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Breast Cancer and Genetics

of breast cancer cases
are hereditary

“An alteration or a
mutation in a gene

(BRCA 1, 2)

does not equal cancer,

and of these, BRCA
mutations are responsible
for approximately 20–
25% of the diagnoses.

it just means there is

an increased risk.”
			
Huma Rana, MD,
		
Cancer Geneticist,
	
Dana-Farber Cancer Institute

New Breast Cancer Cases Every Year

new cases
of invasive breast cancer

232,340

in women in

2013
cases of carcinoma

in situ (CIS) in 2013

(non-invasive and earliest form of breast cancer)

64,640

Risk of Cancer if you have
BRCA 1, 2 mutations
Women with inherited alterations in BRCA 1, 2 have a

40-80%

chance of developing breast
cancer during their lifetimes.

5-10%

Family Members
with Breast Cancer

risk
factors

5–10% of women have a mother
or sister with breast cancer, and
about twice as many have either
a first-degree relative or seconddegree relative with breast cancer.

for
breast cancer

•	 Age
•	 Reproductive and
menstrual history
•	 Oral contraceptives
•	 Hormone replacement
therapy
•	 Radiation exposure
•	 Alcohol intake
•	 Obesity

Bilateral preventative
mastectemy can reduce risk
of breast cancer by 90%.

Curable Breast Cancer
Percent of Survival
93%

88%

81%

74%

Stage 0

Stage I

Stage IIA

Stage IIB

67%

41%

49%

15%

Stage IIIA

Stage IIIB

Stage IIIC

Stage IV

Sources
•	
•	
•	
•	
•	

Dana-Farber Turning Point, 2009: http://www.dana-farber.org/uploadeFiles/
Library/newsroom/publications/turning-point/2009/TurningPoint_2009.pdf
NCI – Genetics of Breast and Ovarian Cancer: http://www.cancer.gov/
cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional/page1
American Cancer Society: http://www.cancer.org/cancer/breastcancer/
overviewguide/breast-cancer-overview-key-statistics
American Cancer Society: http://www.cancer.org/cancer/breastcancer/
overviewguide/breast-cancer-overview-survival-rates
“Outsmart Your Genes: Understanding BRCA 1/2 Cancer Risk” by Huma Q. Rana, MD, Dana-Farber Cancer
Institute, July 2013

S USAN F. S MITH C ENTER

FOR

W OMEN ’ S C ANCERS

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Infographic: Breast Cancer and Genetics

  • 1. Breast Cancer and Genetics of breast cancer cases are hereditary “An alteration or a mutation in a gene (BRCA 1, 2) does not equal cancer, and of these, BRCA mutations are responsible for approximately 20– 25% of the diagnoses. it just means there is an increased risk.” Huma Rana, MD, Cancer Geneticist, Dana-Farber Cancer Institute New Breast Cancer Cases Every Year new cases of invasive breast cancer 232,340 in women in 2013 cases of carcinoma in situ (CIS) in 2013 (non-invasive and earliest form of breast cancer) 64,640 Risk of Cancer if you have BRCA 1, 2 mutations Women with inherited alterations in BRCA 1, 2 have a 40-80% chance of developing breast cancer during their lifetimes. 5-10% Family Members with Breast Cancer risk factors 5–10% of women have a mother or sister with breast cancer, and about twice as many have either a first-degree relative or seconddegree relative with breast cancer. for breast cancer • Age • Reproductive and menstrual history • Oral contraceptives • Hormone replacement therapy • Radiation exposure • Alcohol intake • Obesity Bilateral preventative mastectemy can reduce risk of breast cancer by 90%. Curable Breast Cancer Percent of Survival 93% 88% 81% 74% Stage 0 Stage I Stage IIA Stage IIB 67% 41% 49% 15% Stage IIIA Stage IIIB Stage IIIC Stage IV Sources • • • • • Dana-Farber Turning Point, 2009: http://www.dana-farber.org/uploadeFiles/ Library/newsroom/publications/turning-point/2009/TurningPoint_2009.pdf NCI – Genetics of Breast and Ovarian Cancer: http://www.cancer.gov/ cancertopics/pdq/genetics/breast-and-ovarian/HealthProfessional/page1 American Cancer Society: http://www.cancer.org/cancer/breastcancer/ overviewguide/breast-cancer-overview-key-statistics American Cancer Society: http://www.cancer.org/cancer/breastcancer/ overviewguide/breast-cancer-overview-survival-rates “Outsmart Your Genes: Understanding BRCA 1/2 Cancer Risk” by Huma Q. Rana, MD, Dana-Farber Cancer Institute, July 2013 S USAN F. S MITH C ENTER FOR W OMEN ’ S C ANCERS