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C O M P A N Y               R E P O R T

             India

        4 Jun 2012
                                                Venus Remedies                                               Rs 166.1
   Sector: Pharma                               Building a unique formulation

BSE Code               526953          NSE Code            VENUSREM      Venus Remedies (Venus), a high-growth mid-sized
CMP (Jun 1)             166.1           52W H/L              276/141     pharma company in the injectables space, has two key
Nifty                   4,842             Sensex               15965     differentiators: presence in high value therapeutic
Equity Cap (m)          2,369         Face Value                  10
Shares (m)               9.74          Free Float            65.29%      segments and a strong research focus. This has allowed
Market Cap (m)          1,618            Avg Vol               9,514     the company to maintain robust revenue CAGR of
                                        (weekly)
                                                                         around 18% over last 4 years, at healthy operating
                                                                    Rs
                                                                         margins. The company’s growth rates and margins
                                                                         could get a boost as its growing repository of research
           Shareholding Pattern (March 31,                               products and patents comes into play.
                       2012)
                                                                         In highly attractive injectables segment

               Promoter
                                               FII                       Venus is among top 10 players globally in combination
                                              14%
                 35%                                                     drugs space. This is a high margin space within injectables.
                                                 DII                     Venus has further focussed on highly specialised products
                                                 0%                      within this space, helping it maintain high profitability and
                                                                         robust top-line growth.
                                                Others
            Bodies                               32%                     Concentrated focus on IP development
           Corporate
             19%                                                         The Company has maintained high focus on IP
                                                                         development. Its R&D spends reached a high of 19% of its
                                                                         revenue for FY11, growing from a level of 5% in FY07. The
                                                                         company expects to maintain spends in double digits. This
                                                                         puts Venus Remedies among top 5 pharma companies in
         Price Performance (Last 6 months)
                                                                         R&D investment as ‘% of sales’ and top 15 by total amount.
                            Venus Remedies               Nifty           The Company has developed many path breaking products
  200.00                                                                 such as Sulbactomax, a novel combination product with
  190.00                                                                 market potential of US$400mn in India, and patents in
  180.00                                                                 more than 42 countries including EU and Australia. Venus is
  170.00                                                                 currently exploring out licensing deals for Sulbactomax for
  160.00                                                                 global markets and has hired a leading global consulting
  150.00                                                                 firm for the same.
  140.00                                                                 Antimicrobial Resistance: A winning strategy
         30-Dec   30-Jan     29-Feb    31-Mar    30-Apr     31-May
                                                                         Venus correctly identified anti-microbial resistance (AMR)
                                                                         as its core area for R&D efforts around 10 years ago. AMR
Consolidated Financials                                                  has emerged as the biggest threat to global health in
                                                                         recent years, so much that even WHO has proposed a
                          FY'11    FY'12E       FY'13E     FY'14E
                                                                         global strategy to fight AMR. Venus Remedies’ entire
Sales                      3,631      4,196      4,788       5,546
                                                                         antibiotic research product chain caters to the AMR
EBITDA                      892       1,022      1,186       1,395
                                                                         segment including Sulbactomax, Vancoplus, Potentox and
PAT                         462        493           610         755
                                                                         Tobracef.
EBITDA margin(%)           24.57      24.35      24.78       25.14
Net margin(%)
                                                                         Low Valuations
                           12.73      11.74      12.75       13.62
ROE(%)                     22.65      18.07      18.01       18.56       At current price, Venus Remedies quotes at around 3.3x
ROCE(%)                    19.11      16.28      16.37       17.39       FY12 and around 2.6x FY13e earnings, below peer
P/E Ratio(x)                3.99       3.28       2.65           2.14
                                                                         averages. These are values below its historical trading
EV/EBITDA(x)                                                             range. We expect Venus’s price to cross Rs 200 over a 12
                            4.12       3.60       3.10           2.64
EPS (Rs)                   50.63                                         month period. Any big out licensing deal will give further
                                      50.56      62.65       77.55
                                                              Rs mn      upside. This is an upside of 23% from current levels.


                            Four-s reports are available on BLOOMBERG, Reuters, Thomson Publishers and Market Publishers
Company Report: Venus Remedies                     4 Jun 2012




                  Investment Rationale

                  A top player in the attractive injectables space

                  Venus is among top 10 players globally in combination drugs space
                  with the biggest capacity in Asia in manufacturing for injectables.
                  The US$200bn injectable market is higher on margins and faces
                  lower pricing pressure compared to oral pharmaceuticals.
                  A consistent focus on injectables, the highest end of the formulation
                  value chain marked by stringent manufacturing standards,
                  demanding quality parameters and low competition (only 1% of
                  India’s over 10,000 pharmaceutical companies produce injectables)
                  gives Venus a better ability to deliver higher margins.

                  High growth segments

Focussed on       Venus Remedies has focused on high growth segments like anti-
high growth,      infective (33% of revenue) and oncology (30.7%) which are
high margin       considered to be the fastest growing segments and expected to
segments within   contribute 50 to 60% of product launches globally by 2015.
injectables
                  With changing demography and overall changes in lifestyle, anti-
                  infective, oncology, cardiovascular and neurology segments are
                  expected to benefit the most in the coming years, not only in India
                  but globally.
                  Venus has been investing strongly in R&D for all of these segments
                  which will sooner than later start benefiting the company. Venus has
                  already launched products in segments like anti-biotic, oncology, and
                  neurology in last few years.

                  Maintains high margin with highly specialised products

                  Venus Remedies’ reported operating margins are better than the
                  peer set, reflecting its focus on high margin segments within
                  injectables. The company has margins better than all peers except
                  Claris. The reason behind this is Venus Remedies’ conscious strategy
                  to move away from its me-too products to enter high margin
                  specialised segment with the backing of strong R&D process.

                              Better profitability supporting the growth
                                       FY11 Margin (%)      TTM Margin (%)
                   Company             EBIDTA      PAT     EBIDTA       PAT
                   Mid-Cap Peers


                   Ajanta Pharma           19%      10%         21%      12%
                   Indoco                  13%      11%         14%        9%


Four-S Research                                                                      2
Company Report: Venus Remedies                      4 Jun 2012

                   Natco Pharma                19%          12%   23%       12%
                   Nectar                      20%           9%   18%        6%
                   Parabolic Drugs             15%           8%   18%        6%
                   Average                    17%           10%   19%       9%
                   Injectable Peers
                   Strides Arcolab             21%           7%   21%       32%
                   Ahlcon                      16%           6%   16%        7%
                   Parenteral Drugs            10%           1%   -2%      -20%
                   Claris                      31%          19%   32%       17%
                   Kilitch                     15%           7%   17%        9%
                   Average                    19%           8%    17%       9%

                   Industry
                   Average                    18%           9%    18%       9%
                   Venus                      25%           13%   22%      13%
                    (Source: Ace Equity, company reports)


                  Profitability set to improve

                  The company is confident that it can improve margins going forward.
                  The key reason behind this is the high revenue flow expected from
                  out-licensing of the already developed technology. This revenue will
                  add to the top-line without putting much strain on cost side of the
                  company’s profit and loss sheet.

                  Creating significant opportunities through R&D

                  Focus on formulation R&D products to beat me-too generic
                  products competition

                  Venus has evolved an innovative approach to its R&D investments to
                  overcome competition in generic drugs. Its R&D is focussed on
                  creating new drug candidates through formulation focused research,
                  where it aims to combine two or more already patented APIs into a
Research          new formulation or a dosage form. Venus aims to make formulations
pipeline based    that are more effective than alternatives available in the market. It
on novel          aims to offer a therapeutic advantage and differ from me-too generic
formulations      products.
                  This strategy offers a low-risk, low-cost alternative to the traditional
                  pharmaceutical development of new medicines, due to their shorter
                  development timeline. New Chemical Entities (NCEs) take a long time
                  to develop, often at a cost of over US$1bn. Conversely, the
                  development of new therapies through Venus’ method is cheaper and
                  less time consuming, as it has a known mechanism of action and an
                  established safety and efficacy profile. This offers products a less
                  complex clinical development process.
                  It also has a simpler pathway to patent approval that can potentially
                  save pharmaceutical sponsors both time and money.


Four-S Research                                                                        3
Company Report: Venus Remedies                       4 Jun 2012

                   Some of its key products like Sulbactomax and Vancoplus are novel
                   formulations of previously approved APIs.

                   Concentrating on future epidemic : Anti-Microbial Resistance

                   Venus has maintained strong focus on Antimicrobial resistance (AMR)
                   while developing research products. Antimicrobial resistance (AMR) is
                   the resistance of a microorganism to an antimicrobial medicine to
                   which it was previously sensitive. These resistant organisms are able
                   to withstand attack by antimicrobial medicines, such as antibiotics,
                   antivirals, and antimalarials, so that standard treatments become
                   ineffective and infections persist and may spread to others.
                   Infections caused by resistant microorganisms often fail to respond to
                   the standard treatment, resulting in prolonged illness and greater risk
                   of death. Once resistance evolves, it can spread very rapidly across
                   borders and around the world. This drug resistance threatens to
                   erase gains made in disease treatment and control in developing
                   countries.
                   Venus Remedies is one of the few R&D led companies which has
                   innovated and developed a comprehensive range of novel antibiotic
                   combinations which not just provide relief from the aggravated
                   problem of antibiotic resistance but also are cost-effective and have
                   reduced side effects.

                   The Company could foresee the potential of antibiotics fading 10
                   years back and it is the result of its focused approach that today it
                   has some SUPER BUG tackling solutions under patent protection. The
                   entire antibiotic research products of Venus like Vancoplus,
                   Sulbactomax, Potentox, Tobracef and many more cater to the
                   Antimicrobial Resistance segment.

                   Sulbactomax – a key growth driver

                   The biggest product from Venus’s R&D initiative is Sulbactomax, an
                   anti-infective product, used to combat beta-lactamase generated
Sulbactomax, a
                   drug resistance, the only product in its category to prevent growth
likely winner
                   and spread of bacterial resistance.
                   Sulbactomax is a combination of Ceftriaxone and Sulbactam with
                   VRP1034. Venus’s tests show that Sulbactomax is much more
                   effective than all the existing third generation cephalosporins and
                   their combinations.

                   Research pipeline robust, several launches ahead
Research           Besides Sulbactomax, Venus’s R&D has come up with several new
launches           unique formulations like Vancoplus, Potentox, and Tobracef.
beginning to hit
                   Achnil, launched in FY11, is a revolutionary once-a-day pain killer,
the market
                   given Product of the Year award by Biospectrum Asia for its
                   uniqueness in addressing critical health conditions.


Four-S Research                                                                        4
Company Report: Venus Remedies                       4 Jun 2012

                  Many new products like Tumatrek, Trois and Stermex were lauched in
                  FY12 and many more to be launched in coming years. These new
                  products are estimated to generate revenue of 5-10% for the
                  company in the next 2-3 years. Venus Remedies is coming up with
                  constant flow of research products mainly due to its well thought out
                  R&D process which looks for novel solutions that fill the vast gap
                  between challenging ailments and available molecules.

                  Aims to create Sizeable IP wealth by 2015

                  Venus now has 80+ global patents out of more than 360+ filed for its
                  13 research products. There is a clear indication that the company
                  has created strong traction in R&D as well as Global presence.

                  Rightly positioned to capitalise IP wealth

Licensing         Sulbactomax itself is patented in 42 countries including the EU
discussions on    countries; patents are awaited from 8 more countries including US
for Sulbactomax   and Japan. Sulbactomax has US$400mn market in India itself,
                  according to Venus. Global potential is indicated by third generation
                  cephalosporins and carbapenems, a close substitute, which have
                  market of around US$2bn globally. Venus Remedies has already out-
                  licensed Sulbactomax successfully to a South Korean pharma
                  company to monetise the South Korean US$585mn market.
                  In a similar way, Venus Remedies is looking to capitalise its IP wealth
                  from its range of research products by striking deals with global
                  pharma companies for specific geographies.
                  Venus Remedies has already shortlisted a number of companies and
                  is very close to finalising the deal with these companies. The
                  company has hired renowned external agencies to make sure these
                  deals are executed in the best interest of Venus Remedies’
                  stakeholders.

                  Market authorisation in regulated markets

                  Venus Remedies has marketing authorisations for EU markets for
                  multiple products like Meropenem. It is the first Indian company to
                  get GCC market authorisation for its oncology and Carbepenem
                  products. This authorisation will further increase market reach of its
                  products, pushing revenue growth.

                  Vast pool of patented R&D products to capitalise on

                  Since Venus Remedies has reorganized its priorities and started
                  investing in R&D, it has developed respectable IP wealth within a
                  very short period. Venus currently has more than 13 research
                  products in development, with 11 products already under patent
                  protection. 7 of these products are already commercialised not only
                  in India but are also launched in emerging export markets through
                  various alliances, and are selling in 12 countries.
                  Overall, Venus Remedies boasts of 80+ patents out of more than

Four-S Research                                                                       5
Company Report: Venus Remedies                       4 Jun 2012

                  360+ filed in over 51 countries. It has 44 product registered in
                  developed countries and has filed 108 CTDs for 7 products. Venus
                  Remedies also has more than 375 market authorizations in semi-
                  regulated market. Strong IP wealth with patented technology and
                  ready to launch products along with EU GMP certified plant will enable
                  Venus Remedies to monetise this wealth in the near future.

                  Traction from research products to grow

Revenue from      With ever growing investment in R&D by Venus Remedies (from
R&D products      14.5% of revenue in 2009 to 19% in 2011) and a strong R&D team
could grow 20-    of 60 scientists, in-licensing and R&D alliances with many
25% annually      international universities, Venus Remedies is on right path to grow its
                  IP wealth. This is also evident from range of their products in phase
                  II & III of research.
                  Research products contributed around 25% of Venus’ total revenue in
                  FY12. Revenue from research products is expected to grow at a rate
                  of 20-25%, higher than the generics in its portfolio. This strong
                  traction is expected in near future because of new research products
                  and established products.

                  Superior operational efficiencies

                  Better working capital management

                  The chart below shows debtor turnover for the latest financial year.
                  Venus Remedies performance here is above peer averages.


