1. Lymph Node
Prof. Dr. Yehia El Alfy

2. Patterns of reactive hyperplasia

3. Benign reactive lymph node

4. Reactive follicular hyperplasia

5. TUMORS OF LYMPH NODES
1- Primary tumors
 Lymphoma:
Malignancy of lymphocytes. (within lymph nodes
or extranodal tissues) , including:
a. Hodgkin’s lymphoma (HL), with important clinical &
histological distinction
b. Non-Hodgkin’s lymphoma (NHLs), comprising
all forms besides HL
 Leukemias: usually exhibit widespread involvement of bone
marrow, accompanied by large numbers of circulating tumor
cells
2- Secondary tumors or metastasis: More
frequent than the primary group and occur in the L.N.s
draining cancer. The nodes become enlarged, firm and fixed.
The cut surface is grayish-white

6. Burkitt‘s Lymphoma

7. Lymphoma, Lymph node

8. Splenomegaly
Spleen

10. (Non-Hodgkin’s Lymphoma (NHL
Malignant neoplasms characterized by proliferation of the cells originating from
lymphoid tissue (lymphocytes, histiocytes and their precursors and
derivatives) .
Classification of NHL
- Based on the clinical behaviour and prognosis:
1- Low-grade NHL:
Small lymphocytic * Follicular small cell
2- Intermediate-grade NHL:
Follicular large cell * Diffuse small cell
3- High-grade NHL:
Immunoblastic * Lymphoblastic * Burkitt’s lymphoma
4- Miscellaneous: Histiocytic lymphoma, Mycosis fungoides ..etc.

11. Follicular lymphoma
 1- Section of lymph node.
 2- Complete loss of normal lymph node
architecture and
 Effaced by follicles formed of monotonous
malignant lymphocytes with deeply staining
pleomorphic hyperchromatic nuclei and thin rim
of cytoplasm.

12. Follicular lymphoma

13. Follicular lymphoma

14. Follicular lymphoma

15. Diffuse Non Hodgkin’s lymphoma
 1- Section of lymph node.
 2- Complete loss of normal lymph node
architecture and
 Effaced by diffuse monotonous malignant
lymphocytes with deeply staining
pleomorphic hyperchromatic nuclei and
thin rim of cytoplasm.

16. Diffuse NHL

17. Diffuse NHL

18. Diffuse NHL

19. Diffuse NHL

20. Lymphoma

21. Metastasis of lymph node
 1- Section of lymph node.
 2- Lymph node tissue is partially or
totally replaced by masses or
sheets or irregular glandular
structures, of pleomorphic
hyperchromatic malignant cells
separated by fibrous tissue stroma

23. R espect for self,
Respect for others and
Responsibility for all
.your actions