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KARÉN MATEVOSYAN, MD
Assistant Professor, Department of Pathology
The University of Texas Southwestern Medical Center
Date January 20, 2015
Contact Information
Business Address: 5323 Harry Hines Blvd, suite CS3.114
Dallas, Texas 75390-9073
Business Phone (214) 648-7886 (office)
(469) 877-6744 (mobile)
Fax: (214) 648-8037
e-mail: Karen.Matevosyan@UTSouthwestern.edu
Foreign Languages: Russian (fluent - read/write/speak)
Armenian (colloquial)
Bulgarian (colloquial)
Azeri-Turkish (colloquial)
Education
1975-1981 M.D., Azerbaijan State Medical Institute, Baku, Azerbaijan
Postgraduate Education and Training
1981-1982 Internship, Pediatrics, No. 8 Children’s Hospital, Azerbaijan State Medical University,
Baku, Azerbaijan
2003-2006 Residency, Clinical Pathology, University of Texas Southwestern Medical Center,
Dallas, TX
2006-2008 Fellowship, Blood Banking/Transfusion Medicine, University of Texas Southwestern
Medical Center, Dallas, TX
Certifications:
12/04/2002 Certificate, Educational Commission for Foreign Medical Graduates
08/04/2010 Diplomate, American Board of Pathology (Clinical Pathology)
09/14/2011 Diplomate, American Board of Pathology (Blood Banking / Transfusion Medicine)
Medical Licensure:
03/16/2009-current Commonwealth of Pennsylvania
12/15/2010-current Texas

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Employment History
Academic Appointment
2008 - present Assistant Professor, Department of Pathology, University of Texas Southwestern
Medical Center at Dallas, TX
Appointments at Hospitals/Affiliated Institutions
2008 - present Associate Medical Director, Transfusion Medicine, University of Texas Southwestern
Medical Center at Dallas, TX
2010 - present Medical Director, Therapeutic Apheresis, University of Texas Southwestern Medical
Center at Dallas, TX
2010 - present Medical Director, Hemostasis Reference Laboratory, Clinical Laboratory Services,
University of Texas Southwestern Medical Center at Dallas, TX.
Past Employments
1982-1984 Pediatrician, General Pediatric Practice, Children’s City Hospital, Sumgait, Azerbaijan
1984-1988 Staff Pediatrician, Emergency Room, Children’s City Hospital, Sumgait, Azerbaijan
1988-1991 Staff Pediatrician, Pediatric Intensive Care, No3 Children’s Hospital, Yerevan, Armenia
1992-1993 Medical Interpreter, Salt Lake City/County Health Department, Salt Lake City, UT
1993-2003 Apheresis Specialist, Parkland Health & Hospital System, Dallas, TX
Professional Society Memberships
2004-current American Society for Apheresis
2004-current College of American Pathologists
2004-current American Society of Clinical Pathology
2005-current North Texas Society of Pathologists
2007-2014 American Society of Hematology
2008-current Ameriacn Association of Blood Banks
Honors and Awards
1982 Internship Certificate with Honors, Azerbaijan State Medical University
Scope of Clinical Practice
2008-current Day to day care of patients undergoing therapeutic apheresis at 2 busy apheresis
units (UT Southwestern Medical Center and Parkland Memorial Hospital); over 3,000
procedures per year
Clinical consultant in transfusion medicine and hemostasis
Interpretive reports of complex hemostasis tests
Hospital Privileges:
2008-current University Hospitals – University of Texas Southwestern Medical Center at Dallas, TX
(full privileges)
2008-current Parkland Health & Hospital System, Dallas County Hospital District, Dallas, TX (full
privileges)
2008-current Children’s Medical Center at Dallas (consultant in therapeutic apheresis)
2011-2015 Veterans Administration North Texas Health Care System, Dallas, TX (research)

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Administrative Service
2010-current Medical Director of Apheresis Unit, UT Southwestern Medical Center, includes a busy
outpatient unit, functioning 7 days a week, 2 hospitals – Zale Lipshy University
Hospital, Clements University Hospital; over 3,000 procedures performed annually.
2010-current Medical Director of Hemostasis Reference Laboratory (Special Coagulation Lab); over
130,000 assays performed annually.
