An overview of ASDI Inc., including; company history, products and services, capabilities, outsourcing impacts, and contact. Please take a moment to view, and download, our company PPT. ASDI is dedicated to reducing discovery cycle time and operational expense.

1. Welcome to ASDI Inc.
ASDI is a CRO that serves the life science industry with research-enabling technologies, services and
products. Providing services such as synthetic chemistry, full-scale compound management programs, and
high throughput purification/reclamation research services; ASDI strives to increase efficiencies and reduce
drug discovery cycle time and operating expense(s).

2. Company History & Development
• Founded in 1988 – Distribution of HTS Samples - Russia
• NMR – Provided Entrance into Service Sector
• 1993 – Weighing of HTS Samples into Tube Racks
• 1995 – NMR Services Included Weighing of 20K HTS Samples

3. Service Development
• Greater Than 1,800,000 HTS Weighing Operations
• Greater Than 30,000,000 Liquid Transfers
• Dynamic Collection of HTS Compounds
• Fragment Screening Collection
• Known Biological Collection
• Lead Generation Libraries
• Diversity Collection
• Greater Than 750,000 Reactive Intermediate Transfers
• Greater Than 1,500,000 Analytical Sample Analysis

4. Facility Development
• Compound Management and Global Distribution
• Newark, Delaware
• 1998 – 800 sq ft
• 2004 – 54,000 sq ft
• 2006 – 76,000 sq ft
• 2007 – 104,000 sq ft
• 2008 – 172,000 sq ft

5. Business Development – Model Expansion
• 1988 – Brokerage of HTS Samples
• 2005 – Full Materials Management Services
• 1994 – HTS Powder Weighing Services
• 2006 – Lead Generation Libraries (Hit to Lead Custom
Library Synthetic Services)
• 2001 – Liquid Handling Services
• 2002 – Reactive Intermediate Services • 2007 – Bio-Analytical Services (Fragment Screening
Collection & Associated Services)
• 2003 – Chemical Custom Synthesis
• 2004 – Analytical Chemistry

6. Strategic Partners – Custom Synthesis
• Custom Synthesis
• Advanced Synthesis Group
• Acquired in 2006
• ASDI Ukraine, Ltd
• ASDI Thailand, Ltd
• ASDI China, Ltd
• Information Technologies
• Intelligent Systems, Inc.
• Under Development
• Computational Chemistry
• High Throughput Screening
• PK Studies

7. Nature Reviews. Drug Discovery, 5(11):941-955, copyright 2006
ASDI Impacting Drug Discovery
ASDI has extensive liquid handling
Stoichiometric weighing service
& sample formatting capabilities
ASDI integrated
management & distribution
of screening compounds ASDI bio-analytical & in-vitro ADMET
ASDI PK in-vivo assays
ASDI lead generation libraries
HTS screening samples ASDI custom synthesis
Fragment screening libraries & purification laboratory (LC/MS)
ASDI integrated proprietary
Intelligent Solutions (IS)
building block management
IT software & support
& distribution model

8. Drug Discovery Process: Integrated Services
Compound Purification
Custom Library Synthesis ADME Profiling
LC/MS
Pharmacokinetics
Studies
Compound Plating,
Database
Materials Management /
Compound Storage
Stoichiometric weighing,
Neats/Liquids
Liquid Handling, etc
Shipping to Multiple Acquisition of
Screening Groups Biological Data

9. Enabling & Accelerating Drug Discovery
• Increase the rate, diversity and quality of compounds entering the biological screening
assays.
• Provide necessary resources to enable the chemist and biologists to focus on the design,
elaboration and evaluation of novel series within a therapeutic program.
• Shorten the overall time for an idea to move through the discovery process and enter
development.
• Assist the pharmaceutical sector in making the most efficient use of R&D dollars in their
pursuit of new drug therapies.

