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Sharing Innovation in the Fight Against
Neglected Tropical Diseases




World Intellectual Property Organization
Secretariat
                                                        Jennifer Dent – VP, Commercialization &
                                                        Alliance Management
BIO Ventures for Global Health
Partnership Hub Administrator


                                     www.wipoReSearch.org
Agenda


 •   WIPO Re:Search
 •   Partnership Hub
 •   WIPO Re:Search Resources
 •   Database
 •   Q&A




                                2
What is WIPO Re:Search?

• Led by the World Intellectual Property Organization
  in collaboration with BIO Ventures for Global Health
• Makes intellectual property, know-how and other
  resources available to Member researchers working
  in the neglected tropical disease, malaria and
  tuberculosis fields
• Provides free access and royalty free licenses
   – No upfront licensing fee
   – Royalty free products for Least Developed
      Countries
• Facilitates collaboration to develop new
  drugs, vaccines, and diagnostics
                                                         3
WIPO Re:Search Roles

 WIPO Re:Search is a voluntary Consortium governed by its
 Members and a set of Guiding Principles
 • WIPO – Secretariat
 • BVGH – Partnership Hub Administrator
 • Members – Contribute and access intellectual property
   and other resources and partner to drive R&D for
   neglected tropical diseases, malaria and tuberculosis
    • Providers
    • Users
    • Supporters

                                                            4
Highlights of the Guiding Principles

 • Royalty-free licenses for neglected tropical disease, malaria and TB
   research and development for the least developed countries (LDCs)
 • Members will consider in good faith the issue of access to these
   products for all developing countries, including those which do not
   qualify as LDCs
 • Users shall be allowed to retain ownership of new intellectual
   property but are encouraged to make new inventions available
   through WIPO Re:Search
 • License Agreements will be individually negotiated between
   Members in accordance with the Guiding Principles


                                                                          5
WIPO Re:Search Providers & Users
Providers                                          •    U.S. National Institutes of Health
•   Alnylam Pharmaceuticals                        •    Walter Reed Army Institute of Research (WRAIR)
•   AstraZeneca                                    Potential Users
•   California Institute of Technology             •    Anacor Pharmaceuticals
•   Center for World Health & Medicine             •    Center for World Health & Medicine
•   Drugs for Neglected Diseases initiative        •    Drugs for Neglected Diseases initiative
•   Eisai                                          •    Emory University
•   Fundação Oswaldo Cruz (Fiocruz)                •    Fundação Oswaldo Cruz (Fiocruz)
•   GlaxoSmithKline                                •    Galvmed
•   Infectious Disease Research Institute (IDRI)   •    Infectious Disease Research Institute (IDRI)
•   Liverpool School of Tropical Medicine          •    iThemba Pharmaceuticals
•   Massachusetts Institute of Technology          •    Liverpool School of Tropical Medicine
•   McGill University                              •    McGill University
•   Medicines for Malaria Venture                  •    Medicines for Malaria Venture
•   Merck                                          •    National Center for Genetic Engineering and Biotechnology (BIOTEC)
•   Northeastern University                        •    Northeastern University
•   Novartis                                       •    PATH
•   PATH                                           •    Sabin Vaccine Institute
•   Pfizer                                         •    South African Medical Research Council
•   Sanofi                                         •    Stanford University
•   South African Medical Research Council         •    University of California, Berkeley
•   Stanford University                            •    University of California, San Francisco
•   Swiss Tropical and Public Health Institute     •    University of Dundee
•   University of California, Berkeley             •    Walter Reed Army Institute of Research (WRAIR)
•   University of Dundee