Institutional service
2004-current Blood Utilization Review Committee Member. Parkland Health & Hospital System,
Dallas County Hospital District.
2005-current Blood Utilization Review Committee Member. University of Texas Southwestern
Medical Center.
2008-current Interviewer, Pathology residency applicants.
National Service
2008-current Ad Hoc Reviewer, Journal of Clinical Apheresis, Archives of Pathology and Clinical
Laboratory
Teaching Service
Medical Student Teaching
2008-current Small group discussion leader, Pathology course, 1st and 2nd year medical students, 18
contact hours/year
Lecturer, Introduction to Hemostasis, Pathology Course, 2nd year medical students, 1
contact hour/year
Resident and Fellow Teaching
2008-current Attending Physician; 2 fellows, 2 residents; Transfusion Medicine – 13 weeks/year,
therapeutic apheresis - daily.
Didactic lectures in Transfusion Medicine and Apheresis.
Transfusion Medicine Residents and Fellows. 44 contact hours/year.
Lecturer, Therapeutic Plasma Exchange – Principles.
Hematology-Oncology Fellowship Program. 1 contact hour/year.
Lecturer, Therapeutic Plasma Exchange in Renal Practice .
Nephrology Fellowship Program. 1 contact hour/year.
Mentoring, Hematopathology Fellows.
Coordination of monthly rotation in Hemostasis/Special coagulations. 3 months/year.

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Research Activities
Industry Sponsored Studies
2014-current AMIC-003-CMD. Evaluation of the AMICUS Red Blood Cell Exchange (RBCx) System in
Sickle Cell Patients. FDA Multicenter study. Site principal investigator. Sponsor –
Fresenius Kabi.
Departmental Research
2014-current Comparison Of Spectra Optia and COBE Spectra Apheresis Systems Performances For
Red Blood Cell Exchange. Principal investigator.
2014-current Determinants Of Inter-Procedure Interval In Patients With Sickle Cell Anemia Enrolled
In A Chronic Transfusion Program. Co-investigator.
2013-2015 The Role of Whole Blood Platelet Aggregation Studies in the Diagnosis of Unexplained
Bleeding Tendencies. Co-investigator.
2011-2015 Evaluation of the Effect of Therapeutic Plasma Exchange in the Management of
Neuromyelitis Optica. Primary Investigator.
2011-2015 Plaque Regression and Progenitor Cell Mobilization with Intensive Lipid Elimination
Regimen (PREMIER). VAMC. Co-investigator.
2011-2013 Ablynx NV. Phase II, single-blind, randomized, placebo-controlled trial to study the
efficacy and safety of anti-von Willebrand factor nanobody administered as adjunctive
treatment to patients with acquired thrombotic thrombocytopenic purpura. Co-
investigator.
2010-2010 Can HIT be ruled out by a low 4T score without testing? Co-investigator.
2008-2010 Whole Blood Platelet Aggregation Assay: Clinical Correlation with Hyperactive Platelet
Syndrome and Primary Platelet Dysfunction. Co-investigator.
2006-2011 Trauma Coumadin Protocol: Use of Prothrombin Complex Concentrate and
Recombinant Factor VIIa in patients on warfarin and with head or torso trauma. Study
coordinator.
2003-2011 Isovolemic Hemodilution Red Cell Exchange for Prevention of Stroke in Sickle Cell
Disease Patients. Co-investigator.
2007-2008 HIT Observational Thromboembolism Study (Transfusion Medicine/Hemostasis Clinical
Trials Network multicenter study). Study coordinator.
2005-2005 Correlation between optical densities of Heparin-Platelet factor 4 ELISA assay and
clinical thrombosis in patients with Heparin-induced thrombocytopenia. Study
coordinator.
2003-2004 Correlation between clotting factors II, VII and VIII levels and isolated, mild increase in
INR (1.3-1.7) in neurosurgical patients. Study coordinator.

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Publications
Peer-reviewed Journal Articles
1. Refaai MA, Warkentin TE, Axelson M, Matevosyan K, Sarode R. Delayed-onset heparin-induced
thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin
"flushes". Thromb Haemost. 2007 Nov;98(5):1139-40. No abstract available. PMID:18000622.
