Abstract: Jean-Claude Bradley blazed a trail that many of us have followed. A true visionary, a dreamer of dreams, but what was his motivation? What was the goal he was striving towards? What was his vision of the future and why was Open Notebook Science a part of that vision? I will present Jean-Claude's work, from coining the phrase 'Open Notebook Science' to his latest project 'Chemical Rediscovery,' through the lens of defining the future for Open Notebook Science.
3. Q: Why did you decide to adopt an open approach?
A: In thinking about what has meaning for me as a
scientist, I realized that the work I was doing wasn’t
having the kind of impact that I would like it to have, and
it was not benefitting mankind in the way I would have
hoped. I concluded that this was partly a consequence of
secrecy. However, I couldn’t be open with the project I
was then working on, because I was collaborating with
someone who didn’t feel the same way as me.
My decision to do open science meant cutting ties with
my previous collaborators. Having done that in 2005, I
started the project UsefulChem.
http://www.infotoday.com/it/sep10/Poynder.shtml
Interview With Jean-Claude Bradley
The Impact of Open Notebook Science
by Richard Poynder
9. Open and Closed Science
Traditional
Lab Notebook
(unpublished)
Traditional
Journal
Article
Open Access
Journal Article
Open Notebook
Science (full
transparency)
CLOSED OPEN
Traditional
Paper
Textbook
F2F lectures
Lectures
Notes
public
Assigned
problems
public
Archived
Lectures
Public and
free online
textbooks
RESEARCH
TEACHING
12. There are NO FACTS,
only measurements embedded
within assumptions
Open Notebook Science maintains
the integrity of data provenance by
making assumptions explicit
19. There are NO FACTS,
only measurements embedded
within assumptions
Open Notebook Science maintains
the integrity of data provenance by
making assumptions explicit
20. First recrystallized in ethyl acetate in 1906.
Straus and Ecker, Ber. 39, 2988 (1906)
Recrystallized in ethyl acetate in Organic Syntheses
23. Lists solvents and their predicted recrystallization yield.
Prediction is generated by the temperature dependent
solubility curves.
24. The Chemical Rediscovery
Survey and the role of
Openness in Chemistry
Jean-Claude Bradley
March 6, 2014
Research Mini-Symposia
Associate Professor of Chemistry
Drexel University
Drexel University Department of Chemistry
25. The current paradigm of doing and
sharing science in chemistry
1. Design experiments based on
established or potentially new theories.
2. Execute and record experimental
outcomes in private notebooks.
3. When a sufficient narrative emerges
selective experimental data are
combined to publish, with a limited
amount of “supplementary supporting
data”
26. What kind of (chemical) worldview
has this approach created?
1. Selective bias towards which
experiment are even attempted.
2. Overconfidence in our understanding
since deviant or ambiguous results are
rarely reported.
27. Filling in the blind spots with the
Chemical Rediscovery Survey
(chemrs.wikispaces.com)
1. Randomize the mixture of chemicals with
certain criteria*
2. Identify “what happens” after convenient*
periods of time.
3. Follow up on unexpected behavior with the
traditional scientific method.
4. Openly share the entire process, including all
raw data and preliminary hypotheses and
discoveries as it happens.