                                                                                                                         6
WIPO Re:Search Supporters
 Supporters

 •   Africa Fighting Malaria
 •   Association of University Technology Managers
 •   Biotechnology Industry Organization (BIO)
 •   Council on Health Research for Development (COHRED)
 •   Indian Council for Medical Research
 •   International Federation of Pharmaceutical Manufacturers
     & Associations (IFPMA)
 •   Kenya Medical Research Institute
 •   Licensing Executive Society International
 •   Mahidol University
 •   South African Medical Research Council
 •   U.S. Patent and Trademark Office
 •   Walter Reed Army Institute of Research (WRAIR)
 •   World Health Organization (WHO)




                                                                7
21 Neglected Diseases

   Buruli Ulcer                                Lymphatic filariasis

   Chagas disease (American trypanosomiasis)   Onchocerciasis

   Cysticercosis                               Rabies
   Dengue/dengue hemorrhagic fever             Schistosomiasis
   Dracunculiasis (guinea-worm disease)        Soil transmitted helminthiasis
   Echinococcosis                              Trachoma
   Endemic treponematoses (Yaws)               Podoconiosis
   Foodborne trematode infections              Snakebite
   Human African trypanosomiasis               Malaria
   Leishmaniasis                               Tuberculosis
   Leprosy



                                                                                8
The Partnership Hub

 The Partnership Hub is the partnering component of WIPO
 Re:Search
 • Facilitate collaborations between members to drive the
   development of drugs, vaccines and diagnostics for
   neglected tropical diseases, malaria and tuberculosis
 • Recruit new Members
 • Actively engage with members to learn about
   contributions and research needs
 • Build relationships with members to support their
   partnering interests

                                                            9
BVGH - The Partnership Hub Administrator

 How does BVGH establish WIPO Re:Search collaborations?
 • Field member requests
 • Proactively identify partnership opportunities
 • Build knowledge of member contributions and research
   programs
 • Match contributions and resources with member’s
   research needs
 • Facilitate collaboration between members



                                                          10
Partnership Hub: Connecting the Spokes

• Contribute IP                                      • Search WIPO
                               Provider                Re:Search
  & know-how
• Collaborate                                          database
• Host & Mentor                             User     • Identify &
                     User
                                                       communicate
                                                       resource needs
                                                     • Collaborate

• Identify
  collaboration     Provider              Provider
  opportunities
• Connect Users &
  Providers                     User
• Support Members

                                                                   11
WIPO Re:Search Collaborations

 • Various research agreements
       • material transfer agreements – compound
         libraries, compounds
       • confidentiality agreements - sharing data, know-how and
         other confidential information
       • Building expertise and capacity through hosting and
         mentoring arrangements
 • Licensing agreements
 • Other agreements to support the development of
   products for NTDs, malaria and tuberculosis

                                                                   12
Partnership Hub Resources

 • Partnership Hub Monthly Snapshot
       •   Partnership Hub activities
       •   Collaborations in the pipeline
       •   Research requests
       •   New and highlighted contributions
       •   Select upcoming member presentations
 • Quarterly Contribution Highlights
       • Two page scientific piece highlighting a WIPO Re:Search
         contribution



                                                                   13
Partnership Hub Resources

 • Communications “tool-kit”
       •   WIPO Re:Search slide set
       •   One page overview for scientists
       •   One page overview for policy makers
       •   WIPO Re:Search flyer/brochure
       •   WIPO Re:Search scientific poster
       •   List of key neglected tropical disease meetings


 • WIPO Re:Search Database


                                                             14
WIPO Re:Search Database

 WIPO Re:Search provides a searchable, public database
 of intellectual property, know-how and other resources
    • Compounds
    • Compound libraries
    • Technologies
    • Know-how and therapeutic area expertise
    • Hosting and mentoring scientists at various research and
      development sites
    • Coaching scientists

                                                                 15
Jennifer Dent
Structured search by…



                                Provider




                                   Disease


                        Type of data
Q&A
Potential Collaborations

 AstraZeneca and iThemba
     • iThemba developing isocitrate lyase inhibitors for Tuberculosis
     • AstraZeneca is open to considering neglected tropical disease research
       requests to support computational and predictive chemistry needs
     • iThemba expressed interest in accessing computational support to
       improve DMPK properties


  About 1.9 billion people have latent TB.
  According to the WHO approximately 1.4 million people
  died of TB in 2010.