2. Altuntas F, Matevosyan K, Burner J, Shen YM, Sarode R. Higher optical density of an antigen assay predicts
thrombosis in patients with heparin-induced thrombocytopenia. Eur J Haematol. 2008 May;80(5):429-35.
doi: 10.1111/j.1600-0609.2008.01035.x. Epub 2008 Jan 19. PMID:18208574.
3. Park YA, Hay SN, King KE, Matevosyan K, Poisson J, Powers A, Sarode R, Shaz B, Brecher ME. Is it quinine
TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy. J Clin Apher. 2009;24(3):115-9.
doi: 10.1002/jca.20194. PMID:19260037.
4. Sarode R, Refaai MA, Matevosyan K, Burner JD, Hampton S, Rutherford C. Prospective monitoring of
plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.
Transfusion. 2010 Feb;50(2):487-92. doi: 10.1111/j.1537-2995.2009.02413.x. Epub 2009 Oct 5.
PMID:19804569.
5. Bhagat R, Matevosyan K, Jones R, Vetus ML, Burner J, Sarode R. Rinseback during red blood cell exchange
with COBE Spectra does not affect fraction of cells remaining or post-exchange hematocrit. J Clin Apher.
2010;25(6):347-9. doi: 10.1002/jca.20251. PMID:20623784.
6. Matevosyan K, Madden C, Barnett SL, Beshay JE, Rutherford C, Sarode R. Coagulation factor levels in
neurosurgical patients with mild prolongation of prothrombin time: effect on plasma transfusion therapy. J
Neurosurg. 2011 Jan;114(1):3-7. doi: 10.3171/2010.7.JNS091699. Epub 2010 Sep 3. PMID:20815699.
7. Sarode R, Matevosyan K, Rogers ZR, Burner JD, Rutherford C. Advantages of isovolemic hemodilution-red
cell exchange therapy to prevent recurrent stroke in sickle cell anemia patients. J Clin Apher.
2011;26(4):200-7. doi: 10.1002/jca.20294. Epub 2011 Jul 22. PMID:21786315.
8. Sarode R, Matevosyan K, Bhagat R, Rutherford C, Madden C, Beshay JE. Rapid warfarin reversal: a 3-factor
prothrombin complex concentrate and recombinant factor VIIa cocktail for intracerebral hemorrhage. J
Neurosurg. 2012 Mar;116(3):491-7. doi: 10.3171/2011.11.JNS11836. Epub 2011 Dec 16. PMID:22175718.
9. Matevosyan K, Anderson C, Sarode R. Isovolemic hemodilution-red cell exchange for prevention of
cerebrovascular accident in sickle cell anemia: the standard operating procedure. J Clin Apher.
2012;27(2):88-92. doi: 10.1002/jca.21203. Epub 2012 Feb 2. PMID:22302664.
10. De Simone N, Racsa L, Bevan S, Matevosyan K, Valley T, Girod C, Sarode R. Therapeutic plasma exchange in
the management of sepsis and multiple organ dysfunction syndrome: a report of three cases. J Clin Apher.
2013 Sep 2. doi: 10.1002/jca.21296. [Epub ahead of print]. PMID:24000124.
11. Shah N, Rutherford C, Matevosyan K, Shen YM, Sarode R. Role of ADAMTS13 in the management of
thrombotic microangiopathies including thrombotic thrombocytopenic purpura (TTP). Br J Haematol.
2013 Nov;163(4):514-9. doi: 10.1111/bjh.12569. Epub 2013 Sep 20. PMID:24111495.
12. Yates S, Matevosyan K, Rutherford C, Shen YM, Sarode R. Bortezomib for chronic relapsing thrombotic
thrombocytopenic purpura: a case report. Transfusion. 2014 Aug;54(8):2064-7. doi: 10.1111/trf.12614.
Epub 2014 Mar 24. PMID: 24655327.
13. DeSena AD, Noland DK, Matevosyan K, King K, Phillips L, Qureshi SS, Greenberg BM, Graves D. Intravenous
methylprednisolone versus therapeutic plasma exchange for treatment of anti-n-methyl-d-aspartate
receptor antibody encephalitis: A retrospective review. J Clin Apher. 2015 Aug;30(4):212-6. doi:
10.1002/jca.21363. Epub 2015 Feb 9. PMID: 25664728.
