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Alterations of the digestive function
1.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 1 Alterations of Digestive Function
2.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 2 Clinical Manifestations of Gastrointestinal Dysfunction Anorexia A lack of a desire to eat despite physiologic stimuli that would normally produce hunger Vomiting The forceful emptying of the stomach and intestinal contents through the mouth Several types of stimuli initiate the vomiting reflex
3.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 3 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Nausea A subjective experience that is associated with a number of conditions The common symptoms of vomiting are hypersalivation and tachycardia Retching Nonproductive vomiting
4.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 4 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Projectile vomiting Projectile vomiting is spontaneous vomiting that does not follow nausea or retching
5.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 5 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Constipation Constipation is defined as infrequent or difficult defecation Pathophysiology • Neurogenic disorders • Functional or mechanical conditions • Low-residue diet • Sedentary lifestyle • Excessive use of antacids • Changes in bowel habits
6.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 6 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Diarrhea Increased frequency of bowel movements Increased volume, fluidity, weight of the feces Major mechanisms of diarrhea: • Osmotic diarrhea • Secretory diarrhea • Motility diarrhea Associated with malabsorption syndromes
7.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 7 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Abdominal pain Abdominal pain is a symptom of a number of gastrointestinal disorders Parietal pain Visceral pain Referred pain
8.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 8 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d) Gastrointestinal bleeding Upper gastrointestinal bleeding • Esophagus, stomach, or duodenum Lower gastrointestinal bleeding • Below the ligament of Treitz or bleeding from the jejunum, ileum, colon, or rectum Hematemesis Hematochezia Melena Occult bleeding
9.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 9 Clinical Manifestations of Gastrointestinal Dysfunction (cont’d)
10.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 10 Disorders of Motility Dysphagia Dysphagia is difficulty swallowing Types: • Mechanical obstructions • Functional obstructions Achalasia: • Denervation of smooth muscle in the esophagus and lower esophageal sphincter relaxation
11.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 11 Achalasia
12.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 12 Disorders of Motility Gastroesophageal reflux disease (GERD) GERD is the reflux of chyme from the stomach to the esophagus If GERD causes inflammation of the esophagus, it is called reflux esophagitis A normal functioning lower esophageal sphincter maintains a zone of high pressure to prevent chyme reflux
13.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 13 Disorders of Motility (cont’d) Gastroesophageal reflux disease (GERD) (cont’d) Conditions that increase abdominal pressure can contribute to GERD Manifestations: • Heartburn • Regurgitation of chyme • Mid-epigastric pain within 1 hour of eating
14.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 14 Disorders of Motility (cont’d) Hiatal hernia Sliding hiatal hernia Paraesophageal hiatal hernia
15.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 15 Hiatal HerniaHiatal Hernia
16.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 16 Disorders of Motility Pyloric obstruction The blocking or narrowing of the opening between the stomach and the duodenum Can be acquired or congenital Manifestations: • Epigastric pain and fullness • Nausea • Succussion splash • Vomiting • With a prolonged obstruction, malnutrition, dehydration, and extreme debilitation
17.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 17 Disorders of Motility (cont’d) Intestinal obstruction and paralytic ileus An intestinal obstruction is any condition that prevents the flow of chyme through the intestinal lumen or failure of normal intestinal motility in the absence of an obstructing lesion An ileus is an obstruction of the intestines Simple obstruction Functional obstruction
18.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 18 Intestinal Obstruction
19.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 19 Gastritis Inflammatory disorder of the gastric mucosa Acute gastritis Chronic gastritis Chronic fundal gastritis Chronic antral gastritis
20.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 20 Gastritis (cont’d)
21.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 21 Peptic Ulcer Disease A break or ulceration in the protective mucosal lining of the lower esophagus, stomach, or duodenum Acute and chronic ulcers Superficial Erosions Deep True ulcers Zollinger-Ellison syndrome
22.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 22 Peptic Ulcer Disease (cont’d) Duodenal ulcers Most common of the peptic ulcers Developmental factors: • Helicobacter pylori infection Toxins and enzymes that promote inflammation and ulceration • Hypersecretion of stomach acid and pepsin • Use of NSAIDs • High gastrin levels • Acid production by cigarette smoking
23.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 23 Duodenal Ulcer
