Enviar pesquisa
Carregar
Cme movement
•
0 gostou
•
201 visualizações
Loveis1able Khumpuangdee
Seguir
Educação
Saúde e medicina
Denunciar
Compartilhar
Denunciar
Compartilhar
1 de 5
Baixar agora
Baixar para ler offline
Recomendados
Unilateral spatial neglect ppt
Unilateral spatial neglect ppt
adewumi adeagbo
Pusher Syndrome
Pusher Syndrome
Ade Wijaya
Dystonia and movement disorder
Dystonia and movement disorder
Avinash Chandra
Ailie turton
Ailie turton
COT SSNP
Chorea: Treatment Update
Chorea: Treatment Update
Ade Wijaya
Recovering repressed visual memories and in parietal lobe syndrome using vest...
Recovering repressed visual memories and in parietal lobe syndrome using vest...
webzforu
Rehabilitation of Unilateral Spatial neglect
Rehabilitation of Unilateral Spatial neglect
Phinoj K Abraham
Parkinson’s disease
Parkinson’s disease
Renard Mulla
Recomendados
Unilateral spatial neglect ppt
Unilateral spatial neglect ppt
adewumi adeagbo
Pusher Syndrome
Pusher Syndrome
Ade Wijaya
Dystonia and movement disorder
Dystonia and movement disorder
Avinash Chandra
Ailie turton
Ailie turton
COT SSNP
Chorea: Treatment Update
Chorea: Treatment Update
Ade Wijaya
Recovering repressed visual memories and in parietal lobe syndrome using vest...
Recovering repressed visual memories and in parietal lobe syndrome using vest...
webzforu
Rehabilitation of Unilateral Spatial neglect
Rehabilitation of Unilateral Spatial neglect
Phinoj K Abraham
Parkinson’s disease
Parkinson’s disease
Renard Mulla
Ten step approach to movement disorders
Ten step approach to movement disorders
webzforu
Recent advances in the mangement of extra pyramidal basal ganglia disorders
Recent advances in the mangement of extra pyramidal basal ganglia disorders
webzforu
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
Srinitha Busam
Parkinson’s disease
Parkinson’s disease
Khairul Nizam
04 21 10 houston neurorehab
04 21 10 houston neurorehab
Lezlie Jones
MEDICATION INDUCED MOVEMENT DISORDERS
MEDICATION INDUCED MOVEMENT DISORDERS
Оладапо Олувабукола
Parkinson's Disease by Dr. Aryan
Parkinson's Disease by Dr. Aryan
Dr. Aryan (Anish Dhakal)
parkinsons disease
parkinsons disease
bhavya sree bhavya sree
Presentation1.pptx, radiological imaging of parkinsonism.
Presentation1.pptx, radiological imaging of parkinsonism.
Abdellah Nazeer
Movement disorders
Movement disorders
Shweta Sharma
Dystonia in Children
Dystonia in Children
EashaKiani1
Basal ganglia parkinson's disease
Basal ganglia parkinson's disease
Pratap Tiwari
Pain management in cardiac sx
Pain management in cardiac sx
thanigai arasu
Parkinsons disease and physiotherapy
Parkinsons disease and physiotherapy
Muthuukaruppan
Perera thushara-parkinsons-disease
Perera thushara-parkinsons-disease
kapilvarma bommagani
Neuro parkinsonism
Neuro parkinsonism
Meghana Nadendla
Sleep in the ICU The Next Delirium Frontier?
Sleep in the ICU The Next Delirium Frontier?
hospira2010
Differential diagnosis of parkinson's disease
Differential diagnosis of parkinson's disease
Randy Rosenberg MD FAAN FACP
Parkinson’s disease
Parkinson’s disease
Rohan Deokar
Involuntary movements
Involuntary movements
Vitrag Shah
ventilator1
ventilator1
Loveis1able Khumpuangdee
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Loveis1able Khumpuangdee
Mais conteúdo relacionado
Mais procurados
Ten step approach to movement disorders
Ten step approach to movement disorders
webzforu
Recent advances in the mangement of extra pyramidal basal ganglia disorders
Recent advances in the mangement of extra pyramidal basal ganglia disorders
webzforu
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
Srinitha Busam
Parkinson’s disease
Parkinson’s disease
Khairul Nizam
04 21 10 houston neurorehab
04 21 10 houston neurorehab
Lezlie Jones
MEDICATION INDUCED MOVEMENT DISORDERS
MEDICATION INDUCED MOVEMENT DISORDERS
Оладапо Олувабукола
Parkinson's Disease by Dr. Aryan
Parkinson's Disease by Dr. Aryan
Dr. Aryan (Anish Dhakal)
parkinsons disease
parkinsons disease
bhavya sree bhavya sree
Presentation1.pptx, radiological imaging of parkinsonism.