                                          Debtors Turnover
                   12.00
                   10.00
                    8.00
                    6.00
                    4.00
                    2.00
                    0.00




                  Running business with higher capital efficiency

                  Venus remedies is utilizing its capital efficiently, resulting in better
                  profitability ratio and better returns to its stakeholders. It can be
                  seen from Venus remedies having highest ROE and ROCE ratios
                  compared to most of its peers and much higher than industry
                  average.

Four-S Research                                                                        6
Company Report: Venus Remedies                                                                                                                                                             4 Jun 2012




                                                            ROE                                                                                                                                                         ROCE
 30%                                                                                                                                                            25%
 25%                                                                                                                                                            20%
 20%
                                                                                                                                                                15%
 15%
                                                                                                                                                                10%
 10%
  5%                                                                                                                                                            5%
  0%                                                                                                                                                            0%
                       Indoco




                                                                                      Ahlcon
       Ajanta Pharma




                                               Nectar
                                Natco Pharma




                                                                                                                                     Industry Average
                                                                                               Parenteral Drugs
                                                                    Strides Arcolab
                                                        Parabolic




                                                                                                                  Claris




                                                                                                                                                        Venus
                                                                                                                           Kilitch




                                                                                                                                                                                      Indoco




                                                                                                                                                                                                                                                     Ahlcon
                                                                                                                                                                      Ajanta Pharma




                                                                                                                                                                                                              Nectar
                                                                                                                                                                                               Natco Pharma




                                                                                                                                                                                                                                                                                                    Industry Average
                                                                                                                                                                                                                                                              Parenteral Drugs
                                                                                                                                                                                                                                   Strides Arcolab
                                                                                                                                                                                                                       Parabolic




                                                                                                                                                                                                                                                                                 Claris




                                                                                                                                                                                                                                                                                                                       Venus
                                                                                                                                                                                                                                                                                          Kilitch
                                                               Valuations – have trended down in FY12

                                                               High discount compared to its peers

Valuations                                                     Venus is currently traded at discounted valuations as compared to its
ignoring steady                                                pharma peers. When we divide peers among injectable segment and
growth, and                                                    mid-cap segment, within injectable segment, Venus Remedies is at
R&D results                                                    lowest multiple compare to its all injectable peers.
                                                               Venus is also at lower range of valuations amongst Pharma
                                                               companies of similar scale. Currently, Venus is traded at a PE ratio of
                                                               3.3 whereas mid-cap Pharma companies are traded at an average of
                                                               9.5 and injectables are traded at an average PE of 13.4.
                                                               Given Venus’ steady growth performance, and reasonable return on
                                                               capital, this gap will get bridged, at least partially, if not wholly. If it
                                                               gets revenue from out-licensing, the process of narrowing of the
                                                               valuation gap could get accelerated, giving a major upside for the
                                                               stock.




Four-S Research                                                                                                                                                                                                                                                                                                                7
Company Report: Venus Remedies                    4 Jun 2012



                    Peer Benchmarking

                    The peer set: mid-cap pharma companies & injectable players

                    Venus Remedies is among the leading injectable manufacturers in
                    India. We have compared it to its injectable peers, as well as midcap
                    pharma peers. We find its performance is within peer averages, and
                    better on some parameters. The strategy of Venus Remedies to focus
                    on niche injectables segment has benefitted company, which is
                    evident from its growth in last few years and margins it has managed
                    through out.


    Company        Market       EV     TTM        TTM       TTM      TTM     TTM    TTM PAT
                     Cap              Sales   Sales 4-   EBITDA   EBITDA     PAT        4-yr
                                              yr CAGR                4-yr             CAGR
                                                                    CAGR
Mid-Cap Peers

Ajanta Pharma        7456      8633   6714       21%       1407      29%     773        37%
Indoco               4981      5980   5389       19%        735      15%     460        11%
Natco Pharma        11517     13717   4831       10%       1095      20%     602        10%
Nectar               4339     12299   13412      15%       2453      18%     804         2%
Parabolic            1253      5997   9288       33%       1666      37%     574        18%

Average             5909      9325    7927       19%      1471      24%      642       16%
Injectable Peers
Strides Arcolab     39986     64181   25645      26%       5399      67%    1,689       15%
Ahlcon               3089      3341    848        9%        139       1%      43        -2%
Parenteral Drugs     1441      7329   3083       10%        -52       NA      50         NA
Claris              10674     14376   7625        0%       2446       5%    1,414        4%
Kilitch               570      1100   1414        5%        235       1%     105         2%

Average             11152     18065   7723       10%       1633      19%     660         5%
Industry
Average             8531     13,695   7825       15%      1552      21%      651       10%

Venus               1617      3486    4049       18%        896     15%      493        9%



Better P&L           Venus Remedies has performed better than its injectable peers in the
growth numbers       last 4 years as peers’ overall profit declined. Venus managed to
than injectables     improve PAT at a CAGR of 9%.
peer average
                     Peer revenues have grown at an average of 15%, while Venus has
                     delivered growth rates of 18% over last four years.

                     Among the best organic growths

                     Among the companies performing better than Venus on growth,
                     Strides Arcolab revenue was boosted by its acquisitions of Ascent
                     Pharmahealth. Ascent Pharmahealth, one of the biggest branded
                     generic drug manufacturer in Australia, had sales of US$140mn in
                     FY10. Strides recently sold out 94% of its stake in Ascent to refocus

Four-S Research                                                                          8
Company Report: Venus Remedies                     4 Jun 2012

                  on speciality injectables.
                  As can be seen in the table below, Venus Remedies is among the
                  outperformers in its peer group on standalone basis as well, signifying
                  success of Venus Remedies to grow organically at very comfortable
                  rate. Venus Remedies has managed to propel its growth organically
                  using its strong product portfolio and strong presence in highly
                  growing injectable space.



                   Company                     Revenue CAGR (FY08-FY11)
                   Ahlcon Parenterals                              11%
                   Ajanta Pharma                                   17%
                   Claris Lifesciences                              4%
                   Indoco Remedies                                 22%
                   Kilitch Drugs                                    8%
                   Natco Pharma                                    16%
                   Nectar Lifesciences                             13%
                   Parabolic Drugs                                 31%
                   Parenteral Drugs                                22%
                   Strides Arcolab                                  9%
                   Industry Avg                                   15%
                   Venus Remedies                                 19%
                  Standalone revenues, Rs mn




                  Comparing key P&L items

                  Better profitability parameters

Focus on high     Venus Remedies has outperformed most of its peers in profitability in
margin products   midcap as well as injectable peers while generating strong growth
has boosted       numbers in last few years.
margins
                  While injectable peers have EBITDA margins of 17% on average and
                  9% PAT margins, Venus Remedies has managed to clock 22% EBITDA
                  margin for TTM and 12% PAT TTM margins.
                  Venus Remedies has better margins among its mid-cap peer
                  companies which are averaging 19% EBITDA and 9% PAT margins
                  compared to 22% EBITDA and 12% PAT TTM margins of Venus
                  Remedies.




Four-S Research                                                                      9
Company Report: Venus Remedies                    4 Jun 2012

                                       FY11 Margin (%)           TTM Margin (%)
                   Company                  EBIDTA      PAT      EBIDTA       PAT
                   Mid-Cap Peers

                   Ajanta Pharma                 19%      10%        21%        12%
                   Indoco                        13%      11%        14%         9%
                   Natco Pharma                  19%      12%        23%        12%
                   Nectar                        20%       9%        18%         6%
                   Parabolic Drugs               15%       8%        18%         6%
                   Average                       17%     10%        19%         9%
                   Injectable Peers
                   Strides Arcolab               21%       7%        21%        32%
                   Ahlcon                        16%       6%        16%         7%
                   Parenteral Drugs              10%       1%        -2%       -20%
                   Claris                        31%      19%        32%        17%
                   Kilitch                       15%       7%        17%         9%
                   Average                       19%      8%        17%         9%
                   Industry Average              18%      9%        18%         9%
                   Venus                         25%     13%        24%        12%


                  Balance sheet ratios

                  Reasonable leverage


                                          Debt Equity (x)     Interest Coverage (x)
                  Company                FY10            FY11 FY10            FY11
                  Mid-Cap Peers
                  Ajanta Pharma           0.83             0.8        2.87           4.02
                  Parabolic               2.65            1.25        2.03           2.27
                  Indoco                  0.21            0.29        14.3          21.22
                  Nectar                  0.97             1.1        2.59           2.35
                  Natco Pharma            0.39            0.62        4.88           4.99

                  Average                 1.01            0.81       5.33           6.97
                  Injectable Peers
                  Ahlcon                  0.29            0.66        7.35           3.17
                  KIlitch Drugs           0.57            0.63        4.27           4.94
                  Parenteral Drugs        0.62            0.75        3.17            1.3
                  Claris                  0.39            0.38        4.07           4.07
                  Strides Arcolab         1.57            1.74        1.79           0.97

                  Average                 0.69            0.83       4.13           2.89
                  Industry Average        0.85            0.82       4.73            4.93
                  Venus                   0.87            0.79       4.28            3.77


                  Although Venus Remedies has investing heavily in its R&D and
                  capacity ramp up in last 3-4 years, its debt condition is in line with
                  industry scenario. Its financial position is pretty much on par

Four-S Research                                                                       10
Company Report: Venus Remedies                       4 Jun 2012

                  compared to most of its peers as can be seen table above.


                  Liquidity ratios on par

                                          Current Ratio (x)         Cash Ratio (x)
                   Company             FY9      FY10      FY11      FY10      FY11
                   Mid-Cap Peers

                   Ajanta Pharma       1.62     1.85       1.55      0.16      0.12
                   Indoco              2.7      2.79       2.63      0.48      0.31
                   Nectar              1.26     2.11       1.72      0.17      0.13
                   Natco Pharma        1.27     1.31       1.53      0.08      0.31

                   Average            1.71      2.02      1.86      0.21       0.2
                   Injectable Peers
                   Ahlcon              1.11     1.58       1.37      0.36      0.1
                   KIlitch Drugs       1.68     1.42       1.08      0.17      0.38
                   Claris              1.54     2.53       3.43      1.08      1.04
                   Strides Arcolab     1.39     2.12       1.86      0.37      0.19

                   Average            1.43      1.91      1.94      0.43      0.36
                   Industry
                   Average            1.57      1.96      1.90      0.32      0.28
                   Venus              1.65      1.50      1.67      0.11      0.11

                  Venus Remedies is maintaining liquidity status similar to peers in the
                  industry even though it has under taken high capex in last few years
                  in R&D and capacity up-gradation.

                  In March 2012, ICRA has assigned a BBB- rating to Venus Remedies
                  on its debt facilities, citing comfortable financial risk profile marked
                  by healthy size of net worth.




Four-S Research                                                                        11
Company Report: Venus Remedies                             4 Jun 2012



                         Comparing Peer Valuation

                         Dividing peer set into two parts

                         In the table below, as earlier, we have presented two sets of peers:
                         mid-cap pharma companies and companies in injectable space.



                                Valuation*               EV/                CAGRs 4 year           Ratios
                                                       EBIDTA
Company                 P/E       P/E         EV/                    EV/    TTM     TTM    D/E     ROCE      ROE
                                                        (TTM)
                                 (TTM)       EBIDTA                 TTM     Sales    NP           (FY11)    (FY11)
                                                                    Sales
Mid-Cap Peers

Ajanta Pharma            4.62      9.72         8.96        6.13     1.69    17%    32%    0.80     22%       27%
Indoco                  10.70     10.84         9.28        8.13     1.24    21%    19%    0.29     14%       15%
Natco Pharma            14.48     19.13        15.80       12.52     2.97    11%    10%    0.62     16%       16%
Nectar                   5.35      5.41         5.58        5.58     1.10    13%    11%    1.10     14%       15%
Parabolic                5.00      2.18         5.95        3.60     0.89    31%    21%    1.25     15%       20%
Average                  8.03      9.45        9.11         7.19    1.58     19%    19%    0.81     16%       19%
Injectable Peers
Strides Arcolab          9.59      4.85        13.80       11.89     2.53    35%    31%    1.74     12%       17%
Ahlcon                  10.83     53.63        31.17       24.11     4.98     4%    -11%   0.66     17%       12%
Parenteral Drugs        88.27      -2.29       14.78     -139.91     1.51    32%    -36%   0.75      4%        2%
Claris                   7.24      7.24         6.07        6.07     1.90     7%    19%    0.38     16%       15%
Kilitch                  7.48      4.58         4.97        4.69     0.75     8%    -3%    0.63     13%       13%

Average                24.68      13.60       14.16       11.69     2.33     17%     0%    0.83     12%       12%

Industry Average         16.4     11.53        11.6         9.44    1.96     18%     9%    0.82     14%       15%

Venus                      3.98     3.28        3.91         4.06   0.96     19%     9%    0.79     19%       23%
*based on latest financial year, +excluding Parenteral Drugs




                         Venus Remedies is discounted lower compared to all its peers

Sharp valuation          Venus Remedies is valued at a sharp discount by the market
discount to both         compared to all of its peers. While Venus Remedies’ PE is ~3x FY12,
injectables and          industry average is hovering at 8-9x. Amongst the peer set listed
pharma peers             above, parenteral peers get similar valuation compared to pharma
                         companies, but within the parenteral set as well, Venus is getting a
                         low valuation.
                         On a ttm basis Venus Remedies trades at discount of 70%, with a PE
                         ratio of 3 compared to industry average of 10.63x. Venus Remedies’
                         EV/EBITDA is at discount of 43% and EV/Sales shows a discount of
                         38% with respect to industry average.




Four-S Research                                                                                     12
Company Report: Venus Remedies                                                                                                          4 Jun 2012



                                                  Valuation and Price Target

                                                  Scope for higher valuations

Business                                          In terms of business ratios, like growth rates, operating margins,
performance                                       balance sheet ratios, Venus is doing as well as its peers.
supports better
                                                  It is likely Venus’ valuations are still suffering from the resettlement
valuation
                                                  of FCCB redemptions in FY10. This FCCB was issued in 2006, and
                                                  given the bear phase the Indian markets were going through in
                                                  FY10, the prevailing share price was much lower than the market
                                                  price. Accordingly, investors wanted redemption. However,
                                                  ultimately both parties agreed for a settlement at a lower price.
                                                  Liquidity situation continues to remain reasonable. The company’s
                                                  current rating is BBB-, as awarded by ICRA in March 2012.
                                                  Another reason for the low valuation is the high R&D spends, some
                                                  of which is passed through the balance sheet. Investors may be
                                                  wanting to see more tangible results from the investment on R&D.

