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IRCCS Ospedale San Raffaele Milano
        Università Vita-Salute San Raffaele




PROLASSO ED INCONTINENZA ASSOCIATI:
        COSA E COME FARE
          STEFANO SALVATORE
SUI E POP          1-


   40% of women with POP report SUI symptoms
                                                  Grody


   Occult SUI ranges from 36% to 80%
                                   Bergman/Richardson


   11-22% preoperatively continent women developed
    SUI after POP repair
                               Stanton/ Borstad and Rud
SUI E POP   2-




             CONCOMITANT SUI
 GENITAL
PROLAPSE     OCCULT SUI
Latent (Occult) urinary stress
 incontinence

             What is it?
    How and when to diagnose?
     If, when and how to treat?
OCCULT SUI -DEFINITION-
External   O
Urethral                C
             urethral       E
kinking
            compressi   C   T
               on       U   I
      Increased         L   O
    intra-urethral      T   L
       pressure
                            O
                        S   G
                        U   Y
                        I

    Occult SUI
OCCULT SUI -HOW TO DIAGNOSE?-
 In women presenting with POP w/o SUI the rate of urodynamic
  stress incontinence detection is lower with pessary than with
  speculum prolapse reduction (LE1)
 The pessary test has also been suggested to predict the result
  of POP surgery on urinary symptoms. In this indication the
  predictive value of the pessary test remains unclear (LE3), and
  it is not recommended to use it routinely (Grade C)
 Different methods for POP reduction:
         Large swab placed at the apex
         Posterior blade of a bivalve
          speculum
         Sims speculum
         Vaginal pessary
OCCULT SUI -HOW TO
                 DIAGNOSE?-




Pessary test procedure:
 Pessary placed at maximum cystometric capacity or at
  400mls (whatever reached first)
 Patients were asked to cough repeatedly for 5-6 times
OCCULT SUI -HOW TO
                DIAGNOSE?-


   VAGINAL
     PACK
  Pessaries have a tendency to fall out in the
absence of the uterus and it is difficult to know
whether the prolapse is adequately reduced and
whether urethral obstruction has occured -> use
of vaginal pack
                                          Gallentine
OCCULT SUI                -DIAGNOSIS-


   Filling cystometry at 400-500 ml CC

   Cough test at CC in sitting position repeated 3
    times before flowmetry

   Loss of urine after 1 cough -> severe IUS
    Loss of urine after 3 cough -> moderate IUS
    Loss of urine after 5 cough -> mild IUS
OCCULT SUI               -DIAGNOSIS-




   Prolapse reduced by pessary

   In case of pessary loss -> use of vaginal
    pack
VAGINAL VAULT PROLAPSE AND
OCCULT SUI




    Patients with vault prolapse have high incidence of
     uccult SUI

    The change in ALPP is much higher than in patients
     with vault prolapse than in patients with moderate
     grade cystoceles and rectoceles
POSTERIOR VAGINAL DEFECTS AND
OCCULT SUI




  Pessary test procedure:
   A posterior blade of a Pederson speculum was used
   Bladder filled up to 300 mls
   Patients performed three separate sets of Valsalva
     maneuvers, and urine leakage was noted
  Results:
   12 (54%) of 22 women revealed occult SUI
OCCULT SUI -HOW TO TREAT-
322 women randomized

   157 underwent abdominal sacrocolpopexy with Burch
    colposuspension (Burch group)
   165 underwent only abdominal sacrocolopexy (controls)

RESULTS:
23.8% Burch group vs 44.1% controls had stress incontinence after
  surgery

CONCLUSIONS:
Burch colposuspension singnificantly reduced post-operative
   symptoms of
stress incontinence
OCCULT SUI -HOW TO TREAT-




