Weight gain, hypertension, skin alterations, myopathy, and hirsutism were the most frequent symptoms reported in the ERCUSYN database, affecting 81%, 75%, 72%, 67%, and 58% of patients respectively. Cushing's syndrome has a significant negative impact on health-related quality of life, with physical and psychosocial limitations persisting even after long-term biochemical cure. Several quality of life measures like the Visual Analog Scale of the EuroQoL and physical symptoms like sleep, pain, and wound healing showed improvement in the postoperative period, though memory issues did not significantly change.

1. DISTRIBUTION OF SYMPTOMS IN THE OVERALL
POPULATION 2014 (ERCUSYN database)
Weight gain (81%), hypertension (75%), skin alterations (72%),
myopathy (67%) and hirsutism (58%) were the most frequent symptoms.
Great % of not known info (i.e. 63% for reduced libido)
0
10
20
30
40
50
60
70
80
90
w
eightgain
hypertension
skin
alterationsm
yopathyhirsutism
m
enstrualirregularities
diabetes
m
ellitusdepression
hairloss
libido
reduction
fractures

2. Cushing’s syndrome has a significant
impact on health related quality of life (QoL)
• Despite long-term cure of
CS, patients experience
impaired QoL, with
physical and
psychosocial limitations,
especially in the presence
of hypopituitarism
van Aken MO et al. Quality of life in patients after long-term biochemical cure
of Cushing’s disease. J Clin Endocrinol Metab. 2005;90(6):3279-86.

3. Baseline 0-3 3-12 12-24 >24
Time (months)
VASEuroQoL
ERCUSYN: THE VISUAL ANALOG SCALE (VAS) OF THE EUROQoL
SLOWLY IMPROVES IN PATIENTS IN REMISSION AFTER SURGERY

4. Sleep Pain
Wound healing Easy bruising
* *
* **
*
*
*
SIGNIFICANT IMPROVEMENT OF THE CUSHING QoL
PHYSICAL ITEMS IN THE POSTOPERATIVE PERIOD (ERCUSYN
data)
*
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo

5. THE CUSHING QoL PSYCHOLOGICAL ITEMS IMPROVE IN THE
POSTOPERATIVE PERIOD, BUT MEMORY DOES NOT !
(ERCUSYN data)
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
1
2
3
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
Irritability Physical appearance
Daily activity Memory