24.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 24 Gastric Ulcer Gastric ulcers tend to develop in the antral region of the stomach, adjacent to the acid-secreting mucosa of the body Pathophysiology The primary defect is an increased mucosal permeability to hydrogen ions Gastric secretion tends to be normal or less than normal
25.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 25 Gastric Ulcer (cont’d)
26.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 26 Stress Ulcer A stress ulcer is a peptic ulcer that is related to severe illness, neural injury, or systemic trauma Ischemic ulcers • Within hours of trauma, burns, hemorrhage, sepsis Cushing ulcers • Ulcers that develop as a result of a head/brain injury
27.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 27 Postgastrectomy Syndromes Dumping syndrome Alkaline reflux gastritis Afferent loop obstruction Diarrhea Weight loss Anemia Bone and mineral disorders
28.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 28 Dumping Syndrome Dumping syndrome is the rapid emptying of chyme from a surgically created residual stomach into the small intestine Dumping syndrome is a clinical complication of partial gastrectomy or pyloroplasty surgery
29.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 29 Dumping Syndrome (cont’d) Developmental factors: Loss of gastric capacity Loss of emptying control Loss of feedback control by the duodenum when it is removed Late dumping syndrome
30.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 30 Malabsorption Syndromes Maldigestion Failure of the chemical processes of digestion Malabsorption Failure of the intestinal mucosa to absorb digested nutrients Maldigestion and malabsorption frequently occur together
31.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 31 Malabsorption Syndromes (cont’d) Pancreatic insufficiency Insufficient pancreatic enzyme production • Lipase, amylase, trypsin, or chymotrypsin Causes: • Pancreatitis • Pancreatic carcinoma • Pancreatic resection • Cystic fibrosis Fat maldigestion is the main problem, so the patient will exhibit fatty stools and weight loss
32.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 32 Malabsorption Syndromes (cont’d) Lactase deficiency Inability to break down lactose into monosaccharides and therefore prevent lactose digestion and monosaccharide absorption Fermentation of lactose by bacteria causes gas (cramping pain, flatulence, etc.) and osmotic diarrhea
33.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 33 Malabsorption Syndromes (cont’d) Bile salt deficiency Conjugated bile salts needed to emulsify and absorb fats Conjugated bile salts are synthesized from cholesterol in the liver Can result from liver disease and bile obstructions Poor intestinal absorption of lipids causes fatty stools, diarrhea, and loss of fat-soluble vitamins (A, D, E, K)
34.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 34 Malabsorption Syndromes (cont’d) Fat-soluble vitamin deficiencies: Vitamin A • Night blindness Vitamin D • Decreased calcium absorption • Bone pain • Osteoporosis • Fractures Vitamin K • Prolonged prothrombin time • Purpura • Petechiae Vitamin E • Uncertain
35.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 35 Inflammatory Bowel Diseases Chronic, relapsing inflammatory bowel disorders of unknown origin Genetics Alterations of epithelial barrier functions Immune reactions to intestinal flora Abnormal T cell responses
36.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 36 Ulcerative Colitis Chronic inflammatory disease that causes ulceration of the colonic mucosa Sigmoid colon and rectum Suggested causes: Infectious Immunologic (anticolon antibodies) Dietary Genetic (supported by family studies and identical twin studies)
37.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 37 Ulcerative Colitis (cont’d) Symptoms: Diarrhea (10 to 20/day) Bloody stools Cramping Treatment: Broad-spectrum antibiotics and steroids Immunosuppressive agents Surgery An increased colon cancer risk demonstrated
38.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 38 Crohn Disease Granulomatous colitis, ileocolitis, or regional enteritis Idiopathic inflammatory disorder; affects any part of the digestive tract, from mouth to anus Difficult to differentiate from ulcerative colitis Similar risk factors and theories of causation as ulcerative colitis
39.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 39 Crohn Disease (cont’d) Causes “skip lesions” Ulcerations can produce longitudinal and transverse inflammatory fissures that extend into the lymphatics Anemia may result from malabsorption of vitamin B12 and folic acid Treatment similar to ulcerative colitis
40.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 40 Diverticular Disease of the Colon Diverticula Herniations of mucosa through the muscle layers of the colon wall, especially the sigmoid colon Diverticulosis Asymptomatic diverticular disease Diverticulitis The inflammatory stage of diverticulosis
41.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 41 Appendicitis Inflammation of the vermiform appendix Possible causes: Obstruction, ischemia, increased intraluminal pressure, infection, ulceration, etc. Epigastric and RLQ pain Rebound tenderness The most serious complication is peritonitis
42.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 42 Irritable Bowel Syndrome A functional gastrointestinal disorder with no specific structural or biochemical alterations as a cause of disease Characterized by recurrent abdominal pain and discomfort associated with altered bowel habits that present as diarrhea or constipation or both Associated with anxiety, depression, and chronic fatigue syndrome
43.
