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DIARRHOEA: ETIOLOGY

• Infectious:   • Non infectious:
  Bacterial       -Dietary abnormality
  Viral           a. High fiber content
  Parasitic       b. High Ca content
  Fungal          c. Change in diet
                  -Non specific
DIARRHEA: CONSEQUENCES

• Loss of water

• loss of nutrients

• low availability of nutrients

• Less weight gain

• Low productivity
DIARRHOEA: CONTROL PROGRAM
• ESSENTIAL FOR BETTER SURVIVAL
  AND RATE OF GROWTH
  –   Optimize the peristalsis
  –   Limit the growth & progression of pathogens
  –   Adsorb the enterotoxin
  –   Normalize fluid secretion


 DIAROAK IS EMBODIED WITH ALL
       THE ATTRIBUTES
DIARRHOEA: THERAPY

• ANTIBACTERIAL AGENTS:
 – Hamper the intestinal microflora further
   hampering the digestibility
 – Narrow spectrum of activity
 – Physical disturbances not taken care
 – Anti-microbial resistance


       INCOMPLETE SOLUTION
DIAROAK: THE UNIQUENESS

– Reduces transit time of ingesta

– Decreases intestinal secretion

– Increases absorption of intestinal
 absorption

– Inactivation of enterotoxin released by
  bacteria
Andrographis paniculata

– Inhibition of enterotoxin induced secretion

– Interference with adenylate cyclase stimulation

– Non-specifically increase in intestinal
  absorption
           – Int. J. Crude Drug Research, 1990, 28(4), 273-283
Berberis aristata

– Effective in controlling diarrhea in
  bacteriologically positive and negative patients

– Reduction in volume & duration of diarrhea,
  period of hydration and the convalescent
  period
      – Journal of Indian Medical Association, 1967, 48(1), 1-17
Punica granatum

– Stops castor oil induced diarrhea

– Decreases rate of flow of ingesta thus
  controlling diarrhea

                     – Int. J. Pharmacognosy, 30, 1968, 289
Holarrhena Antidysenterica

– Consessine, an alkaloid present in plant is
  responsible for treating chronic Amoebic
  dysentery

                         – Int. J. Pharmacy 30, 1968: 289
DIAROAK: BENEFITS

•   Control irrespective of etiology
•   Assists the repair of damaged GI mucosa
•   Corrects the malabsorption syndrome
•   No damage to friendly microflora
•   Devoid of resistance & residues


    THE THERAPY WITH MULTIPLE BENEFITS
Effect of Diaroak in Controlling
Diarrhea Due to Digestive Disorder
 Groups Sub    6 wk           Feed     FCR Mortality
        Groups body           consumed     (%)
               wt.
 I        A            1483   2803            1.89    1.25
          B            1491   2848            1.91    1.25
 II       A            1338   2970            2.22    8.75
          B            1412   3036            2.15    6.25
          C            1350   2970            2.19    7.50
          D            1386   3049            2.20    8.75
      Diet 1 - Fiber 6%        A - Control
      Diet II - Fiber 8%       B - Diaroak (Preventive)
                               C - Diaroak (Therapeutic)
                               D - Antibiotic - (Therapeutic)
Effect of Diaroak in Controlling
           Diarrhea in Rabbits
Parameter               Treated by Diaroak   Control
Number of weaning       174                  184
Rabbits (On 6th week)
Number of Rabbits in    165                  153
10th week
Mortality % (Number)    5.2% (9)             16.8% (31)


Parameter               Treated by Diaroak   Control
Number of weaning       764                  1241
Rabbits (6th week)
Number of Rabbits       738                  1142
(10th week)
Mortality % (Number)    3.5% (26)            8% (99)
DIAROAK
PROTECITVE, ADSORBANT, ANTIDIARRHOEAL


Indications:
Controls diarrhea irrespective
of etiology

Dosage
•To be mixed in feed @ 0.25%
For 5-7 days as curative
•0.1% as preventive
Presentation:
1 kg and 15 kg pack
DIAROAK
   PROTECITVE, ADSORBANT, ANTIDIARRHOEAL

Pigs -
Upto 10 kg body wt.                      5g
10-40kg body wt.                        10g
40-100 kg body wt.                      20g
100 kg and above                        30g