14. Matevosyan K, Sarode R. Thrombosis, Microangiopathies, and Inflammation. Semin Thromb Hemost.
2015 Aug 15. [Epub ahead of print]. PMID: 26276936

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Non-peer reviewed scientific/medical publications
1. Matevosyan K. Check Sample: Use (and Misuse) of Plasma in Clinical Practice. Transfusion Medicine. Vol.
50; No. TM 07-1 (TM-293); ISSN 1056-5949. ASCP Press. January 2007.
Other Brief Communications
1. Sarode R, Matevosyan K. Prothrombin complex concentrate and fatal thrombosis: poor evidence to
implicate a relatively safe drug. Ann Emerg Med. 2009 Sep;54(3):481-2; author reply 482-3. doi:
10.1016/j.annemergmed.2009.07.004. No abstract available. PMID:19695429.
2. Matevosyan K, Madden C, Barnett SL, Beshay J, Rutherford C, Sarode R. Response to Editorial
“Transfusion” by Hoffer A and Selman W. J Neurosurg. Sept 3, 2010; DOI: 10.3171/2010.6.JNS10436. J
Neurosurg. Jan 11, 2011;114(1):1-2.
Selected Abstracts and Presentations
1. Matevosyan K, Anderson C, Schellhase R, Vetus ML, Jones R, Reagans M, Paranjape G, Sarode R.
Impact of Variation of Hematocrits of RBC Units on the End Hematocrits during RBC Exchange
Procedures. J Clin Apher, 2003;18(2):90. (24th Annual Meeting of American Society for Apheresis,
May 2003. Lake Tahoe, NV [oral presentation]).
2. Paranjape G, Rawal A, Anderson C, Rogers Z, Sartwell C, Wood L, Matevosyan K, Sarode R. Isovolemic
Hemodilution - Red Cell Exchange (IHD-RBC X) in Sickle Cell Disease - A Follow Up. Journal of Clinical
Apheresis, Vol.18, number 2, 2003, page 92, abstract #37.
3. Matevosyan K, Cimo M, Madden C, Sarode R. Hemostatic Levels of Coagulation Factors in Patients
with Isolated Prolongation of Prothrombin Time / INR: Implications for Transfusion Medicine
Practice. Blood. 2004;104(11):745a. (46-th Annual Meeting of the American Society of Hematology.
San Diego, CA. December 5, 2004. [poster presentation]).
4. Matevosyan K, Alsammak MS, Sarode R. Extracorporeal Photopheresis in the Management of Heart
Transplant Rejection. J Clin Apher. 2005;20(1):19. (26th Annual Meeting of American Society for
Apheresis, Chicago, IL. April 29, 2005. [oral presentation]).
5. Altuntas F, Matevosyan K, Burner J, Rutherford C, Sarode R. Lack of Correlation between OD Value
of ELISA and Clinical Thrombosis in Patients with Heparin Induced Thrombocytopenia (HIT).
Thromb Haemost; Volume 3, Supplement 1, August 2005, abstract #P0319.
6. Matevosyan K, Altuntas F, Burner J, Sarode R. Transfusion Medicine: Analysis of Resident Calls.
American Association of Blood Banks. Transfusion. 2005;45(sp3);409. (2005 Annual Meeting and
TXPO. October 15-18 2005, Seattle, WA. [poster presentation]).
7. Matevosyan K, Vetus ML, R. Jones, E. George, R. Sarode. Extracorporeal Immunoadsorption
(Immunosorba) for Treatment of refractory Acquired Hemophilia A (Factor VIII Inhibitor): Case
Report. J Clin Apher.2007;22(2):63-64. (28th ASFA Annual Meeting, April 18-21, 2007, Nashville, TN
[oral presentation]).
8. Stalos S, Matevosyan K, El Sharif M, Burner J, Sarode R. Therapeutic response to plasmapheresis in
patients with Devic’s syndrome (Disease) and multiple sclerosis with optic neuritis.
9. Matevosyan K, Madden C, Aung F, Chason D, Arbique G, Guild J, Shafi S, Sarode R. Management of
Warfarin Associated Intracranial Hemorrhage with a 3-factor Prothrombin Complex Concentrate and
low dose Recombinant Factor VIIa. Blood, 2008;112(11):1165 (50th Annual Meeting of American
Society of Hematology. San Francisco, Dec 4-9, 2008 [poster presentation]).
