Signaling Pathways

Signaling Pathways that Control the Expression of Gene Activity

Transforming Growth Factor β Signals (TGF β ) ,[object Object],[object Object]

Human TGF β Signal Molecules ,[object Object],[object Object],[object Object],[object Object],[object Object]

TGF β Receptors ,[object Object],[object Object],[object Object],[object Object]

Types of Smads ,[object Object],[object Object],[object Object]

The Structure of R-Smads N C DNA- binding segment Nuclear Localization Signal MH1 DOMAIN Linker MH2 DOMAIN

TGF β Signaling Pathway -I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TGF β Signaling Pathway -II ,[object Object],[object Object],[object Object]

Oncoproteins and I-Smads Regulate Smad Signaling ,[object Object],[object Object]

Cancer and TGF β Signals ,[object Object],[object Object]

Cytokine Receptors ,[object Object],[object Object],[object Object],[object Object]

What happens after activation of the cytokine receptor? ,[object Object],[object Object],[object Object]

What are cytokines? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cytokines and the JAK/STAT Pathway ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How is the active cytokine receptor down-regulated? ,[object Object],[object Object],[object Object]

Receptor Tyrosine Kinases (RTKs) ,[object Object],[object Object],[object Object]

Ligands that bind to TRKs ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ras Protein ,[object Object],[object Object],[object Object],[object Object]

Activation of Ras ,[object Object],[object Object],[object Object]

What occurs after Ras is activated? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Role of Scaffold Proteins ,[object Object],[object Object]

Insulin and Protein Kinase B (PKB) ,[object Object],[object Object],[object Object]

Mutations to proteins in the MAP kinase pathway can cause cancer.

Signaling Pathways

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Signaling Pathways