                                                                                19
Potential Collaborations

McKerrow Lab at UCSF interested in statins for
Schistosomiasis
   • Interest in compounds selective for parasite not human
   • Pharmaceutical companies such as Merck have developed statins and are
     exploring availability of compound libraries for UCSF
   • Statins going off patent


                   Schistosomiasis is caused by parasitic worms
                   >207 million affected, 85% in Africa (WHO)




                                                                             20
Potential Collaborations
 Emory Vaccine Center and Sabin Vaccine Institute
 •   Emory scientists have expertise in system vaccinomics (how vaccines affect
     innate and adaptive immunity and biomarker identification).
 •   Sabin is developing hookworm, schistosomiasis and Chagas vaccines.
 •   Potential to collaborate to better understand vaccine effect on immunity and
     to improve vaccine design.




                                                                                    21
Selected Contributions in Database
 Alnylam
      •   More than 1,500 issued or pending RNAi patents, with know-how and expertise
 AstraZeneca (AZ)
      •   Host and mentor researchers working on NTD targets at AZ facilities
      •   Screening of targets against AZ compound libraries
 GlaxoSmithKline (GSK)
      •   Contributed full antimalarial dataset (13,500 compounds)
      •   Tres Cantos Open Lab Program
 Merck
      •   Casein Kinase I Inhibitors against Leishmaniasis (lead series)
      •   Histone Deacetylase (HDAC) inhibitor series - malaria