10. Matevosyan K, Cleveland-Noriega DS, Burner JD, Sarode R. Management of Therapeutic Plasma
Exchange-associated Dilutional Hypofibrinogenemia. J. Clin. Apheresis. 2009;68-69. (30th ASFA
Annual Meeting, April 18-21, 2009, San-Diego, CA [oral presentation]).

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11. Cleveland-Noriega DS, Matevosyan K, Burner JD, Refaai M, Sarode R. Efficacy of Dual Lumen
Implantable Vortex Ports During Isovolemic Hemodilution/Red Blood Cell Exchange in Sickle Cell
Disease Patients. J. Clin. Apheresis. 2009;24:64.
12. Cleveland-Noriega DS, Matevosyan K, Burner JD, Sarode R. Septic Shock With Multiorgan
Dysfunction Syndrome (Mods) Successfully Treated With Therapeutic Plasma Exchange. J. Clin.
Apheresis. 2009;24:88.
13. Mahaldar A, Shen YM, Matevosyan K, Burke C, Frenkel E, Sarode R. Efficacy of Whole Blood
Impedance Aggregometry (WBIA) in Identifying Platelet Abnormalities Relevance in Bleeding
Patients. XXII Congress of the International Society on Thrombosis and Haemostasis. July 11-16,
2009 (poster presentation).
14. Patel PA, Burke C, Matevosyan K, Frenkel EP, Sarode, R and Shen YM. Low Risk 4T Score Can Rule
out Heparin-Induced Thrombocytopenia. 2009 ASH Annual Meeting Abstracts. Blood,
2009;114(22):542, abstract #1328.
15. Ziari M, Burke C, Matevosyan K, Frenkel EP, Sarode, R and Shen YM. Optical Density of 1.0 is a Better
Cutoff for Positive HIT Ab ELISA. 2009 ASH Annual Meeting Abstracts. Blood, 2009;114(22):1363,
abstract #3515.
16. Navarro A , Matevosyan K, Cleveland DS, Sarode R. Cryoprecipitate vs plasma in the management of
dilutional hypofibrinogenemia in patients undergoing therapeutic plasma exchange. J Clin Apher,
2010; 25:7.
17. Shah N, Yamani F, Matevosyan K, Rutherford C, Shen Y-M, Neunert C, Sarode R. ADAMTS13
Distinguishes Thrombotic Thrombocytopenic Purpura (TTP) from Other Forms of Thrombotic
Microangiopathies. J Clin Apher, 2011; 26(2):66.
18. De Simone N, Malbrough R, Filiberto D, Inocando J, Burner J, Matevosyan K, Sarode R. Routine
Prophylactic Intravenous Calcium Supplementation to Prevent Citrate Reactions During Plasma
Exchange is not Indicated. J Clin Apher, 2011; 26(2):67.
19. Shah N, Matevosyan K, Burner J, Sarode R. TherakosTM New Extracorporeal Photopheresis System,
CELLEXTM, Offers Superior Lymphomononuclear Cell Collection in Addition to Shorter Treatment
Times and Lower Extracorporeal volumes over the Old Standard, UVAR-XTSTM. J Clin apher, 2012;
27:2.
20. De Simone N, Matevosyan K, Greenberg B, Sarode R. The Role of Plasma Exchange in the
Management of Neuromyelitis Optica. J Clin apher, 2012; 27:20.
21. Debra Smith, Amit Pandya, Karen Matevosyan, Nicole De Simone, Matt Strunk, Ravi Sarode. Clinical
outcomes in cutaneous T-cell lymphoma patients treated with extracorporeal photopheresis. J Clin
Apher. 2013; vol 28(2).
22. Jasvir Rai, Zoe Morelli, Matthew Strunk, Dorothy Filiberto, Shannan Tujios, Ravi Sarode, Karen
Matevosyan.Therapeutic plasma exchange in the treatment of severe pruritus in advanced chronic
hepatitis C: case report. J Clin Apher. 2013; vol 28(2).
23. Zoe M. Morelli, Lisa Dalton, Matthew Strunk, Karen Matevosyan, Ravi Sarode. Role of maintenance
plasma exchange in stiff person syndrome - a case report. J Clin Apher. 2013; vol 28(2).