                                                  We believe this scenario may change going forward as the market
                                                  begins to see more results from Venus’s R&D pipeline. We also
                                                  expect bottom-line growth to robust over FY12-14, as the company
                                                  derives greater share of sales from high margin products. Any
                                                  significant deal on Sulbactomax can be a further driver of rerating.

                                                  Price Target

                                                                                                  3 year P/E band chart
400
 PE
350
                                                                                                                                                                                                            7x
300

250
                                                                                                                                                                                                            5x
200

150                                                                                                                                                                                                         3x

100

 50

  0
      1-Apr-09



                            1-Aug-09




                                                                        1-Apr-10



                                                                                              1-Aug-10




                                                                                                                                          1-Apr-11



                                                                                                                                                                1-Aug-11
                                                             1-Feb-10




                                                                                                                               1-Feb-11




                                                                                                                                                                                                 1-Feb-12
                                                  1-Dec-09




                                                                                                                    1-Dec-10




                                                                                                                                                                                      1-Dec-11
                 1-Jun-09



                                       1-Oct-09




                                                                                   1-Jun-10



                                                                                                         1-Oct-10




                                                                                                                                                     1-Jun-11



                                                                                                                                                                           1-Oct-11




                                                                          PE                                         PE                                           PE



Even if Venus                                     Venus is currently trading at around 3.3x FY12 eps and 2.6x
maintains                                         expected FY13 eps. This is below its historic trading range of the last
current ttm                                       3 years, and around the valuation at the depth of the 2009 bear


Four-S Research                                                                                                                                                                                                  13
Company Report: Venus Remedies                     4 Jun 2012

valuations,       market. These values are also much below peer levels. Similarly, its
Mar’13 price      EV/EBITDA for FY13 works out to 3.1x, which is much less than peer
could touch       levels.
around Rs 225
                  We expect Venus to rerate upwards as market realises the strides it
                  has made it its R&D portfolio. We expect Venus’s price to cross Rs
                  200 over a 12 month period, implying a rating of 3.3x expected FY13
                  earnings. This is an upside of 23% from current levels.




Four-S Research                                                                    14
Company Report: Venus Remedies                     4 Jun 2012

                  Venus Remedies’ Business

                  As we noted in the valuation section, the low valuation given to
                  Venus could partly derive from a lack of understanding of its
                  business model. Its research model is quite unique compared to
                  most Indian pharma companies.
                  Second, inventors might not be giving much weight to its research
                  capability, and assigning much value to its research pipeline.
                  All of the above could arise because while Venus Remedies’ focus on
                  R&D has resulted in significant investments, strong returns are yet to
                  flow in. As a result, the company has not come close to generating
                  free cash flows in recent years.
                  These issues are discussed in detail below.

                  A vision to break-out from me-too companies

R&D push from     Till year 2000, Venus Remedies was part of the cluttered generic
2006              injectables products segment. At the time, Venus Remedies was
                  involved in generics injectables only. Realising generic products
                  would have a limited scope in the future with patent regime coming
                  into place in India from 2005; Venus Remedies changed its strategy
                  and decided to focus on innovation to drive its growth.
                  Venus Remedies started investing in R&D from year 2001. In a short
                  time of 4 years, they filed for their first patent for Sulbactomax. The
                  R&D effort is beginning to show steady results since then.


                  Understanding Venus’ R&D

R&D spends        Venus Remedies is ranked 3rd among all Indian listed
above peer        pharmaceutical companies in terms of R&D spends as a share of
levels            revenues. It is ranked among the top 15 R&D spenders in absolute
                  terms.



                   Rank    Companies                            R&D Spend (FY11)
                     1     Dr Reddy’s Laboratories                            8464
                     2     Sun Pharmaceutical Inds.                           2860
                     3     Matrix Laboratories                                2820
                     4     Cadila Healthcare                                  2686
                     5     Cipla                                              2598
                     6     Biocon                                             1725
                     7     Ranbaxy Laboratories                               1670
                     8     Torrent Pharmaceuticals                            1527
                     9     Lupin                                              1268
                    10     Glenmark Pharmaceuticals                            983
                    11     Aurobindo Pharma                                    815


Four-S Research                                                                      15
Company Report: Venus Remedies                     4 Jun 2012

                    12      Panacea Biotec                                     772
                    13      Piramal Healthcare                                 716
                    14      Venus Remedies                                     696
                    15      Jupiter Bioscience                                 567
                  (Rs mn)




                   Rank      Companies                            % of revenue
                      1      Vivo Bio Tech                              49
                      2      Suven Life Sciences                        22
                      3      Venus Remedies                             19
                      4      Jupiter Bioscience                         17
                      5      KDL Biotech                                16
                             Sun Pharma Advanced Research
                      6      Company                                    14
                      7      Zenotech Laboratories                      12
                      8      Dr Reddys Laboratories                     11
                      9      Auromed                                    11

                  Venus Remedies has invested more than Rs 1.5bn in the last 3
                  years, which is around 16.5% of its revenue in this period. For last
                  three years, all the capex is done is also mainly in R&D, up-gradation
                  and modernisation.

                  R&D capability of Venus Remedies

A multi-pronged   The Company has proven its R&D capability with the gradual
approach          increase of revenue from the research products and 80+ patents in
                  hand from over 51 countries. Venus has, in all, 11 testing labs
                  working together to develop first-of-its kind product through highly
                  sophisticated technology. It has developed 13 research products in
                  short span of 9-10 years. At any time, R&D has a pipeline of 20+
                  products. On average, the Company comes out with 1-2 new
                  developed products every year.
                  In FY10, Venus Remedies launched Mebatic, an infusion therapy and
                  Ampucare, a wound healing therapy, a first of its kind product in
                  India. In FY12 Venus Remedies launched Achnil, a once-a-day
                  painkiller.
                  Venus has a well developed R&D centre with high tech capabilities at
                  par with stringent cGLP standards. Its R&D centre has a strong 60
                  member scientist team; 70% of them are PhDs and post graduates.
In licensed       The Company also benefits from in-licensing alliances with various
tumour            innovative companies and university. It has in-licensed solid tumour
detection         detection technology for early detection from University of Illinois.
technology from   Such alliances have enhanced company’s R&D capabilities and have
University of     helped to improvise its R&D process.
Illinois
                  As of now, Venus is preparing to file more than 100 CTDs and ACTDs


Four-S Research                                                                      16
Company Report: Venus Remedies                                             4 Jun 2012

                  each in the coming 3 years to take its present count of 600 ACTDs to
                  700 and 108 CTDs to 200 by 2015.

                  Key Research areas

Nano-tech         Novel Drug Delivery System (NDDS): Venus has achieved success in
based sustained   development of nanotechnology-based, sustained release and
release           targeted delivery formulations with NDDS. This has resulted in
formulations      developing formulations with reduced adverse drug reaction and side
                  effects in therapeutics    areas of oncology, NSAID, neuroscience,
                  arthritic disorders, stress and lifestyle-related diseases, immune
                  chemistry, infectious diseases and wound healing. NDDS is advance
                  drug delivery system which improves drug potency, control
                  drug release to give a sustained therapeutic effect and provide
                  greater safety. It is used to target a drug specifically to a desired
                  tissue.

Non-infringing    Formulation Development: Venus is building its IP through
formulations      developing non-infringing formulations. Company is developing
                  various formulations to revitalise established brands, fill product
                  pipeline gaps and enhance patient compliance. With the help of
                  strong regulatory team, Venus has managed to gain early mover
                  advantage in many leading generic markets.

                  Research Capabilities:




                                                         Process
                                                       developme
                                                          nt and
                                                       technology
                                                         transfer
                                                                                 Analytical
                                 Clinical
                                                                                  research
                                 research
                                                                                  division
                                 services
                                                                                   (ARD)




                                                        Research
                                                       Capabilities
                            Office of                                                 Chemical
                            research                                                     and
                            support                                                   stability
                             (ORS)                                                     testing




                                                                        Pre-
                                            Natural
                                                                      clinical
                                            product
                                                                      division
                                            research
                                                                       (PCD)




                  Process development and technology transfer: Ability to
                  transfer technology from laboratory to pilot and to manufacturing
                  scale. This is vital in technology transfer required to scale a

Four-S Research                                                                                          17
Company Report: Venus Remedies                      4 Jun 2012

                  successful molecule and technology transfer in out-licensing deals.
                  Analytical research division: Capable in developing novel
                  formulations, analytical development and drug design support.
                  Chemical and stability testing division: Capability to perform
                  stability tests as per ICH guidelines provides analytical services to
                  research dept and meets international quality and regulatory
                  standards.
                  Pre-clinical division: Performs pre-clinical trials and oxicological
                  studies under GLP environment.
                  Natural product research: screens natural products and drug
                  development as per pharmacopial and medicine standards.
                  Office of research support: Bridges the gap between research
                  and marketing through interactions with the field force, training
                  marketing teams, addressing queries raised by the PMT team and
                  designing experiments for research value-addition.
                  Clinical research services: Division involved in Phase-I, II, III, IV
                  and BA/ BE clinical studies monitoring, as per GCP, for its research
                  products to accelerated the delivery of safe and effective
                  therapeutics.



                  Key Initiatives in R&D

                  Cell Culture Molecular Biology (CCMB) laboratory

Working on a      Venus has setup CCMB laboratory in affiliation with some other
novel cancer      pharma companies to fasten the cancer drugs testing. The company
treatment         has 4-5 such products which are expected launched in next 4-5
                  years. Company is also working on novel cancer drug for target-
                  specific treatment (90% of the drug will go to the affected area
                  against the present 10%). This will reduce the side effects of these
                  drugs and also brings down the costs.

                  Tie-ups with renowned research institutes

A typhoid         Company has tie-ups with IMTECH, a renowned research center of
testing kit       CSIR and Punjab University. Through this alliance, company is
through a         developing a typhoid diagnostic kit. This kit will reduce detection
research tie-up   time from 48 hrs to few minutes. Company has the authorisation to
                  market this kit worldwide.

                  Products conforming to ASEAN CTD

                  Venus has upgraded its entire product pipeline of 75 products to
                  ASEAN CTD preparing the entire portfolio for international.




Four-S Research                                                                     18
Company Report: Venus Remedies                       4 Jun 2012

                  Capitalising the IP

Seeking out       Venus Remedies understands that it is not easy to capitalise the IP
licensing deals   wealth they are creating in the huge global market. So to maximise
to monetise IP    the potential of this IP development, it has a clear strategy in place.
                  Venus Remedies has appointed a leading consulting firm to seek tie-
                  ups with international pharma companies for Sulbactomax.

                  Venus Remedies plans to out-license the patented products to multi-
                  national and regional companies with specific geographical interest
                  considered. This will help Venus Remedies to garner the benefits
                  from market across the globe without having to invest in market
                  development.
                  Venus Remedies has already closed an out-licensing alliance with a
                  major South-Korean Pharma company for Sulbactomax. For FY12,
                  Venus Remedies expects to get 25% of its revenue from its own
                  research products.

                  Venus Remedies’ Manufacturing excellence

                  Among   global        leaders    in    fixed    dosage     injectable
                  manufacturing

                  Venus Remedies is among world’s top 10 injectable manufacturers
                  and has the largest super specialty injectable manufacturing capacity
                  in Asia. Venus has strong presence in relatively uncluttered,
                  specialised, higher margin fixed dosage injectable space. Global
                  injectable market is pegged at US$200bn in 2010 with generic
                  market contributing US$20bn of it.
                  There are limited numbers of players in the injectable space and high
                  investment is required in setting up the complex plants. This will
                  keep margins in this segment high with lesser competition to face in
                  the market.

                  Prominent Products

15% of FY11       Sulbactomax: It is the top product in Venus Remedies kitty with
revenue           15% revenue contribution in FY12. The company holds patents for
                  Sulbactomax in South Africa, India, 37 countries of the European
                  Union, Russia, Ukraine, Mexico, Australia and New Zealand while
                  patent is still awaited in six countries including US and Brazil.
                  Sulbactomax is the only product in its category to prevent bacterial
                  resistance. Sulbactomax is a formulation of ceftriaxone and
                  sulbactam with VRP1034. The global injectable antibiotic market is
                  US$200bn of which Ceftriaxone alone accounts around US$1.2bn.
                  Sulbactomax aims to target a significant share of this market
                  because of the growing bacterial resistance. Venus is currently
                  marketing this product in India and seven other countries.

                  Potentox: It is ranked second in Venus Remedies with respect to


Four-S Research                                                                      19
Company Report: Venus Remedies                       4 Jun 2012

                  revenue contribution (4.6% in FY12). Company has patents in South
                  Africa, New Zealand, South Korea, Australia, Ukraine and India.
4.2% of FY11
                  Patents awaited from 44 other countries including EU and US.
revenue
                  Potentox, a research-based super-specialty product is used for
                  treating hospital and community acquired pneumonia and febrile
                  neutropenia. It reduces pneumonia treatment time from 21-30 days
                  to 7-10 days and reduces drug and disease-induced toxicities. This is
                  the only solution to growing flouroquinolene and aminoglycoside
                  resistance.

3% of FY11        Vancoplus: It is third biggest product of Venus with 3% of revenue
revenue           in FY11. The company holds patent in US, Japan, Australia, South
                  Africa, New Zealand and Ukraine. Patents awaited from 44 other
                  countries including EU and Brazil.
                  It is the only remedy after vaccination to treat superbug like MSRA,
                  VRSA, VRE and multi-drug-resistant microbes causing meningitis.
                  The product effectively stops the spread of resistance by preventing
                  bacterial conjugation.

