1. Quality of life after rectal surgery Emmanuel Tiret Hôpital Saint-Antoine, AP-HP Université Pierre et Marie Curie, Paris VI

6. Medical Outcomes Study Short-Form-36 item questionnaire MOS SF-36 General health questionnaire Non specific for colorectal surgery

8. EORTC QLQ C-30 Functioning scales Physical (1-5) 1. Do you have any trouble doing strenuous activities, like carrying a heavy shopping bag or a suitcase? 2. Do you have any trouble taking a long walk? 3. Do you have any trouble taking a short walk outside of the house? 4. Do you need to stay in bed or a chair during the day? 5. Do you need help with eating, dressing, washing yourself or using the toilet? Not at All : 1 A Little : 2 Quite a Bit : 3 Very Much : 4

18. Day:1 Mon Tue Wed Thurs Fri Sat Sun Bowel diary Michelassi F et al. Arch Surg 1993; 128: 889-94 Day and date Details of bowel function Instructions: Please fill the face of the clock at the time you went to the bathroom for one week (7 days). Fill day and date. On any day please write (see example) B L if you had a liquid stool, B P if you had a pasty stool B F if you had a formed stool. Also write… Sx if you were incontinent of the entire bowel movement Sm if you had a mild to moderate leakage in your underwear or pad E if you went to the bathroom and did not evacuate or E D .if you had difficulty evacuating Comments on evacuation difficulty or incomplete evacuation

20. J-pouch versus coloplasty and straight anastomosis Total daily bowel movemements over 24 months J-pouch vs coloplasty : 0.03 at 4 months 0.03 at 12 months 0.007 at 24 months Ann Surg 2007; 246: 481-90

21. J-pouch versus coloplasty and straight anastomosis Comparison of Fecal Incontinence Severity Index (FISI) over 24 months J-pouch vs coloplasty : 0.001 at 4 months 0.04 at 24 months Ann Surg 2007; 246: 481-90

22. Clustering at 12 and 24 months was more often seen in the CP group than in the J group, but not different in the SA group and CP group Clustering at 24 months CP SA p CP J p Never 7% 16% 0.21 21% 10% <0.03 1-4 / per month 38% 37% 39% 27% >2 per week 22% 22% 20% 24% 1 or >1 per day 33% 25% 20% 39%

23. J-pouch versus coloplasty and straight anastomosis Comparison of Quality of Life with SF-36 Ann Surg 2007; 246: 481-90 No difference at 24 months (score SF 36) Relative insentivity of the SF-36 ??

24. Quality of life at median of 13 years of 97 patients in relation to chemoradiotherapy EORTC QLQ C-30 EORTC QLQ C-38 C Hoerske BJS 2010; 97: 1295-03

25. MRC CR07/NCIC CTG C016 trial PreopRT 25 Gy vs selective postoperative CRT 45 Gy + Fufol Baseline quality of life: no difference RJ Stephens et al. J Clin Oncol 2010

26. MRC CR07/NCIC CTG C016 trial Baseline quality of life

27. MRC CR07/NCIC CTG C016 trial Bowel problems RJ Stephens et al. J Clin Oncol 2010

28. MRC CR07/NCIC CTG C016 trial Unintentional release of stools RJ Stephens et al. J Clin Oncol 2010

29. MRC CR07/NCIC CTG C016 trial Male sexual dysfunction RJ Stephens et al. J Clin Oncol 2010

30. General health No difference RJ Stephens et al. J Clin Oncol 2010

32. COREAN trial: Laparoscopic versus open rectal resection EORTC QLQ-C30 scores Better physical functioning, less fatigue Lancet Oncol 2010; 1: 637-45 p<0.01 p<0.05

33. COREAN trial: Laparoscopic versus open rectal resection EORTC QLQ-C38 scores Fewer micturition, gastro-intestinal and defecation problems Lancet Oncol 2010; 1: 637-45 p<0.05 p<0.05 p<0.01

35. APER versus Sphincter-saving procedure EORTC QLQ C-30 function scales 212 patients No significant difference C Schmidt. Ann Surg Oncol 2005; 12: 117-23

36. APER versus Sphincter-saving procedure EORTC QLQ C-30 symptom scales 212 patients C Schmidt. Ann Surg Oncol 2005; 12: 117-23 Symptoms worse in the group of SSR

37. APER versus Sphincter-saving procedure Colorectal cancer specific module scales C Schmidt. Ann Surg Oncol 2005; 12: 117-23 Significant differences

38. Quality of life at median of 13 years of 97 patients in relation to need for a colostomy/ileostomy EORTC QLQ C-30 EORTC QLQ C-38 C Hoerske BJS 2010; 97: 1295-03

41. Do patients consider preoperative chemoradiotherapy for primary rectal cancer worthwile? Kennedy ED, Cancer 2011 online

42. Do patients consider preoperative chemoradiotherapy for primary rectal cancer worthwile? Kennedy ED, Cancer 2011 online

43. Do patients consider preoperative chemoradiotherapy for primary rectal cancer worthwile? 50 healthy well educated individuals attending screening colonoscopy Kennedy ED, Cancer 2011 online

44. Do patients consider preoperative chemoradiotherapy for primary rectal cancer worthwile? Kennedy ED, Cancer 2011 online

45. Do patients consider preoperative chemoradiotherapy for primary rectal cancer worthwile? 27 patients required a risk of LR≤5% (-10%) before they would choose pre-CRT+surgery Kennedy ED, Cancer 2011 online