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Anti vegf in atypical indications (2)
- 1. jmones@institutmacularetina.com Anti VEGF Therapy in Atypical Indications Jordi Monés Institut de la Màcula i de la Retina CM Teknon, Barcelona
- 2. jmones@institutmacularetina.com Anti VEGF therapyeffective in exudative AMD
- 3. jmones@institutmacularetina.com Anti VEGF therapyeffective in CNV secondarytopathologic MYOPIA
- 4. Anti VEGF therapy in atypicalindications? Angioidstreaks Idiopathic CNV Inflammatoryconditions Heritaryretinaldiseases: Patterndystrophies, Best Opticnervedrusen Central serouscoriorretinopathy Choroidalrupture jmones@institutmacularetina.com
- 5. Angioidstreaks 72-86% patientsdevelop CNV, 50% bilateral PDT poorresults, 50% patients < 20/200 Heimann H, Gelisken F, Wachtlin J, Wehner A, Völker M, Foerster MH et al. Photodynamictherapywithverteporfinforchoroidalneovascularizationassociatedwithangioidstreaks. GraefesArchClinExpOphthalmol 2005; jmones@institutmacularetina.com
- 8. CML, female 74 angioidstreaks CML female 74 AngioidStreaks, RE scar 20/200 LE PDT + macugen 1y avastin 2y before 20/20
- 9. CML, female 74 angioidstreaks 20/20 20/20 20/20 20/20 May 07 June 07 May 08 Jan 07
- 10. CML, female 74 angioidstreaks 20/20 20/20 20/20 20/20 Mar 09 Apr 09 Jun 09 Aug 09
- 11. IG male 50y RE 20/640 LE 20/20 withrecent metamorphopsia
- 12. 20/20 20/20 20/20 20/25 Sep 07 Oct 07 Dec 07 Dec 08
- 13. 20/25 20/20 20/20 20/20 02/09 03/09 06/09 09/09
- 14. Inflammatoryconditions CNV frequentcomplication 2ry to post uveitisoruveiticscars B Gupta. Intravitrealbevacizumabfor CNV 2ry toother causes than AMD. Eye 2009 110 patients Naivepatientsbetteroutcome PRN regimen are fine No inflammationrelatedtothedrug jmones@institutmacularetina.com
- 17. FSB Male 56 Tuberculosis whenyoung RE 20/100 LE 20/32
- 18. 20/32 20/25 20/25+ 20/20 Jul 08 Aug 08 Sep 08 Oct 08
- 19. 20/20 20/20 20/20 20/20 Dec 08 Feb 09 Mar 09 Oct 09
- 21. Idiopathic CNV PDT wasusefulto “stabilize” VA Pooled data B Gupta. Intravitrealbevacizumabfor CNV 2ry toother causes than AMD. Eye 2009 52 eyes, improvement 0,8 logMARto 0,33 Mean #injections 1,55 jmones@institutmacularetina.com
- 22. EPE Female 36 y 20/15 20/200
- 23. EPE Female 36 y 2 yearslater 20/64 20/200
- 24. 20/64 20/20 20/100 20/20 May 09 Jun 09 Jul 09 Aug 09
- 25. 20/32 20/17 20/15 Sep 09 Oct 09 Nov 09
- 26. SFB Female 17y -5 myopia RE 20/20 LE 20/32
- 27. Mujer 17 años -5d, 20/32 M 2,5 20/20 M 1 20/25 M 4 20/50 M 5 20/40 M 8 20/20 20/ 32
- 28. Oct 08 Jan 09 Apr 09 Sep 09
- 29. Anti VEGF therapy in atypicalindications? Angioidstreaks Idiopathic CNV Inflammatoryconditions Heritaryretinaldiseases: Patterndystrophies, Best Opticnervedrusen Central serouscoriorretinopathy Choroidalrupture jmones@institutmacularetina.com
- 30. AGG Male 13y RE 20/63 LE 20/20
- 31. AGG Male 13y CNV 2ry BEST DISEASE 20/63 20/20 20/20 20/20-2 Apr 09 May 09 Aug 09 Oct 09
- 32. Anti VEGF therapy in atypicalindications? Angioidstreaks Idiopathic CNV Inflammatoryconditions Heritaryretinaldiseases: Patterndystrophies, Best Opticnervedrusen Central serouscoriorretinopathy Choroidalrupture jmones@institutmacularetina.com
- 33. AFD Female 45y RE 20/125
- 34. AFD 45y female CNV 2ry OPTIC NERVE DRUSEN 20/125 20/20
- 35. Summary CNV secondary to other causes has numerous subtypes and can not be studied in randomized trials. However, the trend is that ALL respond to bevacizumab/ranibizumab, although agressivity and duration of the effect may vary among the different etiologies Angioid streaks has evolved in a manageable disease, although long term recurrences are frequent, and idiopathic CNV may have very aggressive recurrences PRN seems to be fine for most situations, but perhaps not in idiopathic CNV jmones@institutmacularetina.com