2% of FY11        Tobracef: Tobracef contributed 2% of revenue in FY11. It’s a
revenue           research-based anti-infective product catering to Pseudomonal
                  infections caused in Cystic Fibrosis and HAP with patents in South
                  Africa and patents awaited from other countries. Once company get
                  patents and authorisation in major regulated market, this could also
                  turn out to be major blockbuster project for Venus Remedies.

                  Neurotol: Neurotol is an innovative product which contains mannitol
                  and glycerine. Neurotol is used in the management of raised
                  intracranial pressure and brain oedema associated with cerebral
                  infraction, intracerebral hemorrhage, head injury, subdural
                  hematoma, brain tumour, encephalitis and toxemia. Neurotol is
                  widely accepted by medical fraternity like neurosurgeons and
                  neurophysicians. The synergy of mannitol and glycerin in Neurotol
                  prevents the chances of rebound oedema. Mannitol is known to
                  provide immediate effect while glycerin is helpful for sustained
                  effect. Venus is the first company to introduce this product. Neurotol
                  offers improved patient compliance with no side-effects when
                  compared with plain generic mannitol.

                  Achnil: Achnil is an NDDS based controlled and sustained release
                  NSAID      (non steroidal anti-inflammatory drug) injection. It is the
Launched in
FY11              world’s first once-a-day pain killer injection which replaces the three
                  injections per day therapy. It has already got patent application in
                  EU and India while patent in US in under process. Achnil was
                  launched in FY11 in the domestic market. The product prevents post
                  surgical adhesion and has high levels of safety.



                          Venus Research Product portfolio


Four-S Research                                                                      20
Company Report: Venus Remedies                                    4 Jun 2012

   Products       Therapy                                                                  Nature

   Sulbactomax    Caters to ESBL, NMD-1, Penem Resistance                                  Injection
   Vancoplus      Caters to MRSA, VRSA & VRE                                               Injection
   Potentox       Caters to HAP, Febrile Neutropenia                                       Injection
   Tobracef       Developed for Cystic fibrosis                                            Injection
   Zydotum        For Pseudomonas Infections In Burns                                      Injection
   Supime         Intra-abdominal infections caused by various pathogens and post-         Injection
                  operative infections
   Pirotum        Treatment of peritonitis and complicated intra-abdominal infections,     Injection
                  pirotum is indicated. continuous ambulatory pulmonary dialysis,
                  management of lower respiratory tract infections and febrile
                  neutropenia
   Neurotol       For raised intracranial pressure and brain oedema associated with        Infusion
                  cerebral infraction, intracerebral hemorrhage, head injury, subdural
                  hematoma, brain tumour, encephalitis and toxemia.
   Mebatic        For pre and post surgical procedures, pelvic infections, urinary tract   Infusion
                  infections, urogenital tract infections, typhoid and prevention of ICU
                  infections due to anaerobes.




                   AMR compatible research products

AMR has rapidly    Antibiotic Resistance is spreading faster than expected throughout
emerged as a       world and the poor R&D pipeline for new antibiotics is further adding
big global         up this menace. Recently, World Health Organisation (WHO) has also
health threat      taken this issue with vigour by making this as main theme for World
                   Health Day. According to WHO, AMR results in prolonged illness and
                   greater risk of death. AMR not only increase overall health cost bur
                   WHO feels world may end up in pre anti-biotic era.
                   AMR has become serious problem for treatment for many major
                   diseases like HIV, tuberculosis, malaria, gonorrhoea and many more.
                   Risk factor involved in the infectious diseases has grown much more
                   than it even existed and if it would keep on growing at the same
                   pace, the world will soon reach the pre-antibiotic era again.
                   The situation has deteriorated to an extent that even a mild infection
                   can be deadly in today's world. The rising misuse and under usage
                   has made the life saving antibiotics ineffective against the microbes.
                   Reports say that US households lost approximately US$35bn in 2000
                   to antibiotic resistant infections including lost wages, extended
                   hospital stays and premature deaths. The annual cost to the US
                   health care system of antibiotic resistant infections is US$21bn to
                   US$34bn and more than 8mn additional hospital days.

                   In 29 countries of European union, an estimated 25,000 people die
                   every year because of the infections related to antibiotics resistance.
                   The medical cost per patient suffering from an antibiotic resistance
                   (ABR) infections ranges from US$18,588 to US$ 29,069. According
                   to the BCC Research report, the global market for infectious disease
                   treatments was valued at $90.4 billion in 2009. This market is
                   expected to increase at a compound annual growth rate (CAGR) of

Four-S Research                                                                                        21
Company Report: Venus Remedies                                      4 Jun 2012

                      8.8% to reach US$138bn in 2014. The antibiotics market generated
                      sales of US$42bn in 2009 globally, representing 46 percent of sales
                      of anti-infective agents (which also include antiviral drugs and
                      vaccines) and five percent of the global pharma market.

                      Inception of new antibiotics is getting difficult because of the present
                      drug development scenario which is fraught with financial,
                      regulatory, ethical and scientific bottlenecks. Due to huge investment
                      in R&D and less output (financially) out of the product dejects the
                      pharmaceutical companies to invest in it.

                      Today, Venus Remedies is one of the few R&D led companies to have
                      innovated and developed a comprehensive range of novel antibiotic
                      combinations which not just provide relief from the aggravated
                      problem of antibiotic resistance but also are cost-effective and have
                      reduced side effects. All products which came out of Venus research
                      efforts do cater to antimicrobial resistance.

Products       Category                  Dose                                    Indications

Sulbactomax   Antibiotic   Once daily IM/ IV injection in        Infections caused by ESBL resistant
                           mild to moderate infections and       pathogens:
                           twice daily in severe infections         Lower respiratory tract infection
                                                                    Urinary tract infection
                                                                    Skin infections
                                                                    Surgical prophylaxis
                                                                    Bone and Joint infections
                                                                    Acute bacterial septicemia
                                                                    Acute Otitis media


Potentox      Antibiotic   Twice Daily                           Multi-drug resistance of:
                                                                  Nosocomial Pneumonia
                                                                  Febrile Neutropenia
                                                                  Other severe hospital acquired
                                                                   infections

Vancoplus     Antibiotic   Twice Daily IV injection in mild to   Infections caused by resistant pathogens
                           moderate infections and thrice        such as MRSA:
                           daily in severe infections.            Meningitis
                                                                  Septicemia
                                                                  Skin and skin structure infections
                                                                  Bone and joint infections
                                                                  Post operative infections



Tobracef      Antibiotic   Twice Daily injection                 Acute pulmonary exacerbations due to:
                                                                  Cystis fibrosis
                                                                  Pneumonia
                                                                  COPD




                      Presence in highly specialised generics

                      Within generics, which were around 75% of revenue in FY11, Venus
                      has shifted focus to high margin products. Currently, Venus sells
                      around 75+ products, with around 20+ products under development


Four-S Research                                                                                          22
Company Report: Venus Remedies                         4 Jun 2012

                  phase at any point of time.

Carbapenams, a    Meropenem is one such generic product (carbapenem injection).
key part of       Venus Remedies has received market authorisation for Meropenem
generics folio    in EU. This represents a €150mn market opportunity, putting Venus
                  among the top 3 EU-GMP manufacturers globally of carbapenem
                  antibiotics.
                  The Company has also received market authorisation for
                  Imipenem+Cilastatin, Docitaxel and Irinotecan in the European
                  Union. Similarly Venus also has market authorisation in for
                  Gemcitabine for U.K., Germany, Poland Slovania, Portugal and
                  Macedonia.
                  Venus also has strong presence in oncology segment with 21
Oncology          injectables in its portfolio. Oncology segment contributed more than
generics are      30% to FY11 revenues, with extremely good margins. These are
about 29% of      much specialised products and high technology is required in
revenue           manufacturing these products.
                  A key oncology product for Venus Remedies is Gemcitabine, for
                  which it has marketing authorisation for in EU and UK. Gemcitabine
                  is established as a gold standard therapy in treating pancreatic
                  cancer.
                  Venus understands the importance of this highly specialised, high
                  technology, high margin oncology business. Hence, the Company has
                  setup a dedicated sub-business unit for oncology business covering
                  almost all cancer types just to further strengthen the focus on it.
                  Oncology segment is likely to remain high growth has patents of
                  oncology injectables, currently worth US$8.3bn, are set to expire by
                  FY2015.

                  Products kitty

                  As can be seen, Venus has a strong kitty of 8 R&D products
                  marketed in 12 nations. In the high margin oncology segment, it has
                  19 products with presence in 23 nations. Carbapenem and
                  Cephalosporin has 20 products, with Carbapenem products sold in 23
                  nations.
                   Category                  No. of products                  Presence
                   R&D products              8 products                       12 nations
                   Oncology liquid           10 products (in various dosage   19 nations
                                             forms)
                   Oncology lyphilised       9 products                       23 nations
                   Carbapenem                3 products                       23 nations
                   Cephalosporin and other   17 products                      18 nations
                   injectables
                   PFS and infusions         5 products                       11 nations




Four-S Research                                                                            23
Company Report: Venus Remedies                     4 Jun 2012

                  Bigger the pipeline, greater the in-flow in future

                  Venus Remedies has strong R&D product pipeline as of now with
                  more than 10 products at various stages of research. This comprises
                  of products from therapeutic segments such as oncology, anti-
                  infection and neuro.
Typhoid and       Some of the products close to commercialisation include a Typhoid
tumour            detection kit. With 17mn patients every year for typhoid, this
detection kits    detection kit has the potential to be a key revenue generator for
part of IP        Venus Remedies in future. The kit reduces the time taken for a
pipeline          typhoid test sharply, from 48 hours to few minutes.
                  Similarly Venus has Tumatrek, an early tumour detection test in
                  phase III and DPPC, a novel triple conjugate for targeted delivery of
                  anticancer drug in preclinical phase. Venus also has products on
                  oral, breast and ovarian cancer under pre-clinical tests.
                  This strong pipeline creates strong prospects for Venus Remedies to
                  drive the growth with its research products.

                  Accolades & Awards showcasing research efforts

                  Venus has received number of awards and accolades in last few
                  years affirming the efforts and path chosen by the company. Venus
                  has won awards for its research products and patents filed by
                  company and as emerging company & manufacturing excellence.
                  List of awards won by Venus Remedies:
                   BioSpectrum Product of the Year 2012 award for its novel research
                    product 'ACHNIL', a once-a-day painkiller.
                   Gold Patent award 2011 for the novel research drugs presented by
                    Pharmexcil.
                   The Bizz- Business Excellence Award 2011 received in US.
                   'Silver Certificate of Merit' in the Economic Times' India
                    Manufacturing Excellence Awards (IMEA), 2011 held in Mumbai.
                   'Emerging Company of the Year 2011' award in the 4th annual
                    Pharmaceutical Leadership Summit & Award 2011.
                   Best SMB Award 2008
                   Emerging India Award 2007 presented by Dr. Manmohan Singh
                    Prime Minister of India.
                   Ampucare Gold Medal 2010      'India Innovation Program- 2010'
                    organized by Lockheed Martin (USA), FICCI and DST (India)‫‏‬   .
                   Trois: Gold Medal 2011    'India Innovation Programme - 2011'
                    organized by Lockheed Martin (USA), FICCI.
                   Quality Award 2011 in Gold category from BID International
                    convention at Geneva.
                   2011 Spotlight award for the Annual Report in the LACP's (League
                    of American Communications Professionals) Global Communication
                    Competition In Bronze category in San Diego, USA.


                  Marketing & Distribution




Four-S Research                                                                    24
Company Report: Venus Remedies                       4 Jun 2012

Pan India         Venus has established a pan-India marketing presence covering 24
distribution      States and two Union Territories, supported by over 700 marketing
reach             professionals.
                  Venus Remedies has reach of 2,000 stockists and 40 distributors
                  across India for the domestic market. These help target over 40,000
                  Pharmacies and 120,000 medical practitioners. The company has
                  strong emphasis is on developing network of medical practitioners in
                  critical care segment to address their specialised product market.

                  Marketing Alliances to expand the reach

Enhanced by       To improve the reach within the domestic market, Venus Remedies
tie-ups with      has entered into tie-ups with many renowned Indian Pharma
other pharma      companies like Abbot, IPCA, Glenmark, Lupin, Elder, etc. To target
companies         the international markets in a better way, Venus Remedies has 11
                  overseas offices to cover 60 countries. Venus Remedies sells 44
                  products internationally with 3 research products launched till now.
                  Similar to its domestic market strategy, Venus Remedies has made
                  20+ international alliances for its international market.

                  Global Presence

Direct overseas   To capitalise on its IP pipeline, Venus Remedies has developed multi-
presence in 11    regional presence across the globe. Venus has setup 11 overseas
countries         marketing offices covering 60 countries up from 19 countries in
                  FY08. The 22 member team promotes 52 products across the globe.
                  It has export presence in 25 countries with the help of these offices.

                  World Class manufacturing capacities

3 manufacturing   Venus Remedies has state of the art manufacturing facilities with the
plants, 2 in      latest technology. The company has invested more than Rs 2bn for a
India, one in     100mn units injectable manufacturing facility at its unit in Baddi,
Germany           Himachal Pradesh. This has resulted in more than 20 international
                  GMP certifications from more than 50 countries. This facility
                  manufactures in all 75+ super specialty products.
                  In all, Venus Remedies has 3 manufacturing locations: Baddi,
                  Panchkula (India) and one in Germany. All are with EU-GMP and
                  WHO-GMP certification along with other certifications.
                  Its Panchkula site has 7.5mn units capacity for large volume
                  parenterals accredited with WHO-GMP. Products manufactured at
                  this facility include Mebatic, Calridol, Moximicin, Neurotol, Glutapep,
                  among others.
                  The Baddi campus has eight small volume parenteral facilities. It
                  manufactures oncology injections, oncology lyophilised, lyophilised
                  injections, pre-filled syringes and cephalosphorins. It has been
                  accredited with more than 20GMPs. Recently; its Baddi plant has
                  received GCC certification for oncology and carbepenem products,
                  the first in India.


