Boletín nanomedicina Enero Febrero 2011

Enero-Febrero 2011

Boletín
Nanomedicina

generado por VIGIALE, IALE Tecnología.

HIDDEN TEXT TO MARK THE BEGINNING OF THE TABLE OF CONTENTS

INDICE
NOTICIAS
1. Bhasmas are nano-medicine of ancient times' 2
2. Researchers Bring Plasmonic Nanofields Into Focus 2
3. Consiguen liberar ADN directamente en el núcleo celular mediante nanodiscos de proteínas 2
4. Nanosponges Harvest Rare Cancer Marker from Blood 3
5. Bold Medicine, Golden Innovation 3
6. Three Biotech IPOs Ahead This Week: AcelRx Pharma, Endocyte, Pacira Pharma 3
7. 'Cornell Dots' that light up cancer cells go into clinical trials 4
8. Diagnostic chip may help hearts, cut costs 4
9. Plankton inspires creation of stealth armor for slow-release microscopic drug vehicles 4
10. The Welch Foundation Honors 'Rising Star' For Stellar Work On Nanoparticles, Cell Membranes 5

11. Novel Cancer-Targeting Investigational Nanoparticle Receives FDA IND Approval For First-In-Huma... 5

12. Early tests find nanoshell therapy effective against brain cancer 5
13. Detecting Lethal Diseases With Rust and Sand 6
14. Physicists scale up invisibility cloaks using natural crystals 6
15. Crece en EEUU el mercado de productos médicos basados en nanotecnología 6
16. UB and Nigeria Partner to Further Nanomedicine Research 7
17. Nanobiotix and the ETPN launch the first Nanomedicine TV 7
18. Scientists Work on New System to Capture Ovarian Cancer Cells Using Magnetic Nanoparticles 7

19. Armor for nano drug release vehicles inspired by plankton 8
20. New nanoparticles make blood clots visible 8
21. UABs new 3-D nanoscaffold could revolutionize human tissue engineering. 8
22. DNA Backbone Assists Nanocrystal Formation 9
23. Scientists Model Tiny Rotors, Key to Future Nanomachines. 9
24. Early tests find nanoshell therapy effective against brain cancer 9

PATENTES
25. Patentes publicadas este mes 10
26. Origen de los principales actores del mes 10
27. Principales entidades que patentaron este mes 11
28. Principales inventores que patentaron este mes 11
29. Principales temas tratados en las patentes del mes 12
30. US20110014124A1 Targeted Atherosclerosis treatment 12
31. US20110021894A1: Glucose sensor employing semiconductor nanoelectronic device 13
32. US20110014131A1: Nanomolding micron and nano scale features 13

INDICE
33. US20110014118A1: Nanotherapeutic colloidal metal compositions and methods 13
34. US20110020243A1: Methods and compositions for imaging cancer cells 14
35. US20110020788A1: NMR device for detection of analytes 14
36. US20110020434A1: Nanoparticle arsenic-platinum compositions 15
37. US20110014264A1: Medical devices having nanostructured regions for controlled tissue biocompati... 15

38. US7871990 Nanoparticles for protein drug delivery 15
39. US7871591 Methods for growing long carbon single-walled nanotubes 16
40. WO2007070572 Probe for nucleic acid sequencing and methods of use. 16
41. CN11317840A: Nano-composition, preparing method and application thereof 17
42. WO2010151173A1: Nano-dispersed composition containing COenzima Q10 and method for producing 17
sam...
43. CZ20090496A3: Process for producing nanofiber-based nanopellets 17

EVENTOS, CURSOS Y
SEMINARIOS
44. 4th European Conference for Clinical Nanomedicine 2011 (CLINAM 2011) 18
45. Conference Innovation in Healthcare: from Research to Market 18
46. 2nd Australian & New Zealand Micro and Nanofluidics Symposium. 18
47. Tercer Encuentro sobre Nanociencia y Nanotecnología (NANOUCO III) 19
48. Nanobiomedica Conference 19
49. Nanotech 2011 Exxhibition & Conference 20
50. First Annual Nanodermatology Society Meeting 20
51. ImagineNano Conference 20
52. 3rd NanoImpactNet Conference 21
53. Nanomedicine Commercialization Workshop 21
54. Jornadas: Clinical Applications of Nanotechnologies in the Field of Cancer 21
55. Jornada "Nanomedicina en España: Presente y Futuro" 22

ARTÍCULOS-
CIENTÍFICOS
56. Principales investigadores que publicaron este mes 22
57. Principales entidades con publicaciones este mes 23
58. Principales temas tratados en los artículos científicos del mes 23
59. Three-dimensional atomic imaging of crystalline nanoparticles 24
60. Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparti... 24

61. Hard-tip, soft-spring lithography 24
62. Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet 25

INDICE
Transpla...
63. Enhanced Lysozyme Imprinting Over Nanoparticles Functionalized with Carboxyl Groups for 25
Noncova...
64. Bioengineering Single Crystal Growth. 26
65. Unfolding and translocation pathway of substrate protein controlled by structure in repetitive ... 26

66. Modulation of biological processes in the nucleus by delivery of DNA oligonucleotides conjugate... 27

67. Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes 27

68. Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanopar... 28

69. In situ green synthesis of biocompatible ginseng capped gold nanoparticles with remarkable stab... 28

70. Enhancement of cell recognition in vitro by dual-ligand cancer targeting gold nanoparticles 28
71. Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro eva... 29

72. Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated 29

73. Liposomal architecture boosts biocompatibility of nanohybrid cerasomes 30
74. Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model 30

75. A living cell quartz crystal microbalance biosensor for continuous monitoring of cytotoxic res... 30

76. Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanopar... 31

77. Carbosilane dendrimers NN8 and NN16 form a stable complex with siGAG1 31

REPORTES
78. Nanomedicina en España 06-10 31
79. Podcast: The Implications for Health, Safety and the Environment of the Nanotech Revolution 32
80. Action Plan Nanotechnology 2015 32
81. HTSM vision document: High Tech Systems and Material 32
82. 2010 Nanotechnology Research Review 33
83. Nanotechnology Market Forecast to 2013 33
84. Nanotechnologies in the 21st century 33
85. Nanotechnology Research Directions for Societal Needs in 2020. Retrospective and Outlook 34

NORMATIVAS
86. AENOR - Normativas de Nanotecnología 34

Nanomedicina
NOTICIAS
Bhasmas are nano-medicine of ancient times'
Publicada el 02/04/2011.

