The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

1. Kidney Disease - Pipeline Review, H1 2014
This report provides comprehensive information on the therapeutic development for Kidney Disease, complete with comparative analysis at various stages,
therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured
news and press releases. It also reviews key players involved in the therapeutic development for Kidney Disease and special features on late-stage and
discontinued projects.
Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built
using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and
featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team. Drug
profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the
latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that
the most recent developments are captured on a real time basis.
The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by
identifying new targets and MOAs to produce first-in-class and best-in-class products.
Scope
The report provides a snapshot of the global therapeutic landscape of Kidney Disease The report reviews key pipeline products under drug profile section which
includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities The report reviews key players involved
in the therapeutics development for Kidney Disease and enlists all their major and minor projects The report summarizes all the dormant and discontinued
pipeline projects A review of the Kidney Disease products under development by companies and universities/research institutes based on information derived
from company and industry-specific sources Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and
undisclosed stages A detailed assessment of monotherapy and combination therapy pipeline projects Coverage of the Kidney Disease pipeline on the basis of
target, MoA, route of administration and molecule type Latest news and deals relating related to pipeline products
Reasons to buy
Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies Identify emerging players
with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage Develop strategic initiatives by understanding the
focus areas of leading companies Identify and understand important and diverse types of therapeutics under development for Kidney Disease Plan mergers and
acquisitions effectively by identifying key players of the most promising pipeline Devise corrective measures for pipeline projects by understanding Kidney
Disease pipeline depth and focus of Indication therapeutics Develop and design in-licensing and out-licensing strategies by identifying prospective partners with
the most attractive projects to enhance and expand business potential and scope Modify the therapeutic portfolio by identifying discontinued projects and
understanding the factors that drove them from pipeline
table Of Contents
table Of Contents 2
list Of Tables 7
list Of Figures 8
introduction 9
global Markets Direct Report Coverage 9
kidney Disease Overview 10
therapeutics Development 11
pipeline Products For Kidney Disease Overview 11
pipeline Products For Kidney Disease Comparative Analysis 12
kidney Disease Therapeutics Under Development By Companies 13
kidney Disease Therapeutics Under Investigation By Universities/institutes 16
kidney Disease Pipeline Products Glance 17
late Stage Products 17
clinical Stage Products 18
early Stage Products 19
kidney Disease Products Under Development By Companies 20
kidney Disease Products Under Investigation By Universities/institutes 21
kidney Disease Companies Involved In Therapeutics Development 22
f. Hoffmann-la Roche Ltd. 22
sanofi 23
nektar Therapeutics 24
chugai Pharmaceutical Co., Ltd. 25
leo Pharma A/s 26
teva Pharmaceutical Industries Limited 27
zydus Cadila Healthcare Limited 28
gentium S.p.a. 29
celldex Therapeutics, Inc. 30
osteologix Holdings Plc. 31
ahn-gook Pharmaceutical Co., Ltd. 32
diamedica Inc. 33
upsher-smith Laboratories, Inc. 34
tetralogic Pharmaceuticals 35
Kidney Disease - Pipeline Review, H1 2014

2. chemocentryx, Inc. 36
anexon, Inc. 37
otsuka Holdings Co., Ltd. 38
bioprojet Scr 39
advicenne Pharma 40
zs Pharma, Inc. 41
g1 Therapeutics, Inc. 42
abbvie Inc. 43
kidney Disease Therapeutics Assessment 44
assessment By Monotherapy Products 44
assessment By Target 45
assessment By Mechanism Of Action 48
assessment By Route Of Administration 51
assessment By Molecule Type 53
drug Profiles 55
adv-7809 - Drug Profile 55
product Description 55
mechanism Of Action 55
r&d Progress 55
benazepril Hydrochloride - Drug Profile 56
product Description 56
mechanism Of Action 56
r&d Progress 56
adv-7103 - Drug Profile 57
product Description 57
mechanism Of Action 57
r&d Progress 57
tolvaptan - Drug Profile 58
product Description 58
mechanism Of Action 58
r&d Progress 58
methylprednisolone - Drug Profile 60
product Description 60
mechanism Of Action 60
r&d Progress 60
zs-9 - Drug Profile 61
product Description 61
mechanism Of Action 61
r&d Progress 61
agnpn-803 - Drug Profile 62
product Description 62
mechanism Of Action 62
r&d Progress 62
hydrocodone Bitartrate Er - Drug Profile 63
product Description 63
mechanism Of Action 63
r&d Progress 63
leo-27847 - Drug Profile 65
product Description 65
mechanism Of Action 65
r&d Progress 65
dm-199 - Drug Profile 66
product Description 66
mechanism Of Action 66
r&d Progress 66
tiprolisant - Drug Profile 67
product Description 67
mechanism Of Action 67
r&d Progress 67
abt-614 - Drug Profile 69
product Description 69
mechanism Of Action 69
r&d Progress 69
anx-042 - Drug Profile 70
product Description 70
mechanism Of Action 70
r&d Progress 70
ccx-872 - Drug Profile 71
Kidney Disease - Pipeline Review, H1 2014