Presentation1.pptx, radiological imaging of parkinsonism.
Abdellah Nazeer
Movement disorders
Movement disorders
Shweta Sharma
Dystonia in Children
Dystonia in Children
EashaKiani1
Basal ganglia parkinson's disease
Basal ganglia parkinson's disease
Pratap Tiwari
Pain management in cardiac sx
Pain management in cardiac sx
thanigai arasu
Parkinsons disease and physiotherapy
Parkinsons disease and physiotherapy
Muthuukaruppan
Perera thushara-parkinsons-disease
Perera thushara-parkinsons-disease
kapilvarma bommagani
Neuro parkinsonism
Neuro parkinsonism
Meghana Nadendla
Sleep in the ICU The Next Delirium Frontier?
Sleep in the ICU The Next Delirium Frontier?
hospira2010
Differential diagnosis of parkinson's disease
Differential diagnosis of parkinson's disease
Randy Rosenberg MD FAAN FACP
Parkinson’s disease
Parkinson’s disease
Rohan Deokar
Involuntary movements
Involuntary movements
Vitrag Shah
Mais procurados
(20)
Ten step approach to movement disorders
Ten step approach to movement disorders
Recent advances in the mangement of extra pyramidal basal ganglia disorders
Recent advances in the mangement of extra pyramidal basal ganglia disorders
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
PARKINSONS DISEASE MEDICAL TREATMENT AND PHYSIOTHERAPY MANAGEMENT
Parkinson’s disease
Parkinson’s disease
04 21 10 houston neurorehab
04 21 10 houston neurorehab
MEDICATION INDUCED MOVEMENT DISORDERS
MEDICATION INDUCED MOVEMENT DISORDERS
Parkinson's Disease by Dr. Aryan
Parkinson's Disease by Dr. Aryan
parkinsons disease
parkinsons disease
Presentation1.pptx, radiological imaging of parkinsonism.
Presentation1.pptx, radiological imaging of parkinsonism.
Movement disorders
Movement disorders
Dystonia in Children
Dystonia in Children
Basal ganglia parkinson's disease
Basal ganglia parkinson's disease
Pain management in cardiac sx
Pain management in cardiac sx
Parkinsons disease and physiotherapy
Parkinsons disease and physiotherapy
Perera thushara-parkinsons-disease
Perera thushara-parkinsons-disease
Neuro parkinsonism
Neuro parkinsonism
Sleep in the ICU The Next Delirium Frontier?
Sleep in the ICU The Next Delirium Frontier?
Differential diagnosis of parkinson's disease
Differential diagnosis of parkinson's disease
Parkinson’s disease
Parkinson’s disease
Involuntary movements
Involuntary movements
Destaque
ventilator1
ventilator1
Loveis1able Khumpuangdee
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Loveis1able Khumpuangdee
Compre 2010
Compre 2010
Loveis1able Khumpuangdee
Atp3xsum
Atp3xsum
Loveis1able Khumpuangdee
Thai hiv guideline
Thai hiv guideline
Loveis1able Khumpuangdee
Fish tips
Fish tips
Dimitris Tsintzas
Destaque
(6)
ventilator1
ventilator1
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Clinical practice guideline_on_the_management_of_acute_bacterial_rhinosinusit...
Compre 2010
Compre 2010
Atp3xsum
Atp3xsum
Thai hiv guideline
Thai hiv guideline
Fish tips
Fish tips
Semelhante a Cme movement
Movement Disorders (pract).ppt...... .....
Movement Disorders (pract).ppt...... .....