Mix the granules with approximately five (5)
times
the quantity of water, shake well to
homogenous
suspension and administer orally, twice daily.
In severe cases repeat dose six hourly. Or as
regular feed supplements in feed regularly as
per the prescribed dosage

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Diaroak pigs

  • 1. DIARRHOEA: ETIOLOGY • Infectious: • Non infectious: Bacterial -Dietary abnormality Viral a. High fiber content Parasitic b. High Ca content Fungal c. Change in diet -Non specific
  • 2. DIARRHEA: CONSEQUENCES • Loss of water • loss of nutrients • low availability of nutrients • Less weight gain • Low productivity
  • 3. DIARRHOEA: CONTROL PROGRAM • ESSENTIAL FOR BETTER SURVIVAL AND RATE OF GROWTH – Optimize the peristalsis – Limit the growth & progression of pathogens – Adsorb the enterotoxin – Normalize fluid secretion DIAROAK IS EMBODIED WITH ALL THE ATTRIBUTES
  • 4. DIARRHOEA: THERAPY • ANTIBACTERIAL AGENTS: – Hamper the intestinal microflora further hampering the digestibility – Narrow spectrum of activity – Physical disturbances not taken care – Anti-microbial resistance INCOMPLETE SOLUTION
  • 5. DIAROAK: THE UNIQUENESS – Reduces transit time of ingesta – Decreases intestinal secretion – Increases absorption of intestinal absorption – Inactivation of enterotoxin released by bacteria
  • 6. Andrographis paniculata – Inhibition of enterotoxin induced secretion – Interference with adenylate cyclase stimulation – Non-specifically increase in intestinal absorption – Int. J. Crude Drug Research, 1990, 28(4), 273-283
  • 7. Berberis aristata – Effective in controlling diarrhea in bacteriologically positive and negative patients – Reduction in volume & duration of diarrhea, period of hydration and the convalescent period – Journal of Indian Medical Association, 1967, 48(1), 1-17
  • 8. Punica granatum – Stops castor oil induced diarrhea – Decreases rate of flow of ingesta thus controlling diarrhea – Int. J. Pharmacognosy, 30, 1968, 289
  • 9. Holarrhena Antidysenterica – Consessine, an alkaloid present in plant is responsible for treating chronic Amoebic dysentery – Int. J. Pharmacy 30, 1968: 289
  • 10. DIAROAK: BENEFITS • Control irrespective of etiology • Assists the repair of damaged GI mucosa • Corrects the malabsorption syndrome • No damage to friendly microflora • Devoid of resistance & residues THE THERAPY WITH MULTIPLE BENEFITS
  • 11. Effect of Diaroak in Controlling Diarrhea Due to Digestive Disorder Groups Sub 6 wk Feed FCR Mortality Groups body consumed (%) wt. I A 1483 2803 1.89 1.25 B 1491 2848 1.91 1.25 II A 1338 2970 2.22 8.75 B 1412 3036 2.15 6.25 C 1350 2970 2.19 7.50 D 1386 3049 2.20 8.75 Diet 1 - Fiber 6% A - Control Diet II - Fiber 8% B - Diaroak (Preventive) C - Diaroak (Therapeutic) D - Antibiotic - (Therapeutic)
  • 12. Effect of Diaroak in Controlling Diarrhea in Rabbits Parameter Treated by Diaroak Control Number of weaning 174 184 Rabbits (On 6th week) Number of Rabbits in 165 153 10th week Mortality % (Number) 5.2% (9) 16.8% (31) Parameter Treated by Diaroak Control Number of weaning 764 1241 Rabbits (6th week) Number of Rabbits 738 1142 (10th week) Mortality % (Number) 3.5% (26) 8% (99)
  • 13. DIAROAK PROTECITVE, ADSORBANT, ANTIDIARRHOEAL Indications: Controls diarrhea irrespective of etiology Dosage •To be mixed in feed @ 0.25% For 5-7 days as curative •0.1% as preventive Presentation: 1 kg and 15 kg pack
  • 14. DIAROAK PROTECITVE, ADSORBANT, ANTIDIARRHOEAL Pigs - Upto 10 kg body wt. 5g 10-40kg body wt. 10g 40-100 kg body wt. 20g 100 kg and above 30g Mix the granules with approximately five (5) times the quantity of water, shake well to homogenous suspension and administer orally, twice daily. In severe cases repeat dose six hourly. Or as regular feed supplements in feed regularly as per the prescribed dosage