While the concept of reduction in particle size of metals is prevailing since Charak Samhita, the oldest classical text in
ayurveda, the recent studies at the department of Rasa Shashtra, Faculty of Ayurveda, Banaras Hindu University,
has claimed the herbo-mineral formulations of ayurveda constituting 'bhasma' to be equivalent and in tune with
nanotechnology witnessing production of nanoparticles in contemporary era.

ver más...

Researchers Bring Plasmonic Nanofields Into Focus
Publicada en Institute of Nanotechnology News, 02/04/2011.

In typical plasmonic devices, electromagnetic waves crowd into tiny metal structures, concentrating energy into
nanoscale dimensions. Due to coupling of electronics and photonics in these metal nanostructures, plasmonic
devices could be harnessed for high-speed data transmission or ultrafast detector arrays.

ver más...

Consiguen liberar ADN directamente en el núcleo celular
mediante nanodiscos de proteínas

Investigadores de la Universitat Autónoma de Barcelona han conseguido encapsular material genético y liberarlo
directamente dentro del núcleo de las células, para llevar a cabo terapia génica, mediante partículas con forma de
disco del tamaño de sólo unos nanómetros. Los nanodiscos, tal y como los han bautizado los investigadores,
atraviesan rápidamente el interior de la célula y se concentran en el núcleo, de forma que incrementarían la
eficiencia del proceso de transferencia genética.

ver más...

Enero-Febrero 2011 Página 2

Nanomedicina
Nanosponges Harvest Rare Cancer Marker from Blood

An international research team from the United States and Italy has shown that it can use a new type of nanoparticle
to selectively trap specific families of proteins from blood and protect them from degradation by enzymes in blood.

ver más...

Bold Medicine, Golden Innovation

The gold-coated liposomes being developed at the UA could offer a new way to target delivery of drugs to cancerous
regions of the body, non-invasively trigger the drugs release using infrared light, and provide a way for the body to
naturally eliminate the toxic byproducts.

ver más...

Three Biotech IPOs Ahead This Week: AcelRx Pharma,
Endocyte, Pacira Pharma

AcelRx Pharma's - developing ARX-01, the Sufentanil NanoTab PCA System, for the management of acute post-
operative pain in adult patients during hospitalization
Endocyte's - Biopharma developing targeted therapies for the treatment of cancer and inflammatory diseases.
Pacira Pharma's - Has filed a New Drug Application, or NDA, for the lead product candidate, EXPAREL, a long-acting
bupivacaine (anesthetic/analgesic) product for postsurgical pain management.

ver más...


Nanomedicina
'Cornell Dots' that light up cancer cells go into clinical trials


"Cornell Dots" brightly glowing nanoparticles may soon be used to light up cancer cells to aid in diagnosing and
treating cancer. The U.S. Food and Drug Administration (FDA) has approved the first clinical trial in humans of the
new technology. It is the first time the FDA has approved using an inorganic material in the same fashion as a drug in
humans.

ver más...

Diagnostic chip may help hearts, cut costs

During National Heart Health Month, Rice Professor John McDevitt will discuss the potential of this technology to
detect cardiac disease early at the annual meeting of the American Association for the Advancement of Science
(AAAS) in Washington, D.C., Feb. 17-21. Cardiac disease is the focus of one of six ongoing major clinical trials of
Rice's programmable bio-nano-chips (PBNCs).

ver más...

Plankton inspires creation of stealth armor for slow-release
microscopic drug vehicles

The ability of some forms of plankton and bacteria to build an extra natural layer of nanoparticle-like armour has
inspired chemists at the University of Warwick to devise a startlingly simple way to give drug bearing polymer vesicles
(microscopic polymer based sacs of liquid) their own armoured protection.

ver más...


Nanomedicina
The Welch Foundation Honors 'Rising Star' For Stellar Work
On Nanoparticles, Cell Membranes

The Welch Foundation has awarded its prestigious Hackerman Award to Rice University scientist Jason Hafner '96,
who was named this year's "rising star" for his innovative chemical research. Hafner's discoveries include a new type
of nanostructure called gold nanostars, which are proving useful for sensing, imaging and medicine, and the first
method for measuring large electrical fields inside cell membranes.

ver más...

Novel Cancer-Targeting Investigational Nanoparticle
Receives FDA IND Approval For First-In-Human Trial

Researchers at Memorial Sloan-Kettering Cancer Center's Nanotechnology Center, along with collaborators at
Cornell University and Hybrid Silica Technologies, have received approval for their first Investigational New Drug
Application (IND) from the US Food and Drug Administration (FDA) for an ultrasmall silica inorganic nanoparticle
platform for targeted molecular imaging of cancer, which may be useful for cancer treatment in the future.

ver más...

Early tests find nanoshell therapy effective against brain
cancer

Rice University bioengineers and physician-scientists at Baylor College of Medicine and Texas Children's Hospital
have successfully destroyed tumors of human brain cancer cells in the first animal tests of a minimally invasive
treatment that zaps glioma tumors with heat. The tests involved nanoshells, light-activated nanoparticles that are
designed to destroy tumors with heat and avoid the unwanted side effects of drug and radiation therapies.

ver más...


Nanomedicina
Detecting Lethal Diseases With Rust and Sand

The next big thing in medical diagnostics could be minutes particles of rust, iron oxide, coated with the material from
which sand is formed, silicon dioxide. These magnetic nanoparticles, a mere 29 to 230 nanometers across, can be
used to trap antibodies to the virus that causes cervical cancer and to the bacteria that causes potentially lethal
diarrhea.

ver más...

Physicists scale up invisibility cloaks using natural crystals

Physicists from the University of Birmingham, with colleagues at Imperial College, London, and Technical University
of Denmark, have demonstrated an 'invisibility cloak' that can hide a three-dimensional object, centimetres in
dimension, large enough for the cloaking area to be visible to the human eye, according to research published today
in the journal Nature Communications.

ver más...