TARUNKUMAR472866
Pediatric movement disorder
Pediatric movement disorder
Vadivelan Kanniappan
JC OROFACIAL DYSKINESIA.pptx
JC OROFACIAL DYSKINESIA.pptx
ShareyaFaizi
practical approach to movement disorders by M.Habeel.pdf
practical approach to movement disorders by M.Habeel.pdf
Mohamed Habeel
Parkinson handbook
Parkinson handbook
Opti Mizam
movement disorder for physiotherapy .pptx
movement disorder for physiotherapy .pptx
Mohamed Rizk Khodair
Issues in brainmapping...Nonspecific EEG patterns
Issues in brainmapping...Nonspecific EEG patterns
Professor Yasser Metwally
Athetosis and dystonia
Athetosis and dystonia
PS Deb
DYSTONIA 2.pptx
DYSTONIA 2.pptx
AakuProductions
Approach to dystonia
Approach to dystonia
NeurologyKota
Akinetic rigid syndrome
Akinetic rigid syndrome
PS Deb
Approach to dystonia by dr srimant pattnaik
Approach to dystonia by dr srimant pattnaik
srimantp
An Update on Tardive Dyskinesia: From Phenomenology to Treatment
An Update on Tardive Dyskinesia: From Phenomenology to Treatment
Lena Setianingsih
Tremor
Tremor
bausher willayat
Movement Disorders
Movement Disorders
Richard Brown
Movement disorder
Movement disorder
Dreams Higher
Parkinson's disease Seminar Presentation
Parkinson's disease Seminar Presentation
pradeepmk8
Parkinsonism.ppt
Parkinsonism.ppt
Shama
Parkinsons disease
Parkinsons disease
Angellavanya1
Parkinson’s disease
Parkinson’s disease
drprashantdubey
Semelhante a Cme movement
(20)
Movement Disorders (pract).ppt...... .....
Movement Disorders (pract).ppt...... .....
Pediatric movement disorder
Pediatric movement disorder
JC OROFACIAL DYSKINESIA.pptx
JC OROFACIAL DYSKINESIA.pptx
practical approach to movement disorders by M.Habeel.pdf
practical approach to movement disorders by M.Habeel.pdf
Parkinson handbook
Parkinson handbook
movement disorder for physiotherapy .pptx
movement disorder for physiotherapy .pptx
Issues in brainmapping...Nonspecific EEG patterns
Issues in brainmapping...Nonspecific EEG patterns
Athetosis and dystonia
Athetosis and dystonia
DYSTONIA 2.pptx
DYSTONIA 2.pptx
Approach to dystonia
Approach to dystonia
Akinetic rigid syndrome
Akinetic rigid syndrome
Approach to dystonia by dr srimant pattnaik
Approach to dystonia by dr srimant pattnaik
An Update on Tardive Dyskinesia: From Phenomenology to Treatment
An Update on Tardive Dyskinesia: From Phenomenology to Treatment
Tremor
Tremor
Movement Disorders
Movement Disorders
Movement disorder
Movement disorder
Parkinson's disease Seminar Presentation
Parkinson's disease Seminar Presentation
Parkinsonism.ppt
Parkinsonism.ppt
Parkinsons disease
Parkinsons disease
Parkinson’s disease
Parkinson’s disease
Mais de Loveis1able Khumpuangdee
Rollup01
Rollup01
Loveis1able Khumpuangdee
Protec
Protec
Loveis1able Khumpuangdee
Factsheet hfm
Factsheet hfm
Loveis1able Khumpuangdee
Factsheet
Factsheet
Loveis1able Khumpuangdee
Eidnotebook54
Eidnotebook54
Loveis1able Khumpuangdee
Data l3 148
Data l3 148
Loveis1able Khumpuangdee
Data l3 147
Data l3 147
Loveis1able Khumpuangdee
Data l3 127
Data l3 127
Loveis1able Khumpuangdee
Data l3 126
Data l3 126
Loveis1able Khumpuangdee
Data l3 113
Data l3 113
Loveis1able Khumpuangdee
Data l3 112
Data l3 112
Loveis1able Khumpuangdee
Data l3 92
Data l3 92
Loveis1able Khumpuangdee
Data l3 89
Data l3 89
Loveis1able Khumpuangdee
Data l2 80
Data l2 80
Loveis1able Khumpuangdee
Hfm reccomment10072555
Hfm reccomment10072555
Loveis1able Khumpuangdee
Hfm work2550
Hfm work2550
Loveis1able Khumpuangdee
Factsheet hfm
Factsheet hfm
Loveis1able Khumpuangdee
Publichealth
Publichealth
Loveis1able Khumpuangdee
แนวทางการดาเน ํ นงานป ิ องก ้ นควบค ั มการระบาดของโรคม ุ ือ เท้า ปาก สําหรบแพ...
แนวทางการดาเน ํ นงานป ิ องก ้ นควบค ั มการระบาดของโรคม ุ ือ เท้า ปาก สําหรบแพ...
