Præsentationen blev holdt ved InfinIT-konferencen SummIT 2013, der blev afholdt den 22. maj 2013 på Axelborg i København. Læs mere om konferencen her: http://www.infinit.dk/dk/arrangementer/tidligere_arrangementer/summit_2013.htm

1. www.nanotech.dtu.dk/nabis
Point-of-Care devices
Winnie E. Svendsen
DTU Nanotech

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Point of Care - Health
http://www.continuaalliance.
org/about-the-alliance

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Point of Care – Health
http://health.rush.edu/HealthInformation/Care%20Guides/28/000278.aspx

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Point of Care Technology
Ref: Center for Bio photonics Science and technology University of California

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Point of Care – Enviroment
Vandforurening i Kalundborg
Børnehave ramt af vandforurening på tredje uge
Udgivet den 02.01.2013 21:18
Advarsel: Drik ikke vandet i KBH
Fredag d. 19. aug. 2011 kl. 17:11
2013
2012
2011
Stadig forbud mod brug af vand i centrum af Kalundborg
Udgivet den 20.12.2012 21:09 af TV2 ØST's Redaktion

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Point of Care – Enviroment
The Law : Lab test
• 30 test per year
• 72 hours response time

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Nano Bio Integrated Systems (NaBIS )
2012
Micro and Nano
Sensor Platforms
Microfluidic Sample handling
and manipulation
Bio – Medical
Applications
Our vision is to incorporate our research in point of care
(POC) technology for diagnostic and monitoring.
This is achieved by application-driven research, adapting
and refining methodologies to micro- and nanotechnology
within bio-medical fields

8. www.nanotech.dtu.dk/nabis
Nano Bio Integrated Systems (NaBIS )
Micro and Nano
Sensor Platforms
Bio – Medical
Applications
Microfluidic Sample
handling and manipulation

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Point of Care – Sensors
Micro and Nano
Sensor Platforms
Bio – Medical
Applications
Microfluidic Sample
handling and manipulation

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Point of Care – Sensors

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Nano Bio sensors - Health
Biomedical engineering for cancer
and brain disease diagnosis and
therapy development
A screenning system for The
plasmacytosis virus in Mink
http://www.engcabra.eu

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64 chips
4 SiNW on one chip
The Silicon Nano Wires Sensor
300 nm
SiNW
h= 50 nm
l = 200 µm
w= 50 µm

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SiNW
h= 50 nm
l = 200 µm
w= 50 µm
Azeem Zulfigar

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Semiconducting Nanowire Sensor
+
+
Acceptors
Holes (mobile)
=> Get a chage in conductance (DG/G)
++
+ +
+
- - -
Receptors binding a target molecule (negative)
Know and can control charge carriers in the wire

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Silicon Nanowire Biosensor
Nanowire
Add a functional layer
Multiple functional layers

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Silicon Nanowire Biosensor

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SiNW sensor for Aleutian Disease Virus (ADV)
Integration of Silicon Nanowires in Microfluidic Devices

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SiNW sensor for Aleutian Disease Virus (ADV)
Aleutian Disease or Mink Plasmacytosis is a highly contagious
parvovirus affecting the animals, causing spontaneous
abortion and death in minks and ferrets.
ADV smallest virus existing d~7 nm
Task : Screen blood samples for antibodies

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Immobilization of whole virus
Goal : Attach the dead virus on the surface
Detect antibodies in the animal sample
APTES

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Test Functionalisation Scheme
Immobilization results
12 hours without
light
3 hours with P
H3CBF4
Conclusion:
1.High selectivity
2.High Yield
3.The catalysts worked as
planned
12 hours
with light

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Screening for ADV virus in Minks sample
Lars Andresen
KU Sund 2010

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Michael Jørgensen Msc
Martin H. Sørensen MSc
Integration of Silicon Nanowires in Microfluidic Devices

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Fully automated system

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POCT Screening of Cancer
Biomedical engineering for cancer
and brain disease diagnosis and
therapy development
CA9 NKG2D ligands

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Functionalisation Scheme
APTES
Andrea
DTU
Lars
KU Sund

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Mouse Antibody – Goat Antibody interaction

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Sample Handling
Andrea Pfreundt
DTU Nanotech

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System Engineering/ Embedded Systems
Jan Madsen
DTU Compute
Francois Patou
DTU NTCH

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Acnowledgements
People NaBIS
Funds
Collaborators
DTU Nanotecth Mads Brandbyge
Kristian Mølhave
KU-life Søren Schou
Lars Andresen
Franziska , Phd student
DTU Farma Åse Uttenthal
DPA Leif Bruun
Rebekka Dam-Tuxen, Phd Stud.
iSAS – Slovakia Prof. Silvia Patrokova
DTU Compute Prof. Jan Madsen