                        Abdominal POP
                                             POP repair
                        repair + Burch
                                             alone
                        colposuspension
       Incontinence
       rate                  54.2%             39.1%
       after surgery
CONCLUSIONS: Burch colposuspension does not provide any
benefity in POP repair in patients with urinary incontinence
OCCULT SUI -HOW TO TREAT-




 Anterior plication of
                         Objective rate   Subjective rate
 endopelvic fascia
        + TVT                92%               96%

        - TVT                56%               64%
OCCULT SUI -HOW TO TREAT-



                                 UROLOGY 76: 1358–1363, 2010




   117 women with POP and occult SUI who had
   concomitant prolapse repair and TVT-O

   RESULTS:
 Subjective cure rate: 97.8%
 Objective cure rate: 86%
UROLOGY 76: 1358–1363, 2010




Comparison of subjective cure rate between anti-incontinence
  procedures
               TVT-O                  97.8%
               TVT
                98%
               Burch                  96%
               Pubovaginal sling
                95%
OCCULT SUI -POSSIBLE
                    SOLUTIONS-


   Perform anti-incontinence surgery in ALL patients
    undergoing POP surgery
   Perform anti-incontinence surgery in NO patients
    undergoing POP surgery
   Perform anti-incontinence surgery in SOME patients
    undergoing POP surgery based on some set of clinical
    predictors (i.e. presence of symptons of SUI, clinical
    observation of SUI on stress testing or occult SUI on
    stress testing with prolapse reduction)
MORE STUDIES ARE NEEDED…
PATIENT INFORMATION


   Risk of develop postoperative SUI
   Need of preoperative urodynamic evaluation to
    reveal occult SUI
   Decide     for    prophylactic  anti-incontinence
    precedure in case of occult SUI
   Decide the more effective and safer anti-
    incontinence procedure
CONCLUSIONS

  Standardized defintion by ICS/IUGA since 2010

  No standardized method for prolapse reduction and evaluation of
   occult SUI

  Treatment choice include postponed or concomitant anti-
   incontinence procedure with prolapse repair

  Overall success rate on a short, medium and long term basis
   should be part of preoperative counseling as well as LUT
   functional effects

Latent (Occult) urinary stress incontinence. What is it? How and
when to diagnose? If, when and how to treat?
GRAZIE!

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Il prolasso ed incontinenza associati_Salvatore