Mosby items and
derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 43 Irritable Bowel Syndrome (cont’d) Cause unknown but mechanisms proposed: Visceral hypersensitivity Abnormal intestinal motility and secretion Intestinal infection Overgrowth of small intestinal flora Food allergy/intolerance Psychosocial factors
44.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 44 Irritable Bowel Syndrome (cont’d) Manifestations: Can be diarrhea-predominant or constipation- predominant Alternating diarrhea/constipation, gas, bloating, and nausea Symptoms are usually relieved with defecation and do not interfere with sleep
45.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 45 Vascular Insufficiency Blood supply to the stomach and intestine Celiac axis Superior and inferior mesenteric arteries Two of three must be compromised to cause ischemia Mesenteric venous thrombosis Acute occlusion of mesenteric artery blood flow Chronic mesenteric arterial insufficiency
46.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 46 Obesity An increase in body fat mass Body mass index greater than 30 A major cause of morbidity, death, and increased health care costs Risk factor for many diseases and conditions
47.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 47 Obesity (cont’d) Hypothalamus Hormones that control appetite and weight: Insulin Ghrelin Peptide YY Leptin Adiponectin Resistin Leptin resistance Hyperleptinemia
48.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 48 Obesity (cont’d)
49.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 49 Anorexia Nervosa and Bulimia Nervosa Characteristics: Abnormal eating behavior Weight regulation Disturbed attitudes toward body weight, body shape, and size
50.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 50 Anorexia Nervosa and Bulimia Nervosa (cont’d) Anorexia nervosa A person has poor body image disorder and refuses to eat Anorexic patients can lose 25% to 30% of their ideal body weight as a result of fat and muscle depletion Can lead to starvation-induced cardiac failure In women and girls, anorexia is characterized by the absence of three consecutive menstrual periods Binge eating/purging anorexia nervosa
51.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 51 Anorexia Nervosa and Bulimia Nervosa (cont’d) Bulimia nervosa Body weight remains near normal but with aspirations for weight loss Findings • Recurrent episodes of binge eating • Self-induced vomiting • Two binge-eating episodes per week for at least 3 months • Fasting to oppose the effect of binge eating, or excessive exercise
52.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 52 Anorexia Nervosa and Bulimia Nervosa (cont’d) Bulimia nervosa (cont’d) Continual vomiting of acidic chyme can cause: • Pitted teeth • Pharyngeal and esophageal inflammation • Tracheoesophageal fistulas Overuse of laxative can cause rectal bleeding
53.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 53 Malnutrition and Starvation Starvation Decreased caloric intake leading to weight loss Cachexia Short-term starvation • Glycogenolysis • Gluconeogenesis Long-term starvation • Marasmus • Kwashiorkor
54.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 54 Liver Disorders Portal hypertension Abnormally high blood pressure in the portal venous system caused by resistance to portal blood flow • Prehepatic • Intrahepatic • Posthepatic
55.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 55 Liver Disorders (cont’d) Portal hypertension (cont’d) Consequences: • Varices: Lower esophagus Stomach Rectum • Splenomegaly • Ascites • Hepatic encephalopathy
56.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 56 Varices
57.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 57 Ascites
58.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 58 Ascites (cont’d)
59.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 59 Liver Disorders Hepatic encephalopathy A neurologic syndrome of impaired cognitive function, flapping tremor, and EEG changes The condition develops rapidly during fulminant hepatitis or slowly during chronic liver disease Cells in the nervous system are vulnerable to neurotoxins absorbed from the GI tract that, because of liver dysfunction circulate to the brain
60.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 60 Liver Disorders (cont’d) Jaundice (icterus) Obstructive jaundice • Extrahepatic obstruction • Intrahepatic obstruction Hemolytic jaundice • Prehepatic jaundice • Excessive hemolysis of red blood cells or absorption of a hematoma
61.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 61 Jaundice
62.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 62 Hepatorenal Syndrome Renal failure demonstrating oliguria, sodium and water retention, hypotension, and peripheral vasodilation as a result of advanced liver disease