 Check out http://www.wipo.int/research/en/search/ for additional contributions


                                                                                        22

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Jennifer Dent

  • 1. Sharing Innovation in the Fight Against Neglected Tropical Diseases World Intellectual Property Organization Secretariat Jennifer Dent – VP, Commercialization & Alliance Management BIO Ventures for Global Health Partnership Hub Administrator www.wipoReSearch.org
  • 2. Agenda • WIPO Re:Search • Partnership Hub • WIPO Re:Search Resources • Database • Q&A 2
  • 3. What is WIPO Re:Search? • Led by the World Intellectual Property Organization in collaboration with BIO Ventures for Global Health • Makes intellectual property, know-how and other resources available to Member researchers working in the neglected tropical disease, malaria and tuberculosis fields • Provides free access and royalty free licenses – No upfront licensing fee – Royalty free products for Least Developed Countries • Facilitates collaboration to develop new drugs, vaccines, and diagnostics 3
  • 4. WIPO Re:Search Roles WIPO Re:Search is a voluntary Consortium governed by its Members and a set of Guiding Principles • WIPO – Secretariat • BVGH – Partnership Hub Administrator • Members – Contribute and access intellectual property and other resources and partner to drive R&D for neglected tropical diseases, malaria and tuberculosis • Providers • Users • Supporters 4
  • 5. Highlights of the Guiding Principles • Royalty-free licenses for neglected tropical disease, malaria and TB research and development for the least developed countries (LDCs) • Members will consider in good faith the issue of access to these products for all developing countries, including those which do not qualify as LDCs • Users shall be allowed to retain ownership of new intellectual property but are encouraged to make new inventions available through WIPO Re:Search • License Agreements will be individually negotiated between Members in accordance with the Guiding Principles 5
  • 6. WIPO Re:Search Providers & Users Providers • U.S. National Institutes of Health • Alnylam Pharmaceuticals • Walter Reed Army Institute of Research (WRAIR) • AstraZeneca Potential Users • California Institute of Technology • Anacor Pharmaceuticals • Center for World Health & Medicine • Center for World Health & Medicine • Drugs for Neglected Diseases initiative • Drugs for Neglected Diseases initiative • Eisai • Emory University • Fundação Oswaldo Cruz (Fiocruz) • Fundação Oswaldo Cruz (Fiocruz) • GlaxoSmithKline • Galvmed • Infectious Disease Research Institute (IDRI) • Infectious Disease Research Institute (IDRI) • Liverpool School of Tropical Medicine • iThemba Pharmaceuticals • Massachusetts Institute of Technology • Liverpool School of Tropical Medicine • McGill University • McGill University • Medicines for Malaria Venture • Medicines for Malaria Venture • Merck • National Center for Genetic Engineering and Biotechnology (BIOTEC) • Northeastern University • Northeastern University • Novartis • PATH • PATH • Sabin Vaccine Institute • Pfizer • South African Medical Research Council • Sanofi • Stanford University • South African Medical Research Council • University of California, Berkeley • Stanford University • University of California, San Francisco • Swiss Tropical and Public Health Institute • University of Dundee • University of California, Berkeley • Walter Reed Army Institute of Research (WRAIR) • University of Dundee 6
  • 7. WIPO Re:Search Supporters Supporters • Africa Fighting Malaria • Association of University Technology Managers • Biotechnology Industry Organization (BIO) • Council on Health Research for Development (COHRED) • Indian Council for Medical Research • International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) • Kenya Medical Research Institute • Licensing Executive Society International • Mahidol University • South African Medical Research Council • U.S. Patent and Trademark Office • Walter Reed Army Institute of Research (WRAIR) • World Health Organization (WHO) 7
  • 8. 21 Neglected Diseases Buruli Ulcer Lymphatic filariasis Chagas disease (American trypanosomiasis) Onchocerciasis Cysticercosis Rabies Dengue/dengue hemorrhagic fever Schistosomiasis Dracunculiasis (guinea-worm disease) Soil transmitted helminthiasis Echinococcosis Trachoma Endemic treponematoses (Yaws) Podoconiosis Foodborne trematode infections Snakebite Human African trypanosomiasis Malaria Leishmaniasis Tuberculosis Leprosy 8
  • 9. The Partnership Hub The Partnership Hub is the partnering component of WIPO Re:Search • Facilitate collaborations between members to drive the development of drugs, vaccines and diagnostics for neglected tropical diseases, malaria and tuberculosis • Recruit new Members • Actively engage with members to learn about contributions and research needs • Build relationships with members to support their partnering interests 9
  • 10. BVGH - The Partnership Hub Administrator How does BVGH establish WIPO Re:Search collaborations? • Field member requests • Proactively identify partnership opportunities • Build knowledge of member contributions and research programs • Match contributions and resources with member’s research needs • Facilitate collaboration between members 10
  • 11. Partnership Hub: Connecting the Spokes • Contribute IP • Search WIPO Provider Re:Search & know-how • Collaborate database • Host & Mentor User • Identify & User communicate resource needs • Collaborate • Identify collaboration Provider Provider opportunities • Connect Users & Providers User • Support Members 11
  • 12. WIPO Re:Search Collaborations • Various research agreements • material transfer agreements – compound libraries, compounds • confidentiality agreements - sharing data, know-how and other confidential information • Building expertise and capacity through hosting and mentoring arrangements • Licensing agreements • Other agreements to support the development of products for NTDs, malaria and tuberculosis 12
  • 13. Partnership Hub Resources • Partnership Hub Monthly Snapshot • Partnership Hub activities • Collaborations in the pipeline • Research requests • New and highlighted contributions • Select upcoming member presentations • Quarterly Contribution Highlights • Two page scientific piece highlighting a WIPO Re:Search contribution 13
  • 14. Partnership Hub Resources • Communications “tool-kit” • WIPO Re:Search slide set • One page overview for scientists • One page overview for policy makers • WIPO Re:Search flyer/brochure • WIPO Re:Search scientific poster • List of key neglected tropical disease meetings • WIPO Re:Search Database 14
  • 15. WIPO Re:Search Database WIPO Re:Search provides a searchable, public database of intellectual property, know-how and other resources • Compounds • Compound libraries • Technologies • Know-how and therapeutic area expertise • Hosting and mentoring scientists at various research and development sites • Coaching scientists 15
  • 17. Structured search by… Provider Disease Type of data
  • 18. Q&A
  • 19. Potential Collaborations AstraZeneca and iThemba • iThemba developing isocitrate lyase inhibitors for Tuberculosis • AstraZeneca is open to considering neglected tropical disease research requests to support computational and predictive chemistry needs • iThemba expressed interest in accessing computational support to improve DMPK properties About 1.9 billion people have latent TB. According to the WHO approximately 1.4 million people died of TB in 2010. 19
  • 20. Potential Collaborations McKerrow Lab at UCSF interested in statins for Schistosomiasis • Interest in compounds selective for parasite not human • Pharmaceutical companies such as Merck have developed statins and are exploring availability of compound libraries for UCSF • Statins going off patent Schistosomiasis is caused by parasitic worms >207 million affected, 85% in Africa (WHO) 20
  • 21. Potential Collaborations Emory Vaccine Center and Sabin Vaccine Institute • Emory scientists have expertise in system vaccinomics (how vaccines affect innate and adaptive immunity and biomarker identification). • Sabin is developing hookworm, schistosomiasis and Chagas vaccines. • Potential to collaborate to better understand vaccine effect on immunity and to improve vaccine design. 21
  • 22. Selected Contributions in Database Alnylam • More than 1,500 issued or pending RNAi patents, with know-how and expertise AstraZeneca (AZ) • Host and mentor researchers working on NTD targets at AZ facilities • Screening of targets against AZ compound libraries GlaxoSmithKline (GSK) • Contributed full antimalarial dataset (13,500 compounds) • Tres Cantos Open Lab Program Merck • Casein Kinase I Inhibitors against Leishmaniasis (lead series) • Histone Deacetylase (HDAC) inhibitor series - malaria Check out http://www.wipo.int/research/en/search/ for additional contributions 22