Crece en EEUU el mercado de productos médicos basados
en nanotecnología

El mercado de nanomedicinas experimentará un fuerte crecimiento a largo plazo, alcanzando los 59.000 millones de
dólares (43.840 millones de euros) en 2014 y hasta 118.000 millones (87.700 millones de euros) para el ejercicio de
2019, debido a la necesidad de terapias nuevas o mejoradas para muchas enfermedades. Las terapias contra el
cáncer avanzado, enfermedades autoinmunes, trastornos neurológicos e infecciones virales darán lugar a la
introducción de nuevos productos y presentarán las mayores oportunidades de crecimiento.

ver más...


Nanomedicina
UB and Nigeria Partner to Further Nanomedicine Research

The Institute for Lasers, Photonics, and Biophotonics (ILPB) at the University at Buffalo signed a Memorandum of
Understanding (MOU) with the National Universities Commission (NUC) of Abuja, Nigeria. The MOU called for the
development of an international joint research center for nanomedicine at Nigerian universities.

ver más...

Nanobiotix and the ETPN launch the first Nanomedicine TV

Nanomed TV www.dailymotion.com/nanomedTV foresees to become the main hub for Nanomedicine thanks to its
initiators, two major European players in nanomedicine: the European Technology Platform on Nanomedicine (ETPN)
and Nanobiotix. Nanomed TV will make information accessible, aiming at answering what people need and wish to
know about Nanomedicine.

ver más...

Scientists Work on New System to Capture Ovarian Cancer
Cells Using Magnetic Nanoparticles

A paper published in the January issue of the journal Nanomedicine could provide the foundation for a new ovarian
cancer treatment option -- one that would use an outside-the-body filtration device to remove a large portion of the
free-floating cancer cells that often create secondary tumors.

ver más...


Nanomedicina
Armor for nano drug release vehicles inspired by plankton

One of the promising areas in the field of nanomedicine is the development of vesicles microscopic polymer sacs,
designed to deliver a payload of medication to specific sites in the body. Unfortunately, the bodys immune system
often sees these vesicles as intruders, sending antibodies to thwart them in their mission. Now, drawing inspiration
from plankton and bacteria, chemists from the University of Warwick are developing armor coatings that should help
vesicles to withstand or avoid those attacks.

ver más...

New nanoparticles make blood clots visible
Publicada en Nanotechweb.org News, 02/02/2011.

For almost two decades, cardiologists have searched for ways to see dangerous blood clots before they cause heart
attacks. Now, researchers at Washington University School of Medicine in St. Louis report that they have designed
nanoparticles that find clots and make them visible to a new kind of X-ray technology.

ver más...

UABs new 3-D nanoscaffold could revolutionize human
tissue engineering.
Publicada en Nanotechwire.com - Bio/Medicine, 02/02/2011.

Researchers from the University of Alabama at Birmingham's School of Engineering have created a three-
dimensional electrospun scaffold on the nano scale that more effectively and efficiently facilitates cell and tissue
growth in the laboratory.

ver más...


Nanomedicina
DNA Backbone Assists Nanocrystal Formation
Publicada en Nanotechnology Now, 02/02/2011.

Recently, researchers from University of Rochester Medical Center, Scripps Research Institute, and Massachusetts
Institute of Technology published a paper in Nature Materials describing the first time a lattice was made using a
combination of nano-sized metal particles (gold in this case) and organic materials (viral particles). The gold and viral
phage capsid particles repel each other, but by stragetically placing them on DNA strands that attract one another, a
rigid crystal structure can be created, with potential uses in optical computing and telecommunications.

ver más...

Scientists Model Tiny Rotors, Key to Future Nanomachines.
Publicada en Nanomedicine Research - News, 02/02/2011.

Kolomeisky and Rice graduate student Alexey Akimov have taken a large step toward defining the behavior of these
molecular whirligigs with a new paper in the American Chemical Society's Journal of Physical Chemistry C. Through
molecular dynamics simulations, they defined the ground rules for the rotor motion of molecules attached to a gold
surface.

ver más...

Early tests find nanoshell therapy effective against brain
cancer
Publicada en Nanotechweb.org News, 02/01/2011.

Rice University bioengineers and physician-scientists at Baylor College of Medicine and Texas Children's Hospital
have successfully destroyed tumors of human brain cancer cells in the first animal tests of a minimally invasive
treatment that zaps glioma tumors with heat. The tests involved nanoshells, light-activated nanoparticles that are
designed to destroy tumors with heat and avoid the unwanted side effects of drug and radiation therapies.

ver más...


Nanomedicina
PATENTES
Patentes publicadas este mes

Fuente: Espacenet, USPTO, OMPI, JPO, DEPATISnet, INPADOC

Origen de los principales actores del mes

Fuente: Espacenet, UPSTO


Nanomedicina
Principales entidades que patentaron este mes

Fuente: Espacenet, UPSTO

Principales inventores que patentaron este mes

Fuente: Espacent, UPSTO


Nanomedicina
Principales temas tratados en las patentes del mes

Fuente: Espacenet, USPTO

US20110014124A1 Targeted Atherosclerosis treatment

Inventores: Lanza, Gregory M.; Wickline, Samuel A
Titulares: Lanza, Gregory M.; Wickline, Samuel A
Resumen: This invention relates generally to methods for ameliorating at least one symptom or aspect of
atherosclerosis. A method for inhibiting atherosclerotic plaques in a subject which method comprises administering to
a subject diagnosed with atherosclerosis, a composition comprising a nanoparticulate carrier contained in an
emulsion and an v3 targeting ligand and an anti-angiogenic agent, wherein the targeting ligand and anti-angiogenic
agent are coupled through colocalization in said nanoparticles.

ver más...


Nanomedicina
US20110021894A1: Glucose sensor employing
semiconductor nanoelectronic device

Inventores: Mohanty, Pritiraj; Erramilli, Shyamsunder; Wang, Xihua; Chen, Yu;
Titular: Trustees of Boston University (EE.UU.)
Resumen: A glucose sensor employs a programmable glucose sensor array of a relatively large number of
nanoelectronic devices (e.g. semiconductor field-effect devices) having control surfaces functionalized with a
glucose-reactive substance and generating sensing signals indicative of sensed glucose level of a bodily fluid. The
devices are divided into sub-sets sequentially enabled over successive intervals to achieve overall sensor lifetime
many times longer than the lifetime of any single device in operation.

ver más...

