1. Introduction to cardiology Dr. Judit Keller

3. CV mortality

7. Angina Classification (Canadian Cardiovascular Society) < 20 W alatt < 4 METs Any physical activity, sometimes occurring at rest C C S-4. degree 20–80 W – 5-6 METs Walking, even 1 or 2 blocks at usual pace and on level ground. Climbing stairs, even 1 flight C C S-3. degree 80–120 W – 6-8 METs Walking rapidly or uphill Emotional stress C CS -2. degree > 120 W – 10 METs Strenuous, rapid, or prolonged exertion C C S-1. degree Excercise toleranc e Activities triggering Chest pain Angina

16. Basic cardiological „hardware”

17. Heart auscultation

18. Cardiac Cycle Diastole Systole

26. Multimetabolic catastrophe!

27. 22 22 Smoking 9 22 Physical inactivity 12 28 Diabetes 23 33 Overweight 27 63 High cholesterin level 72 58 Hypertension stroke CHD Risk factor Ezzati M et al. Lancet 2003;362:271-80. (%) Increasing of the incidence of CHD and stroke

29. ?

30. Risk stratification - Euroscore

31. Effects of hypertension, smoking and hypercholester ol aemia to CHD ri sk X1.6 x4 x3 x6 x16 X4.5 x9 hypertension (SBP 195 Hgmm) High TC (8.5 mmol/L, 330 mg/dl) smoking (Poulter et al, 1993)

32. hypertension High TC diabetes x3 x2 x2 x5 x4 x3 x8 Effects of hypertension, diabetes and hypercholester ol aemia to CHD ri sk

34. Thank you for your attention!