2. Contents
Infertility
◦ Assisted Reproduction Technology (ART)
In Vitro Fertilization
Intracytoplasmic sperm injection (ICSI)
Ovary transfer
Developmental cancer therapy
Gene therapy
Stem cells and therapeutic cloning
3. Infertility
•
•
Inability to achieve or sustain pregnancy.
Not a disease.
•
80% by 1.5 years, beyond 2 years.
•
Failure of ovulation, physical blockage,
sperm defects.
4. In Vitro Fertilization
Assisted reproductive technology (ART).
Four steps
◦
◦
◦
◦
Ovarian stimulation
Eggs retrieval, aspiration
Fertilization, sperm collection and “washing”.
Embryo transfer.
11. Angiogenesis Inhibition
Angiogenesis inhibitors are drugs that prevent
angiogenesis and hence prevent vascularization
from occurring.
Natural and synthetic inhibitors of angiogenesis
have been characterized by several groups.
Some angiogenesis inhibitors have been FDA
approved for humans
12. Gene Therapy
The insertion of normal or genetically altered genes into
cells usually to replace defective genes especially in the
treatment of genetic disorders.
Somatic cell gene therapy
◦ (e.g. through blood or liver stem cells)
Germ line gene therapy
◦ by modifying a germ cell or fertilized egg and transferring to
next generation.
◦ by modifying embryonic stem cells and making a body )
13. Stem Cell - Medicine
The human stem cells can be used to
produce new cells or organs
(neurons, blood cells, pancreas etc.) for
people with diseases or failing organs.