US20110014131A1: Nanomolding micron and nano scale
features

Inventores: Disawal, Sandeep; Rosner, Bjoem; Janosky, Robert J.;
Titular: NanoInk, Inc (EE.UU.)
Resumen: Small scale and nanoscopic identification features can be fabricated for pharmaceutical capsules. A
composition comprising a capsule component, wherein the capsule component comprises a gelled pharmaceutical
capsule material and at least one surface, wherein the at least one surface comprises at least one integral feature
with a lateral dimension smaller than about 100 microns, or less than one micron. Methods of making the same are
described by gelation with heating or cooling. The compositions and methods can be used for anti-counterfeiting.

ver más...

US20110014118A1: Nanotherapeutic colloidal metal
compositions and methods

Inventores: Tamarkin, Lawrence; Pacciotti, Giulio F.; Huhta, Marja S.
Titulares: Tamarkin, Lawrence; Pacciotti, Giulio F.; Huhta, Marja S. (EE.UU.)
Resumen: The present invention comprises compositions and methods for delivery systems of agents, including
therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological
factors. In general, the nanotherapeutic compositions of the present invention comprise a platform comprising a
colloidal metal, a targeting ligand such a tumor necrosis factor, a stealth agent such as polyethylene glycol, and one
or more diagnostic or therapeutic agents for delivery. The invention also comprises methods and compositions for
making such nanotherapeutic compositions and for the


Nanomedicina
treatment of cancer.

ver más...

US20110020243A1: Methods and compositions for imaging
cancer cells

Inventor: Aydogan, Bulent
Titular: Aydogan, Bulent
Resumen: Disclosed are compositions comprising nanoparticles and uses thereof. Such nanoparticles include gold
nanoparticles conjugated to glucose or a glucose derivative, which are useful as contrast agents in imaging methods
such as computed tomography (CT). Nanoparticles disclosed herein are useful in imaging various cells, tissues, and
organs, and are particularly useful in imaging tumors and tumor cells in vitro and in vivo.

ver más...

US20110020788A1: NMR device for detection of analytes

Inventor: Lee, W. David
Titular: T2 Biosystems, Inc (EE.UU.)
Resumen: This invention relates generally to detection devices having one or more small wells each surrounded by,
or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-
assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid
sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the
device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a
patient.

ver más...


Nanomedicina
US20110020434A1: Nanoparticle arsenic-platinum
compositions

Inventores: O'Halloran, Thomas V.; Chen, Haimei; Mazar, Andrew
Titulares: O'Halloran, Thomas V.; Chen, Haimei; Mazar, Andrew (EE.UU.)
Resumen: The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and
methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and
platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer.

ver más...

US20110014264A1: Medical devices having nanostructured
regions for controlled tissue biocompatibility and drug
delivery

Inventores: Helmus, Michael N.; Xu, Yixin; Ranade, Shrirang V.;
Titulares: Boston Scientific Scimed, Inc.
Resumen: According to certain aspects of the invention, implantable or insertable medical devices are provided that
contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of
the invention are directed to implantable or insertable medical devices that contain one or more nanostructured
regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or
insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g.,
glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or
beneath the nanotextured surface regions.

ver más...

US7871990 Nanoparticles for protein drug delivery

Inventores: Sung Hsing-Wen, Liang Hsiang-Fa, Tu Hosheng
Assignee: GP Medical, Inc. (EE.UU.)
Resumen: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one
protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for
paracellular protein drug and bioactive agent delivery.

ver más...


Nanomedicina

US7871591 Methods for growing long carbon single-walled
nanotubes

Inventores: Harutyunyan Avetik, Mora Elena, Tokune Toshio
Titular: Honda Motor Co.,Ltd. (Japón)
Resumen: Methods and processes for synthesizing single-wall carbon nanotubes are provided. A carbon precursor
gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably
nanoparticles having diameters less than about 3 nm. The reaction temperature is selected such that it is near the
eutectic point of the mixture of metal catalyst particles and carbon. Further, the rate at which hydrocarbons are fed
into the reactor is equivalent to the rate of formation of carbon SWNTs for given synthesis temperature. The methods
produce carbon single-walled nanotubes having longer lengths.

ver más...

WO2007070572 Probe for nucleic acid sequencing and
methods of use.
Publicada en Scirus - Patentes sobre Nanomedicina, 02/02/2011.

Inventores: Schneider Thomas D., Lyakhov Ilya G., Needle Danielle
Titular: Department of Health and Human Services (EE.UU.)
Resumen: A nanoprobe for sequencing of nucleic acid molecules is provided, as well as methods for using the
nanoprobe. In particular examples, the probe includes a polymerizing agent and one or more molecular linkers that
carry a chemical moiety capable of reversibly binding to the template strand of a nucleic acid molecule, without being
detached from the linker, by specifically binding with a complementary nucleotide in the target nucleic acid molecule.
The reversible binding of the chemical moiety on the linker with a complementary nucleotide in the target nucleic acid
molecule is indicated by emission of a characteristic signal that indicates pairing of the chemical moiety on the linker
with its complementary nucleotide. An example of such...

ver más...


Nanomedicina
CN11317840A: Nano-composition, preparing method and
application thereof

Inventores: Yawei Zhou
Titular: Yawei Zhou
Resumen: Nanocomposite for preparing medicine for treating hepatitis, comprises silibinin and carrier material wheat
gliadin having predetermined grain size.
URL: no disponible.

ver más...

WO2010151173A1: Nano-dispersed composition containing
COenzima Q10 and method for producing same

Inventores:Pozharitskaya Olga Nikolaevna; Karlina Marina Valerievna; Shikov Alexandr Nikolaevich; Makarov Valeriy
Gennadievich (Rusia)
Titular:Patsiya Merabi Georgievich; Pozharitskaya Olga Nikolaevna; Karlina Marina Valerievna; Shikov Alexandr
Nikolaevich; Makarov Valeriy Gennadievich (Rusia)
Resumen: Coenzyme Q10 nanocomposition useful in the food, pharmaceutical and cosmetic industries comprises
polyethylene glycol and coenzyme Q10

ver más...