Four-S Research                                                                      25
Company Report: Venus Remedies                     4 Jun 2012

                  Venus Pharma GmbH (Germany)

                  With the goal in mind to be a true global Pharma company, Venus
                  acquired the German Pharma company in 2006. It’s strategically
                  located in the second largest Pharma market and largest in Europe,
                  Germany. This acts as an entry vehicle for Venus Remedies products
                  in European market.
                  Venus Pharma GmbH helps Venus Remedies to generate export
                  orders for its products, executes site transfer projects and supports
                  in CTDs filing.

                  Revenue distribution

Dry powder and    Venus Remedies has a strong existence in dry powder segment
oncology are      constituting 33% of revenue in FY11. Cehpalosporin and penem
the two key       products constitute this dry powder segment. Venus Remedies has
segments          strong presence in this segment in both generic products and also in
                  research products. With multiple countries GMP certification for its
                  manufacturing plant, the export market may grow at very good rate
                  for this segment.

                                         Revenue Distribution




                                 24%                                   Anti-cancer
                                                   31%
                                                                       Cephalosporin (Inc
                                                                       Carbapenem)
                                                                       Infusions
                              12%
                                                                       SVP & Others


                                            33%




                  With many products still new in the market and in the process of
                  developing its market, high growth in all the segments especially in
                  oncology, dry powder is very much visible in the coming few years




Four-S Research                                                                       26
Company Report: Venus Remedies                                     4 Jun 2012

                  Focus on higher margin products



                                                         Dry Powder Revenues

                                 1,350                                                              60%

                                 1,300                                                              50%
                                 1,250
                                                                                                    40%
                                 1,200
                                                                                                    30%
                    INR mn




                                 1,150
                                                                                                    20%
                                 1,100

                                 1,050                                                              10%

                                 1,000                                                              0%
                                                FY08     FY09         FY10    FY11      FY12E


                                                         Dry Powder           % of Total Revenues


Dry power share   In line with focus on high margin products, share of revenue of dry
coming down       powder products is coming down.



                  Increasing higher margin oncology segment



                                                         Oncology biz growth
                   1,400                                                                                 35%
                                                 Oncology Segment       % of Revenue
                   1,200                                                                                 30%

                   1,000                                                                                 25%

                      800                                                                                20%

                      600                                                                                15%

                      400                                                                                10%

                      200                                                                                5%

                             0                                                                           0%
                                         FY08          FY09         FY10       FY11        FY12E


Oncology is a     Oncology segment contributes almost 31% of overall revenue of
focus segment     Venus Remedies. Due to complex products, critical nature and
for Venus         sophisticated technology involved in this segment, margins are
                  better here.
                  Venus Remedies has successfully managed to improve oncology
                  contribution. Oncology segment has grown CAGR of 30% in last 4
                  years. With more than 300 market authorisations from 25 countries,

Four-S Research                                                                                               27
Company Report: Venus Remedies                    4 Jun 2012

                  the company should be able to maintain this thrust.



                  Risk Factors

                  Venus Remedies has the policy of capitalising major portion of its
                  R&D expenditure. In FY11, Venus Remedies capitalised Rs 557mn of
                  R&D expenditure out of its Rs 686mn R&D expenditure. R&D
                  expenditure capitalisation is not new for pharma companies as most
                  of Indian pharma companies do capitalise part of their R&D
                  expenditure. Yet amount of R&D expenditure capitalised is much
                  higher compared to many other major pharma companies.
                  The Company attributes this to expenditure on research which is yet
                  to be commercialised; around 360 patent applications are still
                  pending. The Company is capitalising expenditure on R&D, IPR, CTD
                  /ACTD and other product registration expenses, R&D activities like
                  clinical trials, process development & technology transfer, in
                  licensing and formulation development from in-licensed technology,
                  expenses on analytical & chemical research on products under
                  commercialization, etc.
                  This R&D expenditure capitalisation is also reflected in cash flow.
                  Though Venus has good positive operation cash flow, company is
                  suffering from negative free cash flow.




Four-S Research                                                                   28
Company Report: Venus Remedies                          4 Jun 2012



                  Financial Analysis and Growth Outlook

                  15% CAGR for revenue expected during FY’12-14

                  The Company’s net revenues have grown at a CAGR of 18% over
                  FY’08-’12E (for FY12 only stand alone results declared so far,
                  consolidated are our estimates) to Rs 4.78bn from Rs 2.15bn in FY08.



                                           Revenue Growth
                    4,500

                    4,000
4 year revenue      3,500
CAGR is 18%, 3
                    3,000
year growth is
12%                 2,500

                    2,000

                    1,500

                    1,000

                     500

                      -
                              FY'08      FY'09        FY'10            FY'11      FY'12E


                                                                                     (Rs mn)

                  The top line of Venus is expected to grow at CAGR of 15% over FY11-
                  14.

                                       Revenue Growth Expected
                   6,000
Growth to be       5,500
driven by newly
                   5,000
launched
products and       4,500
expansion in       4,000
regional
                   3,500
presence
                   3,000

                   2,500

                   2,000

                   1,500
                               FY'11         FY'12E           FY'13E            FY'14E




Four-S Research                                                                            29
Company report  venus remedies ltd
Company report  venus remedies ltd
Company report  venus remedies ltd
Company report  venus remedies ltd
Company report  venus remedies ltd
Company report  venus remedies ltd
Company report  venus remedies ltd

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Company report venus remedies ltd

