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AHCapabilities - Quebec, Canada (Liquids)
- 2. Alcrea Health & LiquiFab LiquiFab • Founded in 1995 • Located in Quebec City, Quebec • Began operations as the manufacturing arm of both Aeterna Laboratories and Atrium Innovations Aeterna Laboratories • Biopharmaceutical company • Extensive product portfolio in Oncology, Endocrinology, and Infectious Diseases
- 3. Alcrea Health & LiquiFab LiquiFab Today • Under Alcrea Health umbrella • Utilizes 15+ years of liquid manufacturing experience within the health and nutrition to develop finished nutraceuticals: – Simple vitamin and mineral supplements – Complex fish oil emulsions – Herbal extractions – Energy drinks • Alcrea’s experts in product design, formulation and manufacturing of well-crafted nutritional supplements
- 4. Expertise & Certifications Certifications Formulation • Strict compliance with FDA and NHPD good manufacturing practices (GMPs) • Formulation and manufacturing experts on hand to help create custom liquid supplements • Finished products are tested in accordance with USP/AOAC methods where applicable • Flavor system development • Organic certified by CARTV/ECOCERT • Expertise in absorption, bioavailability, content uniformity, regulatory submission and dosage requirements
- 5. Quality Control & Assurance GMP programs for personnel, plant and grounds, sanitation, equipment, quality operations, production and process controls and warehouse Implementation of internal and external audit programs Supplier Qualification Program (SQP) Regulatory affairs specifications and controls for raw material, packaging and labeling material/product licensing
- 6. Unique Technologies Air Quality Sonification • • HVAC system designed to prevent contamination – • • Main production rooms – – Airlock protection & positive pressure protection to maintain the surroundings • Disintegration of cell structures (LYSIS) by means of ultrasound – Controls the direction of air and the differential pressures between production areas High number of air changes per hour reduces airborne dust and controls air quality Ultrasonic extraction and preservation Used for the extraction of intra-cellular compounds Ultrasound has a potential benefit in the extraction and isolation of novel, potentially bioactive components
- 7. Unique Technologies Purified Water System • The purified water system USP grade is composed of three sections: – Pretreatment – Processing – Purification/distribution • Meets USP specifications for TOC, conductivity and microorganisms • Water is in continuous circulation in the distribution loop with a TOC detector to follow the quality of water, ensuring the most pure water source for our formulations
- 8. Manufacturing Facility Overview • Facility Size: 26,000 Square Feet • Bottling Lines: 3 • Building Type: Pharmaceutical Grade • Air Quality: Differential air pressure H/T controlled • Manufacturing Suites: 4 Capacity • Small batch sizes: Flexible manufacturing for small to large runs • Multi-level conditioning capabilities (from 5ML to tons) • 22,000,000 bottles (60ML) annually • Large pressure filter capacity • Bottling rate of 5,000 bottles per hour • Microfiltration • Mixing: 100,000 kgs per month • Oil filling capacity • Multi-level batch size capabilities (from 50L to 5,000L)
- 9. Production Process • Closed manufacturing suites • Pure water based extraction that meets USP standards • Extraction at any temperature from 4 C - 90 C • Molecular fractionation to purify small to large batches (Ultra filtration) • Inline crushing generating particles size from 1 micron • USP-Grade purified water system
- 10. Production Process • Handling for products and materials of ranging viscosities • Adaptable production lines from low speed test batches to high speed, high volume batches • Clean in place systems – sterilization (Absence of harsh solvents) • Oil filing capacity (Nitrogen flushed, proprietary antioxidant blending) • Paperless tracking bar code technology – from ingredient to finished product
- 11. Production Solutions Delivery Forms • Oil based liquids • Water based liquids • Emulsions • Liquid suspensions • Liquid plant extracts • Frozen products
- 12. Production Solutions Packaging • Glass bottles • Plastic bottles • Straight liquids • Droppers • Sprays • Pumps • Shots • Full-body sleeve labels • Pressure sensitive labels
- 13. Benefits A liquid delivery system has proven to be one of the most effective ways to supply nutrients to the human body. Delivery: Scientifically sound way to deliver many beneficial nutrients in one convenient dose. Compliance: Well formulated supplements with a good taste increase compliance among consumers. Absorption: Available for rapid absorption, as they do not need to be dissolved first like tablets and pills. Bioavailability: Two opportunities for digestive absorption: the stomach and the small intestine.
- 14. Benefits Combinations: Optimization of nutrient quantities and ratios, maximize synergistic nutrient combinations. Purity: Limit the need for fillers, binders, disintegrators and coloring. Alternative: Practical alternatives to pills for infants, toddlers and others who prefer or require liquids. Capsules and tablets may be difficult to chew or swallow. Versatility: Nutrients can be delivered by the spoonful or as drops, or stirred into other liquids and consumed as part of a beverage.
- 15. Production Orders & Volume Price Breaks Liquid Fill Weight Minimum Quantity Price Break 1 Price Break 2 Price Break 3 500 ml and < 1,000 2,500 5,000 10,000 501 ml and > 500 1,000 2,000 5,000 120 ml and < shot 25,000 80,000 125,000 250,000 121 ml and > functional beverage 12,000 20,000 40,000 80,000 Sample fees of $200 will be requested for new formulations.
- 16. For additional questions or to discuss a project, please contact: Jessi Mingo, Manager, Business Development and Marketing jmingo@alcrea-health.com • 412-722-0314