ABC1 - G. Viale - Role of pathology in the management of advanced breast cancer
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ABC1 - G. Viale - Role of pathology in the management of advanced breast cancer
- 1. Role of pathology in the management of advanced breast cancer Beppe Viale European Institute of Oncology University of Milan Milan, Italy
- 10. Metastasis from a second primary
- 11. Metastasis from a second primary
- 12. ER Breast carcinoma metastatic to bone
- 13. ER Breast carcinoma metastatic to the stomach
- 18. … also in the metastases
- 21. 1250 liver biopsies from 1999-2009; 255 identified as BC metastases
- 23. Real status - unknown!- (N) ER- (200) ER+ (800) 190 Sensitivity p + = 0.95 Tumor N 10 40 760 180 Metastasis N 10 9 1 2 38 38 722 Specificity p - = 0.95 Changed status from T to M 95/1000 = 9.5% + p + = 0.95 p - = 0.05 p + = 0.95 p - = 0.05 p + = 0.95 p - = 0.05 p - = 0.95 p + = 0.05 p + = 0.05 p + = 0.05 - + + - - + - - + - + p - = 0.95 p - = 0.95 Do tumours change?
Notas do Editor
- Gong Y, et al: Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma. Cancer. 2005 May 1;103(9):1763-9. Simon R, et al: Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst. 2001 Aug 1;93(15):1141-6. Gancberg D, et al: Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites. Ann Oncol. 2002 Jul;13(7):1036-43. Zidan J, et al: Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease. Br J Cancer. 2005 Sep 5;93(5):552-6.