issues and the solutions top-tier vendors can provide. For further information, please visit: www.visiongain.com
For further information please visit: www.futurepharmaus.com

7. Registration Form
2nd Prefilled Syringes Americas
April 5th - 7th 2011, USA
Conf. code
Standard Prices
Conference and workshop Fee: £1699 (USD* 2629)
2nd Prefilled
Conference only
Workshop only
Fee:
Fee:
£1299
£599
(USD* 2010)
(USD* 927)
Syringes Americas
Number of bookings: Total cost:
April 5th - 7th 2011
*USD price is estimate only
USA
Promotional Literature Distribution
Distribution of your company’s promotional literature to all conference attendees
Fee: £999 VAT: £199.80 Total: £1198.80
How to book
Details
Email: conferences@visiongainglobal.com
Forename: Surname: Web: http://www.visiongain.com/pfsamericas
UK Office:
Job Title: Company: Tel: +44(0) 20 7336 6100
Fax: +44(0) 20 7549 9932
Main Switchboard Number: Visiongain Ltd
BSG House
226-236 City Road
Address: London
EC1V 2QY
UK
General information
Country: Postcode: Venue: TBA, USA
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