10. Operational Capacity
Liquid Operations Services
• Sample Dissolution & Transfer (per day)
• Vials to Plates – 23,000 / Minitube to Plate – 40,000
• Replication – 17,280 plates (per day)
• 96 well – 1,600,000 / 384 well – 6,400,000 / 1536 well – a lot
HTS Powder Operations
• Sample Transfer (per day)
• ~12,000 items vials, minitubes racks, or blocks

11. Operational Capacity – Reactive Intermediate Distribution
• Climate Controlled Repositories for the Storage of Reactive Intermediate Collections
• 48,000 cu ft available – additional 24,000 cu ft being added
• High Throughput Intermediate Weighing Suite Utilizing ASDI Designed Glove Boxes
• Vial to vial – 12,000 (per day)
• Intensive IT Monitoring Software for Compound Weighing
• Statistical Data Retained on each Sample and Transfer

12. Operational Capacity – Analytical Services
• Multiple LC-MS Single Quad. Mass Analyzer
• Preparative LC-MS
• Varian Mercury 300 MHz NMR Spectrometer with Zymark Auto-
Sampler
• GC-MS with Auto-Sampler
• Multiple GC with Auto-Sampler
• Scheduled Expansion
• Triple Quadrapole Mass Analyzer
• Additional Preparative LC-MS

13. Pharmaceutical Research Services
Fast, flexible solutions for our partners in drug discovery
Our Philosophy
We adapt our programs, assays, and services to solve your problems in the most cost
effective way

14. Pharmaceutical Research Services
• Custom chemistry
• Purification/Reclamation lab
• High throughput analytical chemistry

15. Pharmaceutical Research Services – Custom Chemistry
• Scaffolds and Building Blocks
• Pre-clinical Tox material (500g to 2 Kg), non-GMP
• Hit to Lead Library Synthesis (parallel, solution phase)
• Lead Optimization Small Library Synthesis

16. Pharmaceutical Research Services – Purification
• Work with the investigator to provide solutions
• Purification of a broad range of chemotypes in a high-throughput milieu
• Provide quality, information rich data

17. Pharmaceutical Research Services – Mass-Directed Preparative LC-MS
• Agilent A2Prep LC-MS
• 2-valve CTC HTC auto-sampler (analytical & preparative)
• 1200 series HPLC stack with DAD
• 2-channel binary gradient cluster
• Single quad MS
• Fraction collection stack (3)
• Capacity > 500 analyses / week

18. Pharmaceutical Research Services – Mass-Directed Preparative LC-MS
• Waters Auto-pure
• 2767 sample manager (analytical – prep – final purity)
• Fluidics manager
• 4-channel binary gradient module
• PDA and ELSD
• Capacity > 300 analyses / week

19. Pharmaceutical Research Services – Bulk Purification
• Quantities: Grams to Kilograms
• Medium pressure chromatography – Biotage
• Distillation
• Crystallization

20. Analytical & Bioanalytical Services
Comprehensive suite supporting
• ASDI Internal collections
• ASDI collaborations
• Synthetic chemistry
LC-MS/MS, GC-MS/MS & NMR
• Average > 300K analyses annually
• Capacity ≈ 1.5M

21. Future Products & Services
You determine ASDI’s future services and products.
What will provide the most value to you in your discovery research efforts?

22. Thank You.
We welcome you an opportunity for the ASDI management team(s) to provide an in depth discussion of
capabilities at our Newark, DE facility. We are also able to have one of our representatives, in your focus or
expertise, meet and present at your facility.
Additionally, we would also like to offer you the ASDI available chemical catalogue, featuring a collection of
reagents and building blocks, available electronically through our web based ordering system. Lastly, we
would like to offer ASDI’s comprehensive structure and computational based online system for searching,
reviewing, and ordering our chemical catalogue, fragment & HTS screening collections.
All available at www.ASDI.net
ASDI Marketing & Customer Service
ASDI Inc.
601 Interchange Blvd.
Newark, DE 19711 USA
Marketing@asdi.net
(p) 302-266-6891 ext 104
We look forward to working with you.