63.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 63 Viral Hepatitis Systemic viral disease that primarily affects the liver Hepatitis A • Formally known as infectious hepatitis Hepatitis B • Formally known as serum hepatitis Hepatitis C, D, E, and G
64.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 64 Hepatitis A Hepatitis A can be found in the feces, bile, and sera of infected individuals Usually transmitted by the fecal-oral route Risk factors: Crowded, unsanitary conditions Food and water contamination
65.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 65 Hepatitis B Transmitted through contact with infected blood, body fluids, or contaminated needles Maternal transmission can occur if the mother is infected during the third trimester The hepatitis B vaccine prevents transmission and development of hepatitis B
66.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 66 Hepatitis C Hepatitis C is responsible for most cases of post-transfusion hepatitis Also implicated in infections related to IV drug use 50% to 80% of hepatitis C cases result in chronic hepatitis
67.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 67 Hepatitis Hepatitis D Depends on hepatitis B for replication Hepatitis E Fecal-oral transmission Developing countries Hepatitis G Recently discovered Parentally and sexually transmitted
68.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 68 Hepatitis (cont’d) Sequence: Incubation phase Prodromal (preicteric) phase Icteric phase Recovery phase Chronic active hepatitis Fulminant hepatitis Results from impairment or necrosis of hepatocytes
69.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 69 Cirrhosis Irreversible inflammatory disease that disrupts liver function and even structure Decreased hepatic function caused by nodular and fibrotic tissue synthesis (fibrosis)
70.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 70 Cirrhosis (cont’d) Biliary channels become obstructed and cause portal hypertension Because of the hypertension, blood can be shunted away from the liver, and a hypoxic necrosis develops
71.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 71 Cirrhosis (cont’d) Alcoholic The oxidation of alcohol damages hepatocytes Biliary (bile canaliculi) Cirrhosis begins in the bile canaliculi and ducts Primary biliary cirrhosis (autoimmune) Secondary biliary cirrhosis (obstruction)
72.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 72 Cirrhosis (cont’d)
73.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 73 Disorders of the Gallbladder Obstruction or inflammation (cholecystitis) is the most common cause of gallbladder problems Cholelithiasis—gallstone formation Types: • Cholesterol (most common) • Pigmented (cirrhosis) Risks: • Obesity • Middle age • Female • Native American ancestry • Gallbladder, pancreas, or ileal disease
74.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 74 Disorders of the Gallbladder (cont’d) Gallstones Obstruction or inflammation (cholecystitis) is the most common cause of gallbladder problems Cholesterol stones form in bile that is supersaturated with cholesterol Theories: • Enzyme defect increases cholesterol synthesis • Decreased secretion of bile acids to emulsify fats • Decreased resorption of bile acids from ileum • Gallbladder smooth muscle hypomotility and stasis • Genetic predisposition • Combination of any or all of the above
75.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 75 Gallstones
76.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 76 Disorders of the Pancreas Pancreatitis Inflammation of the pancreas Associated with several other clinical disorders • Caused by an injury or damage to pancreatic cells and ducts, causing a leakage of pancreatic enzymes into the pancreatic tissue These enzymes cause autodigestion of pancreatic tissue and leak into the bloodstream to cause injury to blood vessels and other organs
77.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 77 Disorders of the Pancreas (cont’d) Pancreatitis (cont’d) Manifestations and evaluation: • Epigastric pain radiating to the back • Fever and leukocytosis • Hypotension and hypovolemia Enzymes increase vascular permeability • Characterized by an increase in a patient’s serum amylase level Chronic pancreatitis • Related to chronic alcohol abuse
78.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 78 Cancer of the Gastrointestinal Tract Esophagus Stomach Colon and rectum Liver Gallbladder Pancreas
79.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 79 Stomach Cancer
80.
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derived items © 2012 Mosby, Inc., an imprint of Elsevier Inc. 80 Colon Cancer
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