CZ20090496A3: Process for producing nanofiber-based
nanopellets

Inventores: Amler EV EN y otros.
Titulares: Student Science, Nanopharma,
Technicka Univerzita y Liberci, Astav EX Mediciny AV CR VVI, Univerzita Karlova V Praze 2 Lakarska Fakulta
(República Checa).
Resumen: No disponible

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Nanomedicina
EVENTOS, CURSOS Y SEMINARIOS
4th European Conference for Clinical Nanomedicine 2011
(CLINAM 2011)

CLINAM 2011 will highlight the joint European way of working together for a future healthcare-based on a cooperative
approach between leading edge technology and science, research, clinical experience, policy, politics, regulations
and industry stakeholders.
Fecha: 23-25 Mayo 2011
Lugar: Basel, Suiza

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Conference Innovation in Healthcare: from Research to
Market

European Commission's DGs Research and Innovation, Enterprise and Industry and Health and Consumers are
jointly organising the Conference Innovation in Healthcare: from Research to Market. The objective of the 2011
conference is to produce an analysis of the strengths, weaknesses, opportunities and threats (SWOT) for innovation
in healthcare and make specific recommendations that will be addressed to policy-makers and stakeholders.
Fecha: 30-31, Marzo 2011
Lugar: Brussels

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2nd Australian & New Zealand Micro and Nanofluidics
Symposium.
Publicada en Nanotechnology Network - Events, 02/02/2011.

This is the only event of its kind in Australia which brings together the multidisciplinary researchers in micro/nano
fluidics. The inaugural event had speakers from Mechanical and Chemical Engineering, Physics, Chemistry and
Biology and we expect this event to be at least that broad, and thus to help foster interdisciplinary collaboration. It will
be held in the newly finished design studio in Mechanical Engineering which is a multifunctional space with excellent
audiovisual facilities. We plan to have one invited speaker, Prof. Steven Wereley from Purdue; one of the founders of
diagnostic microfluidics and the author of the definitive book in the field.
Fecha: 28 - 29 abril, 2011
Lugar: University of New South Wales


Nanomedicina
ver más...

Tercer Encuentro sobre Nanociencia y Nanotecnología
(NANOUCO III)
Publicada en NanoSpain - Eventos, 02/02/2011.

La tercera edición del Encuentro sobre Nanociencia y Nanotecnología (NANOUCO III), que se celebrará en la
Universidad de Córdoba los días 10 y 11 de febrero de 2011, pretende ser un punto de encuentro donde se fomente
el intercambio de ideas y la cooperación entre investigadores y tecnólogos de organismos públicos y empresas de
ámbito andaluz.
Fecha: 10-11 Febrero, 2011
Lugar: Córdoba, España

ver más...

Nanobiomedica Conference
Publicada en NanoConferences.com, 02/02/2011.

A conference focusing on educating and promoting the benefits of nanobiotechnology, the emerging paradigm of
medicine, for the Mexican health industry and showcasing innovative solutions, research and technology.
NanoBioMedica is the only nanobiotech conference in Mexico providing strategic information for education,
infrastructure development and capital investment. Whether operating in the private or public spheres, learn more
about nanobiotechnology and the major role it will play in the decades to come. With a special daylong workshop
provided by the Institute of Nanotechnology and a line-up of keynote speakers and workshops highlighting success
stories and research from around the globe and in Mexico, NanoBioMedica is the perfect platform to learn the latest
nanobiotecnology trends in order to revitalize and capitalize on the strengths of the Mexican private and...

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Nanomedicina
Nanotech 2011 Exxhibition & Conference
Publicada en Fundación Phanton - Events, 02/02/2011.

Again this year, we will be covering the entire nano marketplace and creating a variety of business opportunities at
Tokyo Big Sight by concurrently holding; nano tech 2011.
Fecha: 16-18 Febrero
Lugar: Tokyo, Japón

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First Annual Nanodermatology Society Meeting
Publicada en AzoNanotechnology-Eventos, 02/02/2011.

We have lined up an outstanding faculty of nanotechnology experts to speak on clinically important topics on new and
emerging technologies including:
..Nanodrug delivery for cutaneous infection
..Nanotechnology in cosmecueticals
..Nanodrug delivery for acne/rosacea
..Nanoparticles for the management of cutaneous malignancy
..Nanotechnology and the immune system
..Sunscreens and nanotechnology
..Nanotechnology and the treatment of genetic diseases
..Nanotoxicology
..Intellectual property in nanotechnology
Fecha: 4 Febrero, 2011
Lugar: Hilton New Orleans Riverside, New Orleans

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ImagineNano Conference

ImagineNano will comprise in 15.000 m2, 5 conferences in parallel, a huge exhibition carried out with the latest
nanotrends for the future and a social component where everyone can meet and greet Nanotechnology side by side.
Fecha: 11-14 Abril 2011
Lugar: Bilbao, España

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Nanomedicina
3rd NanoImpactNet Conference

NanoImpactNet is a multidisciplinary European network on the health and environmental impact of nanomaterials.
NanoImpactNet will create a scientific basis to ensure the safe and responsible development of engineered
nanoparticles and nanotechnology-based materials and products, and will support the definition of regulatory
measures and implementation of legislation in Europe.
Fecha: 14 - 17 de Febrero, 2011.
Lugar: Lausanne, Switzerland

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Nanomedicine Commercialization Workshop

The topic of the workshop will be "Actionable Strategies for Company Building & Moving to Market". This workshop is
an add-on to the established North Carolina Nanotechnology Commercialization Conference, which is hosted by the
North Carolina Department of Commerce, in partnership with the Charlotte Research Institute, the Small Business
and Technology Development Center, and COIN.
Fecha: 29 de Marzo, 2011
Lugar: Barnhardt Center, UNC-Charlotte.