Notas do Editor

  1. Recognizing the need for more progress in neglected disease research, WIPO Re:Search was formed in 2011 through the efforts of several of the world’s leading pharmaceutical companies, the World Intellectual Property Organization (WIPO), and BIO Ventures for Global Health. WIPO Re:Search is a multilateral, voluntary organization administered by the World Intellectual Property Organization in partnership with the non-profit organization BIO Ventures for Global Health (BVGH)In WIPO Re:Search, public and private sector organizations make valuableintellectual property available to qualified researchers seeking to develop new solutions for neglected tropical diseases, malaria, and tuberculosis.Providers offer access to intellectual property on a royalty-free basis for use and sale in all Least Developed Countries The intellectual property included in WIPO Re:Search includes free licenses for products, and providers agree to open up opportunities for discussions and the good faith negotiation for license termsWIPO Re:Search provides access to intellectual property for pharmaceutical compounds, technologies, and – most importantly – know-how can be a driving force for innovation in the search for new treatments for these devastating neglected diseases.
  2. Newest Member is McGill University – Tim Geary
  3. WIPO Re:Search focuses it’s efforts to facilitate the development of drugs, vaccines and diagnostics for these 21 neglected tropical diseases include malaria and tuberculosis.
  4. The Partnership Hub is where members and the public can learn about available licensing and research collaboration opportunities, networking possibilities, and funding resources.To support the use of the resources made available in WIPO Re:Search, BIO Ventures for Global Health (BVGH) – a leading global health organization – serves as the nonprofit administrator of the Partnership Hub.In this role, BVGH reaches out to potential users and licensees of WIPO Re:Search resources so that all assets are used as productively as possible.Researchers access information via the WIPO Re:Search website (www.wipoReSearch.org), which is freely available to the public. Users with potential interest in a particular compound, technology, or service can contact BVGH directly on their website.From this connection, partnerships for new neglected disease projects can be created.
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