Loveis1able Khumpuangdee
hand foot mouth
hand foot mouth
Loveis1able Khumpuangdee
Mais de Loveis1able Khumpuangdee
(20)
Rollup01
Rollup01
Protec
Protec
Factsheet hfm
Factsheet hfm
Factsheet
Factsheet
Eidnotebook54
Eidnotebook54
Data l3 148
Data l3 148
Data l3 147
Data l3 147
Data l3 127
Data l3 127
Data l3 126
Data l3 126
Data l3 113
Data l3 113
Data l3 112
Data l3 112
Data l3 92
Data l3 92
Data l3 89
Data l3 89
Data l2 80
Data l2 80
Hfm reccomment10072555
Hfm reccomment10072555
Hfm work2550
Hfm work2550
Factsheet hfm
Factsheet hfm
Publichealth
Publichealth
แนวทางการดาเน ํ นงานป ิ องก ้ นควบค ั มการระบาดของโรคม ุ ือ เท้า ปาก สําหรบแพ...
แนวทางการดาเน ํ นงานป ิ องก ้ นควบค ั มการระบาดของโรคม ุ ือ เท้า ปาก สําหรบแพ...
hand foot mouth
hand foot mouth
Último
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory Inspection
SafetyChain Software
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdf
chloefrazer622
1029-Danh muc Sach Giao Khoa khoi 6.pdf
1029-Danh muc Sach Giao Khoa khoi 6.pdf
QucHHunhnh
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)
eniolaolutunde
A Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy Reform
Chameera Dedduwage
Student login on Anyboli platform.helpin
Student login on Anyboli platform.helpin
RaunakKeshri1
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and Mode
Thiyagu K
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
RAM LAL ANAND COLLEGE, DELHI UNIVERSITY.
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
Marc Dusseiller Dusjagr
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
EduSkills OECD
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Education
pboyjonauth
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
National Information Standards Organization (NISO)
How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptx
manuelaromero2013
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
VS Mahajan Coaching Centre
Advanced Views - Calendar View in Odoo 17
Advanced Views - Calendar View in Odoo 17
Celine George
Staff of Color (SOC) Retention Efforts DDSD
Staff of Color (SOC) Retention Efforts DDSD
David Douglas School District
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
RoyAbrique
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
Sarwono Sutikno, Dr.Eng.,CISA,CISSP,CISM,CSX-F
Código Creativo y Arte de Software | Unidad 1
Código Creativo y Arte de Software | Unidad 1
Maestría en Comunicación Digital Interactiva - UNR
Z Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot Graph
Thiyagu K
Último
(20)
Mastering the Unannounced Regulatory Inspection
Mastering the Unannounced Regulatory Inspection
Arihant handbook biology for class 11 .pdf
Arihant handbook biology for class 11 .pdf
1029-Danh muc Sach Giao Khoa khoi 6.pdf
1029-Danh muc Sach Giao Khoa khoi 6.pdf
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)
A Critique of the Proposed National Education Policy Reform
A Critique of the Proposed National Education Policy Reform
Student login on Anyboli platform.helpin
Student login on Anyboli platform.helpin
Measures of Central Tendency: Mean, Median and Mode
Measures of Central Tendency: Mean, Median and Mode
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
INDIA QUIZ 2024 RLAC DELHI UNIVERSITY.pptx
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Presentation by Andreas Schleicher Tackling the School Absenteeism Crisis 30 ...
Introduction to ArtificiaI Intelligence in Higher Education
Introduction to ArtificiaI Intelligence in Higher Education
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
Mattingly "AI & Prompt Design: Structured Data, Assistants, & RAG"
How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Advanced Views - Calendar View in Odoo 17
Advanced Views - Calendar View in Odoo 17
Staff of Color (SOC) Retention Efforts DDSD
Staff of Color (SOC) Retention Efforts DDSD
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
Contemporary philippine arts from the regions_PPT_Module_12 [Autosaved] (1).pptx
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
Código Creativo y Arte de Software | Unidad 1
Código Creativo y Arte de Software | Unidad 1
Z Score,T Score, Percential Rank and Box Plot Graph
Z Score,T Score, Percential Rank and Box Plot Graph
Cme movement
1.