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Jornadas: Clinical Applications of Nanotechnologies in the
Field of Cancer

Tres instituciones líderes en el área de aplicación de la nanotecnología para el tratamiento y diagnóstico del cáncer
(Cancéropôle Lyon Auvergne Rhône-Alpes, Cancéropôle Grand Sud-Ouest, y el Instituto de Bioingeniería de
Cataluña / BIOPOL L´H) co-organizan las jornadas Clinical Applications of Nanotechnologies in the Field of Cancer.
Fecha: 28 y 29 de Enero, 2011
Lugar: Montpellier, Francia

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Nanomedicina
Jornada "Nanomedicina en España: Presente y Futuro"

La Plataforma Española de Nanomedicina organiza, la jornada Nanomedicina en España: Presente y Futuro. Dicha
jornada tiene como referente el Roadmap 2020, publicado a finales de 2009 por la European Platform on
Nanomedicine (ETPN), donde se proponían rutas de desarrollo concretas para hacer llegar la Nanomedicina a la
clínica, asegurando el liderazgo europeo en este sector emergente.
Fecha: 01 Febrero 2011
Lucgar: Sede CDTI, C/Cid 4, 28001 Madrid

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ARTÍCULOS-CIENTÍFICOS
Principales investigadores que publicaron este mes

Fuente: Scopus


Nanomedicina
Principales entidades con publicaciones este mes

Fuente: Scopus

Principales temas tratados en los artículos científicos del
mes

Fuente: Scopus


Nanomedicina
Three-dimensional atomic imaging of crystalline
nanoparticles
Publicada en Nanomedicine Research Publicaciones, 02/03/2011.

Autores: Sandra Van Aert, Kees J. Batenburg, Marta D. Rossell, Rolf Erni, Gustaaf Van Tendeloo
Resumen: Here we report the 3D reconstruction of a complex crystalline nanoparticle at atomic resolution. To
achieve this, we combined aberration-corrected scanning transmission electron microscopy, statistical parameter
estimation theory and discrete tomography. Unlike conventional electron tomography, only two images of the targeta
silver nanoparticle embedded in an aluminium matrixare sufficient for the reconstruction when combined with
available knowledge about the particles crystallographic structure. Additional projections confirm the reliability of the
result. The results we present help close the gap between the atomic resolution achievable in two-dimensional
electron micrographs and the coarser resolution that has hitherto been obtained by conventional electron
tomography.

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Synthesis, functionalization and bioimaging applications of
highly fluorescent carbon nanoparticles
Publicada en RSC - Nanoscale latest articles, 02/02/2011.

Autores: Sourov Chandra, Pradip Das, Sourav Bag, Dipranjan Laha, Panchanan Pramanik
Resumen: A novel method for synthesizing fluorescent CNPs and their functionalization for enhancement of their PL
property with minimum cytotoxicity are reported.

ver más...

Hard-tip, soft-spring lithography

Autores: W Shim, AB Braunschweig, X Liao, J Chai, JK Lim, G Zheng, CA Mirkin
Resumen: Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and
consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular
means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a registration
accuracy that exceeds most existing technologies. However, increasing the throughput of cantilever-based scanning
probe systems while maintaining their resolution and registration advantages has from the outset been a significant
challenge. Even with impressive recent advances in cantilever array design, such arrays tend to be highly specialized
for a given application, expensive, and often difficult to implement. It is therefore difficult to imagine commercially...

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Nanomedicina
Combined Small Interfering RNA Therapy and In Vivo
Magnetic Resonance Imaging in Islet Transplantation

Autores: P Wang, MV Yigit, Z Medarova, L Wei, G Dai, C Schuetz, A Moore
Resumen: Recent advances in human islet transplantation are hampered by significant graft loss shortly after
transplantation and inability to follow islet fate directly. Both issues were addressed by utilizing a dual-purpose
therapy/imaging small interfering RNA (siRNA)-nanoparticle probe targeting apoptotic-related gene caspase-3. We
expect that treatment with the probe would result in significantly better survival of transplanted islets, which could be
monitored by in vivo magnetic resonance imaging (MRI). RESEARCH DESIGN AND METHODS We synthesized a
probe consisting of therapeutic (siRNA to human caspase-3) and imaging (magnetic iron oxide nanoparticles, MN)
moieties. In vitro testing of the probe included serum starvation of the islets followed by treatment with the probe.
Caspase-3 gene silencing...

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Enhanced Lysozyme Imprinting Over Nanoparticles
Functionalized with Carboxyl Groups for Noncovalent
Template Sorption.

Autores: G Fu, H He, Z Chai, H Chen, J Kong, Y Wang, Y Jiang
Resumen: Surface molecular imprinting, in particular over nanosized support materials, is very suitable for a template
of bulky structure like protein. Inspired by the surface template immobilization method reported previously, we herein
demonstrate an alternative strategy for enhancing specific recognition of core-shell protein-imprinted nanoparticles
through prefunctionalizing the cores with noncovalent template sorption groups. For proof of this concept, silica
nanoparticles chosen as the core materials were modified consecutively with 3-aminopropyltrimethoxysilane and
maleic anhydride to introduce polymerizable double bonds and terminal carboxyl groups, hence capable of physically
adsorbing the print protein. With lysozyme as a template, thin protein-imprinted shells were fabricated according to
our newly...

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Nanomedicina
Bioengineering Single Crystal Growth.

Autores: CH Wu, A Park, D Joester
Resumen: Biomineralization is a "bottom-up" synthesis process that results in the formation of inorganic/organic
nanocomposites with unrivaled control over structure, superior mechanical properties, adaptive response, and the
capability of self-repair. While de novo design of such highly optimized materials may still be out of reach,
engineering of the biosynthetic machinery may offer an alternative route to design advanced materials. Herein, we
present an approach using micro-contact-printed lectins for patterning sea urchin embryo primary mesenchyme cells
(PMCs) in vitro. We demonstrate not only that PMCs cultured on these substrates show attachment to wheat germ
agglutinin and concanavalin A patterns but, more importantly, that the deposition and elongation of calcite spicules
occurs cooperatively by multiple cells and in alignment...

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Unfolding and translocation pathway of substrate protein
controlled by structure in repetitive allosteric cycles of the
ClpY ATPase.
Publicada en Nanomedicine Research Publicaciones, 02/02/2011.

Autores: A Kravats, M Jayasinghe, G Stan
Resumen: Clp ATPases are ring-shaped AAA+ motors in the degradation pathway that perform critical actions of
unfolding and translocating substrate proteins (SPs) through narrow pores to deliver them to peptidase components.
These actions are effected by conserved diaphragm-forming loops found in the central channel of the Clp ATPase
hexamer. Conformational changes, that take place in the course of repetitive ATP-driven cycles, result in mechanical
forces applied by the central channel loops onto the SP. We use coarse-grained simulations to elucidate allostery-
driven mechanisms of unfolding and translocation of a tagged four-helix bundle protein by the ClpY ATPase.
Unfolding is initiated at the tagged C-terminal region via an obligatory intermediate. The resulting nonnative
conformation is competent for translocation, which proceeds...