  • 1. C O M P A N Y R E P O R T India 4 Jun 2012 Venus Remedies Rs 166.1 Sector: Pharma Building a unique formulation BSE Code 526953 NSE Code VENUSREM Venus Remedies (Venus), a high-growth mid-sized CMP (Jun 1) 166.1 52W H/L 276/141 pharma company in the injectables space, has two key Nifty 4,842 Sensex 15965 differentiators: presence in high value therapeutic Equity Cap (m) 2,369 Face Value 10 Shares (m) 9.74 Free Float 65.29% segments and a strong research focus. This has allowed Market Cap (m) 1,618 Avg Vol 9,514 the company to maintain robust revenue CAGR of (weekly) around 18% over last 4 years, at healthy operating Rs margins. The company’s growth rates and margins could get a boost as its growing repository of research Shareholding Pattern (March 31, products and patents comes into play. 2012) In highly attractive injectables segment Promoter FII Venus is among top 10 players globally in combination 14% 35% drugs space. This is a high margin space within injectables. DII Venus has further focussed on highly specialised products 0% within this space, helping it maintain high profitability and robust top-line growth. Others Bodies 32% Concentrated focus on IP development Corporate 19% The Company has maintained high focus on IP development. Its R&D spends reached a high of 19% of its revenue for FY11, growing from a level of 5% in FY07. The company expects to maintain spends in double digits. This puts Venus Remedies among top 5 pharma companies in Price Performance (Last 6 months) R&D investment as ‘% of sales’ and top 15 by total amount. Venus Remedies Nifty The Company has developed many path breaking products 200.00 such as Sulbactomax, a novel combination product with 190.00 market potential of US$400mn in India, and patents in 180.00 more than 42 countries including EU and Australia. Venus is 170.00 currently exploring out licensing deals for Sulbactomax for 160.00 global markets and has hired a leading global consulting 150.00 firm for the same. 140.00 Antimicrobial Resistance: A winning strategy 30-Dec 30-Jan 29-Feb 31-Mar 30-Apr 31-May Venus correctly identified anti-microbial resistance (AMR) as its core area for R&D efforts around 10 years ago. AMR Consolidated Financials has emerged as the biggest threat to global health in recent years, so much that even WHO has proposed a FY'11 FY'12E FY'13E FY'14E global strategy to fight AMR. Venus Remedies’ entire Sales 3,631 4,196 4,788 5,546 antibiotic research product chain caters to the AMR EBITDA 892 1,022 1,186 1,395 segment including Sulbactomax, Vancoplus, Potentox and PAT 462 493 610 755 Tobracef. EBITDA margin(%) 24.57 24.35 24.78 25.14 Net margin(%) Low Valuations 12.73 11.74 12.75 13.62 ROE(%) 22.65 18.07 18.01 18.56 At current price, Venus Remedies quotes at around 3.3x ROCE(%) 19.11 16.28 16.37 17.39 FY12 and around 2.6x FY13e earnings, below peer P/E Ratio(x) 3.99 3.28 2.65 2.14 averages. These are values below its historical trading EV/EBITDA(x) range. We expect Venus’s price to cross Rs 200 over a 12 4.12 3.60 3.10 2.64 EPS (Rs) 50.63 month period. Any big out licensing deal will give further 50.56 62.65 77.55 Rs mn upside. This is an upside of 23% from current levels. Four-s reports are available on BLOOMBERG, Reuters, Thomson Publishers and Market Publishers
  • 2. Company Report: Venus Remedies 4 Jun 2012 Investment Rationale A top player in the attractive injectables space Venus is among top 10 players globally in combination drugs space with the biggest capacity in Asia in manufacturing for injectables. The US$200bn injectable market is higher on margins and faces lower pricing pressure compared to oral pharmaceuticals. A consistent focus on injectables, the highest end of the formulation value chain marked by stringent manufacturing standards, demanding quality parameters and low competition (only 1% of India’s over 10,000 pharmaceutical companies produce injectables) gives Venus a better ability to deliver higher margins. High growth segments Focussed on Venus Remedies has focused on high growth segments like anti- high growth, infective (33% of revenue) and oncology (30.7%) which are high margin considered to be the fastest growing segments and expected to segments within contribute 50 to 60% of product launches globally by 2015. injectables With changing demography and overall changes in lifestyle, anti- infective, oncology, cardiovascular and neurology segments are expected to benefit the most in the coming years, not only in India but globally. Venus has been investing strongly in R&D for all of these segments which will sooner than later start benefiting the company. Venus has already launched products in segments like anti-biotic, oncology, and neurology in last few years. Maintains high margin with highly specialised products Venus Remedies’ reported operating margins are better than the peer set, reflecting its focus on high margin segments within injectables. The company has margins better than all peers except Claris. The reason behind this is Venus Remedies’ conscious strategy to move away from its me-too products to enter high margin specialised segment with the backing of strong R&D process. Better profitability supporting the growth FY11 Margin (%) TTM Margin (%) Company EBIDTA PAT EBIDTA PAT Mid-Cap Peers Ajanta Pharma 19% 10% 21% 12% Indoco 13% 11% 14% 9% Four-S Research 2
  • 3. Company Report: Venus Remedies 4 Jun 2012 Natco Pharma 19% 12% 23% 12% Nectar 20% 9% 18% 6% Parabolic Drugs 15% 8% 18% 6% Average 17% 10% 19% 9% Injectable Peers Strides Arcolab 21% 7% 21% 32% Ahlcon 16% 6% 16% 7% Parenteral Drugs 10% 1% -2% -20% Claris 31% 19% 32% 17% Kilitch 15% 7% 17% 9% Average 19% 8% 17% 9% Industry Average 18% 9% 18% 9% Venus 25% 13% 22% 13% (Source: Ace Equity, company reports) Profitability set to improve The company is confident that it can improve margins going forward. The key reason behind this is the high revenue flow expected from out-licensing of the already developed technology. This revenue will add to the top-line without putting much strain on cost side of the company’s profit and loss sheet. Creating significant opportunities through R&D Focus on formulation R&D products to beat me-too generic products competition Venus has evolved an innovative approach to its R&D investments to overcome competition in generic drugs. Its R&D is focussed on creating new drug candidates through formulation focused research, where it aims to combine two or more already patented APIs into a Research new formulation or a dosage form. Venus aims to make formulations pipeline based that are more effective than alternatives available in the market. It on novel aims to offer a therapeutic advantage and differ from me-too generic formulations products. This strategy offers a low-risk, low-cost alternative to the traditional pharmaceutical development of new medicines, due to their shorter development timeline. New Chemical Entities (NCEs) take a long time to develop, often at a cost of over US$1bn. Conversely, the development of new therapies through Venus’ method is cheaper and less time consuming, as it has a known mechanism of action and an established safety and efficacy profile. This offers products a less complex clinical development process. It also has a simpler pathway to patent approval that can potentially save pharmaceutical sponsors both time and money. Four-S Research 3
  • 4. Company Report: Venus Remedies 4 Jun 2012 Some of its key products like Sulbactomax and Vancoplus are novel formulations of previously approved APIs. Concentrating on future epidemic : Anti-Microbial Resistance Venus has maintained strong focus on Antimicrobial resistance (AMR) while developing research products. Antimicrobial resistance (AMR) is the resistance of a microorganism to an antimicrobial medicine to which it was previously sensitive. These resistant organisms are able to withstand attack by antimicrobial medicines, such as antibiotics, antivirals, and antimalarials, so that standard treatments become ineffective and infections persist and may spread to others. Infections caused by resistant microorganisms often fail to respond to the standard treatment, resulting in prolonged illness and greater risk of death. Once resistance evolves, it can spread very rapidly across borders and around the world. This drug resistance threatens to erase gains made in disease treatment and control in developing countries. Venus Remedies is one of the few R&D led companies which has innovated and developed a comprehensive range of novel antibiotic combinations which not just provide relief from the aggravated problem of antibiotic resistance but also are cost-effective and have reduced side effects. The Company could foresee the potential of antibiotics fading 10 years back and it is the result of its focused approach that today it has some SUPER BUG tackling solutions under patent protection. The entire antibiotic research products of Venus like Vancoplus, Sulbactomax, Potentox, Tobracef and many more cater to the Antimicrobial Resistance segment. Sulbactomax – a key growth driver The biggest product from Venus’s R&D initiative is Sulbactomax, an anti-infective product, used to combat beta-lactamase generated Sulbactomax, a drug resistance, the only product in its category to prevent growth likely winner and spread of bacterial resistance. Sulbactomax is a combination of Ceftriaxone and Sulbactam with VRP1034. Venus’s tests show that Sulbactomax is much more effective than all the existing third generation cephalosporins and their combinations. Research pipeline robust, several launches ahead Research Besides Sulbactomax, Venus’s R&D has come up with several new launches unique formulations like Vancoplus, Potentox, and Tobracef. beginning to hit Achnil, launched in FY11, is a revolutionary once-a-day pain killer, the market given Product of the Year award by Biospectrum Asia for its uniqueness in addressing critical health conditions. Four-S Research 4
  • 5. Company Report: Venus Remedies 4 Jun 2012 Many new products like Tumatrek, Trois and Stermex were lauched in FY12 and many more to be launched in coming years. These new products are estimated to generate revenue of 5-10% for the company in the next 2-3 years. Venus Remedies is coming up with constant flow of research products mainly due to its well thought out R&D process which looks for novel solutions that fill the vast gap between challenging ailments and available molecules. Aims to create Sizeable IP wealth by 2015 Venus now has 80+ global patents out of more than 360+ filed for its 13 research products. There is a clear indication that the company has created strong traction in R&D as well as Global presence. Rightly positioned to capitalise IP wealth Licensing Sulbactomax itself is patented in 42 countries including the EU discussions on countries; patents are awaited from 8 more countries including US for Sulbactomax and Japan. Sulbactomax has US$400mn market in India itself, according to Venus. Global potential is indicated by third generation cephalosporins and carbapenems, a close substitute, which have market of around US$2bn globally. Venus Remedies has already out- licensed Sulbactomax successfully to a South Korean pharma company to monetise the South Korean US$585mn market. In a similar way, Venus Remedies is looking to capitalise its IP wealth from its range of research products by striking deals with global pharma companies for specific geographies. Venus Remedies has already shortlisted a number of companies and is very close to finalising the deal with these companies. The company has hired renowned external agencies to make sure these deals are executed in the best interest of Venus Remedies’ stakeholders. Market authorisation in regulated markets Venus Remedies has marketing authorisations for EU markets for multiple products like Meropenem. It is the first Indian company to get GCC market authorisation for its oncology and Carbepenem products. This authorisation will further increase market reach of its products, pushing revenue growth. Vast pool of patented R&D products to capitalise on Since Venus Remedies has reorganized its priorities and started investing in R&D, it has developed respectable IP wealth within a very short period. Venus currently has more than 13 research products in development, with 11 products already under patent protection. 7 of these products are already commercialised not only in India but are also launched in emerging export markets through various alliances, and are selling in 12 countries. Overall, Venus Remedies boasts of 80+ patents out of more than Four-S Research 5
  • 6. Company Report: Venus Remedies 4 Jun 2012 360+ filed in over 51 countries. It has 44 product registered in developed countries and has filed 108 CTDs for 7 products. Venus Remedies also has more than 375 market authorizations in semi- regulated market. Strong IP wealth with patented technology and ready to launch products along with EU GMP certified plant will enable Venus Remedies to monetise this wealth in the near future. Traction from research products to grow Revenue from With ever growing investment in R&D by Venus Remedies (from R&D products 14.5% of revenue in 2009 to 19% in 2011) and a strong R&D team could grow 20- of 60 scientists, in-licensing and R&D alliances with many 25% annually international universities, Venus Remedies is on right path to grow its IP wealth. This is also evident from range of their products in phase II & III of research. Research products contributed around 25% of Venus’ total revenue in FY12. Revenue from research products is expected to grow at a rate of 20-25%, higher than the generics in its portfolio. This strong traction is expected in near future because of new research products and established products. Superior operational efficiencies Better working capital management The chart below shows debtor turnover for the latest financial year. Venus Remedies performance here is above peer averages. Debtors Turnover 12.00 10.00 8.00 6.00 4.00 2.00 0.00 Running business with higher capital efficiency Venus remedies is utilizing its capital efficiently, resulting in better profitability ratio and better returns to its stakeholders. It can be seen from Venus remedies having highest ROE and ROCE ratios compared to most of its peers and much higher than industry average. Four-S Research 6
  • 7. Company Report: Venus Remedies 4 Jun 2012 ROE ROCE 30% 25% 25% 20% 20% 15% 15% 10% 10% 5% 5% 0% 0% Indoco Ahlcon Ajanta Pharma Nectar Natco Pharma Industry Average Parenteral Drugs Strides Arcolab Parabolic Claris Venus Kilitch Indoco Ahlcon Ajanta Pharma Nectar Natco Pharma Industry Average Parenteral Drugs Strides Arcolab Parabolic Claris Venus Kilitch Valuations – have trended down in FY12 High discount compared to its peers Valuations Venus is currently traded at discounted valuations as compared to its ignoring steady pharma peers. When we divide peers among injectable segment and growth, and mid-cap segment, within injectable segment, Venus Remedies is at R&D results lowest multiple compare to its all injectable peers. Venus is also at lower range of valuations amongst Pharma companies of similar scale. Currently, Venus is traded at a PE ratio of 3.3 whereas mid-cap Pharma companies are traded at an average of 9.5 and injectables are traded at an average PE of 13.4. Given Venus’ steady growth performance, and reasonable return on capital, this gap will get bridged, at least partially, if not wholly. If it gets revenue from out-licensing, the process of narrowing of the valuation gap could get accelerated, giving a major upside for the stock. Four-S Research 7
  • 8. Company Report: Venus Remedies 4 Jun 2012 Peer Benchmarking The peer set: mid-cap pharma companies & injectable players Venus Remedies is among the leading injectable manufacturers in India. We have compared it to its injectable peers, as well as midcap pharma peers. We find its performance is within peer averages, and better on some parameters. The strategy of Venus Remedies to focus on niche injectables segment has benefitted company, which is evident from its growth in last few years and margins it has managed through out. Company Market EV TTM TTM TTM TTM TTM TTM PAT Cap Sales Sales 4- EBITDA EBITDA PAT 4-yr yr CAGR 4-yr CAGR CAGR Mid-Cap Peers Ajanta Pharma 7456 8633 6714 21% 1407 29% 773 37% Indoco 4981 5980 5389 19% 735 15% 460 11% Natco Pharma 11517 13717 4831 10% 1095 20% 602 10% Nectar 4339 12299 13412 15% 2453 18% 804 2% Parabolic 1253 5997 9288 33% 1666 37% 574 18% Average 5909 9325 7927 19% 1471 24% 642 16% Injectable Peers Strides Arcolab 39986 64181 25645 26% 5399 67% 1,689 15% Ahlcon 3089 3341 848 9% 139 1% 43 -2% Parenteral Drugs 1441 7329 3083 10% -52 NA 50 NA Claris 10674 14376 7625 0% 2446 5% 1,414 4% Kilitch 570 1100 1414 5% 235 1% 105 2% Average 11152 18065 7723 10% 1633 19% 660 5% Industry Average 8531 13,695 7825 15% 1552 21% 651 10% Venus 1617 3486 4049 18% 896 15% 493 9% Better P&L Venus Remedies has performed better than its injectable peers in the growth numbers last 4 years as peers’ overall profit declined. Venus managed to than injectables improve PAT at a CAGR of 9%. peer average Peer revenues have grown at an average of 15%, while Venus has delivered growth rates of 18% over last four years. Among the best organic growths Among the companies performing better than Venus on growth, Strides Arcolab revenue was boosted by its acquisitions of Ascent Pharmahealth. Ascent Pharmahealth, one of the biggest branded generic drug manufacturer in Australia, had sales of US$140mn in FY10. Strides recently sold out 94% of its stake in Ascent to refocus Four-S Research 8
  • 9. Company Report: Venus Remedies 4 Jun 2012 on speciality injectables. As can be seen in the table below, Venus Remedies is among the outperformers in its peer group on standalone basis as well, signifying success of Venus Remedies to grow organically at very comfortable rate. Venus Remedies has managed to propel its growth organically using its strong product portfolio and strong presence in highly growing injectable space. Company Revenue CAGR (FY08-FY11) Ahlcon Parenterals 11% Ajanta Pharma 17% Claris Lifesciences 4% Indoco Remedies 22% Kilitch Drugs 8% Natco Pharma 16% Nectar Lifesciences 13% Parabolic Drugs 31% Parenteral Drugs 22% Strides Arcolab 9% Industry Avg 15% Venus Remedies 19% Standalone revenues, Rs mn Comparing key P&L items Better profitability parameters Focus on high Venus Remedies has outperformed most of its peers in profitability in margin products midcap as well as injectable peers while generating strong growth has boosted numbers in last few years. margins While injectable peers have EBITDA margins of 17% on average and 9% PAT margins, Venus Remedies has managed to clock 22% EBITDA margin for TTM and 12% PAT TTM margins. Venus Remedies has better margins among its mid-cap peer companies which are averaging 19% EBITDA and 9% PAT margins compared to 22% EBITDA and 12% PAT TTM margins of Venus Remedies. Four-S Research 9
