Cases in Microscopic Haematology - Gillian Rozenberg
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Cases in Microscopic Haematology is a collection of 80 case studies specifically designed to engage the learner in the laboratory process of data and blood film analysis, differential diagnosis and ...

Cases in Microscopic Haematology is a collection of 80 case studies specifically designed to engage the learner in the laboratory process of data and blood film analysis, differential diagnosis and reporting.

Each case provides the family history, analyser data and blood film/slide. Students use a template to complete the differential diagnosis and reporting. The process and template simulates the laboratory environment. Cases are organised according to difficulty and the worked cases are available in the back of the text.

A suite of 20 Virtual slides will accompany the casebook. Cases in Microscopic Haematology is an excellent companion to Microscopic Haematology: a practical guide for the laboratory and will appeal to both the academic and professional market as either a pack or stand alone resource.

This text will provide the opportunity for the student and laboratory technician to work through the case studies using a template similar to that used in a functioning laboratory.

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  • I work as Biomedical Scientist in Ghana.I have been following your articles since last year. Keep up the good work you are doing. I want to pursue haematology next year if God wills. I would like to be your protege. Thank you.
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    Cases in Microscopic Haematology - Gillian Rozenberg Cases in Microscopic Haematology - Gillian Rozenberg Document Transcript

    • Cases inMicroscopic Haematology Gillian Rozenberg sample only
    • CASES IN sample only
    • sample only
    • CASES IN Gillian RozenbergSydney Edinburgh London New York Philadelphia St Louis Toronto sample only
    • sample only
    • Contents How to Use this Book vi Acknowledgements vii Reviewers viii1 Examination of the Blood Film 1 Preparation of the blood film 1 Artifactual changes seen on the blood film 2 Red cells 2 White cells 20 Platelets 22 Malarial parasites 222 Red Cell Cases 233 White Cell Cases 1034 Platelet Cases 1815 Malaria Cases 193 Answers 206 sample only v
    • How to Use this BookCases in Microscopic Haematology is a compilation of 80 haematology casesrepresenting red cell, white cell, platelet and malaria disorders and neoplasmsand encompassing all age groups. A valuable resource for students, scientists andmedical registrars in haematology in its own right, this collection of case studieswill be most useful when used in conjunction with the author’s MicroscopicHaematology 3rd edition (Churchill Livingstone, Sydney, 2011). Chapter 1 describes how to prepare a good quality blood film. The film isexamined systematically, avoiding mention of any red cell, white cell or plateletartifact that may be present and ensuring that the parameters issued by theanalyser correlate with those seen under the microscope. A blood film comment isperformed using the standard nomenclature, grading the changes according to thenumber of cells seen on the blood film, either slight, moderate or marked. A description is provided of the artifactual changes that may occur in red cells,white cells and platelets, followed by a section on red cell nomenclature that contraststhe appearance of red cells on a stained blood film with their appearance under theelectron microscope. White cell and platelet maturation are also described, referringto the images as they appear in Microscopic Haematology 3rd edition. The case studies have been divided into chapters of red cell, white cell, plateletand malaria cases. Many of these cases will have a differential diagnosis. Consider case study 20, a 25-year-old Asian female who is 4 weeks pregnant.The analyser data and the blood film indicate that this patient has a microcytichypochromic anaemia. From this evidence, the reader should be able to arrive atthe differential diagnosis of iron deficiency, thalassaemia, or a combination of both.The reader is then asked which further tests would be requested by the clinician inorder to make an actual outcome or definitive diagnosis. Case study 38 is that of a 64-year-old male with lassitude, anaemia andsplenomegaly. The analyser data identifies a very high white cell count. The readershould recognise that the white cell count and differential are pathognomonic ofa particular myeloproliferative neoplasm; however, further tests – a bone marrowand cytogenetics – will be requested by the clinician in order to make a definitivediagnosis. indicates a paediatric case. The reference ranges for neonates, infants and children differ from those in adults. This difference continues until twelveyears of age when, haematologically, children are considered comparable to adultsand adult reference ranges can be applied. Many clinical conditions that occur inthe paediatric patient are not seen in adults; conversely, many clinical conditionsthat occur in adults are infrequent in the paediatric patient. The differential diagnosis, further tests, and the actual outcome or diagnosis ofeach case study will be found in the Answers section, with additional explanationwhere appropriate.vi sample only
    • AcknowledgementsThere are a number of people to whom I am indebted for their assistance with theproduction of this book. I would like to thank Professor Robert Lindeman, the Director of theDepartment of Haematology at the Prince of Wales Hospital, for allowing meaccess to the blood films and bone marrows in our laboratory, Virginia Bentink forher expertise in producing all 106 images, and Narelle Woodland, Senior Lecturerand Coordinator of Haematology at the University of Technology, Sydney, for hersupport during the writing of this book. sample only vii
    • ReviewersAnne-Marie Christensen, BAppSc(Med Lab Sci), BSc(Hons), MAppSc(Med Sci)MAIMS, AACB, MIBMSDiscipline of Medical Sciences, Faculty of Science & Technology, QueenslandUniversity of TechnologyAngus Fraser, FIBMS, CSciSingapore PolytechnicInstitute of Biomedical Science (IBMS), UKChris Kendrick, GradDipSci, MSc(Dis)NZ Registered Medical Laboratory Scientist, Senior Lecturer in Haematology &Transfusion ScienceMassey UniversityGweneth F MacDonald, BAppSci (Med Lab), DipEd (TAFE)AAIMLSRoyal Melbourne Institute of Technology (RMIT), MelbourneValerie Ng, PhD MDAlameda County Medical CenterUniversity of California San FranciscoProfessor Emeritus, Department of Laboratory Medicine, School of Medicine,UCSF; Chair, Laboratory Medicine & Pathology, Alameda County MedicalCenter; Director, ACMC Clinical LaboratoryE P Theakston, MBChB, FRCPALabplusAuckland District Health BoardCraig Williams, BAppSci (Med Lab)MAIMSSullivan Nicolaides Pathologyviii sample only
    • 2Red Cell Cases sample only
    • 30 Cases in Microscopic HaematologyCASE STUDY 4Case historyA 75-year-old male presents with shortness of breath. Analyser data Parameters Test Results Reference Range RBC 1.26 × 1012/L 4.50–6.50 × 1012/L Hb 49 g/L 130–180 g/L HCT 0.159 0.40–0.54 MCV 126.2 fL 80–100 fL MCH 38.9 pg 26.5–33.0 pg MCHC 308 g/L 310–360 g/L RDW-SD 86.4 fL 38.0–48.0 fL RDW-CV 50.7 % 12.0–14.5 % RETIC CT 0.1 % 0.2–2.0 % 9 RETIC ABS 1.26 × 10 /L 20–80 × 109/L 9 WBC 3.2 × 10 /L 3.5–11.0 × 109/L Plat 113 × 109/L 150–400 × 109/L Differential Parameters Test Results Reference Range 9 Neutrophil 60 % 1.9 × 10 /L 1.1–6.0 × 109/L Lymphocyte 35 % 1.1 × 109/L 2.7–8.9 × 109/L Monocyte 4 % 0.1 × 109/L 0.2–1.1 × 109/L 9 Eosinophil 1 % 0.03 × 10 /L 0.0–0.6 × 109/L Basophil 0 % 0.00 × 109/L 0.00–0.10 × 109/L sample only
    • 2 | Red Cell Cases 31Blood film commentsRed cell comments Moderate anisocytosis Marked oval macrocytes Slight microcytes Slight teardrop poikilocytesWhite cell comments Hypersegmented neutrophils LymphopeniaPlatelet comments ThrombocytopeniaQuestion 1. What is the differential diagnosis?Based on the differential diagnosis, the following tests should be requestedSerum B12 56 pmol/L RR (109–646) pmol/LSerum folate >45.3 nmol/L RR (6.5–40.5) nmol/LRed cell folate >2000 nmol/L RR (539–1685) nmol/LQuestion 2. Are further tests indicated as part of your final report?If so, which tests? sample only
    • 32 Cases in Microscopic HaematologyCASE STUDY 5Case historyA 10-month-old child presents with fever; he is pale and lethargic. Analyser data Parameters Test Results Reference Range RBC 1.25 × 1012/L 3.88–5.13 × 1012/L Hb 40 g/L 104–132 g/L HCT 0.124 0.30–0.38 MCV 99.2 fL 70–83 fL MCH 32.0 pg 23.1–29.4 pg MCHC 323 g/L 310–360 g/L RDW-SD 82.1 fL 34.8–44.6 fL RDW-CV 53.5 % 12.3–17.0 % RETIC CT 0.1 % 0.2–2.0 % 9 RETIC ABS 1.25 × 10 /L 20–80 × 109/L 9 WBC 5.9 × 10 /L 5.4–13.6 × 109/L Plat 42 × 109/L 205–553 × 109/L Differential Parameters Test Results Reference Range 9 Neutrophil 20.5 % 1.2 × 10 /L 1.1–6.0 × 109/L Lymphocyte 70.3 % 4.1 × 109/L 2.7–8.9 × 109/L Monocyte 7.0 % 0.4 × 109/L 0.2–1.1 × 109/L 9 Eosinophil 0.8 % 0.05 × 10 /L 0.0–0.6 × 109/L Basophil 1.4 % 0.08 × 109/L 0.00–0.20 × 109/L sample only
    • 2 | Red Cell Cases 33Blood film commentsRed cell comments Moderate anisocytosis Moderate oval macrocytes Slight teardrop poikilocytesWhite cell comments Hypersegmented neutrophilsPlatelet comments ThrombocytopeniaQuestion 1. What is the differential diagnosis?Based on the differential diagnosis, the following tests should be requestedSerum B12 100 pmol/L RR (97–394) pmol/LSerum folate 2.1 nmol/L RR (5.5–33.3) nmol/LQuestion 2. Are further tests indicated as part of your final report?If so, which tests? sample only