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Nanomedicina
Modulation of biological processes in the nucleus by
delivery of DNA oligonucleotides conjugated with gold
nanoparticles

Autores: Kim, Dong-Wook. Kim, Jae-Hong. Park, Mira. Yeom, Ji-Hyun. Go, Hayoung. Kim, Sudeok. Han, Min Su.
Bae, Jeehyeon
Resumen: The development of a method that can efficiently deliver nucleic acids into the nucleus of living systems
remains one of the key challenges for experimental and therapeutic use of nonbiological gene delivery agents. In the
current study, we demonstrate a functionalized gold nanoparticle (AuNP) that can serve as a universal carrier for the
delivery of DNA oligonucleotides (oligos) into the nucleus. We designed various types of DNA oligos to redirect
alternative splicing of pre-mRNAs, such as MCL-1 and BCL-6, and to sequester transcriptional factors, including
estrogen receptor and p53. We successfully delivered the oligos into the nucleus, resulting in the targeted effects. In
addition, injection of the antisense DNAs into a xenograft...

ver más...

Multifunctional gadolinium-based dendritic macromolecules
as liver targeting imaging probes

Autores: Kui Luoa, Gang Liua, Bin Hea, Yao Wua, Qingyong Gongb, Bin Songb, Hua Aia y Zhongwei Gu
Resumen: In this paper, a novel series of Gd-based multifunctional peptide dendritic probes (generation 2, 3, and 4)
possessing highly controlled structures and single molecular weight were designed and prepared as liver MRI probes.
These macromolecular Gd-ligand agents exhibited up to 3-fold increase in T1relaxivity comparing to Gd-DTPA
complexes. No obvious in vitro cytotoxicity was observed from the measured concentrations. These dendritic probes
were further functionalized with multiple galactosyl moieties and led to much higher cell uptake in vitro as
demonstrated in T1-weighted scans. During in vivo animal studies, the probes provided better signal intensity (SI)
enhancement in mouse liver, especially at 60 min post-injection, with the most efficient enhancement from...

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Nanomedicina
Synthesis, characterization and cytotoxicity studies of
chitosan-coated tea polyphenols nanoparticles

Autores: Liang J, Li F, Fang Y, Yang W, An X, Zhao L, Xin Z, Cao L, Hu Q
Resumen: Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan
and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols
nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR
spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407
± 50 nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 816% and 4483%,
respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of
CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant
antitumor activities.

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In situ green synthesis of biocompatible ginseng capped
gold nanoparticles with remarkable stability
Publicada en Virtual Journal of Nanotechnology Environment, Health and Safety, 02/01/2011.

Autores: Leonard K, Ahmmad B, Okamura H, Kurawaki J
Resumen: This paper reports a one-step green synthesis of gold nanoparticles (G-AuNps), using naturally occurring
Korean red ginseng root (Panax ginseng C.A. Meyer) and investigates their in vitro stability in various buffers as well
as determining toxicity through detailed cytotoxicity assays using WST-8 counting kit, performed on normal cervical
cells lines.

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Enhancement of cell recognition in vitro by dual-ligand
cancer targeting gold nanoparticles
Publicada en Scirus - Puclicaciones científicas sobre Nanomedicina - 2, 02/01/2011.

Autores: Li, Xi. Zhou, Hongyu. Yang, Lei. Du, Guoqing. Pai-Panandiker, Atmaram S. Huang, Xuefei. Yan, Bing
Resumen: A dual-ligand gold nanoparticle (DLGNP) was designed and synthesized to explore the therapeutic
benefits of multivalent interactions between gold nanoparticles (GNPs) and cancer cells. DLGNP was tested on
human epidermal cancer cells (KB), which had high expression of folate receptor. The cellular uptake of DLGNP was
increased by 3.9 and 12.7 folds compared with GNP-folate or GNP-glucose. The enhanced cell recognition was due
to multivalent interactions between both ligands on GNPs and cancer cells as shown by the ligand competition
experiments. Furthermore, the multivalent interactions increased contrast between cells with high and low expression
of folate receptors. The enhanced cell recognition enabled DLGNP to kill KB cells under X-ray irradiation at...


Nanomedicina
ver más...

Hemocompatible pullulan-polyethyleneimine conjugates for
liver cell gene delivery: In vitro evaluation of cellular uptake,
intracellular trafficking and transfection efficiency

Autores:Rekha MR, Sharma CP
Resumen: In this study, polyethyleneimine (PEI; 25 kDa)-conjugated pullulans (PPE1, PPE2 and PPE3) were
developed and investigated for possible use in gene delivery applications. The study included an investigation of the
cellular uptake and localization of plasmid, as well as transgene expression, following in vitro transfection of HepG2
cells.

ver más...

Proteins of the Innate Immune System Crystallize on Carbon
Nanotubes but Are Not Activated

Autores: Ling WL, Biro A, Bally I, Tacnet P, Deniaud A, Doris E, Frachet P, Schoehn G, Pebay-Peyroula E, Arlaud GJ
Resumen: This study investigates the adsorption mechanisms of macromolecules on carbon nanotubes and the
possibility of using carbon nanotubes for structural studies of macromolecules by observing the organized binding of
C1 components C1q and C1s-C1r-C1r-C1s on carbon nanotubes.

ver más...


Nanomedicina
Liposomal architecture boosts biocompatibility of
nanohybrid cerasomes

Autores: Ma Y, Dai Z, Gao Y, Cao Z, Xha Z, Yue X, Kikuchi JI
Resumen: In this study, the authors report the cellular uptake of cerasomes and their biological effects toward human
umbilical vein endothelial cells (HUVECs) compared with silica nanoparticles.

ver más...

Nanosilver induces minimal lung toxicity or inflammation in
a subacute murine inhalation model

Autores: Stebounova LV, Adamcakova-Dodd A, Kim JS, Park H, O'Shaughnessy PT, Grassian VH, Thorne PS
Resumen: The objective of this study was to determine whether very small commercially available nanosilver induces
pulmonary toxicity in mice following inhalation exposure.

ver más...