PAPER
J R Coll Physicians Edinb 2006; 36:331–335 © 2006 Royal College of Physicians of Edinburgh Movement disorders: a brief practical approach to diagnosis and management DJ Burn Professor on Movement Disorders, Newcastle University, Newcastle upon Tyne, England ABSTRACT The characteristic feature of all movement disorders is an abnormality of Published online June 2006 the form and velocity of movements of the body. The term ‘movement disorder’ has become synonymous with basal ganglia disease and extrapyramidal features. Although Correspondence to DJ Burn, many movement disorders do arise from pathology within the basal ganglia, disorders Department of Neurology, Regional such as myoclonus may also arise from other structures. Abnormality of movement Neurosciences Centre, Newcastle General Hospital, Westgate Road, may be the only manifestation of a disease process, or may be part of a more Newcastle upon Tyne, NE4 6BE widespread neurological disorder. It is important not to divorce the disorder of movement from general medical problems, since these may be directly or indirectly tel. +44 (0)191 256 3425 related (for example, chorea in systemic lupus erythematosus; DIP caused by amiodarone). Basal ganglia disease is commonly associated with neuropsychiatric fax. +44 (0)191 256 3534 symptoms and these may have a greater impact upon the patient and their family than the movement disorder itself. e-mail D.J.Burn@newcastle.ac.uk An essential first step in the approach to the patient with a movement disorder is to correctly determine the phenomenology of the problem (for example, is the dominant problem chorea or dystonia?). Once this first step has been made, appropriately targeted investigations may then be required to determine the diagnosis. Thereafter, consideration is given to treatment, based upon clinical and social factors, as well as patient preference. This overview will describe a practical approach to the patient with a movement disorder. It will also briefly consider CME some broad principles in the investigation and management of such cases. KEYWORDS Chorea, dystonia, examination, movement disorder, parkinsonism, tremor LIST OF ABBREVIATIONS Dopamine receptor blocking agent (DRBA), drug- induced parkinsonism (DIP), magnetic resonance imaging (MRI), mini-mental state examination (MMSE), multiple system atrophy (MSA), Parkinson’s disease (PD), progressive supranuclear palsy (PSP), rapid eye movement (REM), restless legs syndrome (RLS), single-photon emission computed tomography (SPECT) DECLARATION OF INTERESTS No conflict of interests declared. CLASSIFICATION AND DEFINITIONS studies for inter-rater reliability of specific classes of movement disorders, so the final classification remains The key to success in diagnosing and managing a patient somewhat subjective. presenting with a disorder of movement is to establish the phenomenology of the problem. Although the broad FEATURES OF CLINICAL HISTORY AND definition of patients into those who move too much EXAMINATION (hyperkinetic disorder) or too little (hypokinetic or akinetic-rigid disorder) is relatively straightforward, The value of a careful history and examination can differentiating jerky dystonia from tremor, or tics from never be over stated when approaching a patient with a chorea or myoclonus, for example, may not be a simple movement disorder, even if the diagnosis may seem task to the inexperienced physician. To make matters obvious from the outset. Age of onset is often helpful more complicated, the movement disorder may in terms of broad classification. Thus, complex tic sometimes be ‘mixed’ (for example, myoclonic dystonia disorder (Tourette’s syndrome) typically begins in the or dystonic tremor). Definitions of commonly first decade and is seven times more common in boys. encountered movement disorders are listed in Table 1. Generalised dystonia is also more likely to commence Athetosis (a writhing, sinuous distal limb movement) is a in the first two decades, while focal dystonias classically term gradually falling out of use; such movements can be present in later life. Older age is the greatest risk factor more economically classified as dystonic or choreo- for PD, although young onset cases (defined as less than dystonic. An exception is ‘athetoid cerebral palsy’, which 40 years of age) are well recognised and are more likely remains in common use. There have been no good to have a genetic basis. 331
2.
DJ Burn
TABLE 1 Definition of commonly encountered movement haloperidol, prochlorperazine) but can persist for years disorders. thereafter. A complete list of medications previously Movement disorder Definition taken by the patient should be obtained from the general practitioner, if necessary. Dopamine receptor blocking Parkinsonism A clinical syndrome with bradykinesia agents may also cause a range of other movement (slow movement) as the defining disorders, including parkinsonism and dystonia. feature, almost always accompanied Approximately 80% of DIP will resolve within eight weeks by rigidity, and often by tremor. of discontinuing the offending agent, although recovery Dyskinesia May be applied to any involuntary times of up to 18 months have been reported. Drug- movement, although commonly used induced parkinsonism may be impossible to differentiate to refer to drug-induced chorea and from PD, although it tends to be more symmetric, and is dystonia. more common in older women. While DRBAs are well Tremor A rhythmical, involuntary oscillatory known to cause parkinsonism, a link with agents like movement of a body part; subdivided sodium valproate, amiodarone, and cinnarizine is less well into whether the problem occurs at recognised; if in doubt, it is worth checking with the rest, with posture, on action, or with hospital drug information service. intention. Chorea A quick, irregular, semi-purposive, Analysis of the following characteristics (adapted from and predominantly distal involuntary reference 4) may assist in making the diagnosis: movement (patient may look restless or ‘fidgety’). 1 Specific distribution For example, RLS (although this is now known as restless limb syndrome since Dystonia An abnormal movement symptoms may also be reported in the upper limbs) characterised by sustained muscle contraction, frequently causing and ‘painful legs and moving toes’. Parkinson’s twisting and repetitive movements or disease is typically asymmetric in onset. abnormal postures. Blepharospasm (involuntary, prolonged eye closure) affects both eyes whereas hemifacial spasm only CME Ballism A proximal, high-amplitude affects one side of the face. movement, often violent and flinging 2 Specific actions and relationship to voluntary movement in nature; usually unilateral and may resolve through a choreic phase. For example, a task-specific tremor or dystonia. Asking the patient to write or pick up a glass of water Tic An abrupt, jerky non-rhythmic may be very revealing. movement (motor tic) or sound 3 Speed of the movement (vocal tic) that is temporarily Slow Intermediate Fast suppressible by will power; tics may be simple or complex. Parkinsonism, chorea, tremor myoclonus, tics dystonia, and Stereotypy Purposeless voluntary movements dystonic tics carried out in a uniform fashion at the expense of other activity (e.g. 4 Rhythm Continuous (e.g. tremor) or intermittent (e.g. hand wringing, clapping, mouthing). asterixis (‘negative myoclonus’)). 5 Relation to posture For example, orthostatic tremor A video recording, made by the patient’s family, may be (presents as unsteadiness when standing still, but helpful in the case of a paroxysmal movement disorder. If suppressed by walking). this is not volunteered, it is a good idea to ask for one, 6 Relation to sleep Few movement disorders persist particularly when the examination is negative. If no during sleep; examples that do, include palatal tremor problem is apparent after a ‘routine’ neurological and segmental myoclonus. examination, consider whether the complaint may be task 7 Associated sensory symptoms Restless limb syndrome is specific (e.g. certain forms of dystonia, primary writing integrally associated with pain or discomfort; tics may tremor). This could be the perfect excuse to get the golf be associated with a vague discomfort or abnormal clubs out in clinic (the ‘yips’ as a focal dystonia when sensation in the prodrome before the movement. attempting to putt the ball) or even the darts (‘dartitis’ in 8 Suppressibility Volitional in tics (although associated darts players who have difficulty in releasing the dart). with increasing unease and rebound worsening upon release), by sensory ‘tricks’ in dystonia (such as a light Always consider drugs, both past and present, as a touch upon the opposite side of the face to suppress potential cause for the movement disorder. Tardive a spasmodic torticollis). dyskinesias (commonly stereotypic movements, often 9 Aggravating or precipitating factors Stress and anxiety orofacial in distribution) may develop after a relatively have no discriminatory value as they may worsen all short exposure to a DRBA (e.g. chlorpromazine, movement disorders. Myoclonus may be triggered by 332 J R Coll Physicians Edinb 2006; 36:331–335 © 2006 RCPE
3.
Movement disorders TABLE 2
Points to remember in the history and examination. History Time course/functional disability/effect upon quality of life. Past medical history, including infections (e.g. rheumatic fever) and toxin exposure. Drug history – current, previous, and recreational (may need to contact family doctor). Alcohol responsiveness. Family history (draw out pedigree if necessary). Neuropsychiatric features (with carer to inform/corroborate). Autonomic symptoms (may be prominent and early in MSA, a degenerative form of parkinsonism). Sleep problems (REM sleep behaviour disorder – screaming, combative outbursts later in a night’s sleep – may occur early in PD, MSA, and dementia with Lewy bodies). Examination Observe casually during history: • Any involuntary movements and their distribution; • Utterances and vocalisations (Tourette’s syndrome?); • Blink frequency (reduced in parkinsonism, profoundly so in PSP, increased in blepharospasm); • Excessive sighing (suggestive of atypical parkinsonism like MSA and PSP). Cognitive assessment (subcorticofrontal vs cortical problems) – MMSE often insensitive to the former; consider supplementing with verbal fluency task, e.g. number of words beginning with letter ‘C’ in a minute. Cardiovascular – lying and standing blood pressures, cool dusky blue periphery (MSA?). Gait (stance width, stride length, turning, dystonic posturing of limbs, arm swing), postural reflexes (pull test, standing behind patient) and axial tone (turn patient from side to side in vertical axis using shoulders). Eye movements (especially speed of fast eye movements and range). CME Limb examination (including specimen of writing and observe hand posture). Tremors/dystonic posturing. Tone – use reinforcement if necessary. Power and co-ordination. Fine finger and rapid alternating movements. Reflexes/plantars (areflexia in neuropathic tremor). specific stimuli such as sudden, loud noise or touch. depression, which may be the major determinant of Carbohydrate-heavy meals and fatigue may quality of life, while up to 80% of people with PD may precipitate certain forms of paroxysmal dystonia, eventually develop dementia. Tourette’s syndrome may while sudden movement may induce paroxysmal be associated with attention deficit hyperactivity kinesogenic dsytonia. disorder and obsessive-compulsive disorder. 10 Ameliorating factors Alcohol may dramatically Huntington’s disease may be complicated by anxiety improve essential tremor and myoclonic dystonia. and panic attacks, depression, and schizophreniform Running or walking backwards may improve a psychosis, and is associated with an increased risk of dystonic gait, leading the unwary to suspect a non- suicide, in addition to the well-known association with organic cause. dementia. Rapid eye movement sleep behaviour 11 Distractibility and inconsistency Both are suggestive of a disorder may predate the onset of PD, multiple system non-organic (functional) cause, but note the caveat in atrophy, and dementia with Lewy bodies. It may lead to point 10 above. violent motor outbursts during sleep and self-injurious behaviour (as the person flings themselves out of bed Table 2 summarises a number of points to remember while asleep) or injury to the bed partner, yet is readily in the history-taking and examination of the patient treated by low-dose clonazepam. Sleep fragmentation with a movement disorder. The need to include brief is common in PD and is multifactorial in aetiology assessments of neuropsychiatric and sleep status (causes include nocturia, depression, and discomfort should be emphasised. Parkinson’s disease may be due to under-dosing). Many of these causes are accompanied in 20–30% of cases by significant amenable to treatment. J R Coll Physicians Edinb 2006; 36:331–335 © 2006 RCPE 333
4.
DJ Burn
INVESTIGATIONS MANAGEMENT CONSIDERATIONS An increasing range of blood and cerebrospinal fluid Try to remember the following general principles in clinic: analyses, genetics tests, electrophysiological, structural, and functional imaging studies are available to supplement 1 Treat disability or poor quality of life, not recorded clinical acumen. Occasionally, tissue biopsy (for example, impairments. Thus, one patient with PD may tolerate skin, gut, or bone marrow) may even be necessary. It goes moderate to severe tremor, rigidity and/or without saying that establishing the correct bradykinesia and not wish to be treated, while another phenomenology of the patient’s movement disorder is an case could request treatment with much less severe essential first step before embarking upon more complex motor impairment; (and often costly) investigations. Many movement 2 Remove potentially exacerbating/causative drugs disorders are diagnosed clinically and investigations may whenever possible; play only a supportive or exclusionary role. Thus, patients 3 Always consider underlying (masked) depression with typical PD do not require MRI brain scanning. when there appears to be a mismatch between Magnetic resonance imaging scanning may, however, be impairment and reported disability; helpful for patients with ‘atypical parkinsonism’ or a sub- 4 Patients do not always volunteer neuropsychiatric optimal response to treatment. A few general themes features like visual hallucinations or hypersexuality may be summarised: (which may be induced by dopaminergic drugs). Don’t be afraid to ask; 1 Never overlook the value of ‘routine’ blood tests: 5 Members of a multidisciplinary team generally prefer renal, hepatic, and thyroid function tests may yield early referral; useful information as to the cause of tremor or 6 Never forget the need for genetic counselling and the myoclonus, for example; potential implications for other family members; 2 Have a low threshold to perform a serum 7 If a psychogenic movement disorder is suspected, the caeruloplasmin level in the young or middle-aged patient may best be managed by formal admission and person with a movement disorder: Wilson’s disease a staged, multidisciplinary approach; and may present in protean ways and is eminently treatable. 8 Don’t be frightened to admit to the patient that you’re CME At a cut-off of 0·2 g/l, serum caeruloplasmin is a cheap not sure about the diagnosis. Differentiating tremor- and simple test (although not very sensitive, as 5–20% dominant PD from essential tremor, or typical from of homozygous carriers will have normal results); atypical parkinsonism, for example, can be very 3 Phenocopies of PD may result from diverse genetic difficult. The main thing is not to ‘pigeon-hole’ the case causes, including certain spinocerebellar ataxias and too early on, at the risk of having to back-track at a juvenile-onset Huntington’s disease; later date. Invariably, time will tell. 4 Remember, structural imaging is of limited sensitivity in the diagnosis of most movement disorders. Few, if KEYPOINTS any, prospective studies have examined the positive predictive value of modalities such as MRI scanning in • Establishing the phenomenology of a movement patients presenting with early ‘unclassifiable disorder is essential in the diagnostic pathway. parkinsonism’; and • Do not forget to take a full family history, 5 Always remember the limitations of a test, to avoid particularly in a young onset case, or one with over-interpretation of the result. An example is 123I- clinically atypical features. ioflupane SPECT, also known as DaTSCAN. This tool • Dopamine receptor blocking drugs may cause any is helpful in discriminating essential tremor, DIP, or movement disorder and their adverse effects may psychogenic parkinsonism (when the scan is normal) persist after the offending agent has been discontinued. from PD (when the scan is abnormal). DaTSCAN • Many movement disorders are diagnosed clinically and cannot, however, differentiate typical from atypical investigations may play only a supportive or parkinsonism (that is, separating PD from conditions exclusionary role. such as MSA and PSP). It may also occasionally be • Neuropsychiatric and cognitive problems are normal in early tremor-dominant PD. The same point common in movement disorders and may be can be made in the context of caeruloplasmin dominant in determining the patient’s (and carer’s) ‘screening’ for Wilson’s disease. Given the false- quality of life. negative rate, if a high clinical index of suspicion exists, further investigations, including a 24-hour urinary copper excretion and ophthalmological assessment for Kayser-Fleischer rings, should be performed. 334 J R Coll Physicians Edinb 2006; 36:331–335 © 2006 RCPE
5.
Movement disorders REFERENCES
3 Kishore A, Calne DB. Approach to the patient with a movement disorder and overview of movement disorders. In: Watts RL, 1 Barker RA. Disorders of movement excluding Parkinson’s Koller WC (editors). Movement Disorders: Neurologic Principles and disease. In:Warrell DA, Cox TM, Firth JD, Benz EJ (editors). Oxford Practice. New York: McGraw Hill; 2004. Textbook of Medicine. Oxford: Oxford University Press; 2005; 3. 4 Lees AJ. Odd and unusual movement disorders. J Neurol 2 Gasser T, Bressman S, Durr A, Higgins J, Klockgether T, Myers RH. Neurosurg Psychiatry 2002; 72(Suppl 1):I17–I21. State of the art review: molecular diagnosis of inherited 5 Quinn NP. Parkinson’s disease: clinical features. In: Quinn NP movement disorders. Movement Disorders Society task force on (editor). Parkinsonism. London: Balliere Tindall; 1997; 6:1:1–13. molecular diagnosis. Mov Disord 2003; 18(1):3–18. A BOOK YOU SHOULD READ serious depletion of irreplaceable underground aquifers, and When the rivers run dry desalination/reverse osmosis plants have proved expensive. F Pearce ISBN 1903919576 The future, however, is not Eden Project Books,Transworld 2006 hopeless, though salvation means £18.99 facing human desperation, selfishness, greed, special interests, The threat of global warming to and nationalism. Engineers and human life on our planet is hydrologists can now manage changing our world view. rivers better, the loss of a third to CME Politicians vie with one another a half of water supply by leakage over their green credentials in could be stopped, rainwater could relation to global warming, but be conserved, more sewage could much less is heard about world be recycled, agriculture could water problems. Fred Pearce has avoid growing high-water-demand written about the environment for crops in water-short areas and some 15 years, and in this book he could develop fewer water- explores our mistaken, profligate, demanding crops and systems for and often irresponsible, use of Rivers have been dammed and better water use. water and its consequences, and their water removed by canals so points to some ways of avoiding that silt distribution has been Pearce tells a fascinating story future disasters. impaired, down-river land well, and I believe doctors will damaged by excess salt, and want to know more about World demand for water exceeds outflow to the sea grossly something so central to future supply from the world’s rivers; a reduced. Drainage of related human health. billion people have no access to a wetlands has reduced the safe and reliable water source; effectiveness of dams in preventing Niall Finlayson, two-thirds of water consumed by flooding. Inexpensive drilling and Director of Communications, RCPE humans goes for agriculture. pumping equipment has led to J R Coll Physicians Edinb 2006; 36:331–335 © 2006 RCPE 335
Baixar agora