24. Nikki Cole, Zoe M. Morelli, Laura B. Cash, Giovanni Torti, Rebecca Dill, Nellie Sessions, Betty Doggett,
Lisa Dalton, Matthew Strunk, Debra Smith, Karen Matevosyan, and Ravi Sarode. Comparison of
Fenwal Amicus and Terumo BCT Optia Cell Separators For Therapeutic Plasma Exchanges. J Clin
Apher. 2014; vol 29(1).
25. Zoe M. Morelli, Nikki A. Cole, Laura Cash, Rebecca Dill, Lisa Dalton, Jennifer Wintz, Matthew Strunk,
Karen Matevosyan, and Ravi Sarode. Decreasing Central Venous Catheter Utilization in Apheresis
with Bard Siterite Prevue Ultrasound System and Bard Powerglide Midline. J Clin Apher. 2014; vol
29(1).
26. Theresa N. Kinard, Zoe Morelli, Karen Matevosyan, and Ravi Sarode. Red Blood Cell Exchange
Prevents Fulminant Liver Failure from Acute Severe Sickle Cell Hepatopathy: Case Series. J Clin
Apher. 2014; vol 29(1).

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27. Nicole De Simone, Karen Matevosyan, and Ravi Sarode. Confirmed Severe ADAMTS-13 Deficiency in
a Patient with TTP Presenting with Severe Hyperbilirubinemia: A Case Report. J Clin Apher. 2014; vol
29(1).
28. Sean G. Yates , Karen Matevosyan, Cynthia Rutherford, Yu-Min Shen, and Ravi Sarode. Bortezomib
for Chronic Recurring Thrombotic Thrombocytopenic Purpura: A Case Report. J Clin Apher. 2014; vol
29(1).
29. Zoe M. Morelli, Theresa Kinard, Nikki Alexandria Cole, Laura Cash, Matthew Strunk, Sean Yates, Ravi
Sarode, and Karen Matevosyan. Fulminant Erythropoietic Peripheral Neuropathy Managed with
Frequent Red Blood Cell Exchange and Therapeutic Plasma Exchange: A Case Report. J Clin Apher.
2014; vol 29(1).
30. Jaehyup Kim, Theresa Kinard, James Burner, Ravi Sarode, and Karen Matevosyan. Use of
Therapeutic Plasma Exchange for Autoimmune Epilepsy. J Clin Apher. 2014; vol 29(1).
31. Alecia C. Nero, Theresa Nguyen Kinard, Beverley Adams-Huet, Karen Matevosyan, Ravindra Sarode.
Determinants of Inter-Procedure Interval in Patients with Sickle Cell Anemia Enrolled a Chronic Red
Blood Cell Exchange Program. Blood 2014 124:4284; published ahead of print December 5, 2014.
32. Jaehyup Kim, Ranjit Joseph, Jeniffer Peterson, Martin Macias, Marisela Ulloa, Mazen El Sharif, Rebecca
Jones, Ravi Sarode, and Karen Matevosyan,. J Clin Apher. 2015; vol 30(61-133).
33. Jennifer Peterson, Michael J Dalton, Natan Pheil, Brian Gaddy, Karen Matevosyan, and Ravi Sarode.
In Vitro Evaluation Of An Implantable Apheresis Port For Clinical Use. J Clin Apher. 2015; vol 30(61-
133).
34. Rati Chkheidze, Ranjit Joseph, Sean Yates, Nicole De Simone, James Dean Burner, Ravi Sarode, and
Karen Matevosyan. Plasma Exchange – Effective Treatment Option For Patients With Intractable
Pruritus Of Cholestatic Liver Disease: Case Reports. J Clin Apher. 2015; vol 30(61-133).
35. Jennifer Wintz, Rebecca Dill, Jennifer Peterson, Matthew Strunk, Karen Matevosyan, and Ravi
Sarode. A Retrospective Study On Decreasing Central Line Venous Catheter Utilization In Apheresis. J
Clin Apher. 2015; vol 30(61-133).
36. De Simone N, Matevosyan K, Yates S, Reddy M, Gavva C, Zia A Shen Y, Sarode, R. The Role of Whole
Blood Platelet Aggregation Studies in the Diagnosis of Unexplained Bleeding Tendencies. Blood. 2015;
126(23).