  • 1. IRCCS Ospedale San Raffaele Milano Università Vita-Salute San Raffaele PROLASSO ED INCONTINENZA ASSOCIATI: COSA E COME FARE STEFANO SALVATORE
  • 2. SUI E POP 1-  40% of women with POP report SUI symptoms Grody  Occult SUI ranges from 36% to 80% Bergman/Richardson  11-22% preoperatively continent women developed SUI after POP repair Stanton/ Borstad and Rud
  • 3. SUI E POP 2- CONCOMITANT SUI GENITAL PROLAPSE OCCULT SUI
  • 4. Latent (Occult) urinary stress incontinence What is it? How and when to diagnose? If, when and how to treat?
  • 6. External O Urethral C urethral E kinking compressi C T on U I Increased L O intra-urethral T L pressure O S G U Y I Occult SUI
  • 7. OCCULT SUI -HOW TO DIAGNOSE?-
  • 8.  In women presenting with POP w/o SUI the rate of urodynamic stress incontinence detection is lower with pessary than with speculum prolapse reduction (LE1)  The pessary test has also been suggested to predict the result of POP surgery on urinary symptoms. In this indication the predictive value of the pessary test remains unclear (LE3), and it is not recommended to use it routinely (Grade C)  Different methods for POP reduction:  Large swab placed at the apex  Posterior blade of a bivalve speculum  Sims speculum  Vaginal pessary
  • 9. OCCULT SUI -HOW TO DIAGNOSE?- Pessary test procedure:  Pessary placed at maximum cystometric capacity or at 400mls (whatever reached first)  Patients were asked to cough repeatedly for 5-6 times
  • 10. OCCULT SUI -HOW TO DIAGNOSE?- VAGINAL PACK Pessaries have a tendency to fall out in the absence of the uterus and it is difficult to know whether the prolapse is adequately reduced and whether urethral obstruction has occured -> use of vaginal pack Gallentine
  • 11. OCCULT SUI -DIAGNOSIS-  Filling cystometry at 400-500 ml CC  Cough test at CC in sitting position repeated 3 times before flowmetry  Loss of urine after 1 cough -> severe IUS Loss of urine after 3 cough -> moderate IUS Loss of urine after 5 cough -> mild IUS
  • 12. OCCULT SUI -DIAGNOSIS-  Prolapse reduced by pessary  In case of pessary loss -> use of vaginal pack
  • 13. VAGINAL VAULT PROLAPSE AND OCCULT SUI  Patients with vault prolapse have high incidence of uccult SUI  The change in ALPP is much higher than in patients with vault prolapse than in patients with moderate grade cystoceles and rectoceles
  • 14. POSTERIOR VAGINAL DEFECTS AND OCCULT SUI Pessary test procedure:  A posterior blade of a Pederson speculum was used  Bladder filled up to 300 mls  Patients performed three separate sets of Valsalva maneuvers, and urine leakage was noted Results:  12 (54%) of 22 women revealed occult SUI
  • 15. OCCULT SUI -HOW TO TREAT-
  • 16. 322 women randomized  157 underwent abdominal sacrocolpopexy with Burch colposuspension (Burch group)  165 underwent only abdominal sacrocolopexy (controls) RESULTS: 23.8% Burch group vs 44.1% controls had stress incontinence after surgery CONCLUSIONS: Burch colposuspension singnificantly reduced post-operative symptoms of stress incontinence
  • 17. OCCULT SUI -HOW TO TREAT- Abdominal POP POP repair repair + Burch alone colposuspension Incontinence rate 54.2% 39.1% after surgery CONCLUSIONS: Burch colposuspension does not provide any benefity in POP repair in patients with urinary incontinence
  • 18. OCCULT SUI -HOW TO TREAT- Anterior plication of Objective rate Subjective rate endopelvic fascia + TVT 92% 96% - TVT 56% 64%
  • 19. OCCULT SUI -HOW TO TREAT- UROLOGY 76: 1358–1363, 2010 117 women with POP and occult SUI who had concomitant prolapse repair and TVT-O RESULTS:  Subjective cure rate: 97.8%  Objective cure rate: 86%
  • 20. UROLOGY 76: 1358–1363, 2010 Comparison of subjective cure rate between anti-incontinence procedures  TVT-O 97.8%  TVT 98%  Burch 96%  Pubovaginal sling 95%
  • 21. OCCULT SUI -POSSIBLE SOLUTIONS-  Perform anti-incontinence surgery in ALL patients undergoing POP surgery  Perform anti-incontinence surgery in NO patients undergoing POP surgery  Perform anti-incontinence surgery in SOME patients undergoing POP surgery based on some set of clinical predictors (i.e. presence of symptons of SUI, clinical observation of SUI on stress testing or occult SUI on stress testing with prolapse reduction)
  • 22. MORE STUDIES ARE NEEDED…
  • 23. PATIENT INFORMATION  Risk of develop postoperative SUI  Need of preoperative urodynamic evaluation to reveal occult SUI  Decide for prophylactic anti-incontinence precedure in case of occult SUI  Decide the more effective and safer anti- incontinence procedure
  • 24. CONCLUSIONS  Standardized defintion by ICS/IUGA since 2010  No standardized method for prolapse reduction and evaluation of occult SUI  Treatment choice include postponed or concomitant anti- incontinence procedure with prolapse repair  Overall success rate on a short, medium and long term basis should be part of preoperative counseling as well as LUT functional effects Latent (Occult) urinary stress incontinence. What is it? How and when to diagnose? If, when and how to treat?