A living cell quartz crystal microbalance biosensor for
continuous monitoring of cytotoxic responses of
macrophages to single-walled carbon nanotubes

Autores: Wang G, Dewilde AH, Zhang J, Pal A, Vashist M, Bello D, Marx KA, Braunhut SJ, Therrien JM
Resumen: In this study, the authors have developed a device to detect and monitor in real time responses of living
cells to engineered nanomaterials. The device, a living cell quartz crystal microbalance biosensor (QCMB), uses
macrophages adherent to a quartz crystal.

ver más...


Nanomedicina
Inflammatory and cytotoxic responses of an alveolar-
capillary coculture model to silica nanoparticles:
comparison with conventional monocultures

Autores: Kasper J, Hermanns MI, Bantz C, Maskos M, Stauber R, Pohl C, Unger RE, Kirkpatrick CJ
Resumen: In this study, the authors examined the inflammatory and cytotoxic responses of monodisperse amorphous
silica nanoparticles (aSNPs) of 30 nm in size on an in vitro coculture model mimicking the alveolar-capillary barrier
and compared these to conventional monocultures.

ver más...

Carbosilane dendrimers NN8 and NN16 form a stable
complex with siGAG1

Autores: Dzmitry Shcharbina, Elzbieta Pedziwiatrb, Olga Nowackab, Mayank Kumarb, Marian Zaborskic, Paula
Ortegad, F. Javier de la Matad, Rafael Gómezd, Ma Angeles Muñoz-Fernandeze y Maria Bryszewskab
Resumen: A new mechanism of gene expression inhibition has been discovered as RNA interference, in which the
ability of double-stranded RNA to stimulate specific degradation of an mRNA target with a complementary sequence
to one of the double-stranded RNA strands. Water-soluble carbosilane dendrimers containing ammonium or amine
groups at their periphery are biocompatible molecules that may be good candidates as non-viral carriers of small
interfering RNA. In studying the formation of complex between anti-HIV siRNA siGAG1 and carbosilane dendrimers
NN8 and NN16 by circular dichroism, fluorescence, and zeta-potential, the size of nanoparticles formed has been
estimated by...

ver más...

REPORTES
Nanomedicina en España 06-10

Documento que recoge las actividades de la Plataforma Española de Nanomedicina y de sus miembros desde la
publicación de Visión de la Nanomedicina en España.

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Nanomedicina
Podcast: The Implications for Health, Safety and the
Environment of the Nanotech Revolution

This podcast examines the issues associated with the nanotechnology revolution, specifically the effects on health,
safety and the environment.

ver más...

Action Plan Nanotechnology 2015

This action plan includes the German federal government action plan for nanotechnology in the period 2010-2015.
The strategic aims include contributing to growth and innovation in Germany, safe and sustainable development of
nanotechnology, using the potential of nanotechnology in education and research, and for solving global challenges.
Applications include environmental protection, energy security, and contributing to a bioeconomy; healthcare,
agrifood, environmentally friendly and energy saving mobility. The action plan includes also public dialogue and
research in Environmental, Health and Safety aspects and Ethical, Legal and Social aspects.

ver más...

HTSM vision document: High Tech Systems and Material
Publicada en Nanoforum.org - Reports, 02/02/2011.

The focus of the vision document is on applications of nanoelectronics in health, mobility and sustainability.

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Nanomedicina
2010 Nanotechnology Research Review
Publicada en Market Research Nano-Medicine 2, 02/01/2011.

This Nanotechnology Research Review provides a sampling of the type of quantitative market information, analysis
and guidance that has been aiding business decision making since BCC was founded in 1971. It includes highlights
from the following reports published in 2010:

* Nanotechnology In Medical Applications: The Global Market
* Nanocomposites, Nanoparticles, Nanoclays, And Nanotubes
* Carbon Nanotubes: Technologies And Global Markets
* Nanotechnology: A Realistic Market Assessment
* Nanofibers: Technologies And Developing Markets
* Nanotechnology In Paper Manufacturing: Global Markets

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Nanotechnology Market Forecast to 2013
Publicada en Market Research NanoMedicine, 02/01/2011.

Nanotechnology Market Forecast to 2013 is a comprehensive research report that contains quality research, in-depth
analysis, and authentic statistics of the global nanotechnology market. It studies emerging market trends, recent
developments and their impact on the market along with an in depth analysis of nanotechnology patents. The report
will help clients analyze leading-edge opportunities, prospective customer base, key players, expected future outlook,
and all other factors critical to the success of a new entrant in the global nanotechnology market.

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Nanotechnologies in the 21st century
Publicada en Nanoforum.org - Reports, 02/01/2011.

Between April 2009 and September 2010, four reports have been published: 1) Challenges and opportunities to
green nanotechnologies 2) Nanomaterials - health and environmental concerns 3) A critical review of governance
issues in Europe and elsewhere 4) Shaping innovation: Policy approaches on innovation governance

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Nanomedicina
Nanotechnology Research Directions for Societal Needs in
2020. Retrospective and Outlook

This report outlines the foundational knowledge and infrastructure development achieved by nanotechnology in the
last decade and explores the potentials of the U.S. and global nanotechnology enterprise to 2020 and beyond. It aims
to redefine the R&D goals for nanoscale science and engineering integration, and to establish nanotechnology as a
general-purpose technology in the next decade. The vision for the future of nanotechnology presented here draws on
scientific insights from U.S. experts in the field, examinations of lessons learned, and international perspectives
shared by participants from 35 countries in 5 international brainstorming meetings hosted or co-hosted by the
principal authors of this report

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NORMATIVAS
AENOR - Normativas de Nanotecnología
Publicada en AENOR - Normativas de Nanotecnología, 02/03/2011.

ISO 10808:2010: Caracterización de nanopartículas en cámaras de exposición por inhalación para ensayos de
toxicidad por inhalación.

Norma ratificada por AENOR en febrero de 2011. Normalización en el campo de las nanotecnologías que incluya
alguno o ambos de los puntos siguientes:

1) Comprensión y control de la materia y los procesos en la nanoescala..
2) Utilización de las propiedades de materiales en nanoescala que se diferencian de las propiedades de átomos,
moléculas y materias individuales.

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Boletín nanomedicina Enero Febrero 2011

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