  • 10. Company Report: Venus Remedies 4 Jun 2012 FY11 Margin (%) TTM Margin (%) Company EBIDTA PAT EBIDTA PAT Mid-Cap Peers Ajanta Pharma 19% 10% 21% 12% Indoco 13% 11% 14% 9% Natco Pharma 19% 12% 23% 12% Nectar 20% 9% 18% 6% Parabolic Drugs 15% 8% 18% 6% Average 17% 10% 19% 9% Injectable Peers Strides Arcolab 21% 7% 21% 32% Ahlcon 16% 6% 16% 7% Parenteral Drugs 10% 1% -2% -20% Claris 31% 19% 32% 17% Kilitch 15% 7% 17% 9% Average 19% 8% 17% 9% Industry Average 18% 9% 18% 9% Venus 25% 13% 24% 12% Balance sheet ratios Reasonable leverage Debt Equity (x) Interest Coverage (x) Company FY10 FY11 FY10 FY11 Mid-Cap Peers Ajanta Pharma 0.83 0.8 2.87 4.02 Parabolic 2.65 1.25 2.03 2.27 Indoco 0.21 0.29 14.3 21.22 Nectar 0.97 1.1 2.59 2.35 Natco Pharma 0.39 0.62 4.88 4.99 Average 1.01 0.81 5.33 6.97 Injectable Peers Ahlcon 0.29 0.66 7.35 3.17 KIlitch Drugs 0.57 0.63 4.27 4.94 Parenteral Drugs 0.62 0.75 3.17 1.3 Claris 0.39 0.38 4.07 4.07 Strides Arcolab 1.57 1.74 1.79 0.97 Average 0.69 0.83 4.13 2.89 Industry Average 0.85 0.82 4.73 4.93 Venus 0.87 0.79 4.28 3.77 Although Venus Remedies has investing heavily in its R&D and capacity ramp up in last 3-4 years, its debt condition is in line with industry scenario. Its financial position is pretty much on par Four-S Research 10
  • 11. Company Report: Venus Remedies 4 Jun 2012 compared to most of its peers as can be seen table above. Liquidity ratios on par Current Ratio (x) Cash Ratio (x) Company FY9 FY10 FY11 FY10 FY11 Mid-Cap Peers Ajanta Pharma 1.62 1.85 1.55 0.16 0.12 Indoco 2.7 2.79 2.63 0.48 0.31 Nectar 1.26 2.11 1.72 0.17 0.13 Natco Pharma 1.27 1.31 1.53 0.08 0.31 Average 1.71 2.02 1.86 0.21 0.2 Injectable Peers Ahlcon 1.11 1.58 1.37 0.36 0.1 KIlitch Drugs 1.68 1.42 1.08 0.17 0.38 Claris 1.54 2.53 3.43 1.08 1.04 Strides Arcolab 1.39 2.12 1.86 0.37 0.19 Average 1.43 1.91 1.94 0.43 0.36 Industry Average 1.57 1.96 1.90 0.32 0.28 Venus 1.65 1.50 1.67 0.11 0.11 Venus Remedies is maintaining liquidity status similar to peers in the industry even though it has under taken high capex in last few years in R&D and capacity up-gradation. In March 2012, ICRA has assigned a BBB- rating to Venus Remedies on its debt facilities, citing comfortable financial risk profile marked by healthy size of net worth. Four-S Research 11
  • 12. Company Report: Venus Remedies 4 Jun 2012 Comparing Peer Valuation Dividing peer set into two parts In the table below, as earlier, we have presented two sets of peers: mid-cap pharma companies and companies in injectable space. Valuation* EV/ CAGRs 4 year Ratios EBIDTA Company P/E P/E EV/ EV/ TTM TTM D/E ROCE ROE (TTM) (TTM) EBIDTA TTM Sales NP (FY11) (FY11) Sales Mid-Cap Peers Ajanta Pharma 4.62 9.72 8.96 6.13 1.69 17% 32% 0.80 22% 27% Indoco 10.70 10.84 9.28 8.13 1.24 21% 19% 0.29 14% 15% Natco Pharma 14.48 19.13 15.80 12.52 2.97 11% 10% 0.62 16% 16% Nectar 5.35 5.41 5.58 5.58 1.10 13% 11% 1.10 14% 15% Parabolic 5.00 2.18 5.95 3.60 0.89 31% 21% 1.25 15% 20% Average 8.03 9.45 9.11 7.19 1.58 19% 19% 0.81 16% 19% Injectable Peers Strides Arcolab 9.59 4.85 13.80 11.89 2.53 35% 31% 1.74 12% 17% Ahlcon 10.83 53.63 31.17 24.11 4.98 4% -11% 0.66 17% 12% Parenteral Drugs 88.27 -2.29 14.78 -139.91 1.51 32% -36% 0.75 4% 2% Claris 7.24 7.24 6.07 6.07 1.90 7% 19% 0.38 16% 15% Kilitch 7.48 4.58 4.97 4.69 0.75 8% -3% 0.63 13% 13% Average 24.68 13.60 14.16 11.69 2.33 17% 0% 0.83 12% 12% Industry Average 16.4 11.53 11.6 9.44 1.96 18% 9% 0.82 14% 15% Venus 3.98 3.28 3.91 4.06 0.96 19% 9% 0.79 19% 23% *based on latest financial year, +excluding Parenteral Drugs Venus Remedies is discounted lower compared to all its peers Sharp valuation Venus Remedies is valued at a sharp discount by the market discount to both compared to all of its peers. While Venus Remedies’ PE is ~3x FY12, injectables and industry average is hovering at 8-9x. Amongst the peer set listed pharma peers above, parenteral peers get similar valuation compared to pharma companies, but within the parenteral set as well, Venus is getting a low valuation. On a ttm basis Venus Remedies trades at discount of 70%, with a PE ratio of 3 compared to industry average of 10.63x. Venus Remedies’ EV/EBITDA is at discount of 43% and EV/Sales shows a discount of 38% with respect to industry average. Four-S Research 12
  • 13. Company Report: Venus Remedies 4 Jun 2012 Valuation and Price Target Scope for higher valuations Business In terms of business ratios, like growth rates, operating margins, performance balance sheet ratios, Venus is doing as well as its peers. supports better It is likely Venus’ valuations are still suffering from the resettlement valuation of FCCB redemptions in FY10. This FCCB was issued in 2006, and given the bear phase the Indian markets were going through in FY10, the prevailing share price was much lower than the market price. Accordingly, investors wanted redemption. However, ultimately both parties agreed for a settlement at a lower price. Liquidity situation continues to remain reasonable. The company’s current rating is BBB-, as awarded by ICRA in March 2012. Another reason for the low valuation is the high R&D spends, some of which is passed through the balance sheet. Investors may be wanting to see more tangible results from the investment on R&D. We believe this scenario may change going forward as the market begins to see more results from Venus’s R&D pipeline. We also expect bottom-line growth to robust over FY12-14, as the company derives greater share of sales from high margin products. Any significant deal on Sulbactomax can be a further driver of rerating. Price Target 3 year P/E band chart 400 PE 350 7x 300 250 5x 200 150 3x 100 50 0 1-Apr-09 1-Aug-09 1-Apr-10 1-Aug-10 1-Apr-11 1-Aug-11 1-Feb-10 1-Feb-11 1-Feb-12 1-Dec-09 1-Dec-10 1-Dec-11 1-Jun-09 1-Oct-09 1-Jun-10 1-Oct-10 1-Jun-11 1-Oct-11 PE PE PE Even if Venus Venus is currently trading at around 3.3x FY12 eps and 2.6x maintains expected FY13 eps. This is below its historic trading range of the last current ttm 3 years, and around the valuation at the depth of the 2009 bear Four-S Research 13
  • 14. Company Report: Venus Remedies 4 Jun 2012 valuations, market. These values are also much below peer levels. Similarly, its Mar’13 price EV/EBITDA for FY13 works out to 3.1x, which is much less than peer could touch levels. around Rs 225 We expect Venus to rerate upwards as market realises the strides it has made it its R&D portfolio. We expect Venus’s price to cross Rs 200 over a 12 month period, implying a rating of 3.3x expected FY13 earnings. This is an upside of 23% from current levels. Four-S Research 14
  • 15. Company Report: Venus Remedies 4 Jun 2012 Venus Remedies’ Business As we noted in the valuation section, the low valuation given to Venus could partly derive from a lack of understanding of its business model. Its research model is quite unique compared to most Indian pharma companies. Second, inventors might not be giving much weight to its research capability, and assigning much value to its research pipeline. All of the above could arise because while Venus Remedies’ focus on R&D has resulted in significant investments, strong returns are yet to flow in. As a result, the company has not come close to generating free cash flows in recent years. These issues are discussed in detail below. A vision to break-out from me-too companies R&D push from Till year 2000, Venus Remedies was part of the cluttered generic 2006 injectables products segment. At the time, Venus Remedies was involved in generics injectables only. Realising generic products would have a limited scope in the future with patent regime coming into place in India from 2005; Venus Remedies changed its strategy and decided to focus on innovation to drive its growth. Venus Remedies started investing in R&D from year 2001. In a short time of 4 years, they filed for their first patent for Sulbactomax. The R&D effort is beginning to show steady results since then. Understanding Venus’ R&D R&D spends Venus Remedies is ranked 3rd among all Indian listed above peer pharmaceutical companies in terms of R&D spends as a share of levels revenues. It is ranked among the top 15 R&D spenders in absolute terms. Rank Companies R&D Spend (FY11) 1 Dr Reddy’s Laboratories 8464 2 Sun Pharmaceutical Inds. 2860 3 Matrix Laboratories 2820 4 Cadila Healthcare 2686 5 Cipla 2598 6 Biocon 1725 7 Ranbaxy Laboratories 1670 8 Torrent Pharmaceuticals 1527 9 Lupin 1268 10 Glenmark Pharmaceuticals 983 11 Aurobindo Pharma 815 Four-S Research 15
  • 16. Company Report: Venus Remedies 4 Jun 2012 12 Panacea Biotec 772 13 Piramal Healthcare 716 14 Venus Remedies 696 15 Jupiter Bioscience 567 (Rs mn) Rank Companies % of revenue 1 Vivo Bio Tech 49 2 Suven Life Sciences 22 3 Venus Remedies 19 4 Jupiter Bioscience 17 5 KDL Biotech 16 Sun Pharma Advanced Research 6 Company 14 7 Zenotech Laboratories 12 8 Dr Reddys Laboratories 11 9 Auromed 11 Venus Remedies has invested more than Rs 1.5bn in the last 3 years, which is around 16.5% of its revenue in this period. For last three years, all the capex is done is also mainly in R&D, up-gradation and modernisation. R&D capability of Venus Remedies A multi-pronged The Company has proven its R&D capability with the gradual approach increase of revenue from the research products and 80+ patents in hand from over 51 countries. Venus has, in all, 11 testing labs working together to develop first-of-its kind product through highly sophisticated technology. It has developed 13 research products in short span of 9-10 years. At any time, R&D has a pipeline of 20+ products. On average, the Company comes out with 1-2 new developed products every year. In FY10, Venus Remedies launched Mebatic, an infusion therapy and Ampucare, a wound healing therapy, a first of its kind product in India. In FY12 Venus Remedies launched Achnil, a once-a-day painkiller. Venus has a well developed R&D centre with high tech capabilities at par with stringent cGLP standards. Its R&D centre has a strong 60 member scientist team; 70% of them are PhDs and post graduates. In licensed The Company also benefits from in-licensing alliances with various tumour innovative companies and university. It has in-licensed solid tumour detection detection technology for early detection from University of Illinois. technology from Such alliances have enhanced company’s R&D capabilities and have University of helped to improvise its R&D process. Illinois As of now, Venus is preparing to file more than 100 CTDs and ACTDs Four-S Research 16
  • 17. Company Report: Venus Remedies 4 Jun 2012 each in the coming 3 years to take its present count of 600 ACTDs to 700 and 108 CTDs to 200 by 2015. Key Research areas Nano-tech Novel Drug Delivery System (NDDS): Venus has achieved success in based sustained development of nanotechnology-based, sustained release and release targeted delivery formulations with NDDS. This has resulted in formulations developing formulations with reduced adverse drug reaction and side effects in therapeutics areas of oncology, NSAID, neuroscience, arthritic disorders, stress and lifestyle-related diseases, immune chemistry, infectious diseases and wound healing. NDDS is advance drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect and provide greater safety. It is used to target a drug specifically to a desired tissue. Non-infringing Formulation Development: Venus is building its IP through formulations developing non-infringing formulations. Company is developing various formulations to revitalise established brands, fill product pipeline gaps and enhance patient compliance. With the help of strong regulatory team, Venus has managed to gain early mover advantage in many leading generic markets. Research Capabilities: Process developme nt and technology transfer Analytical Clinical research research division services (ARD) Research Capabilities Office of Chemical research and support stability (ORS) testing Pre- Natural clinical product division research (PCD) Process development and technology transfer: Ability to transfer technology from laboratory to pilot and to manufacturing scale. This is vital in technology transfer required to scale a Four-S Research 17
  • 18. Company Report: Venus Remedies 4 Jun 2012 successful molecule and technology transfer in out-licensing deals. Analytical research division: Capable in developing novel formulations, analytical development and drug design support. Chemical and stability testing division: Capability to perform stability tests as per ICH guidelines provides analytical services to research dept and meets international quality and regulatory standards. Pre-clinical division: Performs pre-clinical trials and oxicological studies under GLP environment. Natural product research: screens natural products and drug development as per pharmacopial and medicine standards. Office of research support: Bridges the gap between research and marketing through interactions with the field force, training marketing teams, addressing queries raised by the PMT team and designing experiments for research value-addition. Clinical research services: Division involved in Phase-I, II, III, IV and BA/ BE clinical studies monitoring, as per GCP, for its research products to accelerated the delivery of safe and effective therapeutics. Key Initiatives in R&D Cell Culture Molecular Biology (CCMB) laboratory Working on a Venus has setup CCMB laboratory in affiliation with some other novel cancer pharma companies to fasten the cancer drugs testing. The company treatment has 4-5 such products which are expected launched in next 4-5 years. Company is also working on novel cancer drug for target- specific treatment (90% of the drug will go to the affected area against the present 10%). This will reduce the side effects of these drugs and also brings down the costs. Tie-ups with renowned research institutes A typhoid Company has tie-ups with IMTECH, a renowned research center of testing kit CSIR and Punjab University. Through this alliance, company is through a developing a typhoid diagnostic kit. This kit will reduce detection research tie-up time from 48 hrs to few minutes. Company has the authorisation to market this kit worldwide. Products conforming to ASEAN CTD Venus has upgraded its entire product pipeline of 75 products to ASEAN CTD preparing the entire portfolio for international. Four-S Research 18
  • 19. Company Report: Venus Remedies 4 Jun 2012 Capitalising the IP Seeking out Venus Remedies understands that it is not easy to capitalise the IP licensing deals wealth they are creating in the huge global market. So to maximise to monetise IP the potential of this IP development, it has a clear strategy in place. Venus Remedies has appointed a leading consulting firm to seek tie- ups with international pharma companies for Sulbactomax. Venus Remedies plans to out-license the patented products to multi- national and regional companies with specific geographical interest considered. This will help Venus Remedies to garner the benefits from market across the globe without having to invest in market development. Venus Remedies has already closed an out-licensing alliance with a major South-Korean Pharma company for Sulbactomax. For FY12, Venus Remedies expects to get 25% of its revenue from its own research products. Venus Remedies’ Manufacturing excellence Among global leaders in fixed dosage injectable manufacturing Venus Remedies is among world’s top 10 injectable manufacturers and has the largest super specialty injectable manufacturing capacity in Asia. Venus has strong presence in relatively uncluttered, specialised, higher margin fixed dosage injectable space. Global injectable market is pegged at US$200bn in 2010 with generic market contributing US$20bn of it. There are limited numbers of players in the injectable space and high investment is required in setting up the complex plants. This will keep margins in this segment high with lesser competition to face in the market. Prominent Products 15% of FY11 Sulbactomax: It is the top product in Venus Remedies kitty with revenue 15% revenue contribution in FY12. The company holds patents for Sulbactomax in South Africa, India, 37 countries of the European Union, Russia, Ukraine, Mexico, Australia and New Zealand while patent is still awaited in six countries including US and Brazil. Sulbactomax is the only product in its category to prevent bacterial resistance. Sulbactomax is a formulation of ceftriaxone and sulbactam with VRP1034. The global injectable antibiotic market is US$200bn of which Ceftriaxone alone accounts around US$1.2bn. Sulbactomax aims to target a significant share of this market because of the growing bacterial resistance. Venus is currently marketing this product in India and seven other countries. Potentox: It is ranked second in Venus Remedies with respect to Four-S Research 19
  • 20. Company Report: Venus Remedies 4 Jun 2012 revenue contribution (4.6% in FY12). Company has patents in South Africa, New Zealand, South Korea, Australia, Ukraine and India. 4.2% of FY11 Patents awaited from 44 other countries including EU and US. revenue Potentox, a research-based super-specialty product is used for treating hospital and community acquired pneumonia and febrile neutropenia. It reduces pneumonia treatment time from 21-30 days to 7-10 days and reduces drug and disease-induced toxicities. This is the only solution to growing flouroquinolene and aminoglycoside resistance. 3% of FY11 Vancoplus: It is third biggest product of Venus with 3% of revenue revenue in FY11. The company holds patent in US, Japan, Australia, South Africa, New Zealand and Ukraine. Patents awaited from 44 other countries including EU and Brazil. It is the only remedy after vaccination to treat superbug like MSRA, VRSA, VRE and multi-drug-resistant microbes causing meningitis. The product effectively stops the spread of resistance by preventing bacterial conjugation. 2% of FY11 Tobracef: Tobracef contributed 2% of revenue in FY11. It’s a revenue research-based anti-infective product catering to Pseudomonal infections caused in Cystic Fibrosis and HAP with patents in South Africa and patents awaited from other countries. Once company get patents and authorisation in major regulated market, this could also turn out to be major blockbuster project for Venus Remedies. Neurotol: Neurotol is an innovative product which contains mannitol and glycerine. Neurotol is used in the management of raised intracranial pressure and brain oedema associated with cerebral infraction, intracerebral hemorrhage, head injury, subdural hematoma, brain tumour, encephalitis and toxemia. Neurotol is widely accepted by medical fraternity like neurosurgeons and neurophysicians. The synergy of mannitol and glycerin in Neurotol prevents the chances of rebound oedema. Mannitol is known to provide immediate effect while glycerin is helpful for sustained effect. Venus is the first company to introduce this product. Neurotol offers improved patient compliance with no side-effects when compared with plain generic mannitol. Achnil: Achnil is an NDDS based controlled and sustained release NSAID (non steroidal anti-inflammatory drug) injection. It is the Launched in FY11 world’s first once-a-day pain killer injection which replaces the three injections per day therapy. It has already got patent application in EU and India while patent in US in under process. Achnil was launched in FY11 in the domestic market. The product prevents post surgical adhesion and has high levels of safety. Venus Research Product portfolio Four-S Research 20
  • 21. Company Report: Venus Remedies 4 Jun 2012 Products Therapy Nature Sulbactomax Caters to ESBL, NMD-1, Penem Resistance Injection Vancoplus Caters to MRSA, VRSA & VRE Injection Potentox Caters to HAP, Febrile Neutropenia Injection Tobracef Developed for Cystic fibrosis Injection Zydotum For Pseudomonas Infections In Burns Injection Supime Intra-abdominal infections caused by various pathogens and post- Injection operative infections Pirotum Treatment of peritonitis and complicated intra-abdominal infections, Injection pirotum is indicated. continuous ambulatory pulmonary dialysis, management of lower respiratory tract infections and febrile neutropenia Neurotol For raised intracranial pressure and brain oedema associated with Infusion cerebral infraction, intracerebral hemorrhage, head injury, subdural hematoma, brain tumour, encephalitis and toxemia. Mebatic For pre and post surgical procedures, pelvic infections, urinary tract Infusion infections, urogenital tract infections, typhoid and prevention of ICU infections due to anaerobes. AMR compatible research products AMR has rapidly Antibiotic Resistance is spreading faster than expected throughout emerged as a world and the poor R&D pipeline for new antibiotics is further adding big global up this menace. Recently, World Health Organisation (WHO) has also health threat taken this issue with vigour by making this as main theme for World Health Day. According to WHO, AMR results in prolonged illness and greater risk of death. AMR not only increase overall health cost bur WHO feels world may end up in pre anti-biotic era. AMR has become serious problem for treatment for many major diseases like HIV, tuberculosis, malaria, gonorrhoea and many more. Risk factor involved in the infectious diseases has grown much more than it even existed and if it would keep on growing at the same pace, the world will soon reach the pre-antibiotic era again. The situation has deteriorated to an extent that even a mild infection can be deadly in today's world. The rising misuse and under usage has made the life saving antibiotics ineffective against the microbes. Reports say that US households lost approximately US$35bn in 2000 to antibiotic resistant infections including lost wages, extended hospital stays and premature deaths. The annual cost to the US health care system of antibiotic resistant infections is US$21bn to US$34bn and more than 8mn additional hospital days. In 29 countries of European union, an estimated 25,000 people die every year because of the infections related to antibiotics resistance. The medical cost per patient suffering from an antibiotic resistance (ABR) infections ranges from US$18,588 to US$ 29,069. According to the BCC Research report, the global market for infectious disease treatments was valued at $90.4 billion in 2009. This market is expected to increase at a compound annual growth rate (CAGR) of Four-S Research 21
  • 22. Company Report: Venus Remedies 4 Jun 2012 8.8% to reach US$138bn in 2014. The antibiotics market generated sales of US$42bn in 2009 globally, representing 46 percent of sales of anti-infective agents (which also include antiviral drugs and vaccines) and five percent of the global pharma market. Inception of new antibiotics is getting difficult because of the present drug development scenario which is fraught with financial, regulatory, ethical and scientific bottlenecks. Due to huge investment in R&D and less output (financially) out of the product dejects the pharmaceutical companies to invest in it. Today, Venus Remedies is one of the few R&D led companies to have innovated and developed a comprehensive range of novel antibiotic combinations which not just provide relief from the aggravated problem of antibiotic resistance but also are cost-effective and have reduced side effects. All products which came out of Venus research efforts do cater to antimicrobial resistance. Products Category Dose Indications Sulbactomax Antibiotic Once daily IM/ IV injection in Infections caused by ESBL resistant mild to moderate infections and pathogens: twice daily in severe infections  Lower respiratory tract infection  Urinary tract infection  Skin infections  Surgical prophylaxis  Bone and Joint infections  Acute bacterial septicemia  Acute Otitis media Potentox Antibiotic Twice Daily Multi-drug resistance of:  Nosocomial Pneumonia  Febrile Neutropenia  Other severe hospital acquired infections Vancoplus Antibiotic Twice Daily IV injection in mild to Infections caused by resistant pathogens moderate infections and thrice such as MRSA: daily in severe infections.  Meningitis  Septicemia  Skin and skin structure infections  Bone and joint infections  Post operative infections Tobracef Antibiotic Twice Daily injection Acute pulmonary exacerbations due to:  Cystis fibrosis  Pneumonia  COPD Presence in highly specialised generics Within generics, which were around 75% of revenue in FY11, Venus has shifted focus to high margin products. Currently, Venus sells around 75+ products, with around 20+ products under development Four-S Research 22
  • 23. Company Report: Venus Remedies 4 Jun 2012 phase at any point of time. Carbapenams, a Meropenem is one such generic product (carbapenem injection). key part of Venus Remedies has received market authorisation for Meropenem generics folio in EU. This represents a €150mn market opportunity, putting Venus among the top 3 EU-GMP manufacturers globally of carbapenem antibiotics. The Company has also received market authorisation for Imipenem+Cilastatin, Docitaxel and Irinotecan in the European Union. Similarly Venus also has market authorisation in for Gemcitabine for U.K., Germany, Poland Slovania, Portugal and Macedonia. Venus also has strong presence in oncology segment with 21 Oncology injectables in its portfolio. Oncology segment contributed more than generics are 30% to FY11 revenues, with extremely good margins. These are about 29% of much specialised products and high technology is required in revenue manufacturing these products. A key oncology product for Venus Remedies is Gemcitabine, for which it has marketing authorisation for in EU and UK. Gemcitabine is established as a gold standard therapy in treating pancreatic cancer. Venus understands the importance of this highly specialised, high technology, high margin oncology business. Hence, the Company has setup a dedicated sub-business unit for oncology business covering almost all cancer types just to further strengthen the focus on it. Oncology segment is likely to remain high growth has patents of oncology injectables, currently worth US$8.3bn, are set to expire by FY2015. Products kitty As can be seen, Venus has a strong kitty of 8 R&D products marketed in 12 nations. In the high margin oncology segment, it has 19 products with presence in 23 nations. Carbapenem and Cephalosporin has 20 products, with Carbapenem products sold in 23 nations. Category No. of products Presence R&D products 8 products 12 nations Oncology liquid 10 products (in various dosage 19 nations forms) Oncology lyphilised 9 products 23 nations Carbapenem 3 products 23 nations Cephalosporin and other 17 products 18 nations injectables PFS and infusions 5 products 11 nations Four-S Research 23
  • 24. Company Report: Venus Remedies 4 Jun 2012 Bigger the pipeline, greater the in-flow in future Venus Remedies has strong R&D product pipeline as of now with more than 10 products at various stages of research. This comprises of products from therapeutic segments such as oncology, anti- infection and neuro. Typhoid and Some of the products close to commercialisation include a Typhoid tumour detection kit. With 17mn patients every year for typhoid, this detection kits detection kit has the potential to be a key revenue generator for part of IP Venus Remedies in future. The kit reduces the time taken for a pipeline typhoid test sharply, from 48 hours to few minutes. Similarly Venus has Tumatrek, an early tumour detection test in phase III and DPPC, a novel triple conjugate for targeted delivery of anticancer drug in preclinical phase. Venus also has products on oral, breast and ovarian cancer under pre-clinical tests. This strong pipeline creates strong prospects for Venus Remedies to drive the growth with its research products. Accolades & Awards showcasing research efforts Venus has received number of awards and accolades in last few years affirming the efforts and path chosen by the company. Venus has won awards for its research products and patents filed by company and as emerging company & manufacturing excellence. List of awards won by Venus Remedies:  BioSpectrum Product of the Year 2012 award for its novel research product 'ACHNIL', a once-a-day painkiller.  Gold Patent award 2011 for the novel research drugs presented by Pharmexcil.  The Bizz- Business Excellence Award 2011 received in US.  'Silver Certificate of Merit' in the Economic Times' India Manufacturing Excellence Awards (IMEA), 2011 held in Mumbai.  'Emerging Company of the Year 2011' award in the 4th annual Pharmaceutical Leadership Summit & Award 2011.  Best SMB Award 2008  Emerging India Award 2007 presented by Dr. Manmohan Singh Prime Minister of India.  Ampucare Gold Medal 2010 'India Innovation Program- 2010' organized by Lockheed Martin (USA), FICCI and DST (India)‫‏‬ .  Trois: Gold Medal 2011 'India Innovation Programme - 2011' organized by Lockheed Martin (USA), FICCI.  Quality Award 2011 in Gold category from BID International convention at Geneva.  2011 Spotlight award for the Annual Report in the LACP's (League of American Communications Professionals) Global Communication Competition In Bronze category in San Diego, USA. Marketing & Distribution Four-S Research 24
  • 25. Company Report: Venus Remedies 4 Jun 2012 Pan India Venus has established a pan-India marketing presence covering 24 distribution States and two Union Territories, supported by over 700 marketing reach professionals. Venus Remedies has reach of 2,000 stockists and 40 distributors across India for the domestic market. These help target over 40,000 Pharmacies and 120,000 medical practitioners. The company has strong emphasis is on developing network of medical practitioners in critical care segment to address their specialised product market. Marketing Alliances to expand the reach Enhanced by To improve the reach within the domestic market, Venus Remedies tie-ups with has entered into tie-ups with many renowned Indian Pharma other pharma companies like Abbot, IPCA, Glenmark, Lupin, Elder, etc. To target companies the international markets in a better way, Venus Remedies has 11 overseas offices to cover 60 countries. Venus Remedies sells 44 products internationally with 3 research products launched till now. Similar to its domestic market strategy, Venus Remedies has made 20+ international alliances for its international market. Global Presence Direct overseas To capitalise on its IP pipeline, Venus Remedies has developed multi- presence in 11 regional presence across the globe. Venus has setup 11 overseas countries marketing offices covering 60 countries up from 19 countries in FY08. The 22 member team promotes 52 products across the globe. It has export presence in 25 countries with the help of these offices. World Class manufacturing capacities 3 manufacturing Venus Remedies has state of the art manufacturing facilities with the plants, 2 in latest technology. The company has invested more than Rs 2bn for a India, one in 100mn units injectable manufacturing facility at its unit in Baddi, Germany Himachal Pradesh. This has resulted in more than 20 international GMP certifications from more than 50 countries. This facility manufactures in all 75+ super specialty products. In all, Venus Remedies has 3 manufacturing locations: Baddi, Panchkula (India) and one in Germany. All are with EU-GMP and WHO-GMP certification along with other certifications. Its Panchkula site has 7.5mn units capacity for large volume parenterals accredited with WHO-GMP. Products manufactured at this facility include Mebatic, Calridol, Moximicin, Neurotol, Glutapep, among others. The Baddi campus has eight small volume parenteral facilities. It manufactures oncology injections, oncology lyophilised, lyophilised injections, pre-filled syringes and cephalosphorins. It has been accredited with more than 20GMPs. Recently; its Baddi plant has received GCC certification for oncology and carbepenem products, the first in India. Four-S Research 25
  • 26. Company Report: Venus Remedies 4 Jun 2012 Venus Pharma GmbH (Germany) With the goal in mind to be a true global Pharma company, Venus acquired the German Pharma company in 2006. It’s strategically located in the second largest Pharma market and largest in Europe, Germany. This acts as an entry vehicle for Venus Remedies products in European market. Venus Pharma GmbH helps Venus Remedies to generate export orders for its products, executes site transfer projects and supports in CTDs filing. Revenue distribution Dry powder and Venus Remedies has a strong existence in dry powder segment oncology are constituting 33% of revenue in FY11. Cehpalosporin and penem the two key products constitute this dry powder segment. Venus Remedies has segments strong presence in this segment in both generic products and also in research products. With multiple countries GMP certification for its manufacturing plant, the export market may grow at very good rate for this segment. Revenue Distribution 24% Anti-cancer 31% Cephalosporin (Inc Carbapenem) Infusions 12% SVP & Others 33% With many products still new in the market and in the process of developing its market, high growth in all the segments especially in oncology, dry powder is very much visible in the coming few years Four-S Research 26
  • 27. Company Report: Venus Remedies 4 Jun 2012 Focus on higher margin products Dry Powder Revenues 1,350 60% 1,300 50% 1,250 40% 1,200 30% INR mn 1,150 20% 1,100 1,050 10% 1,000 0% FY08 FY09 FY10 FY11 FY12E Dry Powder % of Total Revenues Dry power share In line with focus on high margin products, share of revenue of dry coming down powder products is coming down. Increasing higher margin oncology segment Oncology biz growth 1,400 35% Oncology Segment % of Revenue 1,200 30% 1,000 25% 800 20% 600 15% 400 10% 200 5% 0 0% FY08 FY09 FY10 FY11 FY12E Oncology is a Oncology segment contributes almost 31% of overall revenue of focus segment Venus Remedies. Due to complex products, critical nature and for Venus sophisticated technology involved in this segment, margins are better here. Venus Remedies has successfully managed to improve oncology contribution. Oncology segment has grown CAGR of 30% in last 4 years. With more than 300 market authorisations from 25 countries, Four-S Research 27
  • 28. Company Report: Venus Remedies 4 Jun 2012 the company should be able to maintain this thrust. Risk Factors Venus Remedies has the policy of capitalising major portion of its R&D expenditure. In FY11, Venus Remedies capitalised Rs 557mn of R&D expenditure out of its Rs 686mn R&D expenditure. R&D expenditure capitalisation is not new for pharma companies as most of Indian pharma companies do capitalise part of their R&D expenditure. Yet amount of R&D expenditure capitalised is much higher compared to many other major pharma companies. The Company attributes this to expenditure on research which is yet to be commercialised; around 360 patent applications are still pending. The Company is capitalising expenditure on R&D, IPR, CTD /ACTD and other product registration expenses, R&D activities like clinical trials, process development & technology transfer, in licensing and formulation development from in-licensed technology, expenses on analytical & chemical research on products under commercialization, etc. This R&D expenditure capitalisation is also reflected in cash flow. Though Venus has good positive operation cash flow, company is suffering from negative free cash flow. Four-S Research 28
  • 29. Company Report: Venus Remedies 4 Jun 2012 Financial Analysis and Growth Outlook 15% CAGR for revenue expected during FY’12-14 The Company’s net revenues have grown at a CAGR of 18% over FY’08-’12E (for FY12 only stand alone results declared so far, consolidated are our estimates) to Rs 4.78bn from Rs 2.15bn in FY08. Revenue Growth 4,500 4,000 4 year revenue 3,500 CAGR is 18%, 3 3,000 year growth is 12% 2,500 2,000 1,500 1,000 500 - FY'08 FY'09 FY'10 FY'11 FY'12E (Rs mn) The top line of Venus is expected to grow at CAGR of 15% over FY11- 14. Revenue Growth Expected 6,000 Growth to be 5,500 driven by newly 5,000 launched products and 4,500 expansion in 4,000 regional 3,500 presence 3,000 2,500 2,000 1,500 FY'11 FY'12E FY'13E FY'14E Four-S Research 29