3. product Description 71
mechanism Of Action 71
r&d Progress 71
rg-7641 - Drug Profile 72
product Description 72
mechanism Of Action 72
r&d Progress 72
cdx-1189 - Drug Profile 73
product Description 73
mechanism Of Action 73
r&d Progress 73
cu-np - Drug Profile 74
product Description 74
mechanism Of Action 74
r&d Progress 74
necrostatin Program - Drug Profile 75
product Description 75
mechanism Of Action 75
r&d Progress 75
oligotide - Drug Profile 76
product Description 76
mechanism Of Action 76
r&d Progress 76
nktr-228 - Drug Profile 77
product Description 77
mechanism Of Action 77
r&d Progress 77
ccr2 Antagonist - Drug Profile 78
product Description 78
mechanism Of Action 78
r&d Progress 78
ch-5451098 - Drug Profile 79
product Description 79
mechanism Of Action 79
r&d Progress 79
skqr-1 - Drug Profile 80
product Description 80
mechanism Of Action 80
r&d Progress 80
tnt-009 - Drug Profile 81
product Description 81
mechanism Of Action 81
r&d Progress 81
slr-080811 Derivative - Drug Profile 82
product Description 82
mechanism Of Action 82
r&d Progress 82
ave-0991 - Drug Profile 83
product Description 83
mechanism Of Action 83
r&d Progress 83
nbs-101 - Drug Profile 84
product Description 84
mechanism Of Action 84
r&d Progress 84
prod-1 - Drug Profile 85
product Description 85
mechanism Of Action 85
r&d Progress 85
messenger Rna Therapeutics Program - Drug Profile 86
product Description 86
mechanism Of Action 86
r&d Progress 86
ahro-200 - Drug Profile 87
product Description 87
mechanism Of Action 87
r&d Progress 87
cdk-4/6 Inhibitors As Renal Protectants - Drug Profile 88
Kidney Disease - Pipeline Review, H1 2014

4. product Description 88
mechanism Of Action 88
r&d Progress 88
a77-based Monobody - Drug Profile 89
product Description 89
mechanism Of Action 89
r&d Progress 89
kidney Disease Recent Pipeline Updates 90
kidney Disease Dormant Projects 98
kidney Disease Product Development Milestones 99
featured News & Press Releases 99
nov 07, 2013: La Jolla Pharmaceutical Company Presents Data At The Annual American Society Of Nephrology Conference 99
may 02, 2013: Arena Pharma Withdraws European Marketing Authorization Application For Belviq 99
mar 28, 2013: Cytori Therapeutics Receives Us Patent Covering Method Of Treating Renal Diseases Using Adipose-derived Regenerative Cells 99
jan 08, 2013: Medicure Announces Filing Of Snda For Aggrastat Label Change 100
nov 06, 2012: Lexicon Pharma Presents Phase Iib Results Of Lx4211 At American Heart Association Annual Conference 101
oct 17, 2012: Raptor Pharma Announces Presentation Of Procysbi Extension Study Data At American Society Of Nephrology Annual Meeting 102
aug 03, 2012: New Published Data Demonstrate Endocyte's Targeted Small Molecule Drug Conjugate Approach Shows Promising Results In Polycystic Kidney
Disease Model 102
mar 05, 2012: Medistem To Begin Clinical Trials Using Erc Stem Cells For Renal, Lung And Peripheral Artery Disease 103
may 11, 2011: Rockwell Medical Receives Us Patent For Sfp Packaging And Method Of Use 104
appendix 105
methodology 105
coverage 105
secondary Research 105
primary Research 105
expert Panel Validation 105
contact Us 106
disclaimer 106
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Kidney